• antigen
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
  • Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. (novusbio.com)
  • The biochemical reaction between the antibody and the target protein (antigen) triggers a signal in the tumor cell, which then absorbs or internalizes the antibody together with the cytotoxin. (wikipedia.org)
  • OX40's value as a drug target primarily lies in the fact that, being transiently expressed after T-cell receptor engagement, it is only upregulated on the most recently antigen-activated T cells within inflammatory lesions. (wikipedia.org)
  • Unlike other DCs and macrophages, FDCs lack MHC class II antigen molecules and express few pattern-recognition receptors, so they have little ability to capture non-opsonized antigens. (wikipedia.org)
  • Follicular DCs receptors CR1, CR2 and FcγRIIb trap antigen opsonized by complement or antibodies. (wikipedia.org)
  • Conjugate
  • An antibody-drug conjugate GSK2857916 is in early clinical trials.Side effects are expected to include corneal toxicity. (wikipedia.org)
  • CAR T-cell therapy bb2121 shows promising efficacy for multiple myeloma Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Clinical Activity of GSK2857916 Early Promise for Experimental Antibody-Drug Conjugate in Multiple Myeloma Human TNFRSF17 genome location and TNFRSF17 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • interleukin
  • However, several pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin (IL)-1, in combination with the RANK-RANKL complex, play a crucial role in enhancing osteoclast differentiation and activation in chronic inflammatory conditions, such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), and chronic gouty arthritis ( 4 - 7 ). (pubmedcentralcanada.ca)
  • They act by inhibiting genes that code for the cytokines Interleukin 1 (IL-1), IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, and TNF-alpha, the most important of which is IL-2. (wikipedia.org)
  • CD122 - This molecule, which is the Interleukin-2 receptor beta sub-unit, is known to increase proliferation of CD8+ effector T cells. (wikipedia.org)
  • They include interleukin-1 (IL-1), IL-12, and IL-18, tumor necrosis factor (TNF), interferon gamma (IFN-gamma), and granulocyte-macrophage colony stimulating factor and play an important role in mediating the innate immune response. (wikipedia.org)
  • Proinflammatory cytokines include interleukin-1 (IL-1), IL-12, and IL-18, tumor necrosis factor (TNF), interferon gamma (IFN-gamma), and granulocyte-macrophage colony stimulating factor. (wikipedia.org)
  • Interleukin 1- and interleukin 2-dependent proliferation of activated T cells, and the activation of quiescent helper T cells and cytotoxic T cells is prevented by the activity of TGF-β1. (wikipedia.org)
  • Furthermore, the expression of monocytic cytokines (including interleukin-1(IL-1)-alpha, IL-1-beta, and TNF-α), and phagocytic killing by macrophages can be increased by the action of TGF-β1. (wikipedia.org)
  • cytotoxic
  • ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic (anticancer) payload or drug. (wikipedia.org)
  • On August 17, 2017 Inotuzumab ozogamicin was also approved by the US FDA for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) A stable link between the antibody and cytotoxic (anti-cancer) agent is a crucial aspect of an ADC. (wikipedia.org)
  • In 1968, Dr. Gale A Granger from the University of California, Irvine, reported a cytotoxic factor produced by lymphocytes and named it lymphotoxin (LT). Credit for this discovery is shared by Dr. Nancy H. Ruddle from Yale University, who reported the same activity in a series of back-to-back articles published in the same month. (wikipedia.org)
  • Subsequently, in 1975 Dr. Lloyd J. Old from Memorial Sloan-Kettering Cancer Center, New York, reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF). (wikipedia.org)
  • TNFR2
  • The induction of the various cellular responses mediated by tumor necrosis factor is initiated by its interaction with the TNFR1 and TNFR2 cell surface receptors. (novusbio.com)
  • TNFR1 is expressed in most tissues, and can be fully activated by both the membrane-bound and soluble trimeric forms of TNF, whereas TNFR2 is found typically in cells of the immune system, and respond to the membrane-bound form of the TNF homotrimer. (wikipedia.org)
  • molecule
  • The biotech company TG Therapeutics is working on anti-GITR antibodies ICOS - This molecule, short for Inducible T-cell costimulator, and also called CD278, is expressed on activated T cells. (wikipedia.org)
  • macrophages
  • In vitro osteoclastogenesis assays were performed using mouse RAW 264.7 cells and bone marrow-derived macrophages (BMMs) treated with receptor activator of nuclear factor-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). (pubmedcentralcanada.ca)
  • While IL-1β is released by monocytes and macrophages, it is also present in nocieptive DRG neurons. (wikipedia.org)
  • citation needed] This inflammation occurs through direct attachment of complement and Fc receptor-mediated recruitment of neutrophils and macrophages. (wikipedia.org)
  • transmembrane
  • Binding of secreted Hh ligands to the receptor homolog (PTCH1, PTCH2) triggers the stimulation of the signaling network: the repressive effect of PTCH on the transmembrane receptor SMO is relieved which leads to the activation of glioma-associated oncogene (GLI) transcription factors. (antibodies-online.com)
  • TNF is primarily produced as a 233-amino acid-long type II transmembrane protein arranged in stable homotrimers. (wikipedia.org)
  • RANKL
  • A synergistic effect of IL-1β on the formation of RANKL-induced osteoclast-like MNCs was found in two experimental cells. (pubmedcentralcanada.ca)
  • The receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-RANK system is a key regulator of osteoclastogenesis under physiological conditions. (pubmedcentralcanada.ca)
  • RANKL (Receptor Activator for Nuclear factor κ B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. (wikipedia.org)
  • The binding of RANKL to RANK trimerizes the receptor and activates a signaling pathway. (wikipedia.org)
  • This system is balanced by the relative expression of OPG to RANKL, which are highly regulated by many factors including hormones, immune signals, and growth factors. (wikipedia.org)
  • Once the tumor is seeded in the bone, the tumor cells stimulate bone resorption by secreting factors such as RANKL or prompting the surrounding stroma to express growth factors. (wikipedia.org)
  • recombinant protein
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • Quality control test: Antibody Reactive Against Recombinant Protein. (novusbio.com)
  • 293T cell line
  • Western Blot analysis of TNFSF18 expression in transfected 293T cell line ( H00008995-T01 ) by TNFSF18 MaxPab polyclonal antibody.Lane 1: TNFSF18 transfected lysate(19.47 KDa).Lane 2: Non-transfected lysate. (acris-antibodies.com)
  • immune
  • The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions (2,3). (acris-antibodies.com)
  • The primary role of TNF is in the regulation of immune cells. (wikipedia.org)
  • A2AR - The Adenosine A2A receptor is regarded as an important checkpoint in cancer therapy because adenosine in the immune microenvironment, leading to the activation of the A2a receptor, is negative immune feedback loop and the tumor microenvironment has relatively high concentrations of adenosine. (wikipedia.org)
  • This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. (wikipedia.org)
  • kinase
  • It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. (novusbio.com)
  • Western Blot
  • Abgent's experienced staff custom validates more than 1,000 antibodies each month in Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FC) and additional applications. (abgent.com)
  • Western Blot: TRAF-6 Antibody [NBP1-- PC-3 cell lysates with TRAF-6 antibody at 1 ug/ml in the presence (A) or absence (B) of 1 ug blocking peptide. (novusbio.com)
  • Western blot analysis of ( A ) 5 ng, ( B ) 25 ng, and ( C ) 50 ng of purified recombinant GITRL with TNFSF18 polyclonal antibody ( Cat # PAB12952 ) at 1 µg/ml. (acris-antibodies.com)
  • cell
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • This means that, in contrast to traditional chemotherapeutic agents, antibody-drug conjugates target and attack the cancer cell so that healthy cells are less severely affected. (wikipedia.org)
  • Notley, Baker, Ehrenstein: Secreted IgM enhances B cell receptor signaling and promotes splenic but impairs peritoneal B cell survival. (antibodies-online.com)
  • TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. (wikipedia.org)
  • This receptor is required for generation and long-term maintenance of T cell immunity. (wikipedia.org)
  • This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. (wikipedia.org)
  • TNFRSF17 has been shown to interact with the B-cell activating factor TNFSF13B. (wikipedia.org)
  • The American biotech company Celldex Therapeutics is working on CDX-1127, an agonistic anti-CD27 monoclonal antibody which in animal models has been shown to be effective in the context of T cell receptor stimulation. (wikipedia.org)
  • This protein and its receptor are both found to be important for B cell development. (wikipedia.org)
  • Helper T2 cells subsequently activate the B cells to become plasma cells and induce the production of antibodies against the cell wall of Streptococcus. (wikipedia.org)
  • S. pyogenes has a cell wall composed of branched polymers which sometimes contain M protein, a virulence factor that is highly antigenic. (wikipedia.org)
  • AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. (wikipedia.org)
  • The end-result is a B cell that is able to mass-produce specific antibodies against an antigenic target. (wikipedia.org)
  • transcription
  • Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-kappaB. (novusbio.com)
  • More recently, research in the Laboratory of Mark Mattson has shown that TNF can prevent the death/apoptosis of neurons by a mechanism involving activation of the transcription factor NF-kappaB which induces the expression of Mn-SOD and Bcl-2. (wikipedia.org)
  • This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. (wikipedia.org)