AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
CollagenAntibodiesAntibody SpecificityCollagen Type IAntibodies, ViralAntibodies, MonoclonalAntibodies, BacterialAntibody FormationAntibodies, NeutralizingFibrillar CollagensCollagen Type IVCollagen Type IIIFluorescent Antibody TechniqueAntibody AffinityReceptors, CollagenCollagen Type IIAntibodies, Anti-IdiotypicBinding Sites, AntibodyEpitopesHIV AntibodiesCollagen Type VIAntibodies, NeoplasmAntibodies, ProtozoanCollagen Type VAntibodies, AntinuclearMolecular Sequence DataCross ReactionsAmino Acid SequenceCells, CulturedCollagen DiseasesAutoantibodiesExtracellular MatrixImmunoglobulin MFibroblastsAntibodies, FungalProcollagenCollagen Type XVIIIHydroxyprolineNeutralization TestsRabbitsMice, Inbred BALB CAntigen-Antibody ReactionsCollagen Type XIAntibodies, BispecificImmunoglobulin GAntibodies, BlockingCattleSingle-Chain AntibodiesAntigen-Antibody ComplexBasement MembraneImmunohistochemistryCell LineImmunoglobulin Fab FragmentsSkinFluorescent Antibody Technique, IndirectElectrophoresis, Polyacrylamide GelRecombinant ProteinsAntibodies, HeterophileCartilageAntibodies, CatalyticExtracellular Matrix ProteinsBlotting, WesternImmune SeraRNA, MessengerGelsPeptide FragmentsEnzyme-Linked Immunosorbent AssayHydroxylysineMicroscopy, ElectronImmunoglobulin AHybridomasFibronectinsImmunoenzyme TechniquesBase SequenceAntibodies, Monoclonal, HumanizedCollagen Type XFibril-Associated CollagensEpitope MappingMolecular WeightImmunizationTime FactorsCell AdhesionTendonsAntigensAntibodies, AntiphospholipidPeptidesImmunoblottingMicrobial CollagenaseLamininPepsin AProteoglycansAntigens, SurfaceCollagen Type XIIMice, Inbred C57BLAntigens, BacterialCollagen Type VIIImmunization, PassiveProtein BindingConnective TissueRadioimmunoassay
SpecificityReactivityProteinsProteinRecombinantAnti-collagenRabbitSerumAntigenAutoimmuneTypeIsotypeConjugatesTissuesExtracellularInflammationAntinuclear antibodyCartilageAssaysSpeciesCloneTitersArthritisPlacentaSclerodermaConjugationImmune complex-mediatedAffinityBiotinHumanVascular diseaseMiceTissueReceptorGeneInflammatoryDiseasesBasementEpitopeAlpha
Specificity2
  • Specificity of antibodies to type II collagen in rheumatoid arthritis. (assayspro.com)
  • The epitope specificity of the antibodies in relapsing polychondritis differs from those in RA, suggesting different mechanisms for formation and pathophysiologic roles. (medscape.com)
Reactivity5
  • N.B. Antibody reactivity and working conditions may vary between species. (bio-rad-antibodies.com)
  • Greatly diminished reactivity and selectivity of these antibodies will result if denaturing and reducing conditions are used for SDS-PAGE and immunoblotting. (rockland.com)
  • Some class-specific anti-collagens may be specific for three-dimensional epitopes which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin embedded tissues. (rockland.com)
  • This antibody reacts with most mammalian Type IV collagens and has negligible cross-reactivity with Type I, II, III, V or VI collagens. (rockland.com)
  • No cross-reactivity towards dog collagen type IV, V and other god plasma proteins. (yoproteins.com)
Proteins10
  • Abcam: antibodies, proteins, kits. (abcam.com)
  • Anti-Collagen Type IV has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted specificities. (rockland.com)
  • Non-specific cross-reaction of anti-collagen antibodies with other human serum proteins or non-collagen extracellular matrix proteins is negligible. (rockland.com)
  • Affinity purification on immobilized human collagen type III with cross-absorption using immobilised human plasma proteins and human collagen type I, II, IV and IV. (yoproteins.com)
  • 3. Philips N, Chalensouk-Khaosaat J and Gonzalez S (2015) Stimulation of the Fibrillar Collagen and Heat Shock Proteins by Nicotinamide or Its Derivatives in Non-Irradiated or UVA Radiated Fibroblasts, and Direct Anti-Oxidant Activity of Nicotinamide Derivatives. (yoproteins.eu)
  • If you buy Antibodies supplied by Chondrocytes and collagens they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (assayspro.com)
  • Chondrocytes and collagens supplies antibodies that are for research of human proteins.Chondrocytes and collagens supplies other types of Assays as 1.Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. (assayspro.com)
  • Proteins provide a range of functions in the body, including creating muscles, hormones and antibodies. (hollandandbarrett.com)
  • Antibodies are immune system proteins that normally attack foreign substances such as bacteria or viruses, but in people with Goodpasture syndrome, they target alpha3(IV) collagen chains. (medlineplus.gov)
  • however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)
Protein12
  • The antibody detects endogenous Collagen II protein. (biocheminfo.org)
  • In this Review, the authors provide an overview of what is known of the clinical features, pathogenesis and treatment of anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis, including emerging biomarkers and clinical subtypes. (nature.com)
  • The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. (nih.gov)
  • Researchers recovered protein from inside a massive T. rex leg bone buried for 68 million years, and sequenced seven fragments that identify it as collagen, the most abundant protein in bone. (newscientist.com)
  • Until now, the oldest recognised protein was collagen from a mastodon that died within the past 600,000 years. (newscientist.com)
  • Although the samples contained little protein, he was able to reconstruct the amino acid sequences of seven collagen fragments. (newscientist.com)
  • Protein is also needed to support your hair, skin (collagen) and nails. (hollandandbarrett.com)
  • GPVI-Fc, a recombinant dimeric fusion protein binding to plaque collagen and concealing binding sites for platelet GPVI, acts as a lesion-focused antiplatelet drug, and does not increase bleeding in vivo. (thieme-connect.com)
  • Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
  • SP600125 inhibited platelet-derived growth factor-induced proliferation, inducible monocyte chemoattractant protein-1 production, and serum-induced type I collagen production. (aspetjournals.org)
  • The COL4A3 gene provides instructions for making one piece of a protein called collagen IV. (medlineplus.gov)
  • Most of these variants change single protein building blocks (amino acids) in a region where the alpha3(IV) collagen chain combines with other collagen IV chains. (medlineplus.gov)
Recombinant2
  • Recombinant human collagen XV regulates cell adhesion and migration. (nih.gov)
  • Western Blot: TNF-alpha Antibody [NBP1-19532] - Recombinant human TNF alpha (10 ng) was separated on a 12% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST. (novusbio.com)
Anti-collagen3
  • Anti-Collagen Type IV has been tested by dot blot and IHC and is suitable for indirect trapping ELISA for quantitation of antigen in serum using a standard curve, immunoprecipitation, native (non-denaturing, non-dissociating) PAGE, immunohistochemistry, and western blotting for highly sensitive qualitative analysis. (rockland.com)
  • On the basis of its potential to block anti-collagen type II (CII) antibody-induced arthritis (CAIA) and to suppress the conformational activation of β 2 -integrins in leukocytes, the present study was undertaken to investigate its interference with leukocyte adherence to cytokine-activated endothelium. (biomedcentral.com)
  • More recently it has been demonstrated that treatment with ALP significantly decreased the incidence and severity of anti-collagen type II (CII) antibody-induced arthritis (CAIA). (biomedcentral.com)
Rabbit5
  • Mice with collagen-induced arthritis (CIA) were treated with polyclonal rabbit anti-murine IL-17 (anti-IL-17) antibody-positive serum or normal rabbit serum after the first signs of arthritis. (nih.gov)
  • Collagen I Alpha 1 antibody LS-C343921 is an unconjugated rabbit polyclonal antibody to Collagen I Alpha 1 (COL1A1) (aa1192-1207) from mouse. (lsbio.com)
  • Antibodies are isolated from rabbit antiserum and are extensively cross-adsorbed by immunoaffinity purification to produce 'type' specific antibodies. (rockland.com)
  • Rabbit antibodies to human type III collagen, affinity-purified, are ideal for use in Western blot and immunohistochemistry (paraffin-embedded tissue sections), as they bind to both native and thermally denatured type III collagen. (viscoll.com)
  • arigo's Collagen I antibody was used to demonstrate the fibrochondrogenic gene expression induced in a rabbit meniscal defect model and was published in Chemical Engineering Journal . (arigobio.cn)
Serum6
  • In addition, during a later stage of CIA mice were selected and treated with anti-IL-17 antibody or control serum. (nih.gov)
  • Description: A competitive ELISA for quantitative measurement of Rat Collagen Type VII in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (cropsciencejournal.org)
  • The Collagen Type Vii Antibody Elisa reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (cropsciencejournal.org)
  • Description: A competitive ELISA for quantitative measurement of Human Collagen Type VII in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (cropsciencejournal.org)
  • The prevalence of serum IgG antibodies to Type II Collagen in American patients with rheumatoid arthritis. (assayspro.com)
  • As a consequence, the identification of anti-GBM antibodies in the patient's serum or tissues is of paramount importance in the diagnosis of Goodpasture disease. (medscape.com)
Antigen8
  • See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more. (lsbio.com)
  • This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (viscoll.com)
  • Anti-glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane, specifically the alpha-3 chain of type IV collagen. (medscape.com)
  • Particle-enhanced assays are based on the reaction between a soluble analyte and the corresponding antigen or antibody bound to polystyrene particles. (cdc.gov)
  • CRP present in the test sample will form an antigen-antibody complex with the latex particles. (cdc.gov)
  • The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
  • Anti-glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane. (medscape.com)
  • The target antigen is the alpha-3 chain of type IV collagen. (medscape.com)
Autoimmune7
  • In Autoimmune diseases, these antibodies work against the immune response and attack the body's healthy tissues. (ganeshdiagnostic.com)
  • Pulmonary and/or renal manifestations can be encountered in various conditions, such as antineutrophilic cytoplasmic antibody (ANCA)-positive vasculitis and other autoimmune disorders. (medscape.com)
  • Tests for antibodies, especially for autoimmune conditions. (kyoto2.org)
  • Collagen vascular disease, also known as connective tissue disease, is a group of autoimmune diseases that attack the connective tissues in the body that hold muscles, ligaments, and bones together. (kyoto2.org)
  • Collagen vascular diseases are autoimmune diseases that occur when the body's immune system attacks its own skin, tissues and organs. (kyoto2.org)
  • Autoimmune and collagen vascular diseases such as rheumatoid arthritis, systemic lupus erythematosus without renal disease, autoimmune hepatitis, hemolytic anemia, and endocrinopathies have been described. (lu.se)
  • Clinical manifestations of chronic GVHD are similar to autoimmune collagen vascular disease and the two main types of cutaneous chronic GVHD are lichenoid and sclerodermatous. (bvsalud.org)
Type21
Isotype3
  • Anti-GBM antibodies are almost exclusively of the immunoglobulin G (IgG) isotype. (medscape.com)
  • As positive control a polyclonal anti-C1q antibody was used and as negative control an isotype matched monoclonal antibody (Ref.1). (origene.com)
  • Patients with undetectable IgA antibodies may develop anti-IgA antibodies of the IgE isotype after receiving blood products. (lu.se)
Conjugates1
Tissues3
  • Collagen disease is the name of a cluster of diseases that affect the body's connective tissues. (ganeshdiagnostic.com)
  • Scleroderma results from the overproduction of collagen in affected tissues, one study claims that there is an increased density of Topoisomerase I sites in the collagen genes, and that the antibodies may be altering transcription at these loci. (wikipedia.org)
  • In this article, Goodpasture disease and anti-GBM disease are used synonymously and refer to the presence of anti-GBM antibodies in tissues (eg, kidney, lungs, or both), independent of clinical manifestations. (medscape.com)
Extracellular1
  • Collagens are fibrous extracellular matrices that are present in abundance in the human body. (ganeshdiagnostic.com)
Inflammation3
  • Histologic analysis confirmed the suppression of joint inflammation and showed prevention of cartilage and bone destruction after anti-IL-17 antibody therapy. (nih.gov)
  • Our results corroborate previous results in Balb/c mice that repeated inhalation of live A. fumigatus spores is suffcient to induce mucus production and inflammation by day 3 post last challenge, and antibody titers and collagen production by day 28 post-challenge. (cdc.gov)
  • The antibodies cause inflammation when they attach (bind) to the basement membranes of blood vessels in the air sacs (alveoli) of the lungs and filtering units (glomeruli) of the kidneys. (medlineplus.gov)
Antinuclear antibody1
  • Since this activity occurs in the nucleus of the cell ATA is a form of antinuclear antibody. (wikipedia.org)
Cartilage5
  • Rockland extensively purifies collagens for immunization from human and bovine placenta and cartilage by limited pepsin digestion and selective salt precipitation. (rockland.com)
  • Various studies find circulating antibodies to cartilage-specific collagen types II, IX, and XI to be present in 30%-70% of patients with relapsing polychondritis. (medscape.com)
  • Autoantibodies to minor cartilage-specific collagens (ie, types IX and XI) have been described. (medscape.com)
  • Most patients with relapsing polychondritis had high titers of antifetal cartilage antibodies during the early acute phase. (medscape.com)
  • The antifetal cartilage antibodies were found in 6 of 9 patients and only 4 (1.5%) of 260 patients with RA, exclusively in long-standing disease. (medscape.com)
Assays2
  • This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. (abcam.com)
  • Functional assays (Ref.1): Antibody JL-1 was administered to mice resulting in depletion of circulating C1q, glomerular deposition of C1q and induction of anti-C1q autoantibodies in susceptible mice. (origene.com)
Species2
  • Collagen evolves very slowly, and all the fragment sequences matched those of living species, including chickens, newts and frogs. (newscientist.com)
  • Immunoglobulin A (IgA) responses directly determine the composition of commensal species that colonize the intestinal tract but require substantial metabolic resources to fuel antibody production by tissue-resident plasma cells. (bvsalud.org)
Clone1
Titers1
  • Treatment with prednisone is associated with a decrease in antibody titers. (medscape.com)
Arthritis3
  • Interestingly, initiation of anti-IL-17 antibody therapy during a later stage of CIA, using mice with higher clinical arthritis scores, still significantly slowed the progression of the disease. (nih.gov)
  • Meanwhile, the inhibitory effect of AK106-001616 was more effective than that of naproxen in the mouse collagen antibody-induced arthritis model with leukotrienes contributing to the pathogenesis. (aspetjournals.org)
  • Mice with collagen induced arthritis exhibited extensive changes in rhythmic gene expression in the colon, and reduced barrier integrity. (bvsalud.org)
Placenta1
  • [ 8 ] A report of relapsing polychondritis in the newborn of a mother with relapsing polychondritis suggests that antibodies crossing the placenta are necessary and sufficient to elicit the entire clinical syndrome. (medscape.com)
Scleroderma3
  • The panel includes the following tests- ANA Anti-ds-DNA Anti-Smith Antibody IgG SS-A/Ro Antibody SS-B/La Scl-70 (Scleroderma) Antibody, Jo-1 Antibody Centromere. (ganeshdiagnostic.com)
  • Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma. (wikipedia.org)
  • Scl-70 antibodies are associated with more severe scleroderma disease. (wikipedia.org)
Conjugation1
  • Conjugation service and the corresponding secondary antibody are available. (biomatik.com)
Immune complex-mediated1
  • In adult mink, AD is a persistent, slowly progressive AMDV infection in which a dysregulated immune system and a postinfectious antibody response cause an immune complex-mediated vasculitis ( 2 ). (cdc.gov)
Affinity1
  • The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions. (biolegend.com)
Biotin1
  • CusabioALB Antibody, Biotin conjugated is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible or send. (joplink.net)
Human5
  • A synthetic peptide corresponding to a sequence at the C-Terminus of mouse Collagen I(1192-1207 aa QPPQEKSQDGGRYYRA), identical to the related rat sequence, and different from the related human sequence by two amino acids. (lsbio.com)
  • Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis. (nih.gov)
  • Crystal structure of the human collagen XV trimerization domain: a potent trimerizing unit common to multiplexin collagens. (nih.gov)
  • Collagen Types in bones and muscles can be hydrolyzed and used in human grafts. (assayspro.com)
  • The 35‑40 kDa, 313 amino acid (aa) human Ficolin-2 contains a 25 aa signal sequence, an N-terminal collagen domain and a C-terminal fibrinogen-like domain that includes a calcium binding site and two potential N-glycosylation sites. (rndsystems.com)
Vascular disease3
  • What are the symptoms of collagen vascular disease? (kyoto2.org)
  • What is undifferentiated collagen vascular disease? (kyoto2.org)
  • However, 2 mink farmers with vascular disease and microangiopathy similar to that in mink with Aleutian disease were found to have AMDV-specific antibodies and AMDV DNA. (cdc.gov)
Mice3
  • Leukocyte rolling and firm adhesion to the synovial endothelium in an early response to the anti-CII antibody transfer were significantly decreased in ALP-pretreated mice. (biomedcentral.com)
  • A statistical analysis of intravital microscopic images recorded from the knee joints of untreated control mice during an early time span of 24 hours after the transfer of anti-CII mAbs [ 10 ] revealed an antibody-induced increase in leukocyte adhesion to the vessel walls. (biomedcentral.com)
  • The antibody has been generated by immunization of C1q-/- C57BL/6 mice with purified mouse C1q. (origene.com)
Tissue4
  • ab138492 works in western blot in samples with high level of collagen I, like HFF-1, MRC-5, skin tissue etc. (abcam.com)
  • Immunohistochemistry-Paraffin: TNF-alpha Antibody [NBP1-19532] - Analysis of a FFPE tissue section of mouse intestine using TNF-alpha antibody (NBP1-19532) at 1:300 dilution. (novusbio.com)
  • A noteworthy group of maladies of unknown origin which primarily involve connective tissue has been termed collagen diseases. (kyoto2.org)
  • We report finding anti-AMDV antibodies and AMDV genome in tissue from 2 mink farmers with relevant virus exposure and clinical disease similar to that in mink with AD. (cdc.gov)
Receptor1
  • GPVI-Fc added on top of abciximab, a clinically used anti-fibrinogen receptor antibody which blocks platelet aggregation, strongly inhibited total (81%) and stable (89%) platelet adhesion. (thieme-connect.com)
Gene1
Inflammatory1
  • [ 5 ] The more abundant D-hexamers have dimer-reinforced crosslinks between NC1 domains that help to retain the cryptic nature of the Goodpasture epitopes, whereas the less abundant M-hexamers, composed of only monomeric subunits, allow epitope unmasking and antibody binding under inflammatory states. (medscape.com)
Diseases2
Basement3
  • Alpha345(IV) collagen networks play an especially important role in the basement membranes of the kidney, inner ear, and eye. (medlineplus.gov)
  • These changes in the structure or amount of alpha3(IV) chains severely impair the formation of alpha345(IV) collagen networks in the basement membranes of the kidney, inner ear, and eye. (medlineplus.gov)
  • In the kidney, other types of collagen build up in the basement membranes, eventually scarring the kidneys and leading to kidney failure. (medlineplus.gov)
Epitope1
Alpha4
  • Collagen VII is composed of three identical alpha chains, each having an amino-terminal non-collagenous domain and a carboxy-terminal collagenous domain. (bio-rad-antibodies.com)
  • Western Blot: TNF-alpha Antibody [NBP1-19532] - Scutellarin attenuates hypertension-induced brain expression of NF-kappaB, TNF-alpha, IL-1beta, and IL-18. (novusbio.com)
  • This chain combines with two other types of alpha (IV) chains (the alpha4 and alpha5 chains) to make alpha345(IV) collagen molecules. (medlineplus.gov)
  • Antibodies to beta-4 integrin have been identified in generalized MMP and ocular MMP, and antibodies to alpha-6 integrin have been identified in oral MMP. (msdmanuals.com)