• Conjugate
  • An antibody-drug conjugate GSK2857916 is in early clinical trials.Side effects are expected to include corneal toxicity. (wikipedia.org)
  • CAR T-cell therapy bb2121 shows promising efficacy for multiple myeloma Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Clinical Activity of GSK2857916 Early Promise for Experimental Antibody-Drug Conjugate in Multiple Myeloma Human TNFRSF17 genome location and TNFRSF17 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • interleukin
  • The protein expression levels of mitogen-activated protein kinases (MAPKs), the p65 subunit of nuclear factor-κB (NF-κB), c-Fos, c-Jun, nuclear factor of activated T cells, cytoplasmic 1 (NFATc1), TNF receptor-associated factor-6 (TRAF6), and interleukin-1β (IL-1β) were assessed by western blot analysis. (pubmedcentralcanada.ca)
  • They act by inhibiting genes that code for the cytokines Interleukin 1 (IL-1), IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, and TNF-alpha, the most important of which is IL-2. (wikipedia.org)
  • CD122 - This molecule, which is the Interleukin-2 receptor beta sub-unit, is known to increase proliferation of CD8+ effector T cells. (wikipedia.org)
  • They include interleukin-1 (IL-1), IL-12, and IL-18, tumor necrosis factor (TNF), interferon gamma (IFN-gamma), and granulocyte-macrophage colony stimulating factor and play an important role in mediating the innate immune response. (wikipedia.org)
  • Proinflammatory cytokines include interleukin-1 (IL-1), IL-12, and IL-18, tumor necrosis factor (TNF), interferon gamma (IFN-gamma), and granulocyte-macrophage colony stimulating factor. (wikipedia.org)
  • Interleukin 1- and interleukin 2-dependent proliferation of activated T cells, and the activation of quiescent helper T cells and cytotoxic T cells is prevented by the activity of TGF-β1. (wikipedia.org)
  • TRAF6
  • The increased expression of IL-1β following the stimulation of RAW 264.7 cells with RANKL activated TRAF6, p-ERK, p-JNK, p-p65, p-c-Fos and NFATc1. (pubmedcentralcanada.ca)
  • Immunocytochemistry/ Immunofluorescence: TRAF-6 Antibody [NBP1-- K562 cells with TRAF6 antibody at 0.5 ug/ml. (novusbio.com)
  • Antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human TRAF6. (novusbio.com)
  • TRAF6 antibody can be used for detection of TRAF6 by Western blot at 1 to 2 mg/ml. (novusbio.com)
  • TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. (novusbio.com)
  • TRAF6 stimulates the activation of the c-jun N-terminal kinase (JNK) and nuclear factor kappa-b (NF-kB) pathways which trigger differentiation and activation of osteoclasts. (wikipedia.org)
  • immune
  • The primary role of TNF is in the regulation of immune cells . (wn.com)
  • A2AR - The Adenosine A2A receptor is regarded as an important checkpoint in cancer therapy because adenosine in the immune microenvironment, leading to the activation of the A2a receptor, is negative immune feedback loop and the tumor microenvironment has relatively high concentrations of adenosine. (wikipedia.org)
  • This system is balanced by the relative expression of OPG to RANKL, which are highly regulated by many factors including hormones, immune signals, and growth factors. (wikipedia.org)
  • The antibodies which the immune system generates against the M protein may cross-react with heart muscle cell protein myosin, heart muscle glycogen and smooth muscle cells of arteries, inducing cytokine release and tissue destruction. (wikipedia.org)
  • 2001
  • Feldmann M, Maini RN (2001) Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? (springer.com)
  • ELISA
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • RANKL
  • A synergistic effect of IL-1β on the formation of RANKL-induced osteoclast-like MNCs was found in two experimental cells. (pubmedcentralcanada.ca)
  • In in vitro studies, IL-1 has been found to be a pluripotent cytokine that exhibits bone resorption activity through interaction with the RANKL-RANK system or binding with the IL-1 receptor (IL-1R) ( 8 - 10 ). (pubmedcentralcanada.ca)
  • The binding of RANKL to RANK trimerizes the receptor and activates a signaling pathway. (wikipedia.org)
  • Once the tumor is seeded in the bone, the tumor cells stimulate bone resorption by secreting factors such as RANKL or prompting the surrounding stroma to express growth factors. (wikipedia.org)
  • Clinical
  • In 2017, a phase 1 clinical trial employed a CAR-T therapy that targeted BCMA02 in multiple myeloma with a drug labeled bb2121. (wikipedia.org)
  • At least one anti-APRIL monoclonal antibody has been announced to enter phase I clinical trials for multiple myeloma. (wikipedia.org)
  • differentiation
  • This suggests that IL-1 is a crucial cytokine for osteoclast differentiation and activation, and can thus be considered a potent therapeutic target in the treatment of bone disorders ( 11 ). (pubmedcentralcanada.ca)
  • BCMA
  • A conserved domain at the N-terminus, BCMA TALL-1 binding domain, is required for binding to the TNFSF13B. (wikipedia.org)
  • downstream
  • In addition, most TNF receptors require specific adaptor protein such as TRADD , TRAF , RIP and FADD for downstream signalling. (wn.com)
  • kinase
  • It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. (novusbio.com)
  • Western Blot
  • Abgent's experienced staff custom validates more than 1,000 antibodies each month in Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FC) and additional applications. (abgent.com)
  • Western Blot: TRAF-6 Antibody [NBP1-- PC-3 cell lysates with TRAF-6 antibody at 1 ug/ml in the presence (A) or absence (B) of 1 ug blocking peptide. (novusbio.com)
  • molecules
  • Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-kappaB. (novusbio.com)
  • ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic (anticancer) payload or drug. (wikipedia.org)
  • As a large variety of mAb-based agents targeting a plethora of cytokines, chemokines, adhesion and co-stimulatory molecules, receptors, as well as diverse cell types, are presently under investigation, the therapeutic armamentarium of the clinician is expected to greatly broaden in the near future, providing improved patient care for a wide range of devastating diseases of our times. (springer.com)
  • Four stimulatory checkpoint molecules are members of the tumor necrosis factor (TNF) receptor superfamily - CD27, CD40, OX40, GITR and CD137. (wikipedia.org)
  • Adhesion between FDCs and B cells is mediated by ICAM-1 (CD54)-LFA-1 (CD11a) and VCAM-VLA-4 molecules. (wikipedia.org)
  • cytotoxic
  • On August 17, 2017 Inotuzumab ozogamicin was also approved by the US FDA for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) A stable link between the antibody and cytotoxic (anti-cancer) agent is a crucial aspect of an ADC. (wikipedia.org)
  • In 1968, Dr. Gale A Granger from the University of California, Irvine, reported a cytotoxic factor produced by lymphocytes and named it lymphotoxin (LT). Credit for this discovery is shared by Dr. Nancy H. Ruddle from Yale University, who reported the same activity in a series of back-to-back articles published in the same month. (wikipedia.org)
  • cell
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • Tumor necrosis factor ( TNF , tumor necrosis factor alpha , TNFα , cachexin , or cachectin ) is a cell signaling protein ( cytokine ) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction . (wn.com)
  • TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia , inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. (wn.com)
  • This means that, in contrast to traditional chemotherapeutic agents, antibody-drug conjugates target and attack the cancer cell so that healthy cells are less severely affected. (wikipedia.org)
  • This receptor is required for generation and long-term maintenance of T cell immunity. (wikipedia.org)
  • This diminishes both B cell clone expansion and antibody synthesis. (wikipedia.org)
  • This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. (wikipedia.org)
  • TNFRSF17 has been shown to interact with the B-cell activating factor TNFSF13B. (wikipedia.org)
  • The American biotech company Celldex Therapeutics is working on CDX-1127, an agonistic anti-CD27 monoclonal antibody which in animal models has been shown to be effective in the context of T cell receptor stimulation. (wikipedia.org)
  • The biotech company TG Therapeutics is working on anti-GITR antibodies ICOS - This molecule, short for Inducible T-cell costimulator, and also called CD278, is expressed on activated T cells. (wikipedia.org)
  • This protein and its receptor are both found to be important for B cell development. (wikipedia.org)
  • Helper T2 cells subsequently activate the B cells to become plasma cells and induce the production of antibodies against the cell wall of Streptococcus. (wikipedia.org)
  • S. pyogenes has a cell wall composed of branched polymers which sometimes contain M protein, a virulence factor that is highly antigenic. (wikipedia.org)