Antibacterial gyrase and topoisomerase fluoroquinolones. Medical search. Frequent questions

Sparkle is a fluoroquinolone antibiotic used in the treatment of bacterial infections. (sdrugs.com)
Evo 500 mg/100 ml is a synthetic, broad-spectrum, third generation fluoroquinolone antibiotic. (medeasy.health)
Antibiotic resistance is a global threat to public health, and the search for new antibacterial therapies is a current research priority. (bvsalud.org)
Levoquin tablets 250mg contain levofloxacin, a synthetic broad spectrum antibiotic of the fluoroquinolone class that is used to treat various infections with antibacterial activity against a wide range of bacteria, including Staphylococcus, Streptococcus Enterococcus, Proteus and Haemophilus. (inhousepharmacy.vu)
Levoquin tablets 250mg contain the active ingredient levofloxacin, a synthetic broad spectrum antibiotic of the fluoroquinolone class that is used to treat a wide range of infections caused by a many susceptible bacteria in various parts of the body. (inhousepharmacy.vu)
Gemifloxacin is a fluoroquinolone antibiotic with the antimicrobial property. (illnesshacker.com)
Gemifloxacin is a fourth generation, an oral fluoroquinolone antibiotic used in the therapy of mild-to-moderate respiratory tract infections caused by susceptible organisms. (illnesshacker.com)
Gemifloxacin is a quinolone/fluoroquinolone antibiotic. (illnesshacker.com)
Moxifloxacin is a fluoroquinolone antibiotic that inhibits A subunits of DNA gyrase (topoisomerase type II) and topoisomerase IV, resulting in inhibition of bacterial DNA replication and transcription. (medscape.com)
The purpose of the study is to discuss the correlation between the resistance rate of gram negative bacteria to fluoroquinolones (FQ) and antibiotic consumption intensity of 145 China tertiary hospitals in 2014. (biomedcentral.com)
Then the correlation between antibiotic usage and fluoroquinolones -resistant (FQR) rate was consequently investigated. (biomedcentral.com)
Ofloxacin is a synthetic, broad-spectrum, second-generation fluoroquinolone antibiotic that is an analog of nalidixic acid. (toku-e.com)
Ciprofloxacin is a widely used antibiotic medication that belongs to the fluoroquinolone class. (topdollsites.com)
Ciprofloxacin 500 is a broad-spectrum antibiotic that belongs to the fluoroquinolone class of drugs. (topdollsites.com)
This study's results confirmed an explosion of antibiotic resistance amongst E. coli isolates from UTI against β-lactams and fluoroquinolones. (biomedcentral.com)

Fluoroquinolones are broad-spectrum antibiotics, effective for both gram-negative and gram-positive bacteri, that play an important role in treatment of serious bacterial infections, especially hospital-acquired infections and others in which resistance to older antibacterial classes is suspected. (galchimia.com)
Safety Announcement [12-20-2018] A U.S. Food and Drug Administration (FDA) review found that fluoroquinolone antibiotics can increase the occurrence of rare but serious events of ruptures or tears in the main artery of the body, called the aorta. (kpaddock.com)
Fluoroquinolone antibiotics are approved to treat certain bacterial infections and have been used for more than 30 years. (kpaddock.com)
Health care professionals should avoid prescribing fluoroquinolone antibiotics to patients who have an aortic aneurysm or are at risk for an aortic aneurysm, such as patients with peripheral atherosclerotic vascular diseases, hypertension, certain genetic conditions such as Marfan syndrome and Ehlers-Danlos syndrome, and elderly patients. (kpaddock.com)
It is also noted in an article in Science Translational Medicine entitled "Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells" that fluoroquinolones, and other bactericidal antibiotics, "damage mammalian tissues by triggering mitochondrial release of reactive oxygen species (ROS). (hormonesmatter.com)
Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics. (mcmaster.ca)
Fluoroquinolone antibiotics are a clinically important class of broad-spectrum antibiotics to which bacteria have acquired a high frequency of resistance in many parts of the world [ 9 ]. (biomedcentral.com)
The response to local changes induced by fluoroquinolone antibiotics, which target DNA gyrase subunit A and/or topoisomerase IV, involves an increase in oxygen radicals which reduces cell viability, while the induction of global supercoiling changes by novobiocin (a DNA gyrase subunit B inhibitor), or by seconeolitsine (a topoisomerase I inhibitor), has revealed the existence of topological domains that specifically respond to such changes. (ucm.es)
Fluoroquinolones (FQs) were introduced as broad-spectrum antibiotics. (biomedcentral.com)
Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. (toku-e.com)
Seay TM, Peretsman SJ and Dixon PS (1996) Inhibition of human transitional cell carcinoma in vitro proliferation by fluoroquinolone antibiotics. (toku-e.com)
Recoveries ranged from The spiked recoveries and relative standard deviations RSDs were Stevens Johnson Syndrome May Be Side Effect of Maxaquin Fluoroquinolones, or quinolones, are a popular group of antibiotics that are some of the most widely prescribed drugs in the nation. (buyotcantibiotics.com)
This study aimed to assay the prevalence of common β-lactam resistance genes including bla TEM , bla SHV , bla CTX-M and bla CMY and phenotypic resistance to commonly used β-lactam and fluoroquinolone antibiotics in UTIs. (biomedcentral.com)
Several antibiotics are considered for treatment of cystitis and pyelonephritis, including oral β-lactams (amoxicillin-clavulanic acid or third-generation cephalosporin), fluoroquinolones (ciprofloxacin or levofloxacin), nitrofurantoin, fosfomycin or trimethoprim-sulfamethoxazole [ 5 ]. (biomedcentral.com)

Quinolones and fluoroquinolones are bactericidal drugs, eradicating bacteria by interfering with DNA replication. (wikipedia.org)
The bactericidal action of ciprofloxacin results from the inhibition of both type II topoisomerase (DNA-gyrase) and topoisomerase IV, required for bacterial DNA replication, transcription, repair and recombination. (rxreasoner.com)
Gemifloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. (illnesshacker.com)
Smith JT (1991) Ofloxacin, a bactericidal antibacterial. (toku-e.com)

DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. (sdrugs.com)
Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. (medindex.am)
Ofloxacin is a fluoroquinolone antibacterial which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair, transposition and recombination. (azurewebsites.net)
Evo 500 mg/100 ml exerts antibacterial action by inhibiting bacterial topoisomerase IV and DNA gyrase, the enzymes required for DNA replication, transcription repair and recombination. (medeasy.health)
It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, thereby inhibiting cell replication. (galchimia.com)
by inhibiting the activity of DNA gyrase and topoisomerase, enzymes essential for bacterial DNA replication. (msdmanuals.com)
Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. (illnesshacker.com)
It inhibits bacterial topoisomerase IV and DNA gyrase (topoisomerases type II), enzymes required for DNA replication, transcription, repair, and recombination. (medscape.com)
Fluoroquinolones inhibit type II topoisomerases, DNA gyrase and topoisomerase VI, which are enzymes that introduce double-stranded breaks in DNA to maintain DNA topology during replication and transcription. (biomedcentral.com)
Fluoroquinolones inhibit bacterial DNA synthesis and, consequently, growth by inhibiting DNA gyrase and topoisomerases, which are required for replication, transcription, and translation of genetic material. (medscape.com)
It was developed by Daiichi Seiyaku to be resistant to metabolic oxidation in the liver and inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. (toku-e.com)
Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited. (toku-e.com)
It belongs to a class of drugs known as fluoroquinolones, which work by inhibiting the growth and replication of bacteria. (topdollsites.com)
The main mechanism of action of ciprofloxacin involves inhibiting the activity of bacterial DNA gyrase and topoisomerase IV, which are enzymes essential for the replication and repair of bacterial DNA. (topdollsites.com)
It works by inhibiting the DNA gyrase enzyme, which is responsible for the replication and repair of bacterial DNA. (topdollsites.com)

Molecular docking and simulation studies of the compounds at putative bacterial target enzymes suggest that the antimicrobial potency of these synthesized analogues could be due to enzyme inhibition via their favorable binding at the fluoroquinolone binding site at the GyrA subunit of DNA gyrase and/or the ParC subunit of topoisomerase-IV. (abo.fi)
This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. (illnesshacker.com)
These drugs inhibit the DNA transcription in bacteria by inhibiting the DNA gyrase enzyme . (studyread.com)
This enzyme acts by inhibiting DNA gyrase topoisomerase two and topoisomerase four. (cyno.co.in)

Point mutations in DNA gyrase subunit B (gyrB) can result in resistance to aminocoumarins. (mcmaster.ca)
One of these hypothesis suggests the inhibition of subunit A of DNA-gyrase in presence of ATP [ 5 - 7 ]. (hindawi.com)

Levofloxacin and sparfloxacin are examples of third generation quinolones, also known as fluoroquinolones, but they are more effective against gram-positives organism. (hindawi.com)

Levofloxacin works by inhibiting several bacterial enzymes (bacterial topoisomerase IV and DNA gyrase) needed for the bacteria to replicate and repair its DNA. (inhousepharmacy.vu)
This moiety is the mainly responsible for the antibacterial properties of all these molecules, due to their ability to block the bacterial cell wall synthesis as a result of their covalent binding to penicillin-binding proteins (PBPs), which are essential enzymes involved in the terminal steps of the synthesis of peptidoglycan, the main component of the bacterial cell wall [ 9 ] . (encyclopedia.pub)
Both enzymes are tetramers (X 2 Y 2 ), where DNA gyrase encoded by genes gyrA and gyrB, and topoisomerase IV is encoded by parC and parE . (biomedcentral.com)

Gatifloxacin is a fluoroquinolone antibacterial which acts by inhibiting DNA synthesis in susceptible organisms via inhibition of both DNA gyrase (essential for bacterial reproduction) and topoisomerase IV (essential during bacterial cell division). (medicscientist.com)
Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are essential for bacterial growth. (illnesshacker.com)

Decreased fluoroquinolone susceptibility and then fluoroquinolone resistance have developed in association with chromosomal mutations in the quinolone resistance-determining region of genes encoding DNA gyrase and topoisomerase IV and also by plasmid-mediated resistance mechanisms. (nih.gov)
Gemifloxacin is an oral broad-spectrum quinolone antibacterial agent used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. (illnesshacker.com)
Levonadifloxacin (LND) is a broad-spectrum benzoquinolizine fluoroquinolone with potent activity against quinolone-resistant S. aureus and MRSA phenotypes developed by an Indian company Wockhardt. (vjim.org)
Yes No. Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents. (buyotcantibiotics.com)
Some quinolone and fluoroquinolone drugs chemical structures. (hindawi.com)
Another hypothesis supports the existence of a cooperative bond between the quinolone-DNA-DNA-gyrase [ 8 - 11 ]. (hindawi.com)

Ciprofloxacin is a fluoroquinolone antibacterial agent. (rxreasoner.com)
Although cross-resistance can occur between gemifloxacin and other fluoroquinolones, gemifloxacin may be active against some strains of S. pneumoniae resistant to ciprofloxacin and other fluoroquinolones. (illnesshacker.com)
Ciprofloxacin has been found to affect mammalian topoisomerase II, especially in mitochondria. (hormonesmatter.com)
Further analysis found protein-linked double-stranded DNA breaks in the mtDNA from ciprofloxacin-treated cells, suggesting that ciprofloxacin was targeting topoisomerase II activity in the mitochondria. (hormonesmatter.com)
Phenotypic resistance against β-lactams (ceftazidime, cefotaxime, aztreonam and ceftriaxone) and fluoroquinolones (ciprofloxacin) were identified by the disc diffusion technique. (biomedcentral.com)

Doing levofloxacin inhibits DNA gyrase resulting in an abnormal association between open DNA and gyrase and impaired negative supercoiling. (cyno.co.in)

Sparfloxacin is a broad-spectrum antibacterial agent that inhibit DNA gyrase and topoisomerase IV and kills many of the types of bacteria that can infect the breathing airways and lungs and has been shown in a large number of clinical trials to be safe and effective for the treatment of bacterial infections. (com.bd)

It is found to be more effective in vitro than other fluoroquinolones against some gram positive organisms (Streptococcus pneumoniae, Staphylococcus aureous), Mycobacteria and Chlamydia spp. (com.bd)
Ulifloxacin is generally more active in vitro than other fluoroquinolones against a variety of clinical isolates of Gram-negative bacteria, including community and nosocomial isolates of Escherichia coli, Klebsiella spp. (ncats.io)

Sparkle is a synthetic fluoroquinolone broad-spectrum antimicrobial agent in the same class as ofloxacin and norfloxacin. (sdrugs.com)
The antibacterial activity of ofloxacin resides primarily in the L-isomer. (medscape.com)
Ofloxacin is a Cytochrome P-450 inhibitor and DNA Topoisomerase II inhibitor. (toku-e.com)

As a fluoroquinolone antibacterial agent, levofloxacin inhibits bacterial type II topoisomerases-DNA gyrase and topoisomerase IV. (medico-labs.com)

Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent developed by Bayer. (galchimia.com)

To decrease selec- that demonstrate the best pharmacokinetic and pharmacody- tive pressure, antibacterial therapy should only be prescribed namic profile against suspected pathogens might also reduce in patients with known or suspected bacterial infections. (cdc.gov)

A study of fluoroquinolone-resistant clinical E. coli isolates in Houston, TX, USA, showed that all isolates had one or several amino acid substitutions in GyrA, and 85 % of these isolates had additional substitutions in ParC [ 12 ]. (biomedcentral.com)
Molecular characterization of clinical Streptococcus pneumoniae isolates with reduced susceptibility to fluoroquinolones emerging in Italy. (ncats.io)

Studies in murine models have shown that fluoroquinolones demonstrate efficacy similar to that of the aminoglycosides. (medscape.com)

Like other fluoroquinolone anti-infective agents, gemifloxacin inhibits DNA synthesis in susceptible organisms via inhibition of type II DNA topoisomerases (DNA gyrase, topoisomerase IV). (illnesshacker.com)

ever, if newer agents are overused or used inappropriately, Moreover, mechanisms of resistance to fluoroquinolones, resistance will invariably develop to the newer drug. (cdc.gov)
However, it did not explain the resistance to fluoroquinolones found in the 15 strains. (scielo.br)

Systemic fluoroquinolones have been associated with hypersensitivity reactions, even following a single dose. (medico-labs.com)
Without treatment, some infections can spread and lead to serious health problems (see List of Currently Available FDA-Approved Systemic Fluoroquinolones). (kpaddock.com)
Discontinue the drug immediately and avoid the use of systemic fluoroquinolones in patients who experience any of these serious adverse reactions. (cyno.co.in)

Norfloxacin is a fluoroquinolone anti-infective agent. (antiinfectivemeds.com)

Fluoroquinolones, including levofloxacin, may exacerbate muscle weakness in patients with myasthenia gravis. (nih.gov)
The use of fluoroquinolones is not recommended in patients with myasthenia gravis. (medscape.com)

Levofloxacin is a fluoroquinolone antibacterial indicated in adults (18 years of age and older) with infections caused by designated, susceptible bacteria and in pediatric patients where indicated (1, 12.4). (nih.gov)
To reduce the development of drug-resistant bacteria and maintain the effectiveness of levofloxacin and other antibacterial drugs, levofloxacin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria (1.15). (nih.gov)
Levofloxacin preferentially targets DNA gyrase in Gram-negative bacteria and topoisomerase IV in Gram-positive bacteria. (medico-labs.com)
Since our body cells have DNA topoisomerase instead of DNA gyrase, there is selectivity for bacteria alone. (studyread.com)
Ulifloxacin is a fluoroquinolone with potent antibacterial activity against a broad spectrum of Gram-positive and -negative bacteria. (ncats.io)

The aim of this in silico study was to test nine new fluoroquinolones previously designed with potential leishmanicidal activity against Campylobacter jejuni, Escherichia coli, Neisseria gonorrhoeae, Pseudomonas aeruginosa, and Salmonella typhi, all of which are considered by the World Health Organization to resistant pathogens of global concern, through molecular docking and molecular dynamics (MD) simulations using wild-type (WT) and mutant-type (MT) DNA gyrases as biological targets. (bvsalud.org)
However, unlike many other fluoroquinolones, gemifloxacin targets both DNA gyrase and topoisomerase IV in susceptible S. pneumoniae. (illnesshacker.com)

Second-generation fluoroquinolones, such as gatifloxacin and moxifloxacin, have excellent cerebrospinal fluid (CSF) penetration, and animal models suggest that they are effective in penicillin- and ceftriaxone-resistant pneumococcal meningitis. (medscape.com)

Topoisomerase Mutations That Are Associated with High-Level Resistance to Earlier Fluoroquinolones in Staphylococcus aureus Have Less Effect on the Antibacterial Activity of Besifloxacin. (mcmaster.ca)

Resistance genes of aminocoumarin producers: two type II topoisomerase genes confer resistance against coumermycin A1 and clorobiocin. (mcmaster.ca)
The control of DNA-supercoiling in S. pneumoniae occurs mainly via the regulation of topoisomerase gene transcription: relaxation triggers the up-regulation of gyrase and the down-regulation of topoisomerases I and IV, while hypernegative supercoiling down-regulates the expression of topoisomerase I. Relaxation affects 13% of the genome, with the majority of the genes affected located in 15 domains. (ucm.es)

Sparkle exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. (sdrugs.com)
The hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. (medindex.am)
Thus, these newly designed molecules could have antibacterial activity against Gram-negative microorganisms. (bvsalud.org)
Compound 5 displayed antibacterial activity against aquatic pathogens, Vibrio harveyi and V. alginolyticus, with MICs of 8 µg/mL. (bvsalud.org)
Older fluoroquinolones have poor activity against streptococci and anaerobes. (msdmanuals.com)

it displays antibacterial efficacy by inhibiting DNA gyrase and topoisomerase IV. (lktlabs.com)

Although cross-resistance has been observed between Sparkle and other fluoroquinolones, some microorganisms resistant to other fluoroquinolones may be susceptible to Sparkle. (sdrugs.com)
Different emodin derivatives, including the recently reported haloemodin, which inhibits bacterial topoisomerases, can be designed to generate future drugs against resistant pathogens. (longdom.org)

Notably, the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. (illnesshacker.com)

Enoxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. (wikipedia.org)

By achieve the latter objective when prescribing agents belonging withholding the more potent agents for selected cases, these to the fluoroquinolone class. (cdc.gov)
Fluoroquinolones are active against a wide range of approach is to use a newer more potent antimicrobial in set- multiresistant pathogens since their mode of action is against tings where resistance has emerged to an older agent. (cdc.gov)

Like other fluoroquinolones, enoxacin functions by inhibiting bacterial DNA gyrase and topoisomerase IV. (wikipedia.org)
Enoxacin, like other fluoroquinolones, is known to trigger seizures or lower the seizure threshold. (wikipedia.org)
Enoxacin, like other fluoroquinolones, can cause degenerative changes in weightbearing joints of young animals. (wikipedia.org)

Levofloxacin is a broad-spectrum antibacterial agent. (cyno.co.in)

Tendon inflammation and rupture may occur with systemic fluoroquinolone therapy including levofloxacin, particularly in older patients and those treated concurrently with corticosteroids. (medico-labs.com)
They can occur with fluoroquinolones for systemic use given by mouth or through an injection. (kpaddock.com)

How do fluoroquinolones damage tendons, muscles, cartilage and nerves? (hormonesmatter.com)
Both oral and injectable fluoroquinolones are associated with side effects affecting the tendons, muscles, joints, nerves, and the central nervous system. (cyno.co.in)

Rapid and simultaneous determination of three fluoroquinolones in animal-derived foods using excitation-emission matrix fluorescence coupled with second-order calibration method. (buyotcantibiotics.com)

Synergistic effect of fosfomycin and fluoroquinolones against Pseudomonas aeruginosa growing in a biofilm. (ncats.io)

Anatomy4

Organisms44

Diseases27

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes49

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care3

Antibiotic15

Antibiotics14

Bactericidal4

Replication15

Enzyme4

Subunit2

Quinolones1

Enzymes3

Essential for bacterial2

Quinolone6

Ciprofloxacin5

Inhibits DNA gyrase1

Inhibit1

Vitro than other fluoroquinolones2

Ofloxacin3

Levofloxacin inhibits1

Synthetic fluoroquinolone1

Suspected pathogens1

Isolates2

Aminoglycosides1

Synthesis1

Resistance to fluoroquinolones2

Systemic Fluoroquinolones3

Anti-infective1

Patients with myasthenia gravis2

Bacteria5

Targets2

Moxifloxacin1

Staphylococcus1

Genes2

Activity5

Efficacy1

Resistant2

Mammalian1

Infections1

Potent2

Enoxacin3

Agent1

Occur2

Tendons2

Fluorescence1

Fosfomycin1