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Cathepsin DCathepsinsCathepsin BCathepsin LCathepsin KCathepsin EAntibodiesCathepsin HCathepsin GPepstatinsAntibody SpecificityCathepsin CAntibodies, ViralLysosomesAntibodies, MonoclonalAntibodies, BacterialCathepsin FAntibody FormationAntibodies, NeutralizingCathepsin ZCysteine EndopeptidasesFluorescent Antibody TechniqueAntibody AffinityMolecular Sequence DataAmino Acid SequenceCathepsin WAntibodies, Anti-IdiotypicBinding Sites, AntibodyEndopeptidasesEpitopesEnzyme PrecursorsHIV AntibodiesMannosephosphatesAntibodies, NeoplasmAntibodies, ProtozoanCystatinsAntibodies, AntinuclearProtease InhibitorsCross ReactionsCathepsin ACysteine Proteinase InhibitorsHydrogen-Ion ConcentrationAntigen-Antibody ReactionsCell LineRabbitsElectrophoresis, Polyacrylamide GelImmunoglobulin MMice, Inbred BALB CAutoantibodiesMolecular WeightCells, CulturedAntibodies, FungalBlotting, WesternRecombinant ProteinsImmunohistochemistryReceptor, IGF Type 2Neutralization TestsAspartic Acid EndopeptidasesKineticsCattleFluorescent Antibody Technique, IndirectImmunoglobulin GAntibodies, BispecificDipeptidesLysosome-Associated Membrane GlycoproteinsBase Sequencebeta-N-AcetylhexosaminidasesImmunoenzyme TechniquesSingle-Chain AntibodiesAntibodies, BlockingSerine EndopeptidasesAntigen-Antibody ComplexPeptide FragmentsSpleenProtein Processing, Post-TranslationalImmunoglobulin Fab FragmentsImmune SeraSubstrate SpecificityAcid PhosphataseDiazomethaneAntibodies, HeterophileAntibodies, CatalyticAcetylglucosaminidaseImmunoblottingOligopeptidesPeptide HydrolasesRNA, MessengerEnzyme-Linked Immunosorbent AssayCloning, MolecularBreast NeoplasmsMucolipidosesHybridomasImmunoglobulin APhagosomesAntibodies, Monoclonal, HumanizedEndosomesPapainMice, Inbred C57BLAutolysisImmunodiffusion
Reagents distributedSpecificityLaboratoriesGenpriceELISA KitPolyclonal AntibodyInhibitorsBiotinAssay KitProteinsCysteine cathepsinAntineutrophil cytoplasRecombinant monoclonalProteaseRabbitSpeciesProductsConjugateProteinSerumPeptideCTSKElastaseANCAsHybridomaTissueConjugatesCatalogInhibitorPrimaryHumanDetectionEnzymeInhibitionEfficacyPotent
Reagents distributed8
Specificity2
Laboratories1
Genprice1
  • CusabioIFITM2 Antibody, HRP conjugated is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible or send. (joplink.net)
ELISA Kit2
  • Description: Qualitativeindirect ELISA kit for measuring Human platelet antibodies IgM (PA-IgM) in samples from serum, plasma. (csb-bioenergetics.nl)
  • Description: A sandwich ELISA kit for detection of Cathepsin K from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (srbiosystem.com)
Polyclonal Antibody1
  • The following product was used in this experiment: OPA1 Polyclonal Antibody from Thermo Fisher Scientific, catalog # 27733-1-AP. (thermofisher.com)
Inhibitors11
  • Cathepsin K inhibitors show great potential in the treatment of osteoporosis. (wikipedia.org)
  • Other cathepsin K inhibitors are in various stages of development. (wikipedia.org)
  • Specific Furin and Cathepsin L inhibitors which block proteolytic activation of the S Protein , and thus SARS-CoV-2 virus entry and replication, are potential antiviral agents to counteract SARS-CoV-2 infection and pathogenesis. (promocell.com)
  • In addition to our assays for studying binding of SARS-CoV-2 to the ACE2 receptor and screening for respective inhibitors/drugs (see below), we offer the Furin Activity Assay Kit & Furin Inhibitor Screening Kit as well as Cathepsin L Activity Assay Kit & Cathepsin L Inhibitor Screening Kit as tools to develop new targeted therapeutics for Covid-19. (promocell.com)
  • In addition, a broad range of other Cathepsin Assays , Cathepsin Inhibitors as well as recombinant Cathepsins , Cathepsin antibodies & ELISAs also useful to study SARS-CoV infections (e.g. (promocell.com)
  • This invention relates to a compound of formula I and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases. (justia.com)
  • Thus, inhibitors of Cathepsin C could potentially be useful therapeutics for the treatment of neutrophil-dominated inflammatory diseases such as chronic obstructive pulmonary disease (COPD), pulmonary emphysema, asthma, multiple sclerosis, and cystic fibrosis (Guay et al. (justia.com)
  • By screening a combinatorial pentapeptide amide collection in an inhibition assay, we systematically evaluated the potential of 19 proteinogenic amino acids and seven nonproteinogenic amino acids to serve as building blocks for inhibitors of human cathepsin L. Particularly efficient were aromatic, bulky, hydrophobic amino-acid residues, especially leucine, and positively charged residues, especially arginine. (uni-bielefeld.de)
  • This random approach for the design of inhibitors was introduced to compensate for the inaccuracy induced by shifted docking of combinatorial compound collections at the active center of cathepsin L. Thereby, we obtained structurally defined pentapeptide amides which inhibited human cathepsin L at nanomolar concentrations. (uni-bielefeld.de)
  • Among the most potent novel inhibitors, one peptide, RKLLW-NH2, shares the amphiphilic character of the nonamer fragment VMNGLQNRK of the autoinhibitory, substrate-like, but reverse-binding prosegment of human cathepsin L which blocks the active center of the enzyme. (uni-bielefeld.de)
  • Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections", EUROPEAN JOURNAL OF BIOCHEMISTRY , vol. 267, 2000, pp. 5085-5092. (uni-bielefeld.de)
Biotin1
Assay Kit3
Proteins5
  • Abcam: antibodies, proteins, kits. (abcam.com)
  • Epithelial immunospot (EPISPOT) is an antibody-based method for quantification of live CTCs by detection of CTCs which are capable of secreting proteins such as cathepsin D, MUC1 and CK19. (medscape.com)
  • The most common method for monitoring internalization relies on labeling proteins with antibodies modified with a fluorophore or other tag that can also be used to report on whether the protein of interest has been internalized. (aacrjournals.org)
  • Here we report a method for the characterization of protein internalization in real time through the sortase-mediated, site-specific labeling of single domain antibodies or viral proteins with a newly developed, cathepsin-sensitive quenched-fluorophore probe. (aacrjournals.org)
  • 135 antibodies against 65 mainly immunoregulatory proteins, we of a multitude of different genes (8, 9). (lu.se)
Cysteine cathepsin2
  • The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease involved in bone remodeling and resorption. (wikipedia.org)
  • Furthermore, we are developing cysteine cathepsin activity targeting small molecules to study and manipulated tumor-associated macrophages. (irbbarcelona.org)
Antineutrophil cytoplas1
  • It has been demonstrated that antineutrophil cytoplasmic antibody (ANCA) positivity could be detected in many cases of vasculitis associated with viruses. (hindawi.com)
Recombinant monoclonal1
  • Reduce immunogenicity in mouse models or humanized mouse models with our recombinant monoclonal antibodies. (bioxcell.com)
Protease2
  • A further host protease required for activation of the S Protein is Cathepsin L which also facilitates SARS-CoV-2 entry into target cells through an alternative route. (promocell.com)
  • Inhibition of the Furin protease and Cathepsin L might therefore be an efficient way to attenuate the infection process and reduce the spread and severity of COVID-19. (promocell.com)
Rabbit1
  • Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. (abcam.com)
Species5
Products1
Conjugate2
  • In July 2018, Daiichi Sankyo Company, Limited and Glycotope GmbH have inked a pact regarding the combination of Glycotope's investigational tumor-associated TA-MUC1 antibody gatipotuzumab and Daiichi Sankyo's proprietary ADC technology for developing gatipotuzumab antibody drug conjugate. (wikipedia.org)
  • Find VPS53 Antibodies with a specific conjugate such as Alexa Fluor 488, Alexa Fluor 555, Alexa Fluor 594. (antibodies-online.com)
Protein10
  • Reacts with mouse CTSD / Cathepsin D. Cross reacts with human and rat protein. (covalab.com)
  • Two different monoclonals to Cathepsin D are available and each clone is purified by protein A chromatography. (scrippslabs.com)
  • An anticancer drug is coupled to an antibody that targets a specific tumor antigen (or protein ) that, ideally, is only found in or on tumor cells. (wikipedia.org)
  • Green: RRM2 protein stained by RRM2 antibody [N1C1] diluted at 1:500. (novusbio.com)
  • The isolated CTCs are then cultured in tissue culture plates pre-coated with antibodies which capture the secreted protein of interest. (medscape.com)
  • After the incubation period, cells are washed out and the released protein spots are detected by the incubation with a fluorochrome-conjugated antibody and counted. (medscape.com)
  • This protein mediates either fusion of the virus membrane with the host cell membrane (TMPRSS2 activated mediation) or endocytosis of the virus particle (Cathepsin-activated mediation) and its entry into the cell. (promocell.com)
  • The S Protein is important in both mechanism studies and the development of vaccines and therapeutics such as antibodies and chemical drug compounds. (promocell.com)
  • The S Protein is then processed/activated by the lysosomal Cathepsin L in the late endosomes (endo-lysosomes) following endocytosis of the virus. (promocell.com)
  • Explore the largest catalog of antibodies specifically formulated for in vivo research-preservative, stabilizer, and carrier protein-free. (bioxcell.com)
Serum4
  • The Anti Human Dr5 Antibody From Biolegend Antibodies reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (iowaodes.com)
  • Description: A sandwich ELISA for quantitative measurement of Human Cathepsin Antibodies in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (iowaodes.com)
  • Description: Quantitative sandwich ELISA for measuring Sheep Antibody against Foot and Mouth Disease IgM (FMDV-IgM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (ataxin.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Cathepsin K (CTSK) in serum, plasma, tissue homogenates and other biological fluids. (srbiosystem.com)
Peptide2
  • Synthetic peptide surrounding aa 140 of mouse cathepsins D. (covalab.com)
  • This peptide releases the AMC (7-amino-4-methylcoumarin) fluorophore upon cathepsin B cleavage and can be detected with excitation at 354 nm and emission at 442 nm. (eurogentec.com)
CTSK1
  • Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene. (wikipedia.org)
Elastase1
  • Neutrophils are recruited to the site of joint inflammation and release Cathepsin G, elastase and proteinase 3, proteases which are believed to be responsible for cartilage destruction associated with rheumatoid arthritis. (justia.com)
ANCAs2
  • Antineutrophil cytoplasmic antibodies (ANCAs) are sensitive and specific markers for vasculitides. (hindawi.com)
  • Antineutrophil cytoplasmic antibodies (ANCAs) are autoantibodies, usually of IgG structure, formed against azurophilic granules and lysosomal components in the cytoplasm of neutrophils and monocytes [ 16 ]. (hindawi.com)
Hybridoma2
  • We have developed a platform for functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering. (irbbarcelona.org)
  • Enlist our experienced team to grow hybridoma cells, purify antibodies, and produce other materials and QC data. (bioxcell.com)
Tissue1
  • Cathepsin K expression is stimulated by inflammatory cytokines that are released after tissue injury. (wikipedia.org)
Conjugates3
  • Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. (wikipedia.org)
  • [3] Antibody-drug conjugates are an example of bioconjugates and immunoconjugates . (wikipedia.org)
  • These findings help to explain the utility of certain single domain antibody-antigen conjugates for inducing humoral immune responses. (aacrjournals.org)
Catalog2
  • Antibodies.com online catalog. (wikipedia.org)
  • Rely on us to deliver the largest catalog of MAbs formulated specifically for in vivo use and provide customizable antibody production services - backed by 25 years of experience. (bioxcell.com)
Inhibitor3
  • Merck had a cathepsin K inhibitor, odanacatib, in Phase III clinical trials for osteoporosis. (wikipedia.org)
  • Medivir has a cathepsin K inhibitor, MIV-711 (L-006235), in Phase IIa clinical trial, as a disease modifying osteoarthritis drug, as of October 2017. (wikipedia.org)
  • Pharmacokinetics and bone resorption evaluation of a novel Cathepsin K inhibitor (VEL‐0230) in healthy adult horses. (wikipedia.org)
Primary2
Human1
  • Cathepsin K is expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. (wikipedia.org)
Detection1
Enzyme2
  • Cathepsin K antibodies are marketed for research into expression of this enzyme by various cells. (wikipedia.org)
  • Moreover, cathepsin inhibition abolished the interaction between NLRP3 and ASC, measured by immunofluorescence imaging in H37Rv-infected macrophages, demonstrating a critical role of the enzyme in NLRP3-inflammasome activation. (frontiersin.org)
Inhibition1
  • Pharmacological inhibition of cathepsin activity with CA074-Me resulted in a substantial reduction of both mature IL-1β production and caspase-1 activation in infected macrophages. (frontiersin.org)
Efficacy1
Potent1
  • It has been surprisingly found that the bicyclic compounds of the present invention possess potent Cathepsin C activity, high selectivity against other Cathepsins, e.g. (justia.com)