• serum
  • Indirect immunofluorescence using commercial HEp-2 cells with human serum and human-affinity-purified anti-Jo-1 antibodies was performed using confocal microscopy. (semanticscholar.org)
  • The presence of antibodies against extractable nuclear antigens in serum: a comparison of immunoblotting versus radial immunodiffusion. (semanticscholar.org)
  • The ENAs consist of ribonucleoproteins and non-histone proteins, named by either the name of the donor who provided the prototype serum (Sm, Ro, La, Jo), or the name of the disease setting in which the antibodies were found (SS-A, SS-B, Scl-70). (wikipedia.org)
  • It is sometimes said to be the same as undifferentiated connective tissue disease, but other experts specifically reject this idea because undifferentiated connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP, and MCTD is associated with a more clearly defined set of signs/symptoms. (wikipedia.org)
  • inflammatory
  • Diagnostic criteria require one or more antisynthetase antibodies (which target tRNA synthetase enzymes), and one or more of the following three clinical features: interstitial lung disease, inflammatory myopathy, and inflammatory polyarthritis affecting small joints symmetrically. (wikipedia.org)
  • Bowel dysfunction Back pain Erectile problems Psoriasis Individuals with TSP may also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung tissues), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). (wikipedia.org)
  • Rheumatology
  • Reveille, J. D., Solomon, D. H. and The American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines (2003), Evidence-based guidelines for the use of immunologic tests: Anticentromere, Scl-70, and nucleolar antibodies. (wiley.com)
  • In two medical centres for rheumatology and one for pulmonology, all patients with suspected connective tissue disease were screened over a 5-year period for anti-Jo-1 antibodies by ELISA. (springer.com)
  • Diagnosis
  • In the presence of suspicious symptoms a number of test are helpful in the diagnosis: Muscle enzymes are often elevated, i.e. creatine kinase Anti-Jo-1 antibody testing Electromyography Muscle biopsy Pulmonary function testing Lung biopsy In certain situations, testing of other antibodies, specific imaging (MRI, thoracic high resolution computed tomography), and swallowing evaluation may be needed. (wikipedia.org)
  • Diagnosis depends on which diseases the patient shows symptoms and has positive antibodies for in their lab serology. (wikipedia.org)
  • autoimmunity
  • The increasing importance of autoimmunity based diseases attracts the interest of pathologists, for whom the wide acceptance of indirect fluorescent antibody (IFA) technique at autoantibody screening is relevant diagnostic approach. (ke-i.org)
  • They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. (wikipedia.org)
  • inflammation
  • It usually shows perimysium inflammation i.e. inflammation of the outermost layer of the muscle as opposed to endomysium inflammation i.e. inflammation of the innermost layer of the muscle, as is seen in the case of polymyositis. (medindia.net)
  • immune system
  • Antibodies are proteins made by your immune system . (healthline.com)
  • Antibodies normally target harmful substances, such as bacteria and viruses, by activating the immune system to get rid of them. (healthline.com)
  • In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). (wikipedia.org)
  • They are characterized as a group by the presence of spontaneous overactivity of the immune system that results in the production of extra antibodies into the circulation. (wikipedia.org)
  • proteins
  • Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. (wikipedia.org)
  • These cells coordinate an immune response upon the detection of foreign proteins (antigens), producing antibodies that bind to these antigens. (wikipedia.org)
  • weakness
  • In polymyositis, progressive weakness occurs in the proximal muscles, i.e. the muscles in upper arm, thigh, neck and other such muscles that are closer to the trunk. (medindia.net)
  • detection
  • As result of this, the IFA technique dominates not only in the detection of anti-nuclear antibodies (ANA) and of anti-neutrophil cytoplasmic antibodies (ANCA), but is useful also in the search for serological markers in many other autoimmune disorders. (ke-i.org)
  • At last but not least, detection of anti-sperm antibodies (ASA) has become important due to their association with infertility occurring in the absence of mechanical obstruction of female reproductive system. (ke-i.org)