AntigenTransferaseSpecificityMonoclonalSmooth Muscle AntibodyConjugateELISASerum antibodiesAlanine aminotransferaseAssay KitRecombinantNeutropeniaLiverDetectsInfectionPapillomavirusZYNLONTAConjugatesBindsProteinBelongsTumorGeneMetabolismRabbitReagentIndirectOccasionalImmunogensLaboratoriesVirusAcuteResearchTestAtherosclerosis
Antigen4
- 12. Positive result of hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab), human immunodeficiency virus (HIV) antibody, or syphilis at screening. (who.int)
- Rabbit polyclonal antibodies (pAb) were used for preparing a gold-pAb conjugate, and the rGroEL-specific mouse monoclonal antibody was used as the antigen detection reagent at the ICT test line. (jsce-ip.com)
- Infectious diseases were excluded by negative results for viral markers [hepatitis B surface antigen and hepatitis C virus antibody, hepatitis A virus antibody (IgM), and anti-human immunodeficiency virus (HIV) antibody], serum antibodies to helminthic parasites, serologic test for Fasciola hepatica , and stool examinations for parasites and protozoa were all negative. (biomedcentral.com)
- Belantamab mafodotin is an antibody-drug conjugate that contains belantamab, an afucosylated humanised monoclonal IgG1k antibody specific for B cell maturation antigen (BCMA), produced using recombinant DNA technology in a mammalian cell line (Chinese Hamster Ovary) that is conjugated with maleimidocaproyl monomethyl auristatin F (mcMMAF). (medicines.org.uk)
Transferase3
- The most common Grade 3 or 4 laboratory abnormalities (≥ 2%) were decreased lymphocytes, decreased albumin, decreased phosphate, decreased potassium, increased alkaline phosphatase, increased glucose, increased gamma-glutamyl transferase, and decreased sodium. (drugs.com)
- Furthermore, in animals that received the BNT162b2 injection, reversible hepatic effects were observed, including enlarged liver, vacuolation, increased gamma glutamyl transferase (γGT) levels, and increased levels of aspartate transaminase (AST) and alkaline phosphatase (ALP) [26]. (blogspot.com)
- In addition, patient N03 had a grade 3 elevation of gamma-glutamyl transferase, and not grade 2 (see corrected Table 2 overleaf). (uni-frankfurt.de)
Specificity1
- Introduction: ScFv(FRP5)-ETA is a recombinant antibody toxin with binding specificity for ErbB2 (HER2). (uni-frankfurt.de)
Monoclonal4
- Loncastuximab tesirine, sold under the brand name Zynlonta, is a monoclonal antibody conjugate medication used to treat large B-cell lymphoma and high-grade B-cell lymphoma. (wikipedia.org)
- The humanized monoclonal antibody is stochastically conjugated via a valine-alanine cleavable, maleimide linker to a cytotoxic (anticancer) pyrrolobenzodiazepine (PBD) dimer. (wikipedia.org)
- BLENREP is indicated as monotherapy for the treatment of multiple myeloma in adult patients, who have received at least four prior therapies and whose disease is refractory to at least one proteasome inhibitor, one immunomodulatory agent, and an anti-CD38 monoclonal antibody, and who have demonstrated disease progression on the last therapy. (medicines.org.uk)
- We have determined expression of human GGT gene encoding γ-glutamyl transpeptidase (GGT) during fetal development of liver using the Northern-blot analysis with a cloned human GGT cDNA and immunohistochemistry with a monoclonal antibody. (elsevierpure.com)
Smooth Muscle Antibody1
- Also, the workup for autoimmune hepatitis [antinuclear antibodies (ANA), smooth muscle antibody (SMA), anti-liver kidney microsomal type 1 (anti-LKM antibody 1) and anti-mitochondrial antibody (AMA)] was negative. (biomedcentral.com)
Conjugate2
- ZYNLONTA is a CD19-directed antibody and alkylating agent conjugate indicated for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low-grade lymphoma, and high-grade B-cell lymphoma. (nih.gov)
- It is an antibody-drug conjugate (ADC) composed of a humanized antibody targeting the protein CD19. (wikipedia.org)
ELISA2
- Methods: This dissertation should prove the reliability of the recently approved anti-IgA human transglutaminase ELISA for the diagnosis of coeliac disease. (uni-tuebingen.de)
- The presence of C. burnetii DNA in swabs and the tick H. lusitanicum was determined by PCR and serum antibodies by ELISA. (jsce-ip.com)
Serum antibodies1
- Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003-2012. (cdc.gov)
Alanine aminotransferase1
- The Clinical Laboratory Improvement Amendments criteria were used in evaluating the laboratories, and their success rates were compared with the World Health Organization Regional Office for Africa's target of 80%.Results: The overall rate of acceptable results at the laboratories was over 80% for glucose, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase and triglycerides tests. (bvsalud.org)
Assay Kit1
- Human/Monkey Anti-Bovine Type I Collagen IgA Antibody Assay Kit, TMB is available at Gentaur for next week delivery. (biomedfrontiers.org)
Recombinant1
- CheckMate -67T is a Phase 3 randomized, open-label trial evaluating subcutaneous administration of Opdivo co-formulated with Halozyme's proprietary recombinant human hyaluronidase, rHuPH20, or subcutaneous nivolumab (nivolumab and hyaluronidase) compared to intravenous (IV) Opdivo , in patients with advanced or metastatic clear cell renal cell carcinoma (ccRCC) who have received prior systemic therapy. (businesswire.com)
Neutropenia1
- The most common side effects include increased levels of gamma-glutamyltransferase (GGT, a liver enzyme), neutropenia (low levels of neutrophils, a type of white blood cell), tiredness, anemia (low levels of red blood cells), thrombocytopenia (low levels of blood platelets), nausea (feeling sick), peripheral edema (swelling due to fluid retention, especially of the ankles and feet) and rash. (wikipedia.org)
Liver5
- The liver is the most sensitive target in exposed humans and animals, independent of the route of administration, because of the abundance of CYP2E1 and other cytochromes. (cdc.gov)
- Studies in animals, combined with limited observations in humans, indicate that the principal adverse health effects associated with inhalation exposure to carbon tetrachloride are central nervous system depression, liver damage, and kidney damage. (cdc.gov)
- Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in 'Human Liver Cell Line! (blogspot.com)
- The liver is one of the largest internal and most metabolic organ in human body. (planetayurveda.com)
- The size of the mRNA in the fetal liver was 2.7 kb and mRNA of the same size was detected both in the human fetal kidney and human hepatocellular carcinoma as well as normal adult liver. (elsevierpure.com)
Detects2
- GGT7 Antibody detects endogenous levels of GGT7. (affbiotech.com)
- One of them was an immunofluorescent assay, which detects IgA-endomysium-antibodies (EMA-IFT) on monkey oesophagus sections the other one was an immuneprecipitation assay for the detection of IgA antibodies against hu-tTG. (uni-tuebingen.de)
Infection4
- T. gondii infects humans through different routes, and it is capable of invading a wide range of tissues in the human body following the infection. (mdpi.com)
- Hepatitis G, an RNA flavivirus renamed as human pegivirus, or "HPgV," causes a parenterally transmitted infection of the reticuloendothelial system. (medscape.com)
- [ 6 , 7 ] Because HAV infection induces lifelong protection against reinfection, an elevated IgG antibody would indicate a prior infection or prior vaccination. (medscape.com)
- There is practically no maternal-fetal transmission of HAV, as anti-HAV IgG antibodies present during the initial stages of HAV infection cross the placenta and provide protection to the infant after delivery, which poses a minimal risk to the fetus and newborn. (medscape.com)
Papillomavirus3
- Sustained Cross-Reactive Antibody Responses After Human Papillomavirus Vaccinations: Up To 12 Years Follow-Up In The Finnish Maternity Cohort. (ppshp.fi)
- Long-term follow-up of human papillomavirus type replacement among young pregnant Finnish females before and after a community-randomised HPV vaccination trial with moderate coverage. (ppshp.fi)
- Regional variations in human papillomavirus prevalence across time in NHANES (2003-2014). (cdc.gov)
ZYNLONTA1
- On 15 September 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Zynlonta, intended for the treatment of adults with diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBL). (wikipedia.org)
Conjugates1
- With a new generation of antibody-drug conjugates (ADCs) that contain a drug-to-antibody ratio (DAR) of 2, the question remains whether advances in technology have resulted in more stable and tumor-specific ADCs. (bvsalud.org)
Binds2
- medical citation needed] The antibody binds to CD19, a protein which is highly expressed on the surface of B-cell hematological tumors including certain forms of lymphomas and leukemias. (wikipedia.org)
- The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. (ifn-a.com)
Protein3
- Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. (affbiotech.com)
- Transglutaminase 2 (TG2), encoded by the TGM2 gene, is also known as tissue transglutaminase (tTG), transgluytaminase C (TGC), and protein-glutamine-gamma-glutamyltransferase. (rndsystems.com)
- These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)
Belongs1
- Belongs to the gamma-glutamyltransferase family. (affbiotech.com)
Tumor1
- medical citation needed] After binding to the tumor cells the antibody is internalized, the cytotoxic drug PBD is released and the cancer cells are killed. (wikipedia.org)
Gene1
- This phenotype is rescued by transgenic expression of the human ABCB4 gene, confirming that phospholipid excretion is dependent on ABCB4. (medscape.com)
Metabolism1
- Most other toxic effects of absorbed carbon tetrachloride are related to its metabolism by mixed function cytochrome P-450 oxygenases (in humans, primarily CYP2E1, but also CYP3A). (cdc.gov)
Rabbit1
- Serology performed in samples of both toxicity studies showed significant and substantial anti-VLP-specific antibody titers for rNV-2v vaccines administered via the IM or SC route www.joplink.net/rabbit-antibodies , as well as relevant NoV blocking antibody responses. (jsce-ip.com)
Reagent1
- The Interferon Gamma Release Assay (Igra) reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (ifn-a.com)
Indirect1
- Anaplasma PCR was negative, possibly because blood samples were tested retrospectively after 3 months of storage at -20°C. However, a commercially available indirect fluorescent antibody assay was able to demonstrate seroconversion of HGE-specific IgM antibodies 1 month after the initial onset of symptoms. (cdc.gov)
Occasional1
- Prevalence and persistence of Chlamydia trachomatis-specific antibodies after occasional and recurrent infections. (ppshp.fi)
Immunogens1
- A plant-based expression system (magnICON®) was used to manufacture two different virus-like particle (VLP) immunogens derived from human NoV genogroups I and II, genotype 4 (GI.4 and GII.4), which were subsequently blended 1:1 (w/w) into a bivalent vaccine composition (rNV-2v). (jsce-ip.com)
Laboratories1
- Gamma Assay Laboratories manufactures the interferon gamma release assay (igra) reagents distributed by Genprice. (ifn-a.com)
Virus1
- Active or reactivated virus: human herpes virus-6 (HHV-6), human herpes virus-7 (HHV-7), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) using quantitative polymerase chain reaction (qPCR) on serum or plasma. (dresssyndromefoundation.org)
Acute2
- Acute human granulocytic ehrlichiosis (HGE) caused by A. phagocytophilum has rarely been documented in Europe ( 2 ). (cdc.gov)
- Noroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans worldwide. (jsce-ip.com)
Research2
- Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody for research use. (antibodies-shop.com)
- Compared to studies of non-B, non-T leukemia in human ALL ( 6 , 9 ), there is limited research available on non-B, non-T cell-origin lymphocytic leukemia in veterinary medicine. (e-jvc.org)
Test1
- Four weeks after the onset of symptoms, a test for A. phagocytophilum -specific IgM antibodies was positive and IgG was negative thereafter ( Table ). (cdc.gov)
Atherosclerosis2
- TGM2 has been implicated in a variety of human diseases including celiac disease, inclusion body myositis, atherosclerosis, and neurodegenerative diseases. (rndsystems.com)
- Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. (urv.cat)