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  • AIDS
  • We have designed a clinically relevant Phase III trial program that includes resistance testing for all patients, allows the use of other expanded access HIV/AIDS therapies, and provides access to a significant number of triple class-experienced patients worldwide. (natap.org)
  • HIV/AIDS healthcare providers interested in finding a local RESIST trial site can access a list of U.S. sites at http://us.boehringer-ingelheim.com or http://www.clinicaltrials.gov. (natap.org)
  • The scientific research on hyssop coupled with the ample scientific evidence that exists that the colon is an effective delivery system for therapeutic agents suggests that the hyssop enema and the hyssop suppository are powerful additions to the therapeutic tools in assisting people with AIDS. (optimalhealthnetwork.com)
  • AIDS, or acquired immunodeficiency syndrome, is caused by the human immunodeficiency virus (HIV). (openrepository.com)
  • VIDEX EC (pronounced VY dex ee see ) is a prescription medicine used in combination with other drugs to treat adults who are infected with HIV (the human immunodeficiency virus, the virus that causes AIDS). (pharmacycode.com)
  • Anti-AIDS Agents 69. (wikipedia.org)
  • dead link] "First New NNRTI in Nearly a Decade to Benefit Canadians with HIV/AIDS" (PDF) (Press release). (wikipedia.org)
  • The C-C motif chemokine receptor CCR5 is involved in the process by which HIV, the virus that causes AIDS, enters cells. (wikipedia.org)
  • Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. (wikipedia.org)
  • Anti-AIDS agents--XIX. (wikipedia.org)
  • vitro
  • P. amarus) inhibits HIV replication in vitro and in vivo. (greenmedinfo.com)
  • structural determination of metabolites and/or degradation products of parent agents produced in animals and in model in vitro systems (e.g., animal and/or human liver slices, S9 fractions, and microsomal preparations). (nih.gov)
  • The in vitro and in vivo anti‐retrovirus activity, and intracellular metabolism of 3′‐azido‐2′,3′‐dideoxythymidine and 2′,3′‐dideoxycytidine are highly dependent on the cell species. (currentprotocols.com)
  • In the first part of his talk, the Gilead scientist described the in vitro system they have adapted from Bosque and Planelles (2009) for the screening of drugs capable of acting on HIV latency (figure 1). (hiv-reservoir.net)
  • The fluorocarbocyclic nucleoside carbocyclic 2′-ara-fluoro-guanosine was reported in 1988 as the first example of a carbocyclic analogue of an unnatural nucleoside to exhibit greater anti-herpes activity against the herpesviruses HSV-1 and HSV-2 in-vitro than its furanose parent. (wikipedia.org)
  • Synthesis
  • 1988: Review of Glaxo's synthesis of fluorocarbocyclic nucleosides 1988: (±)-Carbovir first reported with potent anti-HIV activity and low cytotoxicity 1992: First comprehensive review of the synthesis of chiral carbocyclic nucleosides. (wikipedia.org)
  • Researchers performed the reaction via solid-phase synthesis and used formic acid as the reducing agent. (wikipedia.org)
  • Infections
  • By reducing the growth of HIV, VIDEX EChelps your body maintain its supply of CD4 cells, which are important for fighting HIV and other infections. (pharmacycode.com)
  • Even while taking VIDEX EC, you may continue to have HIV-related illnesses, including infections with other disease-producing organisms. (pharmacycode.com)
  • bevirimat
  • C-3 esterification of betulinic acid led to the discovery of bevirimat, an HIV-1 maturation inhibitor patented by Rhone-Poulenc (now Sanofi-Aventis). (wikipedia.org)
  • assay
  • This unit presents an assay that has proven useful as an initial screening test is an HIV cytopathic effect (CPE) inhibition assay in which immortalized T cell lines (e.g. (currentprotocols.com)
  • Efavirenz
  • SUSTIVA (efavirenz) works by lowering the amount of HIV-1 in the blood (viral load). (pharmacycode.com)
  • Etravirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), designed to be active against HIV with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs, mutation K103N for efavirenz and Y181C for nevirapine. (wikipedia.org)
  • antifungal
  • In the course of various studies of its properties, surfactin was found to exhibit effective characteristics like antibacterial, antiviral, antifungal, anti-mycoplasma and hemolytic activities. (wikipedia.org)
  • therapeutic
  • It relates oral presentations given by Romas Geleziunas, on behalf of Gilead, and Roger Sutmuller, on behalf of Janssen on the search for new therapeutic strategies targeting latent HIV reservoirs. (hiv-reservoir.net)
  • Drug
  • Zinc ejectors were patented in 2008 and some have entered Phase I/II trials as a HIV drug. (wikipedia.org)
  • The life cycle of the HIV presents potential targets for drug therapy, one of them being the viral entry pathway. (wikipedia.org)
  • CCR5
  • CROI 2013: CCR5/CCR2 Inhibitor Cenicriviroc Has Both Anti-HIV and Anti-inflammatory Effects. (wikipedia.org)
  • CCR5 and CXCR4 are the main receptors involved in the HIV entry process. (wikipedia.org)
  • Viral entry to the CD4+ cell begins with attachment of the R5 HIV-1 glycoprotein 120 (gp120) to the CD4+ T-cell receptor, which produces a conformational change in gp120 and allows it to bind to CCR5, thereby triggering glycoprotein 41 (gp41) mediated fusion of the viral envelope with the cell membrane and the nucleocapsid enters the host cell (Figure 1). (wikipedia.org)
  • CCR5 co-receptor antagonists prevent HIV-1 from entering and infecting immune cells by blocking CCR5 cell-surface receptor. (wikipedia.org)
  • Resistance
  • Unlike the currently available agents in the class, resistance to other NNRTIs does not seem to confer resistance to etravirine. (wikipedia.org)
  • human
  • HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. (pharmacycode.com)
  • For these reasons it is now rarely used to treat human immunodeficiency virus (HIV), and it has even been removed from pharmacies entirely in some countries. (wikipedia.org)
  • researchers
  • Two of the new agents are extraordinarily potent against the predominant, "wild-type" form of HIV, which is highly adept at mutation, according to the researchers. (yale.edu)
  • scientists
  • The discoveries mark another major achievement by Yale scientists in fighting HIV. (yale.edu)
  • The 2 talks given in a row during this Thursday December 7 afternoon, in front of an audience of more than 210 HIV scientists, contained the same message: some of the major pharmaceutical companies are addressing the search of an HIV cure very seriously. (hiv-reservoir.net)
  • effective
  • A second, closely related compound, JLJ506, is also highly effective against wild-type HIV, as well as against two common mutant forms of the virus. (yale.edu)
  • viral load
  • The purpose of this study is to see if PEG-Intron is safe and tolerated when given to children, to see how much gets into the blood and how long it stays in the blood, and to see how well it works to reduce viral load (level of HIV in the blood). (clinicaltrials.gov)
  • replication
  • T-lymphocyte turnover is promoted by the production of interleukin-6, interleukin-1, interleukin-2, and tumor necrosis factor (TNF)- α , all of which promote HIV replication [ 1 ]. (hindawi.com)
  • hepatitis
  • David Owen has been outspoken that his policy of "Self-Sufficiency" was not put into place and gave rise to the Tainted Blood Scandal which saw 5,000 British Haemophiliacs infected with Hepatitis C, 1,200 of those were also infected with HIV. (wikipedia.org)
  • proteins
  • The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol (by preventing the translocation of other transcription factors from the cytosol into the nucleus). (wikipedia.org)
  • drug
  • Nowadays, two direct antiviral agents (DAAs) have been approved by Food and Drug Administration (FDA) of USA this year, which increases the SVR rate. (clinicaltrials.gov)
  • Blocking communication between the cardiac cells with a drug called heptanol (an agent that reduces the electrical coupling between cells) causes the spiral waves to break up into even more troublesome smaller spirals. (blogspot.com)
  • However, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug. (wikipedia.org)
  • Cobicistat is a component of two four-drug, fixed-dose combination HIV treatments. (wikipedia.org)
  • cells
  • indicated that the exposure of retinal neurosensory and glial cells to HIV Tat resulted in increased activation and release of proinflammatory mediators, predominantly the chemokine and neurotoxic factor CXCL10 and the cytokine TNF- α [ 5 ]. (hindawi.com)
  • HIV-1 Tat protein induced the apoptosis of human retinal microvascular endothelial cells and retinal pigment epithelium cells. (hindawi.com)
  • blood
  • Days 1, 3, 5, 7, 10 and 21 - Blood will be drawn for specialized immunology tests and to measure blood levels of HIV and HBV. (clinicaltrials.gov)
  • Thus, it is clearly an effective agent for promoting weight gain, increasing appetite, gaining strength, and increasing Red Blood Cell count. (blogspot.com)
  • RPE acts as an important outer barrier to prevent the movement of pathogenic microorganisms (including HIV-1) from the blood into the eye. (hindawi.com)
  • study
  • This study will utilize a rising multiple-dose design to assess the safety, tolerability, and pharmacokinetics of single and multiple doses of PEG-Intron in HIV-infected children. (clinicaltrials.gov)
  • found
  • Proponents of this theory claim that 90% of HIV RNA is found in Visna and 10% in HTLV I. Genomic analysis, however, shows that such claims are false. (wikipedia.org)
  • The unsaturated derivatives are illustrated by phenylahistin the anti-cancer microtubule binding agent, and the mycotoxin roquefortine C found in blue cheeses. (wikipedia.org)
  • active
  • The second agent may or may not be fully active (except in Spain, where participants have to receive a fully active second agent, as requested by the Spanish regulatory agency). (clinicaltrials.gov)
  • These range from the hepatoxic brevianamide F (cyclo(L-Trp-L-Pro)) to the annulated tremorogenic verruculogen and the spiro-annulated spirotryprostatin B which represent a promising class of antimitotic arrest agents, to the structurally complex (+)-stephacidin A, a bridged 2,5-diketopiperazine that possess a unique bicyclo[2.2.iazaoctane core ring system and is active against the human colon HCT-116 cell line. (wikipedia.org)
  • Biologically active Tryptophan-Proline 2,5-Diketopiperazine Natural Products Brevianamide F Verruculogen Spirotryprostatin B (+)Stephacidin A Other bridged 2,5-diketopiperazines include bicyclomycin, an antibacterial agent used as food additives to prevent diarrhea in animals while the thio derivatives such as the cytotoxic bridged epipolythiodioxopiperazine are represented by gliotoxin. (wikipedia.org)
  • major
  • In 2011, when new President Thein Sein's government came to power, Burma embarked on a major policy of reforms including anti-corruption, currency exchange rate, foreign investment laws and taxation. (wikipedia.org)