AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
Angiogenesis InhibitorsNeovascularization, PathologicRetinal NeovascularizationCorneal NeovascularizationChoroidal NeovascularizationNeovascularization, PhysiologicVascular Endothelial Growth Factor AAngiogenesis Inducing AgentsEndothelial CellsEndostatinsVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth FactorsEndothelium, VascularEndothelial Growth FactorsRetinal VesselsLymphokinesThrombospondin 1IschemiaFluorescein AngiographyAngiogenic ProteinsMice, Inbred C57BLMice, NudeDisease Models, AnimalCell MovementChorioallantoic MembraneAngiostatinsReceptors, Vascular Endothelial Growth FactorAntigens, CD31Vascular Endothelial Growth Factor Receptor-1Human Umbilical Vein Endothelial CellsFibroblast Growth Factor 2CorneaChoroidCapillariesCell ProliferationHindlimbRetinopathy of PrematurityXenograft Model Antitumor AssaysCells, CulturedAllantoisBlood VesselsUmbilical VeinsLaser CoagulationCell Line, TumorVasa VasorumCyclohexanesReceptor, TIE-2NeoplasmsAngiopoietin-2SerpinsNeoplasm TransplantationIntravitreal InjectionsImmunohistochemistryPericytesChorionCarcinoma, Lewis LungAngiopoietin-1Vitreous BodyIntegrin alphaVbeta3MicrovesselsCell DivisionMacular DegenerationSignal TransductionEye BurnsRetinaRetinal DiseasesReverse Transcriptase Polymerase Chain ReactionAntineoplastic AgentsAntibodies, Monoclonal, HumanizedRNA, MessengerAngiostatic ProteinsDrug CombinationsLamininMicrocirculationAngiogenesis Modulating AgentsIntercellular Signaling Peptides and ProteinsHypoxia-Inducible Factor 1, alpha SubunitApoptosisPyrrolesBurns, ChemicalMice, Inbred BALB CBlotting, WesternWound HealingInjections, IntraocularChick EmbryoTransplantation, HeterologousCell HypoxiaMice, KnockoutMice, SCIDCollagen Type XVIIICollagenNeoplasms, ExperimentalGenetic TherapyIndolesSesquiterpenesRats, Inbred BNDose-Response Relationship, DrugProteoglycansReceptors, Growth FactorMelanoma, Experimental
InhibitorsChoroidal NeovascularizationAngiogenicProgressionVEGFMiceVascularCorneal neovascularizationInhibitionCapillaryPathologicalChick chorioallantoic membraneRegulatesEndothelial cellsMetastasisInhibitVesselsVivoTumor formationMicrovessel densityProangiogenicMetastaticClinicalMoleculesTherapeuticTissueReceptorPathologyRabbitsMalignantActivityOccurPROTEINSProcessCellsTreatment
Inhibitors2
  • This review will describe several inhibitors of angiogenesis currently in clinical trial and their various targets. (ox.ac.uk)
  • Chae YK, Brown EN, Lei X, Melhem-Bertrandt A, Giordano SH, Litton JK, Hortobagyi GN, Gonzalez-Angulo AM, Chavez-MacGregor M. Use of ACE Inhibitors and Angiotensin Receptor Blockers and Primary Breast Cancer Outcomes. (jcancer.org)
Choroidal Neovascularization4
Angiogenic2
  • [1] It is caused by a disruption of the balance between angiogenic and antiangiogenic factors that preserves corneal transparency. (aao.org)
  • Identifying key pathways involved in the regulation and promotion of angiogenesis has resulted in the development of numerous approaches targeting pro-angiogenic signalling pathways. (ox.ac.uk)
Progression7
  • Angiogenesis has emerged as a critical process for tumour progression. (ox.ac.uk)
  • Both angiogenesis and stromagenesis are important mechanisms for the progression of liver metastasis. (duke.edu)
  • We hypothesize that host PEDF inhibits liver metastasis progression through a mechanism involving angiogenesis and stromagenesis. (duke.edu)
  • Multimerin-2 (MMRN2) is a unique endothelial specific extracellular matrix protein that has been implicated in angiogenesis and tumour progression. (ox.ac.uk)
  • Pathological neovascularization plays a pivotal role in the onset and progression of tumors and neovascular eye diseases. (biomedcentral.com)
  • Tumor xenograft model and ocular pathological neovascularization model were constructed as well as Isolectin B4 (IsoB4) staining and immunofluorescence staining were used to assess the effects of AFAP1L1 on the progression of neoplasms and neovascular eye diseases in vivo. (biomedcentral.com)
  • Pathologic angiogenesis was recognized to be important in the progression of solid tumors over 30 years ago [ 4 ]. (biomedcentral.com)
VEGF7
  • The decrease in VEGF levels warrants further investigation of IM862 as an antiangiogenic therapy. (ox.ac.uk)
  • Antiangiogenic drugs prevent the VEGF from binding with the receptors on the surface of the endothelial cells. (preventblindness.org)
  • Topical treatments for corneal neovascularization include steroids and anti-VEGF agents are currently the mainstay initial treatment for corneal neovascularization. (aao.org)
  • Vascular endothelial growth factor (VEGF) and its receptors are among the most widely validated signaling pathways involved in angiogenesis. (arvojournals.org)
  • CLL demonstrates enhanced angiogenesis, with increased MVD, upregulated VEGF and downregulated TSP-1. (biomedcentral.com)
  • A number of molecules, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hypoxia-inducible factor 1α (HIF-1α) have been identified as positive regulators of angiogenesis. (biomedcentral.com)
  • Angiotensin II is now regarded as a tumor growth promoter via angiogenesis from activation of the VEGF pathway[ 4 - 6 ]. (jcancer.org)
Mice1
  • CM101 has been shown in a published Phase I, FDA-approved clinical trial under IND to have clinical safety and effectivity on select stage IV cancer patients, specifically targeting tumor vasculature HP59 is expressed in the adult in wound healing, and in tumor angiogenesis, as shown in mice. (wikipedia.org)
Vascular7
  • Corneal neovascularization is a sight-threatening condition that introduces vascular pathology into the normally avascular cornea. (aao.org)
  • Corneal neovascularization (NV) is a pathologic condition of the cornea, characterized by the formation and extension of new vascular capillaries within and into the previously avascular corneal regions, extending from the limbus into the superficial or deep areas of the cornea. (aao.org)
  • [2] These pathologies lead to a disequilibrium between proangiogenic and antiangiogenic factors that can result in the proliferation and migration of vascular endothelial cells into the corneal stroma. (aao.org)
  • [8] Steroids are thought to work by inhibiting cell chemotaxis and by inhibiting pro-inflammatory cytokines like interleukin-1 and -6, as well as by also causing lymphocyte death and inhibiting vascular dilation, which all amounts to their antiangiogenic effect. (aao.org)
  • Vascular remodeling and clinical resistance to antiangiogenic cancer therapy. (uchicago.edu)
  • HCC is a hypervascular tumor characterized by neovascularization and vascular invasion. (biomedcentral.com)
  • Analogous to events occurring in the corpus luteum, the vascular endothelium of other tissues responds to extracellular signals during the physiologic processes of embryonic development and wound healing, and in the pathologic process of tumor angiogenesis. (biomedcentral.com)
Corneal neovascularization3
Inhibition4
  • Integrin α5β1 inhibition by ATN-161 may be a promising alternative therapy for CNV-related angiogenesis. (arvojournals.org)
  • The lead investigator in this study, Caroline Thomsen, MD, a medical oncologist at Vejle Hospital in Denmark, believes the effects of delta tocotrienol rely not only on its antiangiogenic activity but also on inhibition of additional mechanisms specific to aberrant cellular growth. (naturalmedicinejournal.com)
  • The principal mechanism of angiogenesis inhibition entails the regulation of tip cell behavior through the YAP-DLL4-NOTCH axis. (biomedcentral.com)
  • Inhibiting AFAP1L1 results in the inhibition of angiogenesis by suppressing the germination of endothelial tip cells through the YAP-DLL4-NOTCH axis. (biomedcentral.com)
Capillary5
  • Figure 5: Neovascularization of the wounded mouse cornea by recruitment of functional microvascular loops from the limbal capillary network. (nature.com)
  • HP59 is a pathologic angiogenesis capillary endothelial marker protein (7 or 12 transmembrane domains) which has been identified as the receptor for the Group B Streptococcal Toxin (GBS Toxin) molecule known as CM101, the etiologic agent for early-onset versus late-onset Group B Strep. (wikipedia.org)
  • Thus, using an upstream transcription initiation site, and thus a different start codon, HP59, incorporating the Sialin gene product, becomes a pathologic angiogenesis capillary endothelial cell luminal membrane protein with unknown function, which the GBS Toxin CM101 specifically targets. (wikipedia.org)
  • The antiangiogenic potential of ATN-161 was evaluated in VEFG-stimulated hCECs by MTS proliferation assays, migration assays, and synthetic matrix capillary tube formation assays. (arvojournals.org)
  • The cyclic nature of the capillary bed in the corpus luteum offers a unique experimental model to examine the life cycle of endothelial cells, involving discrete physiologically regulated steps of angiogenesis, blood vessel maturation and blood vessel regression. (biomedcentral.com)
Pathological6
  • coined the term "pathological angiogenesis" to distinguish between HP59-expressing, and non-HP59-expressing capillaries, however, other researchers have not used this terminology. (wikipedia.org)
  • Pathological angiogenesis has a causal role in these eye diseases. (deepdyve.com)
  • These results suggest that RSV may be and Ewa Piatkowska ˛ useful in the prevention or treatment of pathological angiogenesis in eye disorders. (deepdyve.com)
  • In recent years, owing to the swift advancement of high-throughput sequencing technology, pan-cancer analysis and single-cell sequencing analysis have emerged as pivotal methodologies and focal areas within the domain of omics research, which is of great significance for us to find potential targets related to the regulation of pathological neovascularization. (biomedcentral.com)
  • Dual luciferase reporting, qRT-PCR and western blot were used to investigate the upstream and downstream mechanisms of pathological neovascularization mediated by AFAP1L1. (biomedcentral.com)
  • Targeted suppression of AFAP1L1 specifically in endothelial cells in vivo proves effective in inhibiting tumor formation and ocular pathological neovascularization. (biomedcentral.com)
Chick chorioallantoic membrane2
  • Ovarian cancer ascites fluid (OCAF) displayed an antiangiogenic property in a chick chorioallantoic membrane (CAM) assay. (mcmaster.ca)
  • Using neovascularization models based on the chick chorioallantoic membrane and the healing mouse cornea, we found that tissue tension generated by activated fibroblasts or myofibroblasts during wound contraction mediated and directed translocation of the vasculature. (nature.com)
Regulates1
  • Epithelial membrane protein 2 (EMP2) regulates hypoxia-induced angiogenesis in the adult retinal pigment epithelial cell lines. (ucla.edu)
Endothelial cells2
  • This study evaluated the antiangiogenic effects of ATN-161, a small peptide inhibitor of integrin α5β1, in human choroidal endothelial cells (hCECs) and in laser-induced CNV in rats. (arvojournals.org)
  • Available evidence indicates that microvascular endothelial cells of the corpus luteum are not alike, and may differ during the process of angiogenesis and angioregression. (biomedcentral.com)
Metastasis1
  • The characteristics of HCC, including its abundant blood supply and its easy metastasis and recurrence, suggest that angiogenesis plays an important role in tumorigenesis [ 5 ]. (biomedcentral.com)
Inhibit2
  • A growing number of human inflammatory disorders are reported to respond to treatment with thalidomide, and recently this drug has been shown to inhibit angiogenesis in the rabbit, in doses which can elicit teratogenicity in this species. (nih.gov)
  • [4] The main therapeutic aim of these treatments is to initiate anti-angiogenesis and inhibit the neoangiogenesis at early stages, whereas the other treatment modality aims to achieve angio-regression by inducing reversion of immature vessels. (aao.org)
Vessels6
  • Formation of new vessels in granulation tissue during wound healing has been assumed to occur solely through sprouting angiogenesis. (nature.com)
  • In contrast, we show here that neovascularization can be accomplished by nonangiogenic expansion of preexisting vessels. (nature.com)
  • Solid tumours need a blood supply, and a large body of evidence has previously suggested that they can grow only if they induce the development of new blood vessels, a process known as tumour angiogenesis. (nature.com)
  • [9] The use of steroids (such as cortisone) in conjunction with heparin and cyclodextrins causes a greater antiangiogenic effect, leading to the development of 'angiostatic steroids', which are thought to modulate collagen metabolism that can completely disintegrate the basement membrane of the blood vessels. (aao.org)
  • Angiogenesis is the intricate process of generating fresh blood vessels from pre-existing ones. (biomedcentral.com)
  • Angiogenesis, the branching of new microvessels from pre-existent larger blood vessels, is of major importance in normal embryogenesis and in physiologic processes such as ovulation and the menstrual cycle. (biomedcentral.com)
Vivo4
  • Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. (nature.com)
  • To evaluate the antiangiogenic effects of ATN-161 in vivo, CNV was induced in rats by laser photocoagulation. (arvojournals.org)
  • In vivo, injection of ATN-161 after laser photocoagulation inhibited CNV leakage and neovascularization to an extent similar to AF564. (arvojournals.org)
  • A novel in vivo model of puncture-induced iris neovascularization. (illumina.com)
Tumor formation1
  • Following ovulation the neovascularization during the early stages of corpus luteum development has been compared to the rapid angiogenesis observed during tumor formation. (biomedcentral.com)
Microvessel density1
  • The microvessel density (MVD) inside the tumor has been widely demonstrated as a reliable index to evaluate angiogenesis [ 7 ]. (biomedcentral.com)
Proangiogenic1
  • The extent of enhanced bone marrow angiogenesis in chronic lymphocytic leukemia (CLL) and relationship to proangiogenic factors and prognostic indicators is largely unexplored. (biomedcentral.com)
Metastatic1
  • Phase II trial of the antiangiogenic agent IM862 in metastatic renal cell carcinoma. (ox.ac.uk)
Clinical1
  • Dynamic, contrast-enhanced MR imaging is a valuable adjunct to conventional imaging in assessing tumor activity during antiangiogenic therapy, and correlates better than conventional studies with clinical status and response to therapy. (ajnr.org)
Molecules1
  • Under normal conditions, an organ system is kept at a set point in which the pro- and antiangiogenic molecules are in a state of equilibrium. (biomedcentral.com)
Therapeutic2
  • Folkman, J. Tumor angiogenesis: therapeutic implications. (nature.com)
  • Weis, S. M. & Cheresh, D. A. Tumor angiogenesis: molecular pathways and therapeutic targets. (nature.com)
Tissue2
  • The CM101-HP59 complex then activates complement, and initiates an inflammatory cytokine cascade which recruits CD69 positive activated granulocytes to destroy the capillaries and surrounding pathologic tissue. (wikipedia.org)
  • Although studies are limited, an increasing body of evidence supports the existence of increased tissue site angiogenesis in chronic lymphocytic leukemia (CLL). (biomedcentral.com)
Receptor1
  • HP59 lectin is expressed later in life only in pathologic angiogenesis, providing a receptor for CM101. (wikipedia.org)
Pathology1
  • The study was performed after approval by MD Anderson Cancer Center Orlando Institutional Review Board under a request of waiver of consent on archived pathologic specimens within the Department of Pathology. (biomedcentral.com)
Rabbits1
  • Recently, immunopurified fibrin(ogen) degradation products (FDPs) from malignant effusions of VX2 tumor-burdened rabbits exhibited antiangiogenic activity on the CAM. (mcmaster.ca)
Malignant1
  • Angiogenesis is one of the most malignant features of recurrent high-grade glioma, and the recent emergence of antiangiogenic agents offers the hope of more effective treatment. (ajnr.org)
Activity1
  • Thalidomide's antiangiogenic properties have been well documented (5-7) and it has shown activity against gliomas in phase I trials (8, 9) . (ajnr.org)
Occur1
  • Angiogenesis and lymphangiogen- esis also occur in several chronic in�ammatory conditions, According to the World Allergy Organization, allergic dis- includingrheumatoidarthritis,in�ammatoryboweldisease, orders a﫿ect 30-40% of the world's population, and the asthma,chronicairwayin�ammation,atopicdermatitis,and prevalence is escalating to epidemic proportions. (sagepub.com)
PROTEINS1
  • The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. (ox.ac.uk)
Process1
  • This process is called "neovascularization," and it acts as a restorative function in other parts of the body. (preventblindness.org)
Cells1
  • Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. (nature.com)
Treatment1
  • Clearly, a method for monitoring the efficacy of antiangiogenic agents would aid both research and treatment planning. (ajnr.org)