Antibody human t lymphotropic virus 1. Medical search. Frequent questions

Following stimulation by HTLV-1 antigens on the surface of infected T cells in the CNS compartment, expansion of immunocompetent T cells directed against viral proteins may result in CNS tissue damage, which may be mediated by cytokines such as tumor necrosis factor (TNF) alpha. (medscape.com)
To detect plasma HHV-8 antibodies an inhouse immunofluorescence assay (IFA) using BC-3 cells expressing only latent-associated nuclear antigens encoded by ORF73 was performed to detect plasma HHV-8 antibodies MK 0893 ( 13 ). (careersfromscience.org)
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. (lookformedical.com)
AHTR usually results from recipient plasma antibodies to donor RBC antigens. (merckmanuals.com)
Antibodies against blood group antigens other than ABO can also cause AHTR. (merckmanuals.com)

Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies. (umassmed.edu)
Monoclonal antibodies and T-cell hybridomas : perspectives and technical advances / editors, Günter J. Hämmerling, Ulrich Hämmerling and John F. Kearney. (who.int)

Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases. (wikipedia.org)

Type 1 Infection in with the PRISM assay (Abbott Laboratories). (cdc.gov)
We considered infection to be acquired outside Israel when tropic virus type 1 (HTLV-1) in blood donors from Israel is 1 infection/100,000 persons. (cdc.gov)
1995. However, the prevalence of HTLV-1 infection in the research review board approved this study. (cdc.gov)
From January 9, 1995, through December 31, 2003, a Israel is an immigration state, providing a unique op- total of 1,256,669 blood donors were screened for HTLV-1 portunity to examine the prevalence of HTLV-1 infection infection in Israel. (cdc.gov)
and Ma- systematic screening of blood donors, enabled us to exam- gen David Adom National Blood Services, Ramat Gan, Israel (V. ine the global epidemiology of HTLV-1 infection. (cdc.gov)
It is thought that about 1-5% of infected persons develop cancer as a result of the infection with HTLV-I over their lifetimes. (wikipedia.org)
The infection rate is about 1% in Papua New Guinea, the Solomon Islands, and Vanuatu, where the genotype C predominates. (wikipedia.org)
The CD4+ T-lymphocyte is the primary target for HIV infection because of the affinity of the virus for the CD4 surface marker (3). (cdc.gov)
These findings have important implications in defining the epidemiological patterns of HTLV-1 infection in Nigeria. (e-cep.org)
The peripartum period is an important transmission time for human T-cell lymphotropic virus-1 (HTLV-1) infection, mainly via breastfeeding and partly through the placental tissues of carrier mothers. (e-cep.org)
Epstein-Barr virus (EBV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Infectious mononucleosis, which is caused by delayed primary EBV infection, increases the risk of developing MS. (vitamindwiki.com)
The US11 protein of herpes simplex virus type 1 (HSV-1) is a small, highly basic phosphoprotein expressed at late times during infection. (biomedcentral.com)
During productive infection, the 152-kb double-stranded HSV-1 genome is rapidly translocated to the nucleus where at least 80 viral genes are transcribed by the host cell RNA polymerase II (Pol II) [ 1 ]. (biomedcentral.com)
The US11 protein expresses at late times during HSV-1 infection and is one of the late genes of HSV-1 [ 3 ]. (biomedcentral.com)
Therefore, it is clear that US11 is a multifunctional protein involved in HSV-1 infection. (biomedcentral.com)
The worldwide prevalence of hepatitis C virus infection is estimated by the World Health Organization (WHO) to be approximately 3% - corresponding to 170 million infected persons [ 1 , 2 ]. (biomedcentral.com)
sexual transmission is also an important infection route in Given the importance of virus transmission through blood Brazil5. (bvsalud.org)
Vertical transmission is a relevant concern in Brazil, as the blotting (WB) and/or polymerase chain reaction (PCR) assays prevalence of HTLV-1 infection in pregnant women ranges from as a confirmatory step. (bvsalud.org)
A recent study evaluated the performance of commercially available serological screening tests for HTLV-1 infection in Brazil, i.e. (bvsalud.org)
HTLV-1 infection is usually diagnosed by serology assays detection of HTLV-1 specific IgG or IgM antibodies. (meridianbioscience.com)
Her second child tested positive for HIV antibodies at birth, but subsequent serologic testing performed at 9 months of age was negative, reflecting the loss of passively derived maternal antibody and the absence of infection. (cdc.gov)
Several epidemiologic and laboratory studies have shown that recipients of hepatitis B immune globulin (HBIG) and immune globulin (IG), including recipients of lots manufactured before April 1985, have not developed either antibody responses indicative of HIV infection or clinical illness associated with HIV infection (4). (cdc.gov)
Safety of therapeutic immune globulin preparations with respect to transmission of human T-lymphotropic (sic) virus type III/lymphadenopathy-associated virus infection. (cdc.gov)
Residual risk of transfusiontransmitted infection with human immunodeficiency virus, hepatitis C virus, and hepatitis B virus in Korea from 2000 through 2010. (medigraphic.com)
Role Description: The goal of this proposal is to generate bi-specific Zika virus-neutralizing antibodies with asymmetric heavy chain mutations to enhance transplacental antibody transport and prevent infection of the fetus. (umassmed.edu)
Role Description: The administration of antibodies blocking viral receptors has the potential to be effective in protecting the host against infection. (umassmed.edu)
Human T lymphotropic virus type I (HTLV-I) infection in neurological patients in Salvador, Bahia, Brazil. (fiocruz.br)
This research includes molecular surveillance of Taiwanese strains, mechanistic study of host-restriction of influenza virus infection, pathogenesis study and development of anti-flu agents. (cgu.edu.tw)
The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
Acute human immunodeficiency virus type 1 infection. (ocu-radiology.jp)
We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. (edu.pe)
Human immunodeficiency virus type 2 infection and cerebral toxoplasmosis. (ocu-radiology.jp)
Strongyloidiasis with human T-lymphotropic virus type 1 infection. (ocu-radiology.jp)
Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and is treated with antiretroviral medications. (msdmanuals.com)
Human Immunodeficiency Virus (HIV) Infection in Children and Adolescents Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and makes people more vulnerable to other infections and some cancers. (msdmanuals.com)
Infection with another type of retrovirus, human T-lymphotropic virus (HTLV), is less common but can also cause serious disease. (msdmanuals.com)
1 ). of VCA IgG and EBNA IgG in the infections according VCA IgM and EBV is a globally prevalent virus and absence of VCA IgM is typical of past VCA IgG positivity, and the presence or over 90% of the world's population is infection. (who.int)
In contrast, infection fector cells or from blockage of intra- of action associated with oncogenic with certain pathogens, such as hu- cel ular pathways essential for anti- viruses, may escape immune sur- man immunodeficiency virus type 1 gen recognition or of other elements veillance in immunosuppressed indi- (HIV-1) or malaria parasites, is per- of the immune response. (who.int)
who are latently infected with an on- Certain pharmaceutical drugs, Immunosuppression as a medi- cogenic virus are at greatly increased ionizing and ultraviolet radiation, cal therapy is used to treat autoim- risk for developing virus-related or infection with certain viruses mune diseases such as lupus ery- cancers when they become immu- and parasites can cause immu- thematosus or rheumatoid arthritis. (who.int)
An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)

All HTLV-1-positive donors had negative sero- logic results for HTLV-2, human immunodeficiency virus, The Study hepatitis C virus, and hepatitis B surface antigen. (cdc.gov)
All blood samples were screened for anti-HCV, hepatitis B surface antigen, hepatitis B core antibody, HIV-1, human T-cell lymphotropic virus types 1 and 2, syphilis (Sexually Transmitted Disease Research Laboratory), Trypanosoma cruzi (etiologic agent of Chagas' disease) and alanine aminotransferase (ALT), using licensed assays. (biomedcentral.com)
Antibodies directed against white blood cell (WBC) human leukocyte antigen (HLA) in otherwise compatible donor blood are one possible cause. (merckmanuals.com)
Most important aspect of therapy is anti CD20 antibody, the Rituximab, which is a kind of immunotherapy or targeted therapy and attacks the CD20 antigen on the cancer cells. (lymphomaindia.com)
The presence or absence of EBV viral capsid antigen (VCA) IgG, VCA IgM and EBV nuclear antigen (EBNA) IgG antibodies was recorded. (who.int)

AIDS research and human retroviruses , 8 (5), 651-657. (johnshopkins.edu)
Similar to other retroviruses, HTLV-1 evolves either through accumulation of point mutations or recombination. (biomedcentral.com)
The human immunodeficiency virus type 1 (HIV-1) is a worldwide distributed pathogen and the occurrence of coinfections with other human retroviruses like the human T-cell lymphotropic virus type I and II (HTLV-I and HTLV-II) has been shown to be a fairly common event in Brazil (Schechter et al. (scielo.br)
HIV infections may be caused by one of two retroviruses, HIV-1 or HIV-2. (msdmanuals.com)
Other RNA viruses (such as polio, influenza, or measles), unlike retroviruses, do not make DNA copies after they invade cells. (msdmanuals.com)
Human T-cell leukemia/lymphoma virus : the family of human T-lymphotropic retroviruses, their role in malignancies and association with AIDS / edited by Robert C. Gallo, Myron E. Essex, Ludwik Gross. (who.int)

Once integrated, HTLV-1 continues to exist only as a provirus which can spread from cell to cell through a viral synapse. (wikipedia.org)
The antibody immunoprecipitates gp46 surface protein from radiolabeled cell lysates, as well as viral precursor protein. (zeptometrix.com)
B cell-tropic viruses may trigger aberrant immune responses in MS in genetically susceptible individuals owing, in part, to a failure in viral surveillance and clearance. (vitamindwiki.com)
The most compelling data supporting an etiologic role for viral involvement in MS have emerged for Epstein-Barr virus (EBV). (vitamindwiki.com)
In this study, we compared patients who maintained virus suppression with patients experiencing viral relapse yet maintaining stable CD4+ lymphocytes while receiving antiretroviral therapy. (diseases-illness.com)
Combination antiretroviral therapies potently suppress plasma human immunodeficiency virus (HIV) RNA levels, although many patients who initially achieve suppression below the limits of detection experience viral relapse to detectable levels. (diseases-illness.com)
Viral Commensalism in Humans. (diseases-illness.com)
HTLV-1 exhibits a remarkable genetic stability, however, viral strains have been classified in several genotypes and subgroups, which often mirror the geographic origin of the viral strain. (biomedcentral.com)
Until now, no viral genotype or subgroup is associated with a specific HTLV-1-associated disease. (biomedcentral.com)
The proposed studies are aimed at understanding the potential of a half-life extended antibody against the co-receptor of AIDS viruses, CCR5, in prevention of viral acquisition against challenges via different routes. (umassmed.edu)
Men who have sex with men (MSM) are considered to be at significant risk for sexually transmitted infections (STI) and bloodborne viruses including viral hepatitis types B, C, and D (HBV, HCV, and HDV) and human T-cell leukemia virus types 1 and 2 (HTLV 1&2). (biomedcentral.com)
Moreover, recent research has shown that even viruses which were hitherto believed not to persist after an acute infectious episode are capable of long-term viral persistence. (investinme.org)
Nora Chapman et al from the Enterovirus Research Laboratory, Department of Pathology and Microbiology, University of Nebraska Medical Centre, have shown that human enteroviruses Coxsackie B can naturally delete sequence from the 5' end of the RNA genome and that this deletional mechanism results in long-term viral persistence, which has substantially altered the previously held view (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440640/?tool=pubmed). (investinme.org)

Dive into the research topics of 'Incidence and risk factors for human T-lymphotropic virus type II seroconversion among injecting drug users in Baltimore, Maryland, U.S.A.'. Together they form a unique fingerprint. (bgu.ac.il)

Human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV), the virus that causes acquired immunodeficiency syndrome (AIDS), is transmitted through sexual contact, parenteral exposure to infected blood or blood components, and perinatally from mother to fetus or neonate. (cdc.gov)

B cells are now known to play a major role in disease, demonstrated by the highly impactful effect of a B cell-depleting antibody on controlling MS. The idea that a virus may play a role in the development of MS has a long history and is supported mostly by studies demonstrating a link between B cell-tropic Epstein-Barr virus (EBV) and disease onset. (vitamindwiki.com)

The most difficult challenge in diagnosis and therapy is patients with symptoms of fibromyalgia (arthralgia, myalgia, fatigue) and oral and ocular dryness in the presence of circulating antinuclear antibodies. (nih.gov)

repeatedly reactive screening tests for HIV antibody (e.g., enzyme immunoassay) with specific antibody identified by the use of supplemental tests (e.g. (cdc.gov)
Blood samples tested by an enzyme immune assay and a discriminatory Western blot were positive for HTLV-I. The familial analysis of one patient showed a possible pattern of sexual and vertical transmission of the virus. (scielo.br)
To determine the incidence of and risk factors for human T-lymphotropic virus, type II (HTLV-II) seroconversion among injecting drug users (IDUs), specimens from IDUs recruited into the ALIVE Study in 1988/1989 were assayed at baseline for antibody to HTLV with use of enzyme immunoassay and Western blot. (bgu.ac.il)
We developed a monoclonal antibody (5D2) to FTC and demonstrated its high specificity and physiologically relevant linear range of detection in a competitive enzyme immunoassay (EIA). (cdc.gov)
A group of 149 patients attending the AIDS Reference Unit of the State Department of Health was tested for the presence of antibodies to HTLV-I/II using an enzyme immunoassay and the positive reactions were confirmed with a Western blot that discriminates between HTLV-I and HTLV-II infections. (scielo.br)
When HIV enters a human cell, it releases its RNA, and an enzyme called reverse transcriptase makes a DNA copy of the HIV RNA. (msdmanuals.com)

A patient infected with HTLV can be diagnosed when antibodies against HTLV-1 are detected in the serum. (wikipedia.org)
The antibody is of the IgG1 subclass and has been purified from serum-free culture supernatant by ammonium sulfate precipitation. (zeptometrix.com)
Serum specimens obtained were tested for the presence of HBV, HCV, HDV and HTLV-1&2 infections. (biomedcentral.com)

The presence of antibodies against HTLV-1 was assessed using ELISA (HTLV I + II ELISA recombinant v.4.0, Wiener lab, Rosario, Argentina). (edu.pe)

Finally, the reactivity and specificity of the polyclonal antibody were characterized by Western blot and immunofluorescent assays. (biomedcentral.com)
HTLV-1 proviral load (PVL) in It is highly important to implement an accurate and cost- the blood and/or CSF is also useful in establishing diagnosis effective strategy for laboratory diagnosis and systematically and, when combined with other tests, such as evaluation of evaluate the performance of both screening assays and intrathecal synthesis of HTLV-1 specific antibodies, may also aid confirmatory testing. (bvsalud.org)
Role Description: Our recombinant standard reagents will support the development of rigorous coronavirus-specific antibody assays for nonhuman primate research and colony management. (umassmed.edu)
Thus, this monoclonal antibody is a key reagent that will enable simple and low-cost lateral flow assays and EIAs for adherence monitoring. (cdc.gov)

In donors originating from East- the donor or 1 parent was born outside Israel. (cdc.gov)
H classification of geographic origin of blood donors (both uman T-cell lymphotropic virus type 1 (HTLV-1) is HTLV-1 positive and HTLV-1 negative) is given in the prevalent mostly in Japan, Africa, the Caribbean Is- online Technical Appendix (available from www.cdc.gov/ lands, and South America ( 1,2 ). (cdc.gov)
Of these, 73 HTLV-1 carriers were iden- according to donors' countries of origin. (cdc.gov)
This informa- tified, for an overall prevalence of 5.8 infections per 100,000 tion may reflect the distribution of HTLV-1 within the re- donors. (cdc.gov)
Donors from Middle Eastern and East- maternal and paternal countries of birth once for each do- ern European countries were at highest risk for HTLV-1 nor, regardless of the number of blood units donated. (cdc.gov)
The objective of this case-control study was to investigate the risk factors for presence of anti-HCV antibody in blood donors in southern Brazil. (biomedcentral.com)
Brazilian populations have been performed in specific groups, restricted breastfeeding in mothers infected with HTLV-1 and such as blood donors or pregnant women, and the prevalence HTLV-2 (DAB/CAB23, 2009, BMoH). (bvsalud.org)
Incidence and estimated rates of residual risk for HIV, hepatitis C, hepatitis B and human T-cell lymphotropic viruses in blood donors in Canada, 1990- 2000. (medigraphic.com)
Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acidamplification testing. (medigraphic.com)
Guidance for Industry: Use of Nucleic Acid Tests to Reduce the Risk of Transmission of West Nile Virus from Living Donors of Human Cells, Tissues, and Cellular and Tissue-Based Product s (HCT/Ps) , dated 9/2016. (fda.gov)

HTLV-1 is a type C retrovirus, related to other human and primate lymphotropic viruses and the bovine leukemia virus. (medscape.com)
Determine the presence of Human T-Lymphotropic Virus (HTLV) Type I protein. (zeptometrix.com)
This murine monoclonal antibody reacts with Human T-Lymphotropic Virus Type I (HTLV-I) surface protein, gp46. (zeptometrix.com)
Interest is increasing in human T-cell lymphotropic virus type-1 (HTLV-1) transmission due to its adverse health impacts. (e-cep.org)
asked whether human T lymphotropic virus type 1 (HTLV‐1) antibody status is associated with the risk of developing gastric cancer. (diseases-illness.com)
Herpes simplex virus type 1 (HSV-1) is a large DNA virus that latently infects neurons and periodically reinitiates productive growth at epithelial sites, causing blisters, or in the central nervous system, resulting in encephalitis. (biomedcentral.com)
PTLVs consist of simian T-lymphotropic viruses (STLVs) type 1 to 4, which infect non-human primates and human T-lymphotropic viruses type 1-4. (biomedcentral.com)
Inactivation and partition of human T-cell lymphotrophic virus, type III, during ethanol fractionation of plasma. (cdc.gov)
A new international consensus for diagnosis requires objective signs and symptoms of dryness including a characteristic appearance of a biopsy sample from a minor salivary gland or autoantibody such as anti-SS-A. Exclusions to the diagnosis include infections with HIV, human T-lymphotropic virus type I, or hepatitis C virus. (nih.gov)
The antibody for human lymphotropic virus type-I was negative, as well as urinalysis for Bence Jones protein. (biomedres.us)
Incidence and risk factors for human T-lymphotropic virus type II seroconversion among injecting drug users in Baltimore, Maryland, U.S.A. (bgu.ac.il)
Incidence and risk factors for human T-lymphotropic virus type II seroconversion among injecting drug users in Baltimore, Maryland, U.S.A. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology , 9 (1), 89-96. (bgu.ac.il)
مقدمه: شمال شرقی ایران، به‌ویژه شهر مشهد، از نواحی اندمیک ویروس لنفوتروپیک سلول‌های T انسانی نوع 1 (HTLV-I یا Human T-cell lymphotropic virus type 1) می‌باشد؛ اما در مورد شیوع نوع 2 ویروس (HTLV-II) در این منطقه، اطلاعات کافی موجود نیست. (ac.ir)
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE , infecting B-cells in humans. (lookformedical.com)
The type species is HERPESVIRUS 1, HUMAN . (lookformedical.com)
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS , but whose true origin is unknown. (lookformedical.com)
Vasculopathy and myocardial infarction associated with Neurofibromatosis type 1. (ocu-radiology.jp)
Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. (edu.pe)
Des mesures de protection contre cet type d'iinfection devraient être mises en place. (who.int)

HTLV-1 is a member of the Retroviridae family, the Orthoretrovirinae subfamily and the Deltaretrovirus genus, which includes bovine leukemia virus (BLV) and T-lymphotropic viruses infecting primates (PTLV). (biomedcentral.com)

For Herpes Simplex Virus 1 and 2, and syphilis, see above. (hslpathology.com)

Several studies indicate that HTLV-1 transmission occurs through sexual or other intimate contact-intrauterine, perinatal, breastfeeding, sharing of needles by drug users, or blood transfusion from infected persons. (medscape.com)
One study showed that transfusion of HTLV-1 antibody-positive blood causes seroconversion in 60% of recipients. (medscape.com)
Transfusion of plasma alone in humans did not result in seroconversion. (medscape.com)
HTLV-1 transmission occurs through sexual intercourse, prolonged breast-feeding, or blood transfusion. (biomedcentral.com)

Authentic commutable samples: each batch originates from a single human donor. (labquality.com)
Hemolysis is most common and most severe when incompatible donor RBCs are hemolyzed by antibodies in the recipient's plasma. (merckmanuals.com)

In relation to "CFS", the most-studied viruses have been the Epstein-Barr Virus (EBV) and the Human Herpes Virus-6 (HHV-6). (investinme.org)

Simian HTLV-1 genotypes are interspersed in between the human genotypes indicating frequent animal-human and human-animal transmission. (wikipedia.org)
The only human genotype that does not have a simian relative is A. It is thought that genotypes B, D, E, F and G originated in Africa from closely related STLV about 30,000 years ago, while the Asian genotype C is thought to have originated independently in Indonesia from the simians present there. (wikipedia.org)

The retrovirus is now generally called HTLV-I because later studies proved that ATLV is the same as the firstly identified human retrovirus called HTLV discovered by Bernard Poiesz and Francis Ruscetti and their co-workers in the laboratory of Robert C. Gallo at the National Cancer Institute. (wikipedia.org)
HTLV-1 is a retrovirus belonging to the family retroviridae and the genus deltaretrovirus. (wikipedia.org)
The etiologic agent of acquired immunodeficiency syndrome (AIDS) is a retrovirus designated human immunodeficiency virus (HIV). (cdc.gov)
EBV may also contribute to MS pathogenesis indirectly by activating silent human endogenous retrovirus-W. The emerging B-cell depleting therapies, particularly anti-CD20 agents such as rituximab, ocrelizumab, as well as the fully human ofatumumab, have shown promising clinical and magnetic resonance imaging benefit. (vitamindwiki.com)
Additionally, this mode of first retrovirus to be isolated in humans. (bvsalud.org)

Shape 1 A) Age-dependent herpesvirus 8 (HHV-8) seroprevalence prices in 376 Ni-Vanuatu individuals >65 years and surviving in 18 islands representative of the 6 provinces from the Vanuatu MK 0893 Archipelago. (careersfromscience.org)
B-lymphotropic human herpesvirus IgG, VCA IgM and EBNA IgG) can database. (who.int)

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an upper motor neuron syndrome affecting primarily the lower extremities. (medscape.com)
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. (fiocruz.br)

The antibody is used to detect HTLV-I surface protein and its precursor in lysates prepared from virions or infected cells. (zeptometrix.com)
Antibody dilutions should be prepared using buffers containing suitable protein in order to stabilize antibody activity. (zeptometrix.com)
Transcriptomic- and protein-level analysis at the single-cell and bulk levels reveals an age-associated decrease in the numbers of hepatic macrophages that express the scavenger receptor MARCO in mice, non-human primates and humans. (bvsalud.org)
To further investigate the function of the US11 protein, this study was undertaken to express the US11 protein and raise a polyclonal antibody. (biomedcentral.com)
After purification by nickel affinity chromatography and refolding, the recombinant protein was used to raise the anti-US11 polyclonal antibody. (biomedcentral.com)
Western blot analysis demonstrated that the US11 protein was specifically recognized by the polyclonal antibody, and immunofluorescent assay also showed that the antibody was able to probe the US11 protein in the cells infected with HSV-1. (biomedcentral.com)
In the present study, we obtained a high-level expression of the recombinant US11 protein as well as high titers of rabbit polyclonal antibody specially against US11 protein in HSV-1 infected cells. (biomedcentral.com)
This special polyclonal antibody provides a good tool for further studying structural and functional characterization of HSV-1 US11 protein. (biomedcentral.com)
Subsequently, a polyclonal antibody was raised against the purified His-tagged US11 protein in rabbits. (biomedcentral.com)
The full-length US11 gene, which is composed of 459 bp (base pairs) and predicted to encode a protein of 152 amino acids, was amplified successfully from the HSV-1 (strain F) genome (Figure 1 , lane 1). (biomedcentral.com)
Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis. (ocu-radiology.jp)

Although most HTLV-1-infected individuals are asymptomatic, fetal and childhood infections often result in several diseases with disappointing treatment outcomes. (e-cep.org)
Only 0.1%-3% of HTLV‐1 infections result in T cell leukemia. (diseases-illness.com)
We have clearly documented certain enterovirus infections triggering autoimmune responses in some patients…Can you imagine how we would feel if there are viruses surviving in our muscles, brains, hearts and gastrointestinal tracts triggering ongoing immune responses? (investinme.org)
HIV-1 causes most HIV infections worldwide, but HIV-2 causes many HIV infections in West Africa. (msdmanuals.com)
Most primary infections occur between 1 and 5 years while most reactivation infections occur after the age of 25 years. (who.int)

Because of re- analysis was conducted by using 2 analysis of contingency ports of HTLV-1-associated diseases in Mashhadi Jews, tables. (cdc.gov)
Ninety to ninety-five percent of people with MS have proteins in their spinal fluid that are typically found in the spinal fluid of people with nervous system diseases that are known to be reactions to viruses. (vitamindwiki.com)
Nanomedicines have been approved to treat multiple human diseases. (bvsalud.org)
10 years earlier, having had two to four sexually transmitted diseases, incarceration, tattooing, sex with a hepatitis B or C virus carrier or with intravenous drug users. (biomedcentral.com)
Virus diseases caused by the HERPESVIRIDAE. (lookformedical.com)
A general term for diseases produced by viruses. (lookformedical.com)

Proteinase 3 antineutrophil cytoplasmic antibody-associated vasculitis consistent with granulomatosis with polyangiitis. (ocu-radiology.jp)

HTLV-1: a health problem in Brazil can substantially reduce costs associated with confirmatory derived from the blood or produced locally10. (bvsalud.org)
Encouragingly, a more recently developed serological to evaluate intrathecal synthesis of specific and total antibodies, confirmatory assay (INNO-LIA, HTLV-I/II) yielded results for which represent specific inflammatory process markers in the most samples considered indeterminate or untypeable under CNS10. (bvsalud.org)
When required, additional donation testing is performed, including confirmatory testing, and screening for antibodies to CMV, human T-cell lymphotropic virus (HTLV) and malaria. (lifeblood.com.au)

23(1): 154, 2023 Jun 08. (bvsalud.org)

No specific sequence differences have been found between HTLV-1 recovered from patients with HAM, those with adult T-cell leukemia/lymphoma also caused by HTLV-1 (ATLL), and HTLV-1 carriers. (medscape.com)
At least 5-10 million transmission has been associated with adult T-cell leukemia/ individuals harbor the virus worldwide1. (bvsalud.org)
however, about 1 in 20 people will develop adult T-cell leukemia/lymphoma or HTLV-1 associated myelopathy (a chronic nervous system disease). (meridianbioscience.com)
Human T cell leukemia virus (HTLV-1) is an oncoretrovirus that infects at least 10 million people worldwide. (biomedcentral.com)

In Brazil, between lymphoma (ATLL) development in approximately 1-5% of 800,000 and 2.5 million individuals are infected with HTLV- infected children4. (bvsalud.org)
Primary bone lymphoma depicts a 1-2% of adult non-Hodgkin lymphomas. (biomedres.us)
Reports of a primary bone lymphoma (PBL) are rather rare, accounting for less than 1-2% of adult non-Hodgkin lymphomas (NHL) [1], commonly affecting mainly femur, as well as spine and pelvis, causing dominantly localized bone pain [2]. (biomedres.us)
Many factors are implicated, such as interleukin-1, PTHrP, and carcitriol produced by lymphoma cells, which all could mediate in bone destruction. (biomedres.us)

The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, Georgia 30333. (cdc.gov)

Seventeen percent of all adult AIDS patients were heterosexual men or women who abused IV drugs (1,2). (cdc.gov)
it is to be used by all states for AIDS case reporting effective January 1, 1993. (cdc.gov)
A state judge has dismissed a lawsuit filed by a journalist against a prominent AIDS activist for allegedly defaming her in a public dispute over an article she wrote challenging the scientific consensus that AIDS is caused by the human immunodeficiency virus. (blogspot.com)
This paper presents the prevalence of coinfection of HTLV among HIV-1 infected and AIDS patients in Belém, State of Pará, Brazil. (scielo.br)

The presence of at least 2 of the following 3 criteria distinguished MS from migraine and lupus with better sensitivity (85%) and specificity (98%): (1) 5 or more T2-bright foci, (2) 2 or more periventricular T2-bright foci, and (3) one or more T2-bright areas in the brainstem. (medscape.com)
[ 42 ] They reported that the children could be categorized as having MS versus ADEM with 81% sensitivity and 95% specificity based on 2 of the following 3 brain MRI criteria: (1) absence of a diffuse bilateral T2-bright lesion pattern, (2) the presence of T1 "black holes," and (3) the presence of 2 or more T2-bright periventricular foci. (medscape.com)

Flow cytometric analysis of CD21 expression on human peripheral blood lymphocytes. (bdbiosciences.com)

This study analyzed the correlation between antiviral vaccines, including the hepatitis B virus (HBV), human papillomavirus (HPV), measles-mumps-rubella (MMR), varicella zoster virus (VZV), and influenza vaccines, and different manifestations of uveitis. (bvsalud.org)
Influenza virus is another focus of her team. (cgu.edu.tw)

The present results show for the first time in Belém not only the occurrence of HTLV-II/HIV-1 coinfections but also a higher prevalence of HTLV-II in relation to HTLV-I. Furthermore, it also enlarges the geographical limits of the endemic area for HTLV-II in the Amazon region of Brazil. (scielo.br)

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)

Although gaps remain in our understanding of the etiology of MS, the role, if any, of viruses in propagating pathogenic immune responses deserves attention. (vitamindwiki.com)

Applied R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone) is the most common utilized chemotherapy regime, while local radiotherapy is also proposed to be applied directly upon the lesion for the prevention of pathologic fractures [1]. (biomedres.us)

This section looks for mutations that confer resistance to specific types of drugs in the viruses present in patient samples. (hslpathology.com)
We determined the prevalence of surveillance drug resistance mutations (SDRMs) and HIV-1 genetic diversity in Bulgaria during 2012-2020 using polymerase sequences from 1053 of 2010 (52.4%) antiretroviral therapy (ART)-naive individuals. (cdc.gov)

Antibody-based testing for emtricitabine (FTC), a critical component of pre-exposure prophylaxis and antiretroviral therapy would provide low-cost detection for clinical monitoring to improve adherence. (cdc.gov)

[ 1 ] CTCL subtypes demonstrate a variety of clinical, histologic, and molecular features, and can follow an indolent or a very aggressive course. (medscape.com)
Human T-cell lymphotropic virus (HTLV) and its subtypes were estimated to have infected 5-10 million people worldwide [ 1 - 3 ]. (e-cep.org)

The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
There is increasing awareness that the dysregulated immune system that is a hall-mark of ME/CFS allows multiple latent viruses and microbial agents to become reactivated (Co-Cure NOT:12th November 2009). (investinme.org)

Age was described as mean ± standard de- began screening all blood units for HTLV-1 antibodies in viation. (cdc.gov)
Few, if any, free virions are produced and there is usually no detectable virus in the blood plasma though the virus is present in genital secretions. (wikipedia.org)
According to one theory, supply of HTLV-1-infected CD4 cells via the blood to the CNS is essential for development of CNS lesions. (medscape.com)
A myriad of agents can potentially be transmitted through blood transfusions, including bacteria, viruses, and parasites. (medscape.com)
The estimated residual risk of contamination of blood products with bacterial agents is 1 in 5,000 for platelets and 1 in 30,000 for red blood cells. (medscape.com)
Prevalence of HIV-1 in blood donations following implementation of a structured blood safety policy in South Africa. (medigraphic.com)
The Study Our work was performed on a large collection of ≈4 500 plasma and peripheral blood buffy coat (PBBC) samples from different islands of the archipelago obtained in the framework of our previous studies on human T-cell lymphotropic virus (HTLV-1) ( 11 12 ). (careersfromscience.org)
Whole blood was stained with either PE-Cy™5 Mouse Anti-Human CD21 (Cat. (bdbiosciences.com)
plasma antibodies, or hemolyzed or fragile RBCs (eg, by overwarming stored blood or contact with hypotonic IV solutions). (merckmanuals.com)
The most common way is when an individual who is infected with a virus contracts it from contact with blood or body fluids that have been exposed to the virus. (picukiways.com)
In addition, viruses may also be present in donated blood products. (picukiways.com)
Blood tests to check for HIV antibody and to measure the amount of HIV virus can confirm the diagnosis. (msdmanuals.com)

Molecular studies point to a fairly low evolution rate of HTLV-1 (between 5.6E−7 and 1.5E−6 substitutions/site/year), supposedly because the virus persists within the host via clonal expansion (instead of new infectious cycles that use reverse transcriptase). (biomedcentral.com)

Then, the recombinant plasmid was verified by colony PCR (Figure 1 , lane 2) and restriction enzymes digestion (Figure 1 , lane 3). (biomedcentral.com)

Respondent Abbott is infected with the human immunodeficiency virus (HIV), but had not manifested its most serious symptoms when the incidents in question occurred. (justia.com)

A conditioning regimen may include chemotherapy, monoclonal antibody therapy, and radiation to the entire body. (scdstudies.com)
Note: To be performed within 28 days prior to Day 1 of protocol therapy. (scdstudies.com)
Radiation therapy is good enough for a patient who is having an early stage disease/ localized disease (stage-1) and having some symptoms because of it. (lymphomaindia.com)

This previously unknown and unsuspected aspect of enterovirus replication provides an explanation for reports of enteroviral RNA detected in diseased tissue in the apparent absence of virus particles" (Journal of IiME 2009:3:1). (investinme.org)

[ 2 ] Whereas only a small proportion of HTLV-1-infected individuals develop HAM/TSP (1-4%), the mechanisms responsible for the progression of a HTLV-1 carrier state to clinical disease are not clear. (medscape.com)
The system is based on three ranges of CD4+ T- lymphocyte counts and three clinical categories and is represented by a matrix of nine mutually exclusive categories (Table 1). (cdc.gov)
This system replaces the classification system published in 1986, which included only clinical disease criteria and which was developed before the widespread use of CD4+ T-cell testing (1). (cdc.gov)
This study aimed to conduct a pooled estimate of HTLV-1 prevalence among pregnant women in Nigeria to quantify its clinical burden and public health implications. (e-cep.org)

Reduction of sexual and IV transmission of HTLV-III/LAV should be enhanced by using available serologic tests to give asymptomatic, infected individuals in high-risk groups the opportunity to know their status so they can take appropriate steps to prevent the further transmission of this virus. (cdc.gov)
Les études qui doivent être menées, en particulier dans les pays où la transmission est active, sont répertoriées dans le présent article. (who.int)
it derives from interspecies zoonotic transmission from non-human primates to humans (ancient or recent). (biomedcentral.com)
Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). (lookformedical.com)
The occurrence of HTLV-I/II and HIV-1 coinfections have been shown to be frequent, probably in consequence of their similar modes of transmission. (scielo.br)
1997). The similar modes of transmission of the same organic fluids in which HIV and HTLV are present, favours their joint transmission, sharing the same human host when the viruses occur in the same epidemiological setting (Galvão-Castro 1994). (scielo.br)

Her team has been studying many aspects of emerging RNA viruses, including identification of unknown viruses using novel biotechnologies, mechanisms of pathogenesis and development of antiviral compounds. (cgu.edu.tw)

Optimal dilution of antibody must be determined experimentally by the investigator. (zeptometrix.com)
Among these 376 plasma examples 170 (45.2%) were IFA positive in a 1:160 dilution teaching a definite typical nuclear spotted seroreactivity. (careersfromscience.org)

Anatomy11

Organisms25

Diseases14

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes23

Information Science4

Named Groups3

Health Care2

Geographicals6

Antigens5

Monoclonal Antibodies2

Adult T-cell l1

Infection40

Antigen5

Retroviruses6

Viral13

Form a unique fingerprint1

Lymphadenopathy-Assoc1

Cell-depletin1

Antinuclear antibodies1

Enzyme6

Serum3

Presence of antibodies1

Assays4

Donors10

Type19

Bovine leuke1

Syphilis1

Transfusion4

Donor2

Epstein-Barr1

Simian2

Retrovirus5

Herpesvirus2

Tropical spastic par2

Protein11

Infections5

Diseases6

Antineutrophil1

Confirmatory3

20231

Leukemia4

Lymphoma4

MMWR1

AIDS4

Specificity2

Lymphocytes1

Influenza2

HTLV-II1

Affinity1

Pathogenic1

Rituximab1

Mutations2

Detection1

Subtypes2

Latent viruses2

Blood12

Reverse transcriptase1

Recombinant1

Abbott1

Therapy3

Absence1

Clinical4

Transmission6

Pathogenesis1

Dilution2