• Autoimmune Disease
  • Antinuclear antibody is a marker of inflammation and autoimmune processes and, as such, is a general marker of autoimmune disease. (questdiagnostics.com)
  • Anti-cardiolipin antibodies can be classified in two ways: As IgM, IgG or IgA As β2-glycoprotein dependent or independent In autoimmune disease ACA are beta-2 glycoprotein dependent syphilis ACA are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease. (wikipedia.org)
  • antigen
  • Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)". Proc. (wikipedia.org)
  • protein
  • Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. (wikipedia.org)
  • Antibodies are produced by B cells in two ways: (i) randomly, and (ii) in response to a foreign protein or substance within the body. (wikipedia.org)
  • The antibodies are directed against a particular protein found in the GBM, type IV collagen, specifically the noncollagenous region of its α3 chain. (wikipedia.org)
  • In the absence of rheumatoid factor and anti-citrullinated protein antibody they are associated with a milder disease in RA. (wikipedia.org)
  • ELISA
  • We wanted to keep ANA IFA as our principle screening method, possibly reserving multiplex or ELISA methods to determine specific antibodies-a decision with which our physicians concurred. (aacc.org)
  • It certainly detects more antibodies than any other method, but ELISA and multiplex techniques specifically identify which antibody a patient has as opposed to providing a pattern in the IFA procedure. (aacc.org)
  • Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories. (wikipedia.org)
  • disease
  • Antibodies to Scl-70, Jo-1, and rRNP were not detected in any of the sera from the disease groups. (biomedcentral.com)
  • There is a debate about whether the antibody is a cause of, or rather an effect of, the disease process. (wikipedia.org)
  • Newer studies suggest the antibodies are an effect, not a cause, of the condition, with a consensus that a patient's own T cells are playing a major role in the disease process. (wikipedia.org)
  • Anti-Hu encephalitis is a disease characterized by production of anti-Hu antibodies and rapid development of particular signs and symptoms. (wikipedia.org)
  • However, anti-RA33 antibodies are not associated with significant bone erosions or disease activity. (wikipedia.org)
  • Higher titres of anti-dsDNA antibodies are more suggestive of SLE and lower titres can be found in people without the disease. (wikipedia.org)
  • The levels of circulating anti-dsDNA antibodies fluctuate with disease activity in SLE. (wikipedia.org)
  • Increases in titres of the antibodies can coincide with, or even precede an increase of disease activity. (wikipedia.org)
  • known
  • Epstein-Barr virus is also known to induce dsDNA antibodies, as seen after immunisation of animals with EBNA-1 epitopes. (wikipedia.org)