• This assay has high sensitivity and excellent specificity for detection of Collagen Type VIII Alpha 1 (COL8a1). (biomatik.com)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
  • In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Collagen Type XI Alpha 1 (COL11a1) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (unicoupi.com)
  • Greatly diminished reactivity and selectivity of these antibodies will result if denaturing and reducing conditions are used for SDS-PAGE and immunoblotting. (rockland.com)
  • Some class-specific anti-collagens may be specific for three-dimensional epitopes which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin embedded tissues. (rockland.com)
  • This antibody reacts with most mammalian Type IV collagens and has negligible cross-reactivity with Type I, II, III, V or VI collagens. (rockland.com)
  • No significant cross-reactivity or interference between Collagen Type VIII Alpha 1 (COL8a1) and analogues was observed. (biomatik.com)
  • N.B. Antibody reactivity and working conditions may vary between species. (bio-rad-antibodies.com)
  • See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more. (lsbio.com)
  • Anti-glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane, specifically the alpha-3 chain of type IV collagen. (medscape.com)
  • This is a classic type II reaction in the Gell and Coombs classification of antigen-antibody reactions. (medscape.com)
  • Anti-Collagen Type IV has been tested by dot blot and IHC and is suitable for indirect trapping ELISA for quantitation of antigen in serum using a standard curve, immunoprecipitation, native (non-denaturing, non-dissociating) PAGE, immunohistochemistry, and western blotting for highly sensitive qualitative analysis. (rockland.com)
  • Particle-enhanced assays are based on the reaction between a soluble analyte and the corresponding antigen or antibody bound to polystyrene particles. (cdc.gov)
  • CRP present in the test sample will form an antigen-antibody complex with the latex particles. (cdc.gov)
  • The SR84 monoclonal antibody specifically recognizes CD49a (CD49 antigen-like family member A). CD49a is a ~200 kDa type I transmembrane molecule that is encoded by ITGA1 ( Integrin subunit alpha 1). (bdbiosciences.com)
  • Anti-glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane. (medscape.com)
  • The target antigen is the alpha-3 chain of type IV collagen. (medscape.com)
  • The Anigen Rapid CaniV-4 (Leishmania) Test Kit is a chromatographic immunoassay for the qualitative detection of Heartworm antigen, Ehrlichia canis antibody, Leishmania infantum antibody, Anaplasma phagocytophilum antibody/Anaplasma platys antibody. (msc-alff.org)
  • The immune system produces large amounts of IgE antibodies against an antigen. (shiken.ai)
  • An individual may possess or develop IgG and IgM antibodies directed against cell surface or extracellular matrix antigen. (shiken.ai)
  • For example, if antibodies are targeted toward red blood cell surface antigen, it can cause haemolytic anaemia. (shiken.ai)
  • Type IV hypersensitivity, also known as delayed hypersensitivity, is a T cell-mediated reaction that typically occurs 24 to 72 hours after antigen exposure. (shiken.ai)
  • In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. (roche.com)
  • Description: A sandwich ELISA kit for detection of Collagen Type XI Alpha 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (unicoupi.com)
  • Name: Human Collagen Type II Alpha 1 ELISA Kit Test type: Sandwich (quantitative) Test principle The microtiter plate provided in this kit has been pre-coated with an index-specific antibody. (msc-alff.org)
  • Description: The Zona Pellucida Antibody Ig-Typing ELISA Kit is for measurement of immunoglobulin class specific antibodies directed against zona pellucida. (biolisp.org)
  • The antibody detects endogenous Collagen II protein. (biocheminfo.org)
  • The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. (nih.gov)
  • Collagen alpha-5(IV) chain is a protein that in humans is encoded by the COL4A5 gene. (wikipedia.org)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • In human PTE, hypoxia (1%02, 24hrs) increased total collagen production, decreased MMP-2 actvity and increased Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) protein. (ucl.ac.uk)
  • Amino-terminal amino acid sequence analysis of an immunopurified cyanogen bromide fragment of type XII collagen from embryonic chick tendons gave a single sequence identical to that predicted from the cDNA, thus confirming that the antibody recognizes the type XII protein. (rupress.org)
  • The COL4A3 gene provides instructions for making one piece of a protein called collagen IV. (medlineplus.gov)
  • Most of these variants change single protein building blocks (amino acids) in a region where the alpha3(IV) collagen chain combines with other collagen IV chains. (medlineplus.gov)
  • We report a strategy for efficient transgene knock-in in the endogenous collagen type I alpha 1 chain ( COL1A1 ) gene using the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system. (chinaagrisci.com)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Antibody is intended for laboratory use in the detection of the Inhibin, alpha protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. (roche.com)
  • In SDS/PAGE, all collagen type I preparations showed a protein band [alpha 1s(I)] migrating between alpha 1(I) and alpha 2(I) as well as a band [alpha 2s(I)] migrating in front of alpha 2(I). The collagenous nature of the pepsin-stable alpha 1s(I) protein was clearly demonstrated by digestion with human-leucocyte-derived collagenase, immunoblotting with antibodies against collagen type I and amino acid analysis. (uni-luebeck.de)
  • As a consequence, the identification of anti-GBM antibodies in the patient's serum or tissues is of paramount importance in the diagnosis of Goodpasture disease. (medscape.com)
  • In this article, Goodpasture disease and anti-GBM disease are used synonymously and refer to the presence of anti-GBM antibodies in tissues (eg, kidney, lungs, or both), independent of clinical manifestations. (medscape.com)
  • Anti-GBM antibodies are almost exclusively of the immunoglobulin G (IgG) isotype. (medscape.com)
  • The principal targets for anti-GBM antibodies are two adjacent, conformational disulfide-bond-dependent regions in the NC1 domain of the alpha-3 chain of type IV collagen. (medscape.com)
  • The anti-GBM antibodies can target the EA and EB epitope separately. (medscape.com)
  • Goodpasture disease is a term used to describe glomerulonephritis, with or without pulmonary hemorrhage, and the presence of circulating anti-glomerular basement membrane (anti-GBM) antibodies. (medscape.com)
  • The discovery of anti-GBM antibodies led to the understanding of the pathogenesis of Goodpasture syndrome. (medscape.com)
  • [ 5 , 6 ] Two conformational epitopes of anti-GBM antibodies have been defined at residues 17-31 and 127-141 of alpha3(IV)NC1, which were named as EA and EB, respectively. (medscape.com)
  • Diagnosis is made by renal biopsy and anti-GBM antibodies in the blood. (shiken.ai)
  • The treatment involves aggressive urgent use of steroids, plasmapheresis and cyclophosphamide to remove anti-GBM antibodies. (shiken.ai)
  • Collagen I Alpha 1 antibody LS-C343921 is an unconjugated rabbit polyclonal antibody to Collagen I Alpha 1 (COL1A1) (aa1192-1207) from mouse. (lsbio.com)
  • Find available monoclonal or polyclonal COL4A1 Antibodies. (antibodies-online.com)
  • Description: A polyclonal antibody raised in Goat that recognizes and binds to Human SENP7 (internal region) (internal region). (biolisp.org)
  • We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
  • During the initial infection, alpha-helical M proteins (M8 and M13) on the surface of the streptococcus bind type IV collagen in the host, and this interaction can trigger auto-antibody formation. (medscape.com)
  • Explore our vast selection of antibodies targeting various proteins, receptors, and biomarkers across diverse research areas. (affiab.com)
  • With these data, taken together with previous results showing that a portion of the sequence domains of type XII collagen is similar to domains of type IX, a nonfibrillar collagen associated with cross-striated fibrils in cartilage, we suggest that types IX and XII collagens are members of a distinct class of extracellular matrix proteins found in association with quarter-staggered collagen fibrils. (rupress.org)
  • We are a leading supplier of antibodies, ELISA kits and recombinant proteins, offering over 100,000+ products and related reagents for a focused range of research areas such as immunology, cancer, veterinary research and cell biology through its antibody experts. (abcbiolab.com)
  • Anti-Collagen Type IV has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted specificities. (rockland.com)
  • Non-specific cross-reaction of anti-collagen antibodies with other human serum proteins or non-collagen extracellular matrix proteins is negligible. (rockland.com)
  • Antibodies are immune system proteins that normally attack foreign substances such as bacteria or viruses, but in people with Goodpasture syndrome, they target alpha3(IV) collagen chains. (medlineplus.gov)
  • The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
  • Conjugation service and the corresponding secondary antibody are available. (biomatik.com)
  • Our experienced team can collaborate with you to generate highly specific antibodies tailored to your specific targets. (affiab.com)
  • The development of 'type' specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. (rockland.com)
  • Antibodies are isolated from rabbit antiserum and are extensively cross-adsorbed by immunoaffinity purification to produce 'type' specific antibodies. (rockland.com)
  • An isotype control should be used at the same concentration as the antibody of interest. (bdbiosciences.com)
  • Simultaneously, RAW 264.7 and MLE-15 cells were treated with SWCNT (24 hours, 6 microg/cm2 to 48 microg/cm2) or bleomycin (0.1 microg/ml) in the presence of OPN-blocking antibody or isotype control, and TGF-beta1 was measured in supernatants. (cdc.gov)
  • This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. (wikipedia.org)
  • [ 5 ] The more abundant D-hexamers have dimer-reinforced crosslinks between NC1 domains that help to retain the cryptic nature of the Goodpasture epitopes, whereas the less abundant M-hexamers, composed of only monomeric subunits, allow epitope unmasking and antibody binding under inflammatory states. (medscape.com)
  • Integrin beta 6 is a type I transmembrane Integrin beta subunit that heterodimerizes with alpha V subunits in the epithelial restricted integrin alpha V/ beta 6. (rndsystems.com)
  • Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
  • Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)
  • The building blocks are composed of three alpha subunits of collagen, which form a triple helix. (medscape.com)
  • Type I collagen, the fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. (thermofisher.com)
  • Immunoidentification of type XII collagen in embryonic tissues. (rupress.org)
  • They can cause damage to cells or tissues (cytotoxicity) through direct cell surface receptor binding, activation of the complement pathway, or antibody-dependent cellular cytotoxicity. (shiken.ai)
  • Type IV collagen is a major structural component of all basement membranes, though alpha-3 subtype only occurs in specific tissues like alveoli and glomeruli. (shiken.ai)
  • Description: A competitive ELISA for quantitative measurement of Rat Collagen Type VII in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (cropsciencejournal.org)
  • The Collagen Type Vii Antibody Elisa reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (cropsciencejournal.org)
  • Description: A competitive ELISA for quantitative measurement of Human Collagen Type VII in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (cropsciencejournal.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Collagen Type XI Alpha 2 (COL11a2) in serum, plasma, tissue homogenates and other biological fluids. (unicoupi.com)
  • The Spoligotyping Internation Typing Kit reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (biolisp.org)
  • The protective effect of them were assessed by measuring arthritis index, swelling, the cytokines such as TNF-alpha, IFN-gamma and IL-17 in serum, type II collagen antibodies, splenocyte proliferation and so on. (cyp17-signal.com)
  • Results: The results demonstrated that treatment of CIA rat with either HLJDT aqueous extracts or HLJDT-CG not only ameliorated the symptoms of arthritis, prevented joint damage but also reduced the serum levels of TNF-alpha, IFN-gamma and IL-17 in CIA rats. (cyp17-signal.com)
  • Integrin beta 6 was detected in immersion fixed XB2 mouse teratoma keratinocyte cell line using Rat Anti-Mouse Integrin beta 6 Monoclonal Antibody (Catalog # MAB2389) at 10 µg/mL for 3 hours at room temperature. (rndsystems.com)
  • The extracellular domain of mouse Integrin beta 6 contains a collagen binding von-Willebrand factor A domain and multiple truncated EGF-like motifs. (rndsystems.com)
  • Detects human Integrin alpha 2/CD49b. (novusbio.com)
  • CD49a associates with the integrin β1 subunit (CD29) to form the α1/β1 heterodimer (CD49a/CD29), and serves as receptor for collagen and laminin-1. (bdbiosciences.com)
  • Antibodies to beta-4 integrin have been identified in generalized MMP and ocular MMP, and antibodies to alpha-6 integrin have been identified in oral MMP. (msdmanuals.com)
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • We believe type IV procollagen is a major constituent of the Schwann-cell extracellular matrix based upon (a) its presence in a detergent-insoluble matrix preparation, (b) its presence in the cell layer of the cultures in a state in which it can be removed by brief treatment with bacterial collagenase or trypsin, and (c) positive immunofluorescence of Schwann cell-neuron cultures with anti-type-IV collagen antibodies. (rupress.org)
  • Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. (curehunter.com)
  • If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)
  • Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffinembedded tissue sections. (roche.com)
  • We therefore investigated the involvement of B cells and BAFF in the expression of collagen and profibrotic markers by dermal fibroblasts. (ox.ac.uk)
  • Histomorphometric and immunohistochemical analyses were performed to assess repair time, as well as the expression of collagen III and MMPs. (bvsalud.org)
  • This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). (nih.gov)
  • This gene encodes the major type IV alpha collagen chain of basement membranes. (antibodies-online.com)
  • Thus, the aim of this study was to verify the immunolocalization of MMP-2 and -9 and collagen III in rabbit calvarium bone defects treated with and without L-PRP insertion. (bvsalud.org)
  • The basic monomer of this network is a triple-helical molecule composed of 3 alpha chains (ie, alpha-3, alpha-4, and alpha-5). (medscape.com)
  • it interacts with noncollagenous domains of the alpha-4 and alpha-5 chains to form the alpha-3.alpha-4.alpha-5(IV) triple helical molecule known as promoter, which, in turn, dimerizes to form a hexameric structure that is extensively crosslinked. (medscape.com)
  • Type IV collagen can be expressed as six different chains, alpha1 to alpha6. (medscape.com)
  • Limited pepsin digestion of metabolically labeled medium or cell layers produced a pepsin-resistant fragment characteristic of pro-alpha 1(IV) chains. (rupress.org)
  • This chain combines with two other types of alpha (IV) chains (the alpha4 and alpha5 chains) to make alpha345(IV) collagen molecules. (medlineplus.gov)
  • These changes in the structure or amount of alpha3(IV) chains severely impair the formation of alpha345(IV) collagen networks in the basement membranes of the kidney, inner ear, and eye. (medlineplus.gov)
  • Goodpasture syndrome is a severe disease of the lungs and the kidneys caused by antibodies to the alpha3(IV) collagen chains. (medlineplus.gov)
  • It remains unclear why some people's immune systems make antibodies to their own collagen chains. (medlineplus.gov)
  • Collagen VII is composed of three identical alpha chains, each having an amino-terminal non-collagenous domain and a carboxy-terminal collagenous domain. (bio-rad-antibodies.com)
  • In circular dichroism, the proportion of thermally labile collagen molecules was proportional to the amount of shortened alpha 1(I) and alpha 2(I) chains, respectively. (uni-luebeck.de)
  • Description: This MR6F3 antibody recognizes mouse CD206 also known as Macrophage Mannose Receptor (MMR) or Mannose Receptor C, Type 1 (MRC1). (fishersci.com)
  • Secretion of type IV procollagen was substantially reduced when Schwann cells were maintained in the absence of neurons. (rupress.org)
  • RESULTS: Coculture of blood B cells and dermal fibroblasts isolated from SSc patients induced IL-6, TGF-β1, CCL2, and collagen secretion, as well as Alpha-SMA, TIMP1, and MMP9 expression in dermal fibroblasts. (ox.ac.uk)
  • Addition of anti-IgM and BAFF to the coculture increased IL-6, CCL2, TGF-β1, and collagen secretion. (ox.ac.uk)
  • B cell- and BAFF-induced collagen secretion was highly reduced by anti-TGF-β1 antibodies. (ox.ac.uk)
  • Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary. (roche.com)
  • 2.2e-16) with that of the wild type cells, indicating that the GFP knock-in did not alter the global expression of endogenous genes. (chinaagrisci.com)
  • CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. (fishersci.com)
  • Antibody Elisa Laboratories manufactures the collagen type vii antibody elisa reagents distributed by Genprice. (cropsciencejournal.org)
  • Human IgG antibody Laboratories manufactures the spoligotyping internation typing kit reagents distributed by Genprice. (biolisp.org)
  • This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. (roche.com)
  • Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. (nih.gov)
  • Formation of the resilient alpha-3.alpha-4.alpha-5(IV) network is essential for the proper function of the basement membrane. (medscape.com)
  • Thus, differences of the alpha-3(IV)NC1 monomer-dimer composition in the alveolar basement membrane observed between individuals may explain why some patients with Goodpasture syndrome do not develop pulmonary disease. (medscape.com)
  • The antiglomerular basement membrane antibodies were strongly positive. (medscape.com)
  • This binding of antibodies can be visualized as the linear deposition of immunoglobulin along the glomerular basement membrane and, less commonly, the alveolar basement membranes, by direct immunofluorescent techniques. (medscape.com)
  • The principal component of basement membrane is type IV collagen, which acts as a support structure and is composed of building blocks that are linked end-to-end. (medscape.com)
  • Alpha345(IV) collagen networks play an especially important role in the basement membranes of the kidney, inner ear, and eye. (medlineplus.gov)
  • In the kidney, other types of collagen build up in the basement membranes, eventually scarring the kidneys and leading to kidney failure. (medlineplus.gov)
  • The antibodies cause inflammation when they attach (bind) to the basement membranes of blood vessels in the air sacs (alveoli) of the lungs and filtering units (glomeruli) of the kidneys. (medlineplus.gov)
  • If they are targeted to type IV collagen in the basement membrane, it can cause Goodpasture's syndrome. (shiken.ai)
  • A classic example of type II hypersensitivity is Goodpasture's syndrome, an autoimmune condition caused by antibodies against the alpha-3 chain of type IV collagen found in the basement membrane. (shiken.ai)
  • The following product was used in this experiment: Collagen V Alpha-1 Chain (VR domain) Monoclonal Antibody (6A7) from Thermo Fisher Scientific, catalog # 90009-100UG. (thermofisher.com)
  • In addition to our catalog antibodies, we offer custom antibody development services to meet your unique research requirements. (affiab.com)
  • The Goodpasture epitopes are structurally sequestered by the adjacent alpha-4(IV)NC1 and alpha-5(IV)NC1 molecules. (medscape.com)
  • Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
  • Recombinant human collagen V alpha-1 chain. (thermofisher.com)
  • The antibody, 75d7, has been used to identify the alpha 1(XII) chain on immunoblots of SDS-PAGE tendon extracts as a 220-kD polypeptide, under reducing conditions. (rupress.org)
  • In most patients, the autoantibody in Goodpasture syndrome is directed against a 28-kd monomeric subunit present within the noncollagenous domain of the alpha3 chain of type IV collagen (alpha3[IV]NC1). (medscape.com)
  • collagen type III alpha 1 chain, actin Mouse monoclonal antibody to CaMKIV. (engineering-gdfsuez.com)
  • Specifically, this gene makes the alpha3(IV) chain of collagen IV. (medlineplus.gov)
  • Partial amino acid sequencing of alpha 1(I) and alpha 1s(I) identified alpha 1s(I) as a shortened alpha 1(I) chain due to a specific cleavage site between residues Leu95 and Asp96 which is in close vicinity to the hydroxylysine-derived crosslink at position 87. (uni-luebeck.de)
  • Our data provide clear evidence that a shortened alpha 1-derived collagen chain can be extracted from human adult bone whereas it is hardly found in human skin. (uni-luebeck.de)
  • Extracellular regions of CD206 include an N-terminal cysteine-rich (CR) domain that binds sulfated glycoproteins, a fibronectin II (FNII) domain that binds collagens, and eight carbohydrate recognition domains (CRDs) that bind sugars like mannose and fucose with high affinity. (fishersci.com)
  • Histological examination revealed marked decrease in granuloma formation and less collagen deposition in the lungs of OPN-KO mice compared to WT. (cdc.gov)
  • Introduction and Objective: Because L-PRP constitutes an important source of growth factor that is associated with osteogenesis and fibrogenesis, the aim of this study was to evaluate the effect of L-PRP on the presence of collagen III and MMP-2 and MMP-9, while comparing these results by means of a histomorphometric analysis of bone matrix and fibrous deposition on bone repair. (bvsalud.org)
  • These results coincided with the larger occurrence of diffuse collagen III deposition and the scarce presence of MMP- 2 and -9 spread among the fibrous tissue. (bvsalud.org)
  • Hypersensitivity reactions have been classified into four types known as the Gell and Coombs classification. (shiken.ai)
  • The four types of hypersensitivity reactions, as per the Gell and Coombs classification, are outlined in the following table. (shiken.ai)
  • Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. (thermofisher.com)
  • Tumor suppression by collagen XV is independent of the restin domain. (nih.gov)
  • Elevated levels of interleukin-6 (IL-6), IL-8/CXCL8, and tumor necrosis factor alpha (TNFα) have been detected in these patients. (medscape.com)
  • Rooted in scientific innovation and unwavering quality, AffiAB® has been engineered to empower researchers, scientists, and laboratories with a cutting-edge suite of antibodies. (affiab.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Collagen Type VIII Alpha 1 (COL8a1) were tested 20 times on one plate, respectively. (biomatik.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Collagen Type VIII Alpha 1 (COL8a1) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
  • Immunofluorescence studies with the antibody demonstrate that type XII collagen is localized in type I-containing dense connective tissue structures such as tendons, ligaments, perichondrium, and periosteum. (rupress.org)
  • The 1102 amino acid (aa) human alpha 2 extracellular domain (ECD) shares 83‑89% aa sequence identity with mouse, rat, canine, bovine and equine alpha 2. (novusbio.com)
  • Rockland extensively purifies collagens for immunization from human and bovine placenta and cartilage by limited pepsin digestion and selective salt precipitation. (rockland.com)
  • Materials and methods: CIA was established in male Wistar rats with subcutaneous injection of type II bovine collagen at the base of the tail of animals. (cyp17-signal.com)
  • Collagen was extracted from human adult bone by limited pepsin digestion and collagen types were purified by consecutive salt precipitation first under neutral and then under acid conditions. (uni-luebeck.de)
  • The I domain-containing beta 1 integrins ( alpha 1 beta 1, alpha 2 beta 1, alpha 10 beta 1 and alpha 11 beta 1) all bind collagens, with alpha 2 beta 1 preferring collagens I‑III (4, 5). (novusbio.com)
  • Conclusion: Thus, the results suggest that L-PRP not only induces an intense fibrosis rich in collagen III, which is not degraded, but also suppresses MMP-2 and -9 expressions, mimicking a similar pathological event as that of a cleft-palate or cranial suture. (bvsalud.org)
  • A synthetic peptide corresponding to a sequence at the C-Terminus of mouse Collagen I(1192-1207 aa QPPQEKSQDGGRYYRA), identical to the related rat sequence, and different from the related human sequence by two amino acids. (lsbio.com)
  • We have generated a monoclonal antibody against a synthetic peptide whose sequence was derived from the nucleotide sequence of a cDNA encoding alpha 1(XII) collagen. (rupress.org)
  • Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. (wikipedia.org)
  • ab138492 works in western blot in samples with high level of collagen I, like HFF-1, MRC-5, skin tissue etc. (abcam.com)
  • 1-2 In normal tissue, anti-inhibin alpha labels granulosa cells of the ovary, sertoli and leydig cells of the testis, and the zona reticularis of the adrenal cortex. (roche.com)
  • B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis. (ox.ac.uk)
  • CONCLUSIONS: Our results showed for the first time a direct role of B cells on the production of collagen by dermal fibroblasts, which is further enhanced by BAFF. (ox.ac.uk)
  • Metabolic labeling of primary cultures of Schwann cells plus neurons and analysis by SDS PAGE revealed the presence of a closely spaced pair of polypeptides in the medium of these cultures that (a) were susceptible to digestion by purified bacterial collagenase, (b) co-migrated with type IV procollagen secreted by rat parietal endoderm cells, and (c) were specifically immunoprecipitated by antibodies against mouse type IV collagen. (rupress.org)
  • Moreover, the hypoxia-induced increase in collagen [alpha]1(1) was not mediated by a secreted, soluble factor, suggesting a direct effect of hypoxia on the collagen [alpha]1(1) gene. (ucl.ac.uk)
  • Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. (nih.gov)
  • A dilute solution of test sample is mixed with latex particles coated with mouse monoclonal anti-CRP antibodies. (cdc.gov)
  • Applications Tested: This MR6F3 antibody has been tested by intracellular staining and flow cytometric analysis of mouse resident peritoneal exudate cells using the Intracellular Fixation & Permeabilization Buffer Set (cat. (fishersci.com)
  • Materials and Methods: OPN-knockout female mice (OPN-KO) along with their wild-type (WT) counterparts were exposed to single-walled carbon nanotube s (SWCNT) (40 microg/mouse) via pharyngeal aspiration and fibrotic response was assessed 1, 7, and 28 days post-exposure. (cdc.gov)
  • From the analysis of cytokine regulation in rheumatoid joint cell cultures using neutralizing anti-cytokine antibodies, it was found that blockade of TNF alpha reduced the production of other proinflammatory cytokines. (ox.ac.uk)