• proteins
  • It was found that of the structural proteins, El glycoprotein was the dominant antigen recognized by the study population sampled from normal individuals with no history of rubella associated conditions. (ubc.ca)
  • Immune responses targeting these proteins could thus result in a limited or no generation of antigen-loss variants and, therefore, they may efficiently control in vivo tumor growth, thus meeting the requirements for an ideal TAA set forth above. (aacrjournals.org)
  • Our prediction is that at least some of the CSC antigens will match proteins already known to serve as TAAs and expressed by embryo-fetal tissues (e.g., survivin, telomerase, cancer/testis antigens) reflecting common functions between embryonic stem cells and CSCs, i.e., multipotent differentiation, plasticity, and self-renewal. (aacrjournals.org)
  • react
  • However the antibodies may also react against the myocardium and joints, producing the symptoms of rheumatic fever. (wikipedia.org)
  • Myasthenia gravis (MG) is caused by antibodies that react mainly with the acetylcholine receptor on the postsynaptic site of the neuromuscular junction. (hindawi.com)
  • Although cardiac and skeletal muscle RyRs are antigenically different, anti-RyR antibodies in MG patients cross-react with both subtypes of the receptor [ 12 ]. (hindawi.com)
  • autoimmune
  • Anti-Kv1.4 antibody is a useful marker for the potential development of lethal autoimmune myocarditis and response to calcineurin inhibitors. (hindawi.com)
  • Acquired myasthenia gravis (MG) in an organ-specific autoimmune disorder generally mediated by antiacetylcholine receptor (AChR) or less frequently by antimuscle-specific tyrosine antibodies at the neuromuscular junction [ 1 ]. (hindawi.com)
  • Risk factors for developing antiphospholipid syndrome include:[citation needed] Primary APS genetic marker HLA-DR7 Secondary APS SLE or other autoimmune disorders Genetic markers: HLA-B8, HLA-DR2, HLA-DR3 Race: Blacks, Hispanics, Asians, and Native Americans There is an additional elevated risk of adrenal gland bleeds leading to Waterhouse-Friderichsen syndrome (Neisseria meningitidis caused primary adrenal insufficiency). (wikipedia.org)
  • adverse drug reac
  • Progress on non-HLA genes affecting adverse drug reactions has been less, but some important associations, such as those of SLCO1B1 and statin myopathy, KCNE1 and drug-induced QT prolongation and NAT2 and isoniazid-induced liver injury, are considered. (biomedcentral.com)
  • donors
  • 3 ⇓ - 5 A recently published literature review states that in 80% of all TRALI cases, white blood cell antibodies can be identified in the implicated blood donor, 6 and most implicated donors have been women with a history of pregnancy. (bloodjournal.org)
  • they are also critical in the field of transplant surgery where the donors and the recipients must be HLA-compatible [ 3 ]. (hindawi.com)
  • genes
  • Many of the associations identified for reactions affecting the liver and skin involve human leukocyte antigen (HLA) genes and for reactions relating to the drugs abacavir and carbamazepine, HLA genotyping is now in routine use prior to drug prescription. (biomedcentral.com)
  • cells
  • During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells which differentiate into helper T2 cells. (wikipedia.org)
  • Recently, another group of TAAs was described that include antigens overexpressed by neoplastic and fetal cells, and was weakly expressed in a phase-specific way in a few normal cells ( 14 , 15 ). (aacrjournals.org)
  • However, because these TAAs are expressed even by the majority of cancer cells of a given tumor, while CSCs encompass a small subpopulation of the tumor mass, CSCc may represent a better target if specifically enriched in cancer/testis, IAP-derived and/or mutated (unique) antigens in parallel with stem cell markers (e.g. (aacrjournals.org)
  • clinical
  • Detection of striational antibodies provides more specific and useful clinical information in MG patients. (hindawi.com)
  • The detection of these three striational antibodies can provide more specific clinical information and are associated with the subtypes of MG patients. (hindawi.com)
  • After a decade of cancer immunotherapy (both active and adoptive), based on the use of well-defined tumor-associated antigens (TAA), and despite the large amount of new information that has been collected both in preclinical and clinical settings, the clinical outcome of immunotherapy trials has been altogether disappointing ( 1 , 2 ). (aacrjournals.org)
  • particularly
  • Particularly, three types of striational antibodies including those to titin, ryanodine receptor (RyR), and Kv1.4 have been investigated by many researchers. (hindawi.com)
  • specific
  • Antigen recognition by six D4V-specific clones and three D2V- and D4V-cross-reactive clones was restricted by HLA-DR7. (umassmed.edu)
  • Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure. (nih.gov)
  • Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant. (nih.gov)
  • Other HLA associations are not sufficiently specific for translation but are still of interest in relation to underlying mechanisms for the reactions. (biomedcentral.com)
  • However
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
  • found
  • The most frequent A-B-DR-DQ haplotypes in Korea are found at ~3/4 the Korean frequencies in Japan, except A33-Cw7-B44-DR7-DQ2, which indicates that DR7 likely spread into Korea after the Japan's Yayoi migration when most of the Korean contribution occurred. (wikipedia.org)
  • show
  • The A19 (A29, A30, A31, A32, A33, A74) serotypes are very much enriched in sub-sarahan and Western Africa, including Iberia, and disequilibrated components of DR7 show a tendency to be linked to A19 serotypes. (wikipedia.org)
  • primary
  • DR7-DQ2/DR5-DQ7 phenotype (transhaplotype encoded isoform DQα5β2) is the primary risk DQ isoform in celiac disease. (wikipedia.org)
  • risk
  • DR7-DQ2/DR5-DQ7 (/DR11-DQ7 or /DR12-DQ7) is a clarifying identifier for the at risk transhaplotype. (wikipedia.org)