• Alzheimer's
  • We and others have examined patients with various neurodegenerative and behavioral neurological conditions, such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD) and Autistic Spectrum Disorders ([ASD], including Autism, Attention Deficit Disorder, Asperger Syndrome), and found evidence for systemic intracellular bacterial and viral infections in a majority of patients. (townsendletter.com)
  • Autoimmune
  • Autoimmune panel and serological testing for fluorescent treponemal antibody absorption, cryptococcus, and herpes simplex virus were negative or gave normal results. (lww.com)
  • 1 In addition to genetic changes and changes in gene expression, it is thought that nutritional deficiencies, head trauma, environmental toxins, chronic bacterial and viral infections, autoimmune immunological responses, vascular diseases, accumulation of fluid in the brain, changes in neurotransmitter concentrations, and other causes are involved in various neurodegenerative diseases. (townsendletter.com)
  • The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway has been involved in chronic human inflammatory pathologies such as neurodegenerative, autoimmune, or malignant diseases. (readbyqxmd.com)
  • 1 In this second part we continue with psychiatric diseases, autoimmune diseases, fatiguing illnesses, and other chronic diseases where chronic infections play an important role. (bjmp.org)
  • patients
  • showed that patients with neuroborreliosis demonstrate a blood brain barrier disturbance with 62 % showing an elevated albumin ratio and 60 % revealing an increased IgG index, indicative of intrathecal IgG synthesis. (upmc.edu)
  • Patients with neurodegenerative diseases and behavioral disorders often have systemic bacterial, viral, and/or fungal infections that are important in disease progression and severity. (townsendletter.com)
  • Use of bisphosphonates in patients with conditions or diseases affecting renal function is not recommended. (issuu.com)
  • Although most patients with Lyme/tick-borne disease do not become violent, a small percent of patients who become infected develop a type of neurological dysfunction that can increase their risk of aggressiveness. (psychologytoday.com)
  • In working with a number of patients with Lyme/tick-borne diseases it is apparent to many clinicians these conditions can cause reduced frustration tolerance, irritability, depression , cognitive impairments and mood swings, but more significantly, in a few patients, suicidal and aggressive tendencies. (psychologytoday.com)
  • The aim of this retrospective study was to define the pivotal neurological deficits in patients with neuroborreliosis that were the reason for admission in a hospital. (biomedcentral.com)
  • We retrospectively evaluated data of patients with neuroborreliosis. (biomedcentral.com)
  • Sixty-eight patients were identified with neuroborreliosis. (biomedcentral.com)
  • Indeed, signs of meningitis were often found in patients with neuroborreliosis, but usually did not cause admission to a hospital. (biomedcentral.com)
  • Here, we performed a thorough evaluation of clinical and laboratory data in patients with neuroborreliosis. (biomedcentral.com)
  • Dr. Jemsek s Clinic sees more new patients for Lyme Disease than any other facility in the country. (lymediseaseaction.org.uk)
  • More recently he became involved in the care of patients with Lyme Disease and he is a member of the International Lyme and Associated Diseases Society (ILADS). (lymediseaseaction.org.uk)
  • His clinical work has involved advising upon infectious disease for cardiac transplant patients, advising on antibiotics and their use, teaching at the University of North Carolina at Chapel Hill and becoming involved in clinical research associated with these fields. (lymediseaseaction.org.uk)
  • However, about 10-15% of patients with Lyme arthritis fail the initial course of antibiotics, and some of those develop a chronic inflammatory arthritis optimally treated with local or systemic immunosuppressive agents. (springer.com)
  • Antibiotic treatment duration and long-term outcomes of patients with early Lyme disease from a Lyme disease-hyperendemic area. (springer.com)
  • Some patients do not elicit an antibody response great enough to be positive by the currently available ELISA assays. (medcapsules.com)
  • Chronically ill patients with neurodegenerative and neurobehavioural and psychiatric diseases commonly have systemic and central nervous system bacterial and viral infections. (bjmp.org)
  • In 926 consecutive psychiatric patients that were screened for antibodies and compared with 884 simultaneously recruited healthy subjects, seropositive psychiatric patients were found to be significantly younger than seronegative ones, and this was not found in the healthy controls. (bjmp.org)
  • 11 In contrast, if the SF-36 was used to determine Quality of Life (QOL) in post-Lyme patients, the average SF-36 physical component summary (40±9, range 29-44) and mental component summary (39±14, range 23-46) of the QOL assessment were worse than the general USA population, and they could be significantly improved by anti-Lyme antibiotics (46% versus 18%, p =0.007). (blogspot.com)
  • ELISA
  • The rheumatologist then added a screening test for Lyme disease, either ELISA or an IFA quantitative (titer) test. (medcapsules.com)
  • That requirement means that a positive sensitive ELISA/IFA must be followed by a positive Western blot with a defined number of approved antibody bands. (medcapsules.com)
  • Recent studies (14) by the group responsible for Lyme disease proficiency testing for the College of American Pathologists (CAP) came to the conclusion that the currently available ELISA assays for Lyme disease do not have adequate sensitivity to meet the two-tiered approach recommended by the CDC/ASPHLD group (7). (medcapsules.com)
  • spirochetes
  • These observations may contribute to a better underestanding of the pathogenesis of Lyme disease spirochetes in the local inflammatory reaction. (nii.ac.jp)
  • Detection of Lyme disease spirochetes in the skin of naturally infected wild sikd deer (Cervus nippon yesoensis) by PCR. (nii.ac.jp)
  • Just as in neurosyphilis, nervous system involvement begins during early disseminated Lyme disease, when spread of the spirochetes can result in meningeal seeding [ 3 ]. (uptodate.com)
  • neurodegenerative
  • Neurodegenerative diseases are chronic degenerative diseases of the central nervous system (CNS) that often cause dementia in the aging population. (townsendletter.com)
  • There appears to be a genetic link to neurodegenerative diseases, but the genetic changes that occur and the changes in gene expression that are found in these diseases are complex and not related to simple genetic mutations, deletions, or amplifications. (townsendletter.com)
  • In the first part of this review we considered neurodegenerative and neurobehavioural diseases and the findings that these diseases commonly are associated with systemic and central nervous system bacterial and viral infections. (bjmp.org)
  • antigen
  • Immune complexes occur when the antibody binds an antigen which results in a slight shift in antibody migration on the gel resulting in blurring or 'bridging' of the band (4,5). (upmc.edu)
  • Africa
  • With so many vectors, the underlying assumption behind this checklist is that Lyme is not rare in North America, Europe, South America, Russia, Africa or Asia. (lymebook.com)
  • Newly discovered genospecies have also been found to cause disease in humans: B. lusitaniae in Europe (especially Portugal), North Africa and Asia. (wikipedia.org)
  • Epidemic
  • Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. (springer.com)
  • antibiotics
  • The studies did not provide data to indicate the sensitivity of tests used in a clinical setting since the effect of recent use of antibiotics or steroids or other factors affecting antibody response was not factored in. (dovepress.com)
  • 1975
  • It was first identified in 1975 in the town of Old Lyme, CT after an outbreak of juvenile rheumatoid arthritis. (davidson.edu)
  • Lyme disease was diagnosed as a separate condition for the first time in 1975 in Old Lyme, Connecticut. (wikipedia.org)
  • arthritis
  • Orczyk K, Swidrowska-Jaros J, Smolewska E. When a patient suspected with juvenile idiopathic arthritis turns out to be diagnosed with an infectious disease - a review of Lyme arthritis in children. (springer.com)
  • infections
  • An attractive model for neurodegeneration resulting in neurological disease involves the action of toxic products produced as a result of chronic bacterial and/or viral infections. (townsendletter.com)
  • Although the specific roles of chronic infections in various diseases and their pathogeneses have not been carefully determined, the data suggest that chronic bacterial and/or viral infections are common features of progressive chronic diseases. (bjmp.org)
  • laboratory
  • In Lyme disease, much debate exists about laboratory kits, the alteration of kits to have fewer possible bands, and which labs are optimally sensitive and specific. (lymebook.com)
  • neurological disease
  • Can microbes and immune reactions to them actually contribute to cognitive decline, degenerative neurological disease, developmental disabilities, mental illness, personality changes and, at the most extreme, even violent and criminal behavior? (psychologytoday.com)