• VITRO
  • 1 2 To investigate their pathophysiological significance, we have evaluated the effect of SLE sera on megakaryocytic colony formation in vitro. (bmj.com)
  • elisa kit
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • Immunology
  • The antibody formation theory gave Jerne international recognition and in 1956 Jerne went to work for the World Health Organization in Geneva, where he served as the Head of the Sections of Biological Standards and of Immunology. (wikipedia.org)
  • Alfred Nisonoff (1923-2001) was a 20th-century chemist who helped to experimentally determine the molecular structure of the antibody, and, as a result, made major contributions to the field of immunology. (wikipedia.org)
  • These newly formed antibodies would arrive too late in an acute infection, however, so what we think of as "immunology" constitutes only the second half of the process. (wikipedia.org)
  • tetanus
  • 1888 - Identification of bacterial toxins (diphtheria bacillus) (Pierre Roux and Alexandre Yersin) 1888 - Bactericidal action of blood (George Nuttall) 1890 - Demonstration of antibody activity against diphtheria and tetanus toxins. (wikipedia.org)
  • Infections
  • People with this deficiency lack immunoglobulin A (IgA), a type of antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract. (wikipedia.org)
  • mice
  • Formation of reaginic antibodies in mice has been demonstrated by numerous investigators (1-4). (jimmunol.org)
  • Nude mice (nu/nu) were shown to respond poorly to sheep erythrocytes in respect to formation of IgM and IgG antibodies (6-8). (jimmunol.org)
  • Delayed-type hypersensitivity (DTH) appears in mice immunized with less than an optimal immunogenic dose of sheep red blood cells (SRBC), but is blocked progressively as antibody production increases in response to larger doses of SRBC. (rupress.org)
  • When the mAb158 antibody was administered for 4 months to plaque-bearing transgenic mice with both the Arctic and Swedish mutations (tg-ArcSwe), Abeta protofibril levels were lowered while measures of insoluble Abeta were unaffected. (diva-portal.org)
  • Treatment of young tg-ArcSwe mice with an Aβ protofibril-selective antibody, mAb158, cleared protofibrils, prevented amyloid plaque deposition and protected cultured cells from protofibril-mediated toxicity. (diva-portal.org)
  • cells
  • Askonas focused on B cells and determined their role in producing antibodies as part of the immune response. (wikipedia.org)
  • From 1955-59 she studied the sites of antibody formation using radioactivity to develop our understanding of antibody molecules and the cells of the immune system. (wikipedia.org)
  • Immune-system components (e.g. complement) are bound to the antibodies and kept near, in reserve to disable them via phagocytosis by scavenger cells (e.g. macrophages). (wikipedia.org)
  • When they absorb the mother's antibodies against their blood type it causes lysis of the red blood cells leading to anemia. (wikipedia.org)
  • Neonatal isoerythrolysis occurs if a foal is born with a blood group that is different from its dam, and then receives antibodies against those red blood cells (alloantibodies) through the mare's colostrum, leading to the lysis of the foal's red blood cells. (wikipedia.org)
  • After ingestion, these antibodies coat the red blood cells of the foal, leading to lysis through the complement system or removal by the mononuclear phagocyte system, and causing subsequent anemia. (wikipedia.org)
  • production
  • Because of the delay in production of antibody, this first foal is not at risk for isoerythrolysis since the mare will not have circulating antibodies until after colostrum production has ceased, meaning this foal will never have a chance for exposure. (wikipedia.org)
  • sera
  • A total of 35 randomly selected SLE sera were initially screened for the presence of antiplatelet antibodies (APAs), using a commercially available assay (PAK12, GTI Diagnostics, Wauksesha, Wisconsin, USA). (bmj.com)
  • Sera is drawn from participants for neutralizing antibody determination. (clinicaltrials.gov)
  • form
  • Endotoxin from Salmonella typhosa caused the monocytes to form antibody as if they had been taken from hyperimmunized rabbits. (rupress.org)
  • The condition is most commonly seen in kitten with type-A blood born to mothers with type-B blood since type-B cats form very strong anti-type A antibodies. (wikipedia.org)
  • research
  • This network of antibodies has been exploited in research into treatments for autoimmune diseases and cancers, and into the prevention of transplant rejection. (animalresearch.info)
  • From 1943 to 1956 Jerne was a research worker at the Danish National Serum Institute and during this time he formulated a theory on antibody formation. (wikipedia.org)
  • This type of analytical and creative thinking would prove to be useful in his future research on the structure of the antibody. (wikipedia.org)
  • time
  • Because this exposure occurs well before the foal receives colostrum, the mare will have circulating antibodies at the time of parturition and therefore the foal is at risk of developing NI. (wikipedia.org)
  • Certain
  • Of note, selective IgA deficiency can complicate the diagnosis of one such condition, celiac disease, as the deficiency masks the high levels of certain IgA antibodies usually seen in celiac disease. (wikipedia.org)
  • better
  • Antibody 14D9, which catalyzes the stereoselective transformation of achiral enol ethers into the corresponding ( S )-ketals, resolves a racemic mixture of structurally similar chiral enol ethers by selective conversion of the ( R )-enol ether into the ( R )-ketal, raising the possibility that the ( S ) transition state is preferencially stabilized by the antibody despite a better binding of the ( R ) intermediate. (rsc.org)
  • Studies
  • Previous studies demonstrated that combination thiopurine-Infliximab (IFX) therapy reduced the appearance of anti-drug antibodies (ADA) compared with IFX monotherapy. (ecco-ibd.eu)
  • Studies of mechanisms of antibody formation. (jax.org)
  • 1912: (with G.Y. Rusk) Studies in the Locus of Antibody Formation, Fifteenth International Congress on Hygiene and Demography, link from Biodiversity Heritage Library. (wikipedia.org)
  • type
  • It occurs when the mother has antibodies against the blood type of the newborn. (wikipedia.org)
  • If there is a blood-type mismatch, the kittens should not be allowed to nurse for 72 hours from the mother to prevent the passage of antibodies in the colostrum. (wikipedia.org)
  • human
  • For this reason it is proposed that a challenge trial in the rhesus macaque SHIV model be performed, in which the role of such antibodies, which are derived from non-infected human vaccinees, will be evaluated. (clinicaltrials.gov)