• AIDS
  • We have designed a clinically relevant Phase III trial program that includes resistance testing for all patients, allows the use of other expanded access HIV/AIDS therapies, and provides access to a significant number of triple class-experienced patients worldwide. (natap.org)
  • HIV/AIDS healthcare providers interested in finding a local RESIST trial site can access a list of U.S. sites at http://us.boehringer-ingelheim.com or http://www.clinicaltrials.gov. (natap.org)
  • The scientific research on hyssop coupled with the ample scientific evidence that exists that the colon is an effective delivery system for therapeutic agents suggests that the hyssop enema and the hyssop suppository are powerful additions to the therapeutic tools in assisting people with AIDS. (optimalhealthnetwork.com)
  • AIDS, or acquired immunodeficiency syndrome, is caused by the human immunodeficiency virus (HIV). (openrepository.com)
  • VIDEX EC (pronounced VY dex ee see ) is a prescription medicine used in combination with other drugs to treat adults who are infected with HIV (the human immunodeficiency virus, the virus that causes AIDS). (pharmacycode.com)
  • PEG-Intron has been approved by the Food and Drug Administration (FDA) to treat hepatitis C in adults, but in this study, it is being used as an investigational agent for the treatment of HIV/AIDS. (clinicaltrials.gov)
  • Anti-AIDS Agents 69. (wikipedia.org)
  • dead link] "First New NNRTI in Nearly a Decade to Benefit Canadians with HIV/AIDS" (PDF) (Press release). (wikipedia.org)
  • The C-C motif chemokine receptor CCR5 is involved in the process by which HIV, the virus that causes AIDS, enters cells. (wikipedia.org)
  • Anti-AIDS agents--XIX. (wikipedia.org)
  • Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. (wikipedia.org)
  • drugs
  • Two such agents discovered at Yale could result in HIV drugs that are 10 to 2000 times more potent than those now on the market. (yale.edu)
  • Resistance to currently available anti-HIV drugs is an increasingly prevalent concern for highly treatment-experienced HIV-positive patients worldwide, creating an urgent need for new treatments that are effective against multi-drug resistant virus. (natap.org)
  • In January 2008, the Food and Drug Administration approved its use for patients with established resistance to other drugs, making it the 30th anti-HIV drug approved in the United States and the first to be approved in 2008. (wikipedia.org)
  • The ability of betulinic acid to induce two different effects (cytotoxic and cytostatic) on two clones derived from the same human melanoma metastasis suggests the development of clones resistant to this agent will be more unlikely, than that to conventional cytotoxic drugs. (wikipedia.org)
  • These processes play critical roles in the replication of HIV-1 thus making NCp7 a prime target for drugs seeking to contravene the replication process. (wikipedia.org)
  • The mercaptobenzamide and its corresponding prodrug yielded additivity to synergy when combined with known HIV drugs. (wikipedia.org)
  • This information led to the development of a new class of HIV drugs called CCR5 antagonists. (wikipedia.org)
  • treatment
  • These agents could allow for comparatively lower dosages, and also for prophylactic anti-HIV treatment, he said. (yale.edu)
  • HIV rebound after treatment interruption. (hiv-reservoir.net)
  • and X is a residue of D-ornithyl-proline, prolyl-D-ornithine, D-lysylproline, or the like, with the proviso that any one of A1, A3, A4, A5, A6 and A7 is a residue of alanine or the like or that X is citrulline or the like), and methods of using same in the treatment of HIV. (patentsencyclopedia.com)
  • Interferons have been proposed as a possible treatment of HIV. (clinicaltrials.gov)
  • Patients are evaluated with the same safety criteria as Cohort I. Patients in both cohorts who have at least a 0.5 log reduction in HIV RNA at 28 days of treatment are offered continued treatment for a total of 60 weeks. (clinicaltrials.gov)
  • HIV-infected patients taking cenicriviroc had significant reductions in viral load, with the effect persisting up to two weeks after discontinuation of treatment. (wikipedia.org)
  • Etravirine (ETR, brand name Intelence, formerly known as TMC125) is a drug used for the treatment of HIV. (wikipedia.org)
  • Azodicarbonamide (ADA) was the first zinc ejector to go into clinical trial for treatment of HIV. (wikipedia.org)
  • Pharmacokinetics
  • This study will utilize a rising multiple-dose design to assess the safety, tolerability, and pharmacokinetics of single and multiple doses of PEG-Intron in HIV-infected children. (clinicaltrials.gov)
  • reduce viral load
  • When taken with other anti-HIV medicines, SUSTIVA has been shown to reduce viral load and increase the number of CD4+ cells, a type of immune cell in blood. (pharmacycode.com)
  • The purpose of this study is to see if PEG-Intron is safe and tolerated when given to children, to see how much gets into the blood and how long it stays in the blood, and to see how well it works to reduce viral load (level of HIV in the blood). (clinicaltrials.gov)
  • bevirimat
  • C-3 esterification of betulinic acid led to the discovery of bevirimat, an HIV-1 maturation inhibitor patented by Rhone-Poulenc (now Sanofi-Aventis). (wikipedia.org)
  • assay
  • This unit presents an assay that has proven useful as an initial screening test is an HIV cytopathic effect (CPE) inhibition assay in which immortalized T cell lines (e.g. (currentprotocols.com)
  • patients
  • Changes in body fat develop in some patients taking anti-HIV medicine. (pharmacycode.com)
  • There have been reports that HIV patients coinfected with GBV-C can survive longer than those without GBV-C, but the patients may be different in other ways. (wikipedia.org)
  • There is current active research into the virus' effects on the immune system in patients coinfected with GBV-C and HIV. (wikipedia.org)
  • human
  • antigens p17 and p24 are proteins found in human immunodeficiency virus, or HIV). (optimalhealthnetwork.com)
  • HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. (pharmacycode.com)
  • For these reasons it is now rarely used to treat human immunodeficiency virus (HIV), and it has even been removed from pharmacies entirely in some countries. (wikipedia.org)
  • antifungal
  • In the course of various studies of its properties, surfactin was found to exhibit effective characteristics like antibacterial, antiviral, antifungal, anti-mycoplasma and hemolytic activities. (wikipedia.org)
  • therapeutic
  • It relates oral presentations given by Romas Geleziunas, on behalf of Gilead, and Roger Sutmuller, on behalf of Janssen on the search for new therapeutic strategies targeting latent HIV reservoirs. (hiv-reservoir.net)
  • drug
  • These regimens, though effective, do not completely eliminate HIV and the development of drug resistance is a major clinical problem. (clinicaltrials.gov)
  • Zinc ejectors were patented in 2008 and some have entered Phase I/II trials as a HIV drug. (wikipedia.org)
  • The life cycle of the HIV presents potential targets for drug therapy, one of them being the viral entry pathway. (wikipedia.org)
  • CCR5
  • CROI 2013: CCR5/CCR2 Inhibitor Cenicriviroc Has Both Anti-HIV and Anti-inflammatory Effects. (wikipedia.org)
  • CCR5 and CXCR4 are the main receptors involved in the HIV entry process. (wikipedia.org)
  • Viral entry to the CD4+ cell begins with attachment of the R5 HIV-1 glycoprotein 120 (gp120) to the CD4+ T-cell receptor, which produces a conformational change in gp120 and allows it to bind to CCR5, thereby triggering glycoprotein 41 (gp41) mediated fusion of the viral envelope with the cell membrane and the nucleocapsid enters the host cell (Figure 1). (wikipedia.org)
  • CCR5 co-receptor antagonists prevent HIV-1 from entering and infecting immune cells by blocking CCR5 cell-surface receptor. (wikipedia.org)
  • Resistance
  • Unlike the currently available agents in the class, resistance to other NNRTIs does not seem to confer resistance to etravirine. (wikipedia.org)
  • researchers
  • Two of the new agents are extraordinarily potent against the predominant, "wild-type" form of HIV, which is highly adept at mutation, according to the researchers. (yale.edu)
  • scientists
  • The discoveries mark another major achievement by Yale scientists in fighting HIV. (yale.edu)
  • The 2 talks given in a row during this Thursday December 7 afternoon, in front of an audience of more than 210 HIV scientists, contained the same message: some of the major pharmaceutical companies are addressing the search of an HIV cure very seriously. (hiv-reservoir.net)
  • cells
  • They play an important role as co-receptors that HIV type 1 (HIV-1) uses to attach to cells before viral fusion and entry into host cells. (wikipedia.org)
  • HIV enters host cells in the blood by attaching itself to receptors on the surface of the CD4+ cell. (wikipedia.org)
  • It is phosphorylated in T cells and other HIV target cells into its active triphosphate form, ddCTP. (wikipedia.org)