• induce
  • Our results showed that CIGB-247 was able to selleck compound induce an IgG immune response specific for VEGF in the three studied inhibitors species with discrete IgG antibody titers, similarly to our mouse experiments . (pdgfreceptor.com)
  • paratopes
  • The large and diverse population of antibody paratope is generated by random recombination events of a set of gene segments that encode different antigen-binding sites (or paratopes), followed by random mutations in this area of the antibody gene, which create further diversity. (wikipedia.org)
  • immunity
  • We also confirmed that TNFSF13B has an important and conserved role in the regulation of total IgE levels, which supports potential evolutionary links between helminth immunity and allergic response. (diva-portal.org)
  • IgA antibodies are secreted in the respiratory or the intestinal tract and act as the main mediators of mucosal immunity. (wikipedia.org)
  • larvae
  • The carbohydrate larval antigen, CarLA, is present on the exposed surface of all strongylid nematode infective L3 larvae tested, and antibodies against CarLA can promote rapid immune rejection of incoming Trichostrongylus colubriformis larvae in sheep. (nih.gov)
  • bound
  • Subsequently, interaction between FceRI and the Fc portion of helminth-bound IgE signals the eosinophil to degranulate. (wikipedia.org)
  • sIgA has also been shown to potentiate the immune response in intestinal tissue by uptake of antigen together with the bound antibody by dendritic cells. (wikipedia.org)
  • Antibodies can occur in two physical forms, a soluble form that is secreted from the cell to be free in the blood plasma, and a membrane-bound form that is attached to the surface of a B cell and is referred to as the B-cell receptor (BCR). (wikipedia.org)
  • malaria
  • Similarly, the GMT inhibitors HPV-18 antibody response among helminth and malaria uninfected 10-14-year-olds at Month 7 was 5255 EU/mL (95% CI 4109-6720), and for 15-25-year-olds was 2479 EU/mL (95% CI 1807-3399). (pdgfreceptor.com)
  • There was no evidence of a difference in HPV-18 GMT antibody response at Month 12 between participants with malaria parasitaemia at Month 7 and those without (adjusted GMR = 0.93, 95% CI 0.55-1.58, P = 0.79) ( Table 3). (pdgfreceptor.com)
  • Despommier has research interest in the ecotone, a transition area between two biomes, as a zone of high disease transmission and also in the spread of schistosomiasis, malaria, and a variety of helminths (ascaris, hookworm, trichuris) in agricultural areas. (wikipedia.org)
  • glycosylation
  • The ability of an antibody to communicate with the other components of the immune system is mediated via its Fc region (located at the base of the "Y"), which contains a conserved glycosylation site involved in these interactions. (wikipedia.org)
  • antigenic
  • The antigenic determinant or epitope is recognized by the paratope of the antibody, situated at the variable region of the polypeptide chain. (wikipedia.org)
  • helper
  • In most cases, interaction of the B cell with a T helper cell is necessary to produce full activation of the B cell and, therefore, antibody generation following antigen binding. (wikipedia.org)
  • interact
  • ADCC requires an effector cell which classically is known to be natural killer (NK) cells that typically interact with IgG antibodies. (wikipedia.org)
  • serum
  • IgG is the most abundant antibody class in the serum and it is divided into 4 subclasses based on differences in the structure of the constant region genes and the ability to trigger different effector functions. (wikipedia.org)
  • mechanism
  • The effects against solid tumors of trastuzumab and rituximab monoclonal antibodies have been shown in experiments with mice to involve ADCC as an important mechanism of therapeutic action. (wikipedia.org)
  • Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize its target directly (for example, by blocking a part of a microbe that is essential for its invasion and survival). (wikipedia.org)
  • cells
  • Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells. (jimmunol.org)
  • The coating of target cells with antibodies is sometimes referred to as opsonization. (wikipedia.org)
  • The typical ADCC involves activation of NK cells by antibodies. (wikipedia.org)
  • Several laboratory methods exist for determining the efficacy of antibodies or effector cells in eliciting ADCC. (wikipedia.org)
  • After washing, effector cells expressing Fc receptor CD16 are co-incubated with the antibody-labelled target cells. (wikipedia.org)
  • Antibodies are secreted by B cells of the adaptive immune system, mostly by differentiated B cells called plasma cells. (wikipedia.org)
  • The BCR is found only on the surface of B cells and facilitates the activation of these cells and their subsequent differentiation into either antibody factories called plasma cells or memory B cells that will survive in the body and remember that same antigen so the B cells can respond faster upon future exposure. (wikipedia.org)
  • binds
  • Another FcR is expressed on multiple cell types and is similar in structure to MHC class I. This receptor also binds IgG and is involved in preservation of this antibody. (wikipedia.org)
  • blood
  • Soluble antibodies are released into the blood and tissue fluids, as well as many secretions to continue to survey for invading microorganisms. (wikipedia.org)
  • It can also be confirmed by finding antibodies against the disease in the blood. (wikipedia.org)
  • cell
  • A library of ovine recombinant single chain Fv (scFv) antibody fragments, displayed on phage, was prepared from B cell mRNA of field-immune sheep. (nih.gov)
  • Usually, a target cell line expressing a certain surface-exposed antigen is incubated with antibody specific for that antigen. (wikipedia.org)
  • Over the course of a few hours a complex forms between the antibody, target cell, and effector cell which leads to lysis of the cell membrane of the target. (wikipedia.org)
  • locus
  • Basically, the antibody paratope is polygenic, made up of three genes, V, D, and J. Each paratope locus is also polymorphic, such that during antibody production, one allele of V, one of D, and one of J is chosen. (wikipedia.org)
  • type
  • This result supports the possibility of eventually using helminth products to treat type I diabetes in humans as well. (wikipedia.org)
  • The Latin letter used to identify a type of antibody is converted into the corresponding Greek letter, which is placed after the 'Fc' part of the name. (wikipedia.org)
  • differ
  • IgA antibodies are divided into two subclasses that differ in the size of their hinge region. (wikipedia.org)
  • This family includes several members, FcγRI (CD64), FcγRIIA (CD32), FcγRIIB (CD32), FcγRIIIA (CD16a), FcγRIIIB (CD16b), which differ in their antibody affinities due to their different molecular structure. (wikipedia.org)
  • define
  • There are several different types of antibody heavy chains that define the five different types of crystallisable fragments (Fc) that may be attached to the antigen-binding fragments. (wikipedia.org)
  • different
  • Though the general structure of all antibodies is very similar, a small region at the tip of the protein is extremely variable, allowing millions of antibodies with slightly different tip structures, or antigen-binding sites, to exist. (wikipedia.org)