• It is characterized by a central corneal opacity (leukoma) due to defects in the posterior stroma, Descemet membrane, and endothelium. (medscape.com)
  • Furthermore, both air and gas passed through the little perforation of the host Descemet membrane-endothelium complex and enlarged the space between the stroma and Descemet membrane. (unifi.it)
  • Herpes simplex keratitis usually affects the corneal surface but sometimes involves the corneal stroma (the deeper layers of the cornea) or the inner corneal surface (endothelium), anterior chamber, and iris. (msdmanuals.com)
  • Most patients with disciform keratitis, which involves the corneal endothelium primarily, have a history of epithelial keratitis. (msdmanuals.com)
  • C, Stromal bed after trephination of the posterior stroma and endothelium with flap reflected and trephination opening (arrows). (jamanetwork.com)
  • The disc with posterior stroma and endothelium is secured underneath the flap without sutures. (jamanetwork.com)
  • Jumblatt MMMaurice DMMcCulley JP Transplantation of tissue-cultured corneal endothelium. (jamanetwork.com)
  • The transparency of the cornea results from appropriate hydration of the stroma, controlled by endothelium on the posterior surface (right), and the exquisitely regular organization of collagen fibrils and orthogonal order of its stromal lamellae. (digitalhistology.org)
  • The purpose of this study was to determine if non-mulberry varieties of silk are suitable for the culture of corneal endothelium (CE). (arvojournals.org)
  • Given that nearly a half of all the transplantations performed in a year are for replacing only the dysfunctional endothelium, 2 the monolayer of cells that maintain corneal transparency, research has focussed on engineering this layer in the laboratory. (arvojournals.org)
  • Bullous keratopathy is a corneal disease caused by endothelium decompensation. (web.app)
  • The endothelium is a single layer of cells on the inner surface of the cornea that faces the anterior chamber. (web.app)
  • During the anterior capsulotomy portion of extracapsular cataract extraction, a small piece of anterior capsule may become adherent to corneal endothelium. (web.app)
  • Corneal endothelium is #5, labeled at bottom right. (iiab.me)
  • The corneal endothelium are specialized, flattened, mitochondria-rich cells that line the posterior surface of the cornea and face the anterior chamber of the eye . (iiab.me)
  • The corneal endothelium governs fluid and solute transport across the posterior surface of the cornea and maintains the cornea in the slightly dehydrated state that is required for optical transparency. (iiab.me)
  • The corneal endothelium is embryologically derived from the neural crest . (iiab.me)
  • The normal corneal endothelium is a single layer of uniformly sized cells with a predominantly hexagonal shape. (iiab.me)
  • The corneal endothelium is attached to the rest of the cornea through Descemet's membrane , which is an acellular layer composed mostly of collagen. (iiab.me)
  • The principal physiological function of the corneal endothelium is to allow leakage of solutes and nutrients from the aqueous humor to the more superficial layers of the cornea while at the same time pumping water in the opposite direction, from the stroma to the aqueous. (iiab.me)
  • This dual function of the corneal endothelium is described by the "pump-leak hypothesis. (iiab.me)
  • The corneal endothelium then transports water from the stromal-facing surface to the aqueous-facing surface by an interrelated series of active and passive ion exchangers. (iiab.me)
  • Wounding of the corneal endothelium, as from trauma or other insults, prompts healing of the endothelial monolayer by sliding and enlargement of adjacent endothelial cells, rather than mitosis. (iiab.me)
  • There is no medical treatment that can promote wound healing or regeneration of the corneal endothelium. (iiab.me)
  • Only the corneal endothelium needs to be transplanted in diseases where the corneal stroma is clear, has a smooth stromal surface with a regular curvature, and only the corneal endothelium is not functioning well (eg, Fuchs dystrophy, bullous keratopathy resulting from cataract surgery). (merckmanuals.com)
  • In corneal endothelium transplantation, there are 2 techniques: Descemet stripping endothelial keratoplasty (DSEK) and the newest technique, Descemet membrane endothelial keratoplasty (DMEK). (merckmanuals.com)
  • The central corneal endothelium is removed, and the use of topical rho kinase inhibitors speeds the migration of peripheral corneal endothelium cells to fill the defect. (merckmanuals.com)
  • a thick (5 to 10 µm) basement membrane underneath the corneal endothelium. (histologyguide.com)
  • Anterior segment optical coherence tomography revealed the SF graft as a fully integrated component in the corneal tissue, displaying a similar corneal thickness and endothelial cell count when compared with its healthy contralateral cornea. (arvojournals.org)
  • TEM revealed full thickness corneal perforation with an epithelial plug extending to the lower third of the cornea, but without evidence of epithelial cell migration into the anterior chamber. (biomedcentral.com)
  • The damage to the cornea in Fuchs' endothelial dystrophy can be so severe as to cause corneal blindness. (eyewiki.org)
  • There were also inflammatory signs in the cornea adjacent to the entry site including growth of neovascular tissue between 9 and 11 clock creeping through corneal stroma towards the centre of the cornea and early corneal thinning at this area (Fig. 1 ). (openophthalmologyjournal.com)
  • After treatment with topical Cyclosporine-A 1% there is reduction of the neovascularization in the cornea and the appearance of scar tissue in upper corneal stroma. (openophthalmologyjournal.com)
  • To develop and evaluate a three-dimensional organ culture system of the cornea anterior chamber that could replicate the in vivo processes occurring during corneal wound healing and corneal transplantation. (lancs.ac.uk)
  • Gospodarowicz DGreenburg GAlvarado J Transplantation of cultured bovine corneal endothelial cells to rabbit cornea: clinical implications for human studies. (jamanetwork.com)
  • The stroma of the cornea is composed of multiple layers of collagen fibrils. (digitalhistology.org)
  • The hydration of the stroma and the orderly arrangement of both the fibrils and the layers makes the cornea transparent and capable of transmitting light. (digitalhistology.org)
  • These cells pump excess fluid from the cornea, aiding in maintaining the proper hydration of the stroma, thus contributing to the transparency of the cornea. (digitalhistology.org)
  • The anterior chamber of the eye lies posterior to the cornea. (digitalhistology.org)
  • In fatal disease, LASV immunostaining was most prominent in the anterior uvea, especially in the filtration angle, ciliary body, and iris and in and around vessels in the bulbar conjunctiva and peripheral cornea, where it co-localized with an endothelial marker (platelet endothelial cell adhesion molecule). (cdc.gov)
  • Antigen was primarily associated with infiltration of T-lymphocytes around vessels in the anterior uvea and with new vessel formation at the peripheral cornea. (cdc.gov)
  • The anterior segment of the vertebrate eye is comprised of the cornea, lens, iris, ciliary body, and highly specialized tissue at the iridocorneal angle. (biomedcentral.com)
  • the cornea obtained after lamellar keratoplasty showed replacement of most of the Bowman's membrane and the stroma by fibrous tissue, with accumulation of extracellular acid mucopolysaccharides. (paojournal.com)
  • Microphthalmia is a congenital defect characterized by a small eye often associated with other ocular malformations, including defects of the cornea, anterior chamber, lens and/or retina. (ackcsc.org)
  • A corneal disease involving all or part of the cornea, resulting from inadequate blinking. (ackcsc.org)
  • It faces the chamber formed between the cornea and the iris. (iiab.me)
  • Corneal endothelial cells are post-mitotic and divide rarely, if at all, in the post-natal human cornea. (iiab.me)
  • Corneal ulcers tend to heal with scar tissue, resulting in opacification of the cornea and decreased visual acuity. (msdmanuals.com)
  • In patients with Fuchs corneal dystrophy involving the central cornea only, another corneal transplant technique called Descemet stripping only (DSO, not a true transplant because nothing is transplanted) has been used. (merckmanuals.com)
  • Cornea is the transparent structure forming the anterior part of the fibrous tunic of the eye. (acudoctor.com)
  • Although he does have some residual neovascularization in the lower cornea, the lens provides an adequate vault over the surface and has succeeded in maintaining the corneal integrity. (sclerallens.com)
  • Interstitial Keratitis Interstitial keratitis is chronic, nonulcerative inflammation of the mid-stroma (the middle layers of the cornea) that is sometimes associated with uveitis. (msdmanuals.com)
  • Chronic use of PGA probably influences the corneal biomechanical properties directly, which is to make cornea less deformable. (biomedcentral.com)
  • Slitlamp examination demonstrated a solitary dense 3×3-mm infiltration involving anterior and central corneal stroma. (bvsalud.org)
  • One hundred eleven newly diagnosed POAG patients, including 43 high tension glaucoma (HTG) and 68 normal tension glaucoma (NTG), were measured by Corvis ST to obtain intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanical parameters at baseline and at each follow-up visit after initiation of PGA treatment. (biomedcentral.com)
  • Spontaneous corneal perforation in an eye with Peters' anomaly. (medscape.com)
  • Conclusion: This case suggests that an injection of air or gas into the anterior chamber, to deal with a Descemet membrane detachment following perforation during DALK procedure, can enlarge the double anterior chamber by increasing the space between stroma and Descemet membrane. (unifi.it)
  • The examination using confocal microscopy confirmed a corneal perforation at the left eye and revealed corneal epithelial ingrowth capped with scarred stroma in both eyes. (biomedcentral.com)
  • 2) corneal perforation during laser-assisted blepharoplasty, which may be supported by the presence of pigmented cells on the posterior surface of Descemet´s membrane, pointing to a possible iris injury. (biomedcentral.com)
  • Preoperative AS-OCT imaging of recipient stroma can also predict Descemet membrane perforation during big bubble induction. (intechopen.com)
  • corneal perforation with iris prolapse, pus in the anterior chamber (hypopyon), panophthalmitis, and destruction of the eye may occur without treatment and, on occasion, even with the best available treatment, particularly if treatment is delayed. (msdmanuals.com)
  • The anterior segment is formed completely by the 10th week of gestation, and, by the 16th week, most of the Descemet membrane is formed. (medscape.com)
  • The corneal stroma and Descemet membrane contain sheet-like opacities with clear intervening areas. (arizona.edu)
  • About 7 days after surgery a partial detachment of the Descemet membrane from the posterior corneal stroma was revealed using AS-OCT (double anterior chamber appearance). (unifi.it)
  • Intraoperative AS-OCT assures reaching the proper depth in order, and postoperatively, a surgeon can objectively assess the Descemet membrane and donor association and define complications such as a double anterior chamber. (intechopen.com)
  • Histopathology of the second corneal specimen shows ( K ) edematous, densely infiltrated tissue with neutrophilic exudates (hematoxylin-eosin stain, ×10 magnification) and ( L ) Descemet fragmentation (asterisk) (hematoxylin-eosin stain, ×10 magnification). (ajtmh.org)
  • Histologically, it is characterized by an absent or fragmented Bowman layer, thinned stroma with normal lamellar organization, and a thin Descemet membrane. (aao.org)
  • Spontaneous rupture of the Descemet membrane and corneal hydrops can occur, but iron lines, stress lines, and anterior scarring are not typically seen. (aao.org)
  • Porción anterior y transparente de la cubierta fibrosa del ojo constituida por cinco capas: epitelio escamoso estratificado (epitelio anterior), la LÁMINA LIMITANTE ANTERIOR (membrana de Bowman), el estroma (sustancia propia, tela conectiva), LÁMINA LIMITANTE POSTERIOR (membrana de Descemet) y el endotelio mesenquimatoso (mesotelio). (bvsalud.org)
  • Recently reported studies, however, suggest that applying tetracaine to the intact corneal surface preoperatively sufficiently disrupts the tight junctions between epithelial cells to promote the induction of riboflavin into the stroma. (crstoday.com)
  • Bullous keratopathy is the presence of corneal epithelial bullae, resulting from corneal endothelial disease. (web.app)
  • Slitlamp microscope examination showed that corneal edema relieved obviously after the operation, the average time for epithelial blisters. (web.app)
  • Corneal dystrophy-epithelial/stromal. (ackcsc.org)
  • In addition, excessive corneal hydration can result in edema of the corneal epithelial layer, which creates irregularity at the optically critical tear film-air interface. (iiab.me)
  • A corneal ulcer is a corneal epithelial defect with underlying inflammation usually due to invasion by bacteria, fungi, viruses, or Acanthamoeba . (msdmanuals.com)
  • Ulcers are characterized by corneal epithelial defects with underlying inflammation and necrosis of the corneal stroma. (msdmanuals.com)
  • A corneal ulcer begins as a corneal epithelial defect that stains with fluorescein and an underlying dull, grayish, circumscribed superficial opacity (representing an infiltrate). (msdmanuals.com)
  • Corneal ulcers due to Acanthamoeba are often intensely painful and may show transient corneal epithelial defects, multiple corneal stromal infiltrates, and, later, a large ring-shaped infiltrate. (msdmanuals.com)
  • The anterior stroma can become vascularized but the epithelial portion does not. (arizona.edu)
  • Figure 7-35 The presence of corneal thinning and the type of contour abnormality can be helpful to the clinician in recognizing the type of ectatic disorder. (aao.org)
  • Anong the missing genes are those for the 4 small leucine-rich proteoglycans associated with this form of corneal dystrophy. (arizona.edu)
  • Odent S, Casteels I, Cassiman C, Dieltiens M, Hua MT, Devriendt K. Posterior amorphous corneal dystrophy caused by a de novo deletion . (arizona.edu)
  • An early-onset form of Fuchs' dystrophy is caused by mutations in the COL8A2 gene [11] and is associated with formation of bullous keratopathy, or corneal blisters, within the first few decades of life. (eyewiki.org)
  • Abnormal migration, proliferation, differentiation, or survival of these cells contribute to diseases of the anterior segment such as corneal dystrophy, lens cataract, and glaucoma. (biomedcentral.com)
  • A rare disease called X-linked endothelial corneal dystrophy was described in 2006. (iiab.me)
  • Zaidman GW, Flanagan JK, Furey CC. Long-term visual prognosis in children after corneal transplant surgery for Peters anomaly type I. Am J Ophthalmol . (medscape.com)
  • As the scar and keratoconus were visually significant, a corneal transplant was performed restoring her vision. (cybersight.org)
  • Aiken-O'Neill PMannis MJ Summary of corneal transplant activity: Eye Bank Association of America. (jamanetwork.com)
  • Corneal transplant rejection is the most common cause of transplant failure in the post-operative period. (college-optometrists.org)
  • In 'high-risk' corneal transplant recipients up to 70% fail within 10 years despite local or systemic immunosuppressive therapy. (college-optometrists.org)
  • I ) Four weeks after the second transplant, there is dense edema of the graft and blood in the anterior chamber (hyphema), but no infection. (ajtmh.org)
  • The surgery is more technically difficult, and the procedure takes more time to perform than a full-thickness corneal transplant. (merckmanuals.com)
  • The corneal curvature may be as steep as 50-60 D, and generalized thinning appears, especially in the periphery. (aao.org)
  • This lens modality may be considered for any other case involving irregular corneal curvature following surgery and reduced visual acuity. (sclerallens.com)
  • 0.000001) increased statistically significantly with PGA therapy over time after adjusting for age, gender, axial length, corneal curvature, IOP and CCT. (biomedcentral.com)
  • Case description: A 67-year-old healthy woman underwent deep anterior lamellar keratoplasty (DALK) in her right eye for keratoconus with the big-bubble technique. (unifi.it)
  • In deep anterior lamellar keratoplasty (DALK), AS-OCT gives valuable information on preoperative decision process. (intechopen.com)
  • A 49-year-old female patient was referred because of new corneal scars of unclear origin in both eyes, after presenting with reduction in visual acuity (left worse than right), first noticed 6 months earlier. (biomedcentral.com)
  • The study suggests that swab pressing is a feasible technique , but further investigations are needed to determine its effects on the collapse of the anterior chamber and visual acuity outcomes. (farabiretina.com)
  • In a rabbit model of DMEK surgery, SF artificial endothelial graft restored the corneal transparency and thickness at 6 week of follow-up. (arvojournals.org)
  • Bullous keratopathy occurs after cataract surgery, its incidence has decreased since the advent of intraoperative viscoelastic agents that protect the corneal. (web.app)
  • A procedure for removal of the crystalline lens in cataract surgery in which an anterior capsulectomy is performed by means of a needle inserted through a small incision at the temporal limbus, allowing the lens contents to fall through the dilated pupil into the anterior chamber where they are broken up by the use of ultrasound and aspirated out of the eye through the incision. (lookformedical.com)
  • The making of a continuous circular tear in the anterior capsule during cataract surgery in order to allow expression or phacoemulsification of the nucleus of the lens. (lookformedical.com)
  • It is used intracamerally after cataract surgery to break down anterior chamber fibrin. (msdvetmanual.com)
  • A properly constructed phaco incision will allow good access to the anterior chamber for cataract surgery and then will seal in a water-tight manner without inducing unwanted astigmatic effects. (cataractcoach.com)
  • Peters anomaly type 2 is commonly associated with a denser corneal opacification. (medscape.com)
  • There is little or no progression of the corneal opacification and vision varies widely. (arizona.edu)
  • This honeycomb tiling scheme yields the greatest efficiency, in terms of total perimeter, of packing the posterior corneal surface with cells of a given area. (iiab.me)
  • This article discusses corneal collagen cross-linking with riboflavin, the latest addition to our armamentarium for the treatment of keratoconus and for stabilizing corneal ectasia after keratorefractive surgery. (crstoday.com)
  • In 2003, Wollensak et al introduced corneal collagen cross-linking as an alternative to penetrating keratoplasty for treating progressive keratoconus. (crstoday.com)
  • Instead of removing the weakened stroma, cross-linking uses photosensitive riboflavin and UVA light to create new connections between existing collagen fibers. (crstoday.com)
  • The investigators found that treating manufactured collagen hydrogels with riboflavin cross-linking and UVA (n = 4) significantly increased the material's Young modulus (a measure of corneal stiffness). (crstoday.com)
  • Corneal collagen crosslinking in bullous keratopathy. (web.app)
  • The combination causes the formation of new covalent bonds between collagen fibrils increasing corneal stability. (msdvetmanual.com)
  • Excess hydration of the corneal stroma disrupts the normally uniform periodic spacing of Type I collagen fibrils, creating light scatter. (iiab.me)
  • If the problem is not addressed promptly and appropriately, anterior synechiae may form, increasing the risk of graft rejection, glaucoma, or graft failure. (aao.org)
  • Normal or high IOP with a shallow or flat anterior chamber may signify pupillary block or malignant glaucoma (aqueous misdirection). (aao.org)
  • In addition to corneal opacity and cataract, glaucoma and deprivation amblyopia may increase morbidity. (medscape.com)
  • Glaucoma can be due to malformations of the anterior chamber or high episcleral venous pressure and in phakomatosis pigmentovascularis it can also be associated with angle hyperpigmentation. (hindawi.com)
  • We actually have several good operations for glaucoma including trabeculectomy with and without adjunctive antifibrotic agents, anterior chamber to posterior equatorial reservoir tube shunts, and cyclo-photocoagulation. (entokey.com)
  • Primarily, several forms of glaucoma are associated with anterior segment dysgenesis and genes which are essential for formation of this part of the eye can promote glaucoma [ 9 , 10 ]. (biomedcentral.com)
  • To investigate the corneal biomechanical changes in primary open angle glaucoma (POAG) patients treated with long-term prostaglandin analogue (PGA). (biomedcentral.com)
  • Corneal biomechanical properties have recently attracted increasing attention for its involvement in glaucoma and in other ocular diseases, such as keratoconus [ 1 ]. (biomedcentral.com)
  • I ) Histopathology of the other half of the corneal button shows ulceration with thinning on hematoxylin-eosin stain at low magnification (×2 magnification). (ajtmh.org)
  • A progression of superficial ulceration through deep ulceration to descemetocele formation and corneal rupture with uveitis and possible endophthalmitis can occur. (vin.com)
  • The diagnosis of corneal ulceration is usually quite straightforward and the use of fluorescein should be routine in any patient presenting with anterior segment pain. (vin.com)
  • A variable degree of ocular pain accompanies corneal ulceration. (vin.com)
  • 26%), optic nerve hypoplasia, variable degrees of corneal clouding with or without a vascularized pannus, and dysgenesis of the anterior chamber angle are frequently present. (arizona.edu)
  • In addition, large degrees of corneal stromal hydration will induce astigmatism which can take weeks to resolve. (cataractcoach.com)
  • F ) Slit-lamp photograph 2 weeks after the first surgery shows graft edema, 24 sutures in situ, and blood-tinged pus in the anterior chamber (hypopyon). (ajtmh.org)
  • Corneal edema can also occur as the result of compromised endothelial function due to intraocular inflammation or other causes. (iiab.me)
  • The migrated cells reduce the corneal stromal edema and vision improves. (merckmanuals.com)
  • The corneal edema does not clear in everyone. (merckmanuals.com)
  • Five months later the patient has a significant improvement in terms of visual acquity with marked reduction in the inflammatory signs both in sclera and corneal tissue. (openophthalmologyjournal.com)
  • Similarly, the relative timing of tissue differentiation in the anterior segment is also conserved with other vertebrates. (biomedcentral.com)
  • A detailed understanding of the mechanisms of development of the anterior segment can provide general insights into questions such as tissue induction, cell type fate determination, and the regulation of cellular morphogenesis. (biomedcentral.com)
  • transparent, avascular connective tissue that covers the anterior 1/6th of the eye. (histologyguide.com)
  • The process began as an "idea before its time" in the 1950s, with the failed attempts at endothelial radial keratotomy of Barraquer and others at phakic anterior chamber intraocular lens (IOL) implantation. (medscape.com)
  • PURPOSE: To examine postmortem human globes containing an anterior chamber and a posterior chamber intraocular lens (IOL). (cu.edu.eg)
  • The occurrence of pseudophakic bullous keratopathy following anterior chamber intraocular lens implantation is well documented. (web.app)
  • Surgical causes of endothelial failure include both acute intraoperative trauma as well as chronic postoperative trauma, such as from a malpositioned intraocular lens or retained nuclear fragment in the anterior chamber. (iiab.me)
  • In the stromal hydration group, a balanced saltsolution was injected toward the anterolateral walls of the in-cision until visible whitening of the corneal stroma was noted. (farabiretina.com)
  • The technique of using hydration of the corneal stroma works well for incisions of proper architecture, however poorly constructed incisions are best sealed with sutures. (cataractcoach.com)
  • The main outcome measured was the proportion of closed clear corneal incisions evaluated using intraoperative optical coherence tomography. (farabiretina.com)
  • Various surgical procedures including penetrating keratoplasty have been used but the most effective seems to be an optical iridectomy to enable patients to use the relatively clear corneal areas. (arizona.edu)
  • Human and rabbit artificial corneal endothelial grafts were developed through the culture of human and rabbit corneal endothelial cells (CECs) on SF films. (arvojournals.org)
  • As we gain more experience with cross-linking, I believe we will significantly reduce the need for penetrating keratoplasty among most patients with progressive corneal thinning. (crstoday.com)
  • It can be initiated by mechanical trauma or nutritional deficiencies, and uncontrolled inflammation can produce corneal necrosis. (msdmanuals.com)
  • Ulcers caused by Acanthamoeba (also most commonly due to exposure to contaminated water while wearing contact lenses) and fungi (most commonly due to trauma with vegetable material) are indolent but progressive, whereas those caused by Pseudomonas aeruginosa (seen most frequently in contact lens wearers) develop rapidly, causing deep and extensive corneal necrosis. (msdmanuals.com)
  • De Molfetta VBrambilla MDe Casa NArpa PRiva M Residual corneal astigmatism after perforating keratoplasty. (jamanetwork.com)
  • Corneal topography showed symmetrical bow-tie astigmatism of -3.38D for the right eye and -3.00D for the left eye. (paojournal.com)
  • The ocular history included two episodes of anterior nodular scleritis in the right eye for which the work-up showed no specific cause and were both successfully treated with the use of systemic NSAIDS. (openophthalmologyjournal.com)
  • The ocular anterior segment is critical for focusing incoming light onto the neural retina and for regulating intraocular pressure. (biomedcentral.com)
  • Two main functions are ascribed to the ocular anterior segment. (biomedcentral.com)
  • The major ocular feature associated with this syndrome is a corneal leukoma in one or both eyes. (arizona.edu)
  • The core complex of Stromme syndrome consists of intestinal atresia and ocular abnormalities of the anterior segment. (arizona.edu)
  • Peters anomaly is a rare congenital form of anterior segment dysgenesis in which abnormal cleavage of the anterior chamber occurs. (medscape.com)
  • Overall, in this model, LASV antigen was restricted to the anterior uvea and was associated with mild chronic inflammation in animals with severe disease but was not detected in survivors. (cdc.gov)
  • These opacities are concentrated in the posterior stroma and are sometimes seen from limbus to limbus whereas in other cases they occur mostly peripherally. (arizona.edu)
  • Bovine corneoscleral buttons were clamped in a specially designed chamber through the sclera outside the limbus. (lancs.ac.uk)
  • The global anterior segment ophthalmic surgical community has embarked on a new and enticing endeavor called human emmetropia worldwide. (medscape.com)
  • During development, cells from diverse embryonic lineages interact to form the anterior segment. (biomedcentral.com)
  • To lay the foundation for genetic studies of anterior segment development, we have described the morphogenesis of this structure in zebrafish. (biomedcentral.com)
  • As in other vertebrates, the zebrafish anterior segment derives from diverse origins including surface ectoderm, periocular mesenchyme, and neuroepithelium. (biomedcentral.com)
  • However, several morphogenic features of the zebrafish anterior segment differ with those of higher vertebrates. (biomedcentral.com)
  • In addition, substantial dorsal-ventral differences exist within the zebrafish anterior segment. (biomedcentral.com)
  • Cumulatively, our anatomical findings provide a reference point to utilize zebrafish for genetic studies into the mechanisms of development and maintenance of the anterior segment. (biomedcentral.com)
  • The structures of the anterior segment arise from diverse embryonic lineages and there is exquisite coordination among the different compartments during development. (biomedcentral.com)
  • Development of the anterior segment initiates with the invagination of the lens from surface ectoderm. (biomedcentral.com)
  • With establishment of the lens vesicle, head mesoderm and neural crest cells migrate into a periocular location and eventually move into the anterior segment of the rudimentary eye between the surface ectoderm and the neural retina and lens. (biomedcentral.com)
  • However, the relevant cellular interactions between various structures of the anterior segment and the molecular basis of development is just beginning to be understood. (biomedcentral.com)
  • In addition, an understanding of ontogeny of the anterior segment has significance to several human diseases. (biomedcentral.com)
  • A 49-year-old patient presented with a positive Seidel test of unclear origin at her left eye, as well as a sharply defined anterior-stromal corneal scar at both eyes. (biomedcentral.com)
  • Examinations at the slit lamp revealed a dry eye syndrome as well as a sharply defined anterior-stromal corneal scar at both eyes, located paracentrally at the right (Fig. 1 a) and left eye (Fig. 1 b). (biomedcentral.com)
  • Histologic analysis showed that the SF artificial endothelial graft was attached and integrated on the surface of the corneal stroma without a significant inflammatory reaction, and rabbit CECs consisted in a monolayer that showed their characteristic markers ZO-1 and Na + /K + ATPase, suggesting proper intercellular junctions and cellular pump function. (arvojournals.org)
  • Confocal microscopy and corneal biopsy were definitive for Acanthamoeba infection. (bvsalud.org)
  • Acanthamoeba infection should be considered in contact lens wearers who present with intrastromal corneal abscess. (bvsalud.org)
  • The initial (primary) infection is usually nonspecific self-limiting conjunctivitis, often in early childhood and usually without corneal involvement. (msdmanuals.com)
  • Introduction to Corneal Disorders Symptoms that suggest corneal involvement (eg, rather than simple conjunctivitis) include unilateral involvement, pain (foreign body sensation and ache-not just a gritty sensation), particularly. (msdmanuals.com)
  • Superficial corneal ulcers that fail to heal within a normal time period and are refractory to conventional therapy in dogs are common in veterinary practice. (web.app)
  • Superficial ulcers may/may not be seen with the naked eye, but the use of the biomicroscope or the +12d lens of the direct ophthalmoscope is helpful and the uptake of the fluorescein by the denuded stroma is easily noted. (vin.com)
  • An acromegaloid, cutis verticis gyrata, corneal leukoma syndrome. (arizona.edu)