Antibodies lamin type a. Medical search. Frequent questions

Abcam: antibodies, proteins, kits. (abcam.com)
Mutations implicated in other nuclear envelopathies were found in genes coding for lamin-binding proteins such as lamin B receptor (LBR gene), emerin (EMD gene) and LEM domain-containing protein 3 (LEMD3 gene) and prelamin A-processing enzymes such as the zinc metalloproteinase STE24 (ZMPSTE24 gene). (wikipedia.org)
citation needed] Lamins are intermediate filament proteins that form the nuclear lamina scaffold underneath the nuclear envelope in animal cells. (wikipedia.org)
They are attached to the nuclear envelope membrane via farnesyl anchors and interaction with inner nuclear membrane proteins such as lamin B receptor and emerin. (wikipedia.org)
Utilizing this APC-M2 pAb, we immunoprecipitated endogenous APC and its binding proteins from colon epithelial cells expressing wild-type APC. (ku.edu)
Using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS), we identified 42 proteins in complex with APC, including β-catenin and intermediate filament (IF) proteins lamin B1 and keratin 81. (ku.edu)
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (thermofisher.com)
A- and B-type lamins are sort V intermediate filament proteins. (aetox.com)
Lamin A/C proteins have key roles in nuclear structural integrity and chromosomal stability. (mdpi.com)
Label-free quantitation and characterization of proteins by mass spectrometry (MS) is now feasible especially for moderately expressed structural proteins such as lamins that typically yield dozens of tryptic peptides from tissue cells. (ap26113.com)
After lamin-A C knockdown PRF computes an invariant set of "housekeeping" proteins as part of a broader proteomic analysis that also shows the proteome of mesenchymal stem cells (MSCs) is more broadly perturbed than that of a human epithelial cancer line (A549s) with particular variation in nuclear and cytoskeletal proteins. (ap26113.com)
These methods offer exciting prospects for basic and clinical studies of lamin-A C as well as other MS-detectable proteins. (ap26113.com)
In addition we quantify hundreds of other proteins and avoid possible limitations of antibodies such as epitope masking.22 The role of lamins in maintaining the structural integrity of the nucleus had long been postulated 23 and through past measurements of tissue stiffness properties we link the composition of the nuclear lamina and the mechanical properties of the nucleus to the stiffness-and therefore stresses present-in the source tissue. (ap26113.com)
The lamin family of proteins make up the matrix and are highly conserved in evolution. (nih.gov)
During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. (nih.gov)
Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. (nih.gov)
New monoclonal antibodies recognizing phosphorylated proteins in mitotic cells. (mpg.de)
Provided these multiple activities, the primary system where gossypol induces cell loss of life in virtually any particular tumor type will probably vary, with regards to the known degrees of anti-apoptotic BCL-2 proteins as well as other tumor cell-specific elements. (islamophobiacon.com)
This complex includes nuclear membrane integral and associated proteins including emerin, lamin A/C, SUN1, SUN2, nesprin-1, and nesprin-2 that are proposed to form a mechanical link between the nucleoskeleton and cytoskeleton. (medscape.com)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)

Replenishment batches of our polyclonal antibody, ab124205 are tested in IHC-P. Previous batches were additionally validated in WB. (abcam.com)
The following product was used in this experiment: ZO-2 Polyclonal Antibody from Thermo Fisher Scientific, catalog # 71-1400, RRID AB_2533976. (thermofisher.com)
Primary antibodies and primers GSK3b (3D10) mouse mAb, Lef-1 (C12A5) rabbit mAb, b-Catenin (6B3) rabbit mAb, CK1e Factor Xa list polyclonal antibody, CK2a polyclonal antibody, FoxO1 rabbit mAb and b-Catenin (L87A12) mouse mAb were purchased from Cell Signaling Technology. (gpr120inhibitor.com)
GAPDH (0411) mouse monoclonal antibody, GAPDH (FL-335) rabbit polyclonal antibody, Lamin A/C (636) mouse mAb and b-actin (R22) rabbit polyclonal antibody were purchased from Santa Cruz Biotechnology. (gpr120inhibitor.com)

Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)

In X-linked EDMD, immunohistochemical staining using an antiemerin antibody shows the absence of normal staining of the inner nuclear membrane in 95% of patients (see image below). (medscape.com)
A-type lamin-dependent Caveolin-2 homo-oligomerization in the inner nuclear membrane microdomain is a precondition for pY19-Caveolin-2-mediated insulin-response epigenetic activation at the nuclear periphery. (cusabio.com)

The mechanisms by which lamin B3 is transported into GVs and is assembled to form the nuclear lamina are not well understood. (elsevierpure.com)
The results of these experiments indicated that the N-terminal domain plays important roles in both nuclear transport and assembly of lamin B3 to form the nuclear lamina. (elsevierpure.com)

Interaction between lamin A and the nuclear envelope protein emerin appears to be crucial in muscle cells, with certain mutations in lamin mimicking mutations in emerin and causing Emery-Dreifuss muscular dystrophy. (wikipedia.org)
Mutations in the lamin rod domain leading to mislocalization of both lamin A and emerin occur in patients with autosomal dominant forms of muscular dystrophy and cardiomyopathy. (wikipedia.org)
For immunohistochemical studies, antibodies to emerin can help confirm the diagnosis. (medscape.com)

No significant changes were observed upon expression of lamin A. In primary and TERT+ cells, 5 and 142 genes were differentially regulated upon progerin expression, respectively. (elifesciences.org)
Progerin induced senescence, lamin B1 loss, DNA damage, and telomere shortening are prevented by TERT in primary and HGPS fibroblasts, control experiments. (elifesciences.org)
A ) Western blotting showing inducible expression of progerin or wild type lamin A in primary and TERT+ human fibroblasts ± doxycyclin (DOX) as indicated. (elifesciences.org)
D ) Quantification of lamin B1 levels upon progerin or lamin A expression in primary and TERT+ cells. (elifesciences.org)
Lamins A and C, in contrast, arise through alternative splicing of the same primary transcript encoded by the LMNA gene, expression of which is developmentally regulated. (rupress.org)
With direct detection, primary antibodies are conjugated directly to an enzyme, like HRP , for chemiluminescent detection or to fluorochromes including Alexa Fluor® dyes, Janelia Fluor® dyes or DyLight® dyes for fluorescent Western blotting. (novusbio.com)

Messenger RNA produced from the LMNA gene undergoes alternative splicing and is translated into lamins A and C. Lamin A undergoes farnesylation to attach a membrane anchor to the protein. (wikipedia.org)
This allows lamin A to dissociate from the nuclear envelope membrane and fulfill nuclear functions. (wikipedia.org)
The nuclear envelope consists of an outer and inner membrane, nuclear pores and the nuclear lamina, a polymer of A-type lamins (lamin A/C, abbreviated here as lamin A) and B-type lamins (lamins B1 and B2) ( Burke and Stewart, 2013 ). (frontiersin.org)
CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. (thermofisher.com)
The membrane was stripped and reblotted with HRP-conjugated Lamin B1 Monoclonal antibody (HRP-66095) as loading control. (ptglab.com)
Membrane was probed with 2.0 µg/mL of Rabbit Anti LC3B Monoclonal Antibody (1251A) (NBP2-46892) followed by HRP-conjugated Secondary Antibody (HAF008) . (novusbio.com)
Membrane was probed with 0.05 µg/mL of Mouse Anti- GAPDH/G3PDH Monoclonal Antibody (MAB5718) followed by HRP-conjugated Secondary Antibody (HAF007) . (novusbio.com)
Presence of a protein immunologically related to lamin B in the postsynaptic membrane of Torpedo marmorata electrocyte. (silverchair.com)
In this work, we show that polyclonal antibodies specific for lamin B recognizes a component of the plasma membrane of Torpedo electrocyte. (silverchair.com)

In 2006, lamin B2 missense mutations were identified in patients with acquired partial lipodystrophy. (wikipedia.org)
The hot-spot lamin A R482W mutation causing familial partial lipodystrophy of Dunnigan-type (FPLD2), affects lamin A association with chromatin at the nuclear periphery and in the nuclear interior, and is associated with 3-dimensional (3D) rearrangements of chromatin. (frontiersin.org)
Progressive lipodystrophy is the most common type of partial lipodystrophy. (medscape.com)
Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. (nih.gov)
Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in HeLa cells. (mpg.de)
Compared with other types of lipodystrophy, acquired partial lipodystrophy is seldom associated with insulin resistance and its related metabolic derangements. (medscape.com)
Five cases were reported but the phenotype resembles Dunnigan-type familial partial lipodystrophy rather than classic acquired partial lipodystrophy. (medscape.com)

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. (cusabio.com)

The most typical technique for ultrastructural immunocytochemistry is the conjugation of nanogold particles to antibodies as probes. (aetox.com)
Consider if the loading control antibody is suitable for direct conjugation or requires the addition of a conjugated secondary antibody for indirect detection of the loading control. (novusbio.com)

Various lysates were subjected to SDS PAGE followed by western blot with 66466-1-Ig (JAK1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. (ptglab.com)
The cytosolic lysates were immunoprecipitated using an Nck-specific antibody followed by Western blot analysis of Nck, Vav1, and Ezh2. (scienza-under-18.org)

4000). ( G ) Illustration showing the number of genes whose expression changed more than twofold after 28 days of lamin A or progerin expression (I, induced. (elifesciences.org)
Mutations within the genes encoding these lamins trigger uncommon ailments, collectively known as laminopathies. (aetox.com)
In mammalian somatic cells, there are four major lamins, A, B1, B2, and C. The B-type lamins are encoded by separate genes (LMNB1 and LMNB2) and, as a class, are found in the nuclei of all mammalian somatic cells. (rupress.org)
Genetic diseases in lamins termed laminopathies 7 8 include progeria in which young children appear many decades older and since the other known human aging 'progeroid syndromes' involve DNA repair genes (eg. (ap26113.com)

Patients with classical laminopathy have mutations in the gene coding for lamin A/C (LMNA gene). (wikipedia.org)
The most common mutation in the lamin A/C is the homozygous Arg527His (arginine replaced by histidine at position 527) substitution in exon 9 of the LMNA gene Other known mutations are Ala529Val and Arg527His/Val440Met. (wikipedia.org)
Mutations causing progeria are defective in splicing LMNA mRNA, therefore producing abnormal lamin A protein, also known as progerin. (wikipedia.org)
EDMD2/EDMD3 is due to mutations (autosomal dominant and autosomal recessive, respectively) in the LMNA gene that codes for lamins A and C. Mutations in LMNA occur throughout the gene and can cause several different phenotypes (see Causes). (medscape.com)

The mutations activate a cryptic splice site within exon 11 of the gene, thereby causing the deletion of the processing site on prelamin A. This results in an accumulation of progerin that is unable to mature into lamin A, leading to misshapen nuclei. (wikipedia.org)

Some laminopathies however may lead to an early death, and mutations of lamin B1 (LMNB1 gene) may be lethal before or at birth. (wikipedia.org)
citation needed] Mutations in the gene coding for lamin B2 (LMNB2 gene) have been linked to Barraquer-Simons syndrome and duplication in the gene coding for lamin B1 (LMNB1 gene) cause autosomal dominant leukodystrophy. (wikipedia.org)
citation needed] Missense mutations in the lamin A/C rod and tail domains are the cause for a wide array of genetic disorders, suggesting that lamin A/C protein contains distinct functional domains that are essential for the maintenance and integrity of different cell lineages. (wikipedia.org)
citation needed] Most lamin B mutations appear to be lethal with mutations in lamin B1 causing death at birth in mice. (wikipedia.org)
Berardinelli-Seip congenital lipodystrophy type 2, the severest form of human lipodystrophy with an almost complete loss of adipose tissue, is due to loss-of-function mutations in the BSCL2/SEIPIN gene. (medscape.com)

A family with dilated cardiomyopathy associated with lipodystrophy and neurological manifestations and overlapping phenotype from lamin A/C mutation was delineated in detail with a follow-up of 22 years. (medscape.com)
Lamin B2 promotes the malignant phenotype of non-small cell lung cancer cells by upregulating dimethylation of histone 3 lysine 9. (nih.gov)

A-type lamins also associate with chromatin in the nuclear interior, away from the peripheral nuclear lamina. (frontiersin.org)
Association of A-type lamins with chromatin at the nuclear periphery and in the nuclear interior. (frontiersin.org)
(D) Nucleoplasmic lamin A interacts with chromatin in the nuclear interior. (frontiersin.org)
Cells were stained with fluorescently labeled antibodies against Ezh2 (green) and TCR (red), and chromatin was stained with DAPI (blue). (scienza-under-18.org)
During mitosis, PP1 appears largely chromatin bound, but in telophase it is recruited to the nuclear periphery to dephosphorylate B-type lamins and thereby enable polymerization and lamina assembly. (rupress.org)

We discuss associated epigenetic and genome conformation changes elicited by the lamin A R482W mutation at the gene level. (frontiersin.org)

The nuclear lamina appears to be an adaptation to mobility in animals as sessile organisms such as plants or fungi do not have lamins and the symptoms of many laminopathies include muscle defects. (wikipedia.org)

Lamin B and tubulin or histone 3 (H3) were used as loading controls for the nuclear and cytoplasmic extracts, respectively. (scienza-under-18.org)
Multicolor fluorescence images of HeLa cells fixed with 4% formaldehyde followed by incubation with 1 ug/mL mouse tubulin antibody GxM IgG- iFluor 488 conjugates (Green). (aatbio.com)

You may also be interested in our alternative recombinant antibody, ab264038 . (abcam.com)
Q.D.), or recombinant murine IL-10 administration alone (PeproTech, Inc.). Pooled sera from two immunized mice were obtained 2, 4, 6, 14, and 21 days after treatment and were analyzed by enzyme-linked immunosorbent assay for the presence of antibodies (Abs) against -gal protein or wild-type vaccinia virus. (tech-strategy.org)

Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus. (nih.gov)

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)

Taken together, our results suggest that the balance between phosphorylation by interphase lamin kinases and dephosphorylation by phosphatases regulates the conformational changes in the lamin B3 N-terminal head domain that in turn regulates the continual in vivo rearrangement and remodeling of the oocyte lamina. (elsevierpure.com)

Myosin adenosine triphosphatase (ATPase) stains may show type I fiber smallness or type I fiber predominance. (medscape.com)

A ) Immunofluorescence microscopy using v5-tag antibody showing doxycycline-dependent inducible expression of v5-progerin and its localization to the nuclear periphery. (elifesciences.org)
Progerin migrates between lamin A and C as indicated (red arrowhead). (elifesciences.org)
B ) Immunofluorescence microscopy using V5-tag antibody (top panels) showing doxycyclin-dependent expression of v5-lamin A and v5-progerin in TERT+ human fibroblasts and localization to the nuclear periphery. (elifesciences.org)

This eventually leads to dispersal of A- and B-type lamin homooligomers throughout the mitotic cell ( Gerace and Blobel 1980 ). (rupress.org)

At the nuclear periphery, the genome is anchored to A- and B-type nuclear lamins in the form of heterochromatic lamina-associated domains. (frontiersin.org)
The major components of the nuclear lamina are the A- and B-type lamins. (rupress.org)
Clearly then, A-type lamins are not strictly required for the formation of a nuclear lamina and NE. (rupress.org)
gene and are major components-together with B-type lamins-of the nuclear lamina network that protects and co-regulates the genomes in vertebrates.6-8 It is now understood that Palmatine chloride yeast do not express lamins 16 and neither do plants which have even larger genomes than animals consistent with the idea that the Palmatine chloride rigid cell walls of yeast and plants provide sufficient protection of the DNA. (ap26113.com)
The nuclear membranes surrounding fish and frog oocyte germinal vesicles (GVs) are supported by the lamina, an internal, mesh-like structure that consists of the protein lamin B3. (elsevierpure.com)
The former spot disappeared when the native lamina was incubated with lambda phage protein phosphatase (λ-PP), indicating that a portion of the lamin protein was already phosphorylated in the goldfish GV-stage oocytes. (elsevierpure.com)

Embryonic stem cells (ESCs), derived from the blastocyst-stage embryo, are capable of generating all cell types of the mammalian body (pluripotency) and of maintaining the capacity for indefinite self-renewal without compromising their genomic integrity. (biomedcentral.com)

Results: We generated an APC antibody (APC-M2 pAb) raised against the 15 amino acid repeat region, and verified its reliability in applications including immunoprecipitation, immunoblotting, and immunofluorescence in cultured cells and tissue. (ku.edu)
Association of lamin B1 with APC in cultured cells and human colonic tissue was verified by co-immunoprecipitation and colocalization. (ku.edu)
All cells express characteristic markers that can be used to help distinguish unique cell types. (proteomicswiki.com)
Many types of cells are involved in the progression of RA joint inflammation, among which the overactivation of M1 macrophages and osteoclasts has been thought to be an essential cause of joint inflammation and bone destruction. (elifesciences.org)
In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta compared to empty vector. (cusabio.com)
Pluripotent embryonic stem cells (ESCs) have the unique ability to differentiate into every cell type and to self-renew. (biomedcentral.com)
Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3. (nih.gov)
RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome. (mpg.de)
Since our workflow efficiently integrates imaging at three different scales and can be applied to other types of cells, it could be used for large-scale phenotypic studies of frozen-hydrated specimens in a variety of healthy and diseased conditions with and without treatments. (bvsalud.org)

The other types, such as the Kobberling-Dunnigan variety or the familial mandibuloacral dysplasia syndrome, may be familial and tend to be associated with metabolic anomalies such as glucose intolerance and hypertriglyceridemia. (medscape.com)

Conclusion: We introduce a versatile APC antibody that is useful for cell/tissue immunostaining, immunoblotting and immunoprecipitation. (ku.edu)
Use high-quality, validated antibodies manufactured in-house with your work with cell markers in mind. (proteomicswiki.com)
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
The evidence supporting the claims of the authors is solid, although inclusion of the analysis of cell type-specific GLI1-deficient mice would have strengthened the study. (elifesciences.org)
Indeed, some cell types never express A-type lamins. (rupress.org)
In telophase, the dispersed lamins are recycled to form NEs in each daughter cell. (rupress.org)
While lamin-B does seem to change greatly in the hematopoietic system 12 past studies show conflicting results even for the same cell type 18 which highlights a need for standardized approaches. (ap26113.com)
and (c) Although IL-10 did not alter levels of anti-vaccinia antibodies or natural killer cell activity, rVV-primed mice treated with IL-10 had enhanced vaccinia-specific cytotoxic T-lymphocyte activity. (tech-strategy.org)
The Wnt/β-catenin pathway plays a critical role in embryonic development, maintenance of multipotent progenitor cell populations and proliferation of many tissue types [1] , [2] . (plos.org)
Description: A competitive ELISA for quantitative measurement of Porcine C type lectin domain family 7 member A(CLEC7A) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (antibody-tech.com)
Prognostic significance of tumor cell proliferation rate as determined by the MIB-1 antibody in breast carcinoma: Its relationship with vimentin and p53 protein. (mpg.de)
Although the latter is predominantly associated with the NuRD complex they are structurally similar and no functional or cell type specific differentiation between Mi-2α and Mi-2β has yet been made [ 6 ]. (biomedcentral.com)
However, these diseases clearly differ in their etiologies, pathogenic mechanisms, and the cell types associated with each pathogenesis. (biomedcentral.com)

This antibody gave a positive signal in Human, Mouse and Rat Skeletal Muscle tissue lysates. (abcam.com)

This nucleoplasmic lamin A environment tends to be euchromatic, suggesting distinct roles of lamin A in the regulation of gene expression in peripheral and more central regions of the nucleus. (frontiersin.org)

In a study utilizing MRI imaging, researchers found that all patients with Emery-Dreifuss muscular dystrophy type 2 showed a characteristic involvement of the posterior calf muscles. (medscape.com)
Myotonic dystrophy (DM) is considered a subgroup of myopathy and the most common type of muscular dystrophy that begins in adulthood. (rxharun.com)

In this study, we discover a previously unknown type of SBD and identify its causal gene, TMEM53 , which encodes nuclear envelope transmembrane (NET) protein 53 (TMEM53, also known as NET4). (nature.com)
This gene encodes a B type nuclear lamin. (nih.gov)

Antibody-Driven Proximity Labeling in Fixed Tissues. (nih.gov)

32) reported that miR-96, miR-182 and miR-183 have been all upregulated in intestinal-type gastric cancers. (gpr120inhibitor.com)

Wild type, PI3Kγ knock-out (PI3Kγ -/- ) and PI3K kinase dead knock-in (PI3Kδ D910/A910 ) transgenic mice were exposed to cigarette smoke for 3 days and the expression levels of the co-repressor complex components HDAC-2, mSin3a, Mi-2α and Mi-2β and HDAC-2 activity in the lungs were assessed. (biomedcentral.com)
CIA and K/BxN serum transfer were used to generate inflammatory arthritis models in wild-type (WT) and Batf −/− mice. (biomedcentral.com)

The recent identification of well-defined molecular subtypes, driver genetic alterations and signaling pathways makes breast cancer one of the few tumour types in which molecular classification has been used successfully for the design of individualised therapies. (biomedcentral.com)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66466-1-Ig (JAK1 antibody) at dilution of 1:200 (under 10x lens. (ptglab.com)
Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66466-1-Ig (JAK1 antibody) at dilution of 1:200 (under 40x lens. (ptglab.com)
Recommend GTX00693 NUP98 antibody [13C2] on human, T. etrahymena and yeasts samples. (genetex.com)
The role of lamin B2 in human diseases. (nih.gov)

Thus, lamin phosphorylation appears to occur prior to oocyte maturation in vivo in both these species. (elsevierpure.com)

Cytoskeletal dysregulation has been found in various types of cancers and is known to influence tumor formation, along with neurodegenerative diseases, autoinflammation, conditions involving muscular atrophy, and immunodeficiencies. (aatbio.com)
Ramucirumab is an anti-VEGFR2 monoclonal antibody used for the therapy of a number of cancers. (ncbcs.org)

Radial placement of beads is determined from, here, lamin A ChIP-sequencing data in fibroblasts. (frontiersin.org)

Here, we discover a previously unknown type of SBD in four independent families caused by bi-allelic loss-of-function pathogenic variants in TMEM53 , which encodes a nuclear envelope transmembrane protein. (nature.com)

Common labeling antibodies used by researchers include anti-F actin, anti-nexillin, anti-⍺ actin, and anti-ꞵ actin. (aatbio.com)

Myotonic Dystrophy Type II - DM2 typically manifests in adulthood (median age 48 years) and has a variable presentation. (rxharun.com)

Anatomy16

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Form the nuclear lamina2

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