• 9, 10] The ratio of antibody to antigen in circulating cryoglobulin aggregates or immune complexes affects the rate of clearance from the circulation and the resultant rate and location of tissue deposition. (medscape.com)
  • The Fc portion of antibodies in immune complexes can be bound by C1q of the classical complement pathway, which eventually leads to the release of C5a and C3a. (hindawi.com)
  • Several previous MS variants have been recently separated from MS after the discovery of a specific auto-antibody, specially autoantibodies against AQP4, MOG and Neurofascin proteins. (wikipedia.org)
  • Anti-neurofascin autoantibodies have been reported in atypical cases of MS and CIDP, and a whole spectrum of Anti-neurofascin demyelinating diseases has been proposed. (wikipedia.org)
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
  • Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)-expressing T cells is a new approach for treating advanced B-cell malignancies. (ashpublications.org)
  • Previous research suggested that immune-depression was not responsible for higher susceptibility of BB, since BB animals developed P. ovis specific antibodies after infection, which correlated with the mite population density and the progression of the lesions. (biomedcentral.com)
  • c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
  • Anti-TNF associated MS: Several anti-TNF drugs like adalimumab are commonly prescribed by a number of autoimmune conditions. (wikipedia.org)
  • Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. (hindawi.com)
  • B cells have antibody-dependent and antibody-independent pathogenic functions. (hindawi.com)
  • Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
  • Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
  • The antilymphoma efficacy of anti-CD19-CAR-transduced T cells was critically dependent on irradiation of mice before anti-CD19-CAR-transduced T-cell infusion. (ashpublications.org)
  • The underlying B cell disease was a nonmalignant monoclonal gammopathy in 36% and hematologic malignancy in 64%.Treatments included fludarabine and rituximab-based regimens. (medscape.com)
  • In another study, of 64 patients with type I cryoglobulinemia vasculitis (CryoVas), Terrier et al identified 28 patients with monoclonal gammopathy of unknown significance and 36 with hematologic malignancy. (medscape.com)
  • Type I monoclonal CryoVas was characterized by severe cutaneous involvement (necrosis and ulcers) in almost 50% the patients, as well as high serum cryoglobulin levels. (medscape.com)
  • 12 , 13 Clinical trials in which patients with advanced B-cell malignancies receive T cells expressing anti-CD19 CARs are in early stages, and it is not known whether adoptive transfer of T cells targeting this self-antigen will be an effective therapy for B-cell malignancies. (ashpublications.org)
  • 1 In addition, the optimal approach to treating patients with anti-CD19-CAR-expressing T cells is not known. (ashpublications.org)
  • Previously recognized variants of MS like Optic-Spinal MS is now classified as a phenotype of the anti-AQP4 spectrum, and some tumefactive cases of MS as anti-MOG associated encephalomyelitis. (wikipedia.org)
  • Anti-neurofascin associated MS and CIDP: Some Anti-neurofascin demyelinating diseases were previously considered a subtype of Multiple Sclerosis but now they are considered a separate entity, as it happened before to anti-MOG and anti-AQP4 cases. (wikipedia.org)
  • Around 10% of MS cases are now thought to be anti-Neurofascin disease in reality. (wikipedia.org)
  • Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
  • Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
  • To evaluate anti-CD19-CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD19. (ashpublications.org)
  • One infusion of anti-CD19-CAR-transduced T cells completely eliminated normal B cells from mice for at least 143 days. (ashpublications.org)
  • Anti-CD19-CAR-transduced T cells eradicated intraperitoneally injected lymphoma cells and large subcutaneous lymphoma masses. (ashpublications.org)
  • Anti-CD19-CAR-transduced T cells had superior antilymphoma efficacy compared with the anti-CD19 monoclonal antibody from which the anti-CD19 CAR was derived. (ashpublications.org)
  • Our results demonstrated impressive antilymphoma activity and profound destruction of normal B cells caused by anti-CD19-CAR-transduced T cells in a clinically relevant murine model. (ashpublications.org)
  • To evaluate whether B-cell depletion before enzyme replacement therapy (ERT) initiation can block acid alpha-glucosidase (GAA) antibody responses and improve clinical outcomes. (nih.gov)
  • Six subjects with Pompe disease (including 4 cross-reacting immunologic material-negative infants) aged 2-8 months received rituximab and sirolimus or mycophenolate before ERT. (nih.gov)
  • After 17-36 months of rituximab, sirolimus and ERT, all subjects lacked antibodies against GAA, 4 continued to gain motor milestones, yet 2 progressed to require invasive ventilation. (nih.gov)
  • 3) Rituximab is an anti-CD-20 antibody routinely used for B-cell lymphoma. (jeffreydachmd.com)
  • Avidity was determined based on the concentration of ammonium thiocyanate that inhibited 50% of binding of IgG to the capsular antigens by enzyme-linked immunosorbent assay, as detailed in the "Antibody Measurements and Avidity" subsection of the "Subjects and Methods" section. (jamanetwork.com)
  • Two died while receiving high-dose systemic corticosteroids, methotrexate, and after recent exposure to anti-tumor necrosis factor-α biological DMARDs, and 2 during hematopoietic stem cell transplantation procedure. (cdc.gov)
  • 1) A large volume of medical research through the 1980's and 90's investigated the various anti-cancer mechanisms of Cimetidine seeming to involve the drug's ability to reverse immune tumor evasion, block immunosuppressive effects of histamine, and stimulate host immune cell expansion. (jeffreydachmd.com)
  • Antibodies impair normal function of cell surface markers, thus inhibiting stimulation of T-lymphocyte clones directed against foreign antigens. (medscape.com)