• levels of antibodies
  • To determine the prevalence and specificity of antibodies to Borrelia burgdorferi in patients with nonspirochetal subacute bacterial endocarditis and assess whether increased levels of antibodies to B. burgdorferi were attributable to rheumatoid factor. (prohealth.com)
  • Passive immunity can occur naturally, when maternal antibodies are transferred to the fetus through the placenta, and it can also be induced artificially, when high levels of antibodies specific to a pathogen or toxin (obtained from humans, horses, or other animals) are transferred to non-immune persons through blood products that contain antibodies, such as in immunoglobulin therapy or antiserum therapy. (wikipedia.org)
  • Bacteria
  • However, analysis of samples from a patient with invasive S. pyogenes infection revealed dramatic differences in the presence and orientation of IgG antibodies at the surface of bacteria from different sites. (lu.se)
  • As a consequence, the bacteria are protected against phagocytic killing, whereas in blood plasma where the concentration of IgG is high, the antibodies preferentially bind via Fab, facilitating opsonization and bacterial killing. (lu.se)
  • To overcome this problem, identifying new therapeutic targets in bacteria is essential, which necessitates scrutinizing the bacterial infection mechanism. (diva-portal.org)
  • However, there were no differences in the level of specific IgA antibodies to common colonizing bacteria (pneumococcal PS serotype 14 and NTHI OMP6). (biomedsearch.com)
  • Bacterial display (or bacteria display or bacterial surface display) is a protein engineering technique used for in vitro protein evolution. (wikipedia.org)
  • He enjoys international recognition as an authority on the basic biology and medical significance of atypical bacterial organisms and is considered a pioneer and an expert on the role of these unusual bacteria in the persistence and expression of kidney and urological infectious diseases. (wikipedia.org)
  • They noted that the forms, which they called electron dense bodies were so small that they could pass through bacterial filters that normally withheld ordinary bacteria with cell walls. (wikipedia.org)
  • After applying these data to the human condition, Domingue reasoned that in some patients who suffer from chronic bacterial infections, the disease process could be related to the fact that bacteria are able to differentiate into the resistant electron dense bodies that he observed in tissue cultures. (wikipedia.org)
  • The papers detail how L-form bacteria inside an experimental human embryonic kidney tissue culture system are able to persist in cells and explains how they are able to revert into the cell wall-containing parent bacterial form. (wikipedia.org)
  • Passive immunity is also provided through colostrum and breast milk, which contain IgA antibodies that are transferred to the gut of the infant, providing local protection against disease causing bacteria and viruses until the newborn can synthesize its own antibodies. (wikipedia.org)
  • Serum
  • Serum samples from 52 free-ranging brown bears (Ursus arctos) collected in Croatia over a period of 10 yr (1998-2007) were tested by microscopic agglutination test for specific antibodies (Ab) to 12 Leptospira spp. (mendeley.com)
  • Viral hepatitis, including so called serum hepatitis, which is a relatively common disease, has not been heretofore easily detected by a sensitive test which is both specific and reproducible for quickly determining whether or not the serum from a patient or a donor contains hepatitis associated antigens or antibodies. (google.com)
  • ELISA
  • The antibodies were also tested by ELISA-VA1 reacted weakly with glycosylated HMFG but strongly with deglycosylated HMFG, whereas VA2 reacted strongly with both forms of HMFG. (ndsl.kr)
  • Demonstration of antibodies against the agent either with the classic Huddleson, Wright, and/or Bengal Rose reactions, either with ELISA or the 2-mercaptoethanol assay for IgM antibodies associated with chronic disease Histologic evidence of granulomatous hepatitis on hepatic biopsy Radiologic alterations in infected vertebrae: the Pedro Pons sign (preferential erosion of the anterosuperior corner of lumbar vertebrae) and marked osteophytosis are suspicious of brucellic spondylitis. (wikipedia.org)
  • By knowing the epitope sequence of the antibody, ELISA can also be used for antigen detection in a sample. (wikipedia.org)
  • affinity
  • The unique property of specific high-affinity binding to more or less any target of interest has made antibodies tremendously useful in numerous applications. (diva-portal.org)
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
  • These can be addressed by combining targeted affinity enrichment of antibodies with the sensitivity of liquid chromatography-selected reaction monitoring mass spectrometry (LC-SRM MS). However, many virulence factors have evolved properties that make specific detection by conventional antibodies difficult. (jpt.com)
  • FACS
  • Bacterial display is often coupled with magnetic-activated cell sorting (MACS) or fluorescence-activated cell sorting (FACS) techniques. (wikipedia.org)
  • Bacterial display combined with FACS also has the advantage that it is a real-time technique. (wikipedia.org)
  • Detection
  • However, the detection and quantification of bacterial virulence factors in complex biological samples are technically demanding challenges. (jpt.com)
  • We here present an antibody format that is particularly well suited for detection and analysis of immunoglobulin G (IgG)-binding virulence factors. (jpt.com)
  • Fetus
  • Maternal passive immunity is a type of naturally acquired passive immunity, and refers to antibody-mediated immunity conveyed to a fetus or infant by its mother. (wikipedia.org)
  • In humans, maternal antibodies (MatAb) are passed through the placenta to the fetus by an FcRn receptor on placental cells. (wikipedia.org)
  • specific
  • In addition VA1 gave weak reactions with normal breast tissues whereas VA2 was non-reactive and could be a relatively tumour specific antibody for breast cancer. (ndsl.kr)
  • production
  • Quality is embedded in the production process to assure the best antibody for you. (abgent.com)
  • In the 1970s it was noticed that Bregs could suppress immune reaction independently of antibody production. (wikipedia.org)
  • Transmission of the virus from pigs to humans is not common and does not always lead to human flu, often resulting only in the production of antibodies in the blood. (wikipedia.org)
  • Immunofluorescence is performed by the production of anti-antibodies with a fluorescent molecule attached, making it a chemiluminescent molecule, which provides a glow when subject to ultraviolet light. (wikipedia.org)
  • humans
  • Only a few other species besides humans transfer maternal antibodies before birth, including primates and lagomorphs (which includes rabbits and hares). (wikipedia.org)
  • disease
  • For new targets we consult with leading experts to accelerate development of antibodies that will propel state-of-the-art research in cellular health and disease. (abgent.com)
  • Both seroprevalence and antibody optical density index exhibited 1-year cycles, indicating that disease outbreaks were seasonal and suggesting that long-lasting antibody protection was transient. (nih.gov)
  • Passive immunization can be provided when people cannot synthesize antibodies, and when they have been exposed to a disease that they do not have immunity against. (wikipedia.org)
  • gastric
  • By 2003 several PDP products for the treatment of human diseases were under development by nearly 200 biotech companies, including recombinant gastric lipase for the treatment of cystic fibrosis, and antibodies for the prevention of dental caries and the treatment of non-Hodgkin's lymphoma. (wikipedia.org)
  • occurs
  • Further investigation showed that efficient bacterial IgGFc-binding occurs only in IgG-poor environments, such as saliva. (lu.se)
  • Effective bacterial strategies are required to promote survival and proliferation within a human host, and it is important to explore how this adaption occurs. (jpt.com)
  • targets
  • We provide tools for path-breaking research by developing antibodies that detect a comprehensive library of novel and established targets. (abgent.com)
  • common
  • Bacteriophage display is the most common type of display system used although bacterial display is becoming increasingly popular as technical challenges are overcome. (wikipedia.org)
  • OMPs are common scaffolds for bacterial display. (wikipedia.org)
  • high
  • High-resolution imaging was employed to explore the structural features of fimbriae as well as monitoring the antibody-fimbriae interactions. (diva-portal.org)
  • clinical
  • The bacterial evolution, indeed, led to the emergence of antibiotic resistance as soon as the clinical consumption of antibiotics started. (diva-portal.org)
  • differences
  • The aims of this thesis are: to provide insight into the structural and biomechanical differences of fimbriae expressed by enterotoxigenic and uropathogenic Escherichia coli, and to investigate how fimbrial mechanics are affected in the presence of anti-fimbrial antibodies. (diva-portal.org)
  • test
  • Bacterial culture, immunofluorescent antibody testing (IFAT), complement fixation test and haemagglutination can all be used to confirm the diagnosis. (wikipedia.org)
  • Cell
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • presence
  • We used force measuring optical tweezers to characterize the force-extension responses of fimbriae in the absence and presence of antibodies. (diva-portal.org)