• AIDS
  • We have designed a clinically relevant Phase III trial program that includes resistance testing for all patients, allows the use of other expanded access HIV/AIDS therapies, and provides access to a significant number of triple class-experienced patients worldwide. (natap.org)
  • HIV/AIDS healthcare providers interested in finding a local RESIST trial site can access a list of U.S. sites at http://us.boehringer-ingelheim.com or http://www.clinicaltrials.gov. (natap.org)
  • AIDS, or acquired immunodeficiency syndrome, is caused by the human immunodeficiency virus (HIV). (openrepository.com)
  • VIDEX EC (pronounced VY dex ee see ) is a prescription medicine used in combination with other drugs to treat adults who are infected with HIV (the human immunodeficiency virus, the virus that causes AIDS). (pharmacycode.com)
  • PEG-Intron has been approved by the Food and Drug Administration (FDA) to treat hepatitis C in adults, but in this study, it is being used as an investigational agent for the treatment of HIV/AIDS. (clinicaltrials.gov)
  • Anti-AIDS Agents 69. (wikipedia.org)
  • dead link] "First New NNRTI in Nearly a Decade to Benefit Canadians with HIV/AIDS" (PDF) (Press release). (wikipedia.org)
  • The C-C motif chemokine receptor CCR5 is involved in the process by which HIV, the virus that causes AIDS, enters cells. (wikipedia.org)
  • Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. (wikipedia.org)
  • Anti-AIDS agents--XIX. (wikipedia.org)
  • vitro
  • P. amarus) inhibits HIV replication in vitro and in vivo. (greenmedinfo.com)
  • structural determination of metabolites and/or degradation products of parent agents produced in animals and in model in vitro systems (e.g., animal and/or human liver slices, S9 fractions, and microsomal preparations). (nih.gov)
  • The in vitro and in vivo anti‐retrovirus activity, and intracellular metabolism of 3′‐azido‐2′,3′‐dideoxythymidine and 2′,3′‐dideoxycytidine are highly dependent on the cell species. (currentprotocols.com)
  • Interferon-alfa inhibits HIV replication in vitro, and HIV-infected patients appear to have reduced production of interferons. (clinicaltrials.gov)
  • The fluorocarbocyclic nucleoside carbocyclic 2′-ara-fluoro-guanosine was reported in 1988 as the first example of a carbocyclic analogue of an unnatural nucleoside to exhibit greater anti-herpes activity against the herpesviruses HSV-1 and HSV-2 in-vitro than its furanose parent. (wikipedia.org)
  • Lopinavir
  • The objective of this proposal is based on the assumption that the HIV infected Ethiopian population responded in a different way in comparison to the Caucasian subjects to Lopinavir therapy. (clinicaltrials.gov)
  • drugs
  • Resistance to currently available anti-HIV drugs is an increasingly prevalent concern for highly treatment-experienced HIV-positive patients worldwide, creating an urgent need for new treatments that are effective against multi-drug resistant virus. (natap.org)
  • The purpose of this study is to see if indinavir plus two other anti-HIV drugs affect blood clotting in HIV-positive patients with hemophilia. (clinicaltrials.gov)
  • Have been taking a combination of one protease inhibitor plus two other anti-HIV drugs for at least 6 months, or have never taken a protease inhibitor. (clinicaltrials.gov)
  • In January 2008, the Food and Drug Administration approved its use for patients with established resistance to other drugs, making it the 30th anti-HIV drug approved in the United States and the first to be approved in 2008. (wikipedia.org)
  • The ability of betulinic acid to induce two different effects (cytotoxic and cytostatic) on two clones derived from the same human melanoma metastasis suggests the development of clones resistant to this agent will be more unlikely, than that to conventional cytotoxic drugs. (wikipedia.org)
  • These processes play critical roles in the replication of HIV-1 thus making NCp7 a prime target for drugs seeking to contravene the replication process. (wikipedia.org)
  • The mercaptobenzamide and its corresponding prodrug yielded additivity to synergy when combined with known HIV drugs. (wikipedia.org)
  • This information led to the development of a new class of HIV drugs called CCR5 antagonists. (wikipedia.org)
  • treatment
  • and X is a residue of D-ornithyl-proline, prolyl-D-ornithine, D-lysylproline, or the like, with the proviso that any one of A1, A3, A4, A5, A6 and A7 is a residue of alanine or the like or that X is citrulline or the like), and methods of using same in the treatment of HIV. (patentsencyclopedia.com)
  • Interferons have been proposed as a possible treatment of HIV. (clinicaltrials.gov)
  • Patients are evaluated with the same safety criteria as Cohort I. Patients in both cohorts who have at least a 0.5 log reduction in HIV RNA at 28 days of treatment are offered continued treatment for a total of 60 weeks. (clinicaltrials.gov)
  • Numerous treatment options are available to HIV infected patients who are antiretroviral (ARV) therapy naive, but an optimal regimen has not yet been established. (clinicaltrials.gov)
  • HIV-infected patients taking cenicriviroc had significant reductions in viral load, with the effect persisting up to two weeks after discontinuation of treatment. (wikipedia.org)
  • Etravirine (ETR, brand name Intelence, formerly known as TMC125) is a drug used for the treatment of HIV. (wikipedia.org)
  • Azodicarbonamide (ADA) was the first zinc ejector to go into clinical trial for treatment of HIV. (wikipedia.org)
  • compounds
  • Sumac (Rhus chinensis) contains compounds with anti-HIV activity - Article 3. (greenmedinfo.com)
  • All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents. (bjmu.edu.cn)
  • In the same manner as ADA, the compounds interact with an 18-residue polypeptide on the N terminal zinc knuckle region of the HIV nucleocapsid protein which causes ejection of the zinc from the region by covalently modifying the cysteine residues. (wikipedia.org)
  • Many compounds in this family of molecules are central nervous system suppressants and are associated with therapeutic uses and a variety of medications, such as antibiotics, antiulcer, and anti-HIV agents. (wikipedia.org)
  • resistant
  • A particular moronic acid derivative showed potent anti-HIV activity with EC50 values of 0.0085 μM against NL4-3, 0.021 μM against PI-R (a multiple protease inhibitor resistant strain), and 0.13 μM against FHR-2 (an HIV strain resistant to (bevirimat). (wikipedia.org)
  • Since the CCHC binding site is mutation resistant and involved in the replication of HIV-1, it makes a prime candidate for the prevention of HIV through zinc ejectors. (wikipedia.org)
  • reduce viral load
  • When taken with other anti-HIV medicines, SUSTIVA has been shown to reduce viral load and increase the number of CD4+ cells, a type of immune cell in blood. (pharmacycode.com)
  • The purpose of this study is to see if PEG-Intron is safe and tolerated when given to children, to see how much gets into the blood and how long it stays in the blood, and to see how well it works to reduce viral load (level of HIV in the blood). (clinicaltrials.gov)
  • inhibits
  • ADA inhibits HIV by electophilically attacking the sulfur atoms of the zinc coordinated cysteine. (wikipedia.org)
  • Resistance
  • This study evaluated 3 different ART strategies for preventing the development of NVP resistance in HIV infected pregnant women and compared the incidence of NVP resistance mutations postpartum observed with each regimen to the incidence among historical controls. (clinicaltrials.gov)
  • Unlike the currently available agents in the class, resistance to other NNRTIs does not seem to confer resistance to etravirine. (wikipedia.org)
  • bevirimat
  • C-3 esterification of betulinic acid led to the discovery of bevirimat, an HIV-1 maturation inhibitor patented by Rhone-Poulenc (now Sanofi-Aventis). (wikipedia.org)
  • drug
  • Zinc ejectors were patented in 2008 and some have entered Phase I/II trials as a HIV drug. (wikipedia.org)
  • The life cycle of the HIV presents potential targets for drug therapy, one of them being the viral entry pathway. (wikipedia.org)
  • CCR5
  • CROI 2013: CCR5/CCR2 Inhibitor Cenicriviroc Has Both Anti-HIV and Anti-inflammatory Effects. (wikipedia.org)
  • CCR5 and CXCR4 are the main receptors involved in the HIV entry process. (wikipedia.org)
  • Viral entry to the CD4+ cell begins with attachment of the R5 HIV-1 glycoprotein 120 (gp120) to the CD4+ T-cell receptor, which produces a conformational change in gp120 and allows it to bind to CCR5, thereby triggering glycoprotein 41 (gp41) mediated fusion of the viral envelope with the cell membrane and the nucleocapsid enters the host cell (Figure 1). (wikipedia.org)
  • CCR5 co-receptor antagonists prevent HIV-1 from entering and infecting immune cells by blocking CCR5 cell-surface receptor. (wikipedia.org)
  • Nevirapine
  • HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. (pharmacycode.com)
  • A single dose of nevirapine (SD-NVP) given to an HIV infected pregnant woman in labor followed by a single dose to her infant had been shown to be a simple and effective means of reducing mother-to-child transmission (MTCT) of HIV among women who had not received antiretroviral (ART) during pregnancy. (clinicaltrials.gov)
  • exhibit
  • In the course of various studies of its properties, surfactin was found to exhibit effective characteristics like antibacterial, antiviral, antifungal, anti-mycoplasma and hemolytic activities. (wikipedia.org)
  • human
  • For these reasons it is now rarely used to treat human immunodeficiency virus (HIV), and it has even been removed from pharmacies entirely in some countries. (wikipedia.org)
  • strain
  • There are 3 michellamines represented as A, B, and C, however, Michellamine B is the most active against the NID-DZ strain of HIV-2. (wikipedia.org)