• compounds
  • Several compounds are currently in early phase clinical development as potential treatments for solid and hematological cancers both as monotherapy and in combination with cytotoxics and differentiation agents. (wikipedia.org)
  • vivo
  • The histone deacetylase inhibitors are a new class of cytostatic agents that inhibit the proliferation of tumor cells in culture and in vivo by inducing cell cycle arrest, differentiation and/or apoptosis. (wikipedia.org)
  • effects
  • This review, first, gives an overview concerning the growing importance of melatonin in the inflammatory-mediated pathological conditions and, then, focuses on its roles and its protective effects against the activation of the inflammasomes and, in particular, of the NLRP3 inflammasome. (hindawi.com)
  • In the present study, we examined the anti-inflammatory effects of dried fruit methanol extract on carrageenan-induced hind paw edema in rats. (hindawi.com)
  • Histone deacetylase inhibitors exert their anti-tumour effects via the induction of expression changes of oncogenes or tumour suppressor, through modulating that the acetylation/deactylation of histones and/or non-histone proteins such as transcription factors. (wikipedia.org)
  • HDIs have multiple effects on non-histone effector molecules, so the anti-cancer mechanisms are truly not understood at this time. (wikipedia.org)
  • In the mouse forced swimming test palmitoylethanolamide was comparable to fluoxetine in anti-depressant effects. (wikipedia.org)
  • It has anti-proliferative effects on prostate cancer cell lines and promotes synaptogenesis. (wikipedia.org)
  • thereby
  • In addition, A2A receptor can negatively regulate overreactive immune cells, thereby protecting tissues from collateral inflammatory damage. (wikipedia.org)
  • Plant
  • Researchers uncover mechanism for cancer-killing properties of pepper plant reporting on Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine. (wikipedia.org)
  • topical
  • citation needed] Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis) (topical form), allergic rhinitis (such as hay fever) (topical form), asthma (inhalation form) for patients unresponsive to less potent corticosteroids, and penile phimosis. (wikipedia.org)
  • role
  • The protective role of human milk is augmented by multifunctional agents such as lactoferrin and free fatty acids that are part of the innate immune system of milk and also make major contributions to the nutrition of the infant. (springer.com)
  • cells
  • The first process is a sudden stiffening of these endothelial cells and inflammatory part, which occurs during the first few minutes, after an inflammatory mediator enters in bloodstream. (hindawi.com)
  • The second event is a firm adhesion mediated by CD11/CD18 molecules and other adhesion molecules, which are necessary to maintain the inflammatory cells into the capillaries. (hindawi.com)