Antagonists affinity receptors antigen t cell. Medical search. Frequent questions

In addition to molecular studies of cytokines, Garcia's group has also used directed evolution to engineer high affinity cytokine variants (IL-2, IL-4, IFN-λ) with improved therapeutic properties. (wikipedia.org)
This ultrasound-based method enables single-step selection of a high-affinity peptide. (wikipedia.org)
Recombinant soluble Flt-3/Fc chimeric protein has been shown to bind FL with high affinity and is a potent FL antagonist. (rndsystems.com)
Wilson, D. S., Keefe, A. D. & Szostak, J. W. The use of mRNA display to select high-affinity protein-binding peptides. (nature.com)
Montelukast binding to the CysLT1, receptor is high-affinity and selective, preferring the CysLT1 receptor to other pharmacologically important airway receptors, such as the prostanoid, cholinergic, or beta-adrenergic receptor. (illnesshacker.com)
A synthetic, specially- designed oligonucleotide with the ability to recognize and bind a protein ligand molecule or molecules with high affinity and specificity. (genomicglossaries.com)
IgE is an important marker for allergy and plays a central role in the induction of allergic diseases through its binding of the high affinity receptor on mast cells. (unipg.it)
Darolutamide is an androgen receptor inhibitor (ARi) with a distinct chemical structure that binds to the receptor with high affinity and exhibits strong antagonistic activity, thereby inhibiting the receptor function and the growth of prostate cancer cells. (orion.fi)
Valent P, Besemer J, Muhm M, Majdic O, Lechner K, Bettelheim P. Interleukin 3 activates human blood basophils via high-affinity binding sites. (bdbiosciences.com)
Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)
A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist. (bio-techne.com)
Oxidation of specific tryptophan residues inhibits high-affinity binding of cocaine and its metabolites to a humanized anticocaine mAb. (uc.edu)
Structural analysis of free and liganded forms of the Fab fragment of a high-affinity anti-cocaine antibody, h2E2. (uc.edu)

THP-1 human acute monocytic leukemia cell line was stained with Mouse Anti-Human Flt-3/Flk-2 Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB812N, filled histogram) or isotype control antibody (Catalog # IC002N , open histogram). (rndsystems.com)
Antiverse Ltd (Antiverse), a biotechnology company developing a computational antibody drug discovery platform, today announced the successful identification of functional antibody clusters targeting two G-protein-coupled receptors (GPCRs), both displaying versatile binding profiles and nanomolar affinity. (wbsmarketing.com)
The antibodies were identified using Antiverse's proprietary computational antibody drug discovery platform, which uses machine learning to model antibody-antigen interactions and design de novo antibodies. (wbsmarketing.com)
With over 400 GPCRs linked to over 30 diseases, and only two FDA-approved antibody therapeutics existing for this family of receptors, these assets have significant potential for therapeutic applications. (wbsmarketing.com)
Antiverse's AI-powered methods to generate nanomolar binders against "difficult" antigens such as GPCRs in silico is a gamechanger in the antibody discovery industry, the most important innovation since the invention of phage display. (wbsmarketing.com)
The CD123 antibody, clone 9F5, is derived from the hybridization of NS-1 mouse myeloma cells with spleen cells isolated from BALB/c mice immunized with IL-3Rα-transfected COS cells. (bdbiosciences.com)
The CD123 antibody recognizes a 70-kilodalton (kDa) type I integral membrane glycoprotein, also known as the interleukin-3 receptor α-chain (IL-3Rα). (bdbiosciences.com)
Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist. (bdbiosciences.com)
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. (abcam.com)
The antibody was purified by affinity chromatography. (biolegend.com)
Antibody efficacy in preventing RA synovial cell cytokine release, and in modulating collagen-induced arthritis in rats, was assessed. (bmj.com)
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant Angiopoietin-3. (reliatech.de)
The Fc portion of these biological agents binds specifically to cell surface Fcγ receptors (FcγR) and this may affect their half life and certain innate and adaptive immune responses, such as phagocytosis and antibody-dependent cellular cytotoxicity (ADCC). (bmj.com)
The antibody was purified by affinity chromatography and conjugated with Pacific Blue™ under optimal conditions. (biolegend.com)
The fluorochrome-labeled MP1-22E9 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify GM-CSF -producing cells within mixed cell populations. (biolegend.com)
A monoclonal antibody (Mab) designated as GHR106 was generated against the extracellular domain (N1-29 synthetic peptide) of human gonadotropin releasing hormone (GnRH) receptor. (annexpublishers.co)
After washing away unbound material, a biotinylated detection antibody is used to detect only phosphorylated receptor, utilizing a standard HRP format. (bio-techne.com)
and 177 Lu-lilotomab, a CD37 antibody for the treatment of B-cell lymphomas, are being highlighted. (snmjournals.org)
The same antibody molecule can cross-react with related antigens if their epitopes are similar enough to those of the original antigen. (msdmanuals.com)

Garcia's earliest research as a graduate student at Johns Hopkins University focused on understanding how anti-idiotyopic antibodies recognize peptide antigens. (wikipedia.org)
Garcia's research led to the first visualization of a T cell receptor (TCR) bound to a peptide-MHC (pMHC) complex and was published in the journal Science in 1996. (wikipedia.org)
In Garcia's most recent work, his lab developed a peptide-MHC library technology that has enabled the discovery of antigens for orphan T cell receptors, such as those resident in tumors. (wikipedia.org)
A PD-1 peptide antagonist exhibits potent anti-tumor and immune regulatory activity. (ptglab.com)
Synthetic peptide corresponding to Human VEGF Receptor 2 (phospho Y951). (abcam.com)
However, both Mabs were also found to induce complement-dependent cytotoxicity (CDC) reaction for lysis of cancer cells, an immune property which is not shared by peptide analogs of GnRH. (annexpublishers.co)
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. (le.ac.uk)
In parallel, 68 Ga-labeled somatostatin analogs were approved for imaging of NETs and patient selection for peptide receptor radionuclide therapy (PRRT) ( 6 , 7 ). (snmjournals.org)
The stability of peptide-MHC complex (pMHC) is an important factor to shape the fate of peptide-specific T cell immune response, but how it influences on T cell activation process is poorly understood. (molcells.org)
These results imply that binding strength of a peptide for a MHC is a critical factor to determine the duration of pMHC-mediated T cell activation and thus the attainment of productive T cell activation. (molcells.org)

The Company also announced that it has raised $3 million funding, which will enable in-house development of the antibodies showing the highest affinity blocking function, mestinon retard 180 mg making them ideal starting points as therapeutic assets. (wbsmarketing.com)
The platform was used to identify a diverse set of binders to two structurally distinct GPCRs, and following Fluorescence-Activated Cell Sorting (FACS), 8 antibodies were identified as human GPCR binders (Figure 1). (wbsmarketing.com)
Among TH2 cytokines, interleukin (IL)-4 and IL-13 are responsible for class-switching in B cells which resolves in production of allergen-specific IgE antibodies that bind to specific receptor on mast cells. (unipg.it)
Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
Anti-FBG antibodies inhibited cytokine release by RA synovial cells and prevented disease progression and tissue destruction during collagen-induced arthritis. (bmj.com)
these antibodies inhibit cytokine release by RA synovial cells and prevent disease progression and tissue destruction during collagen-induced arthritis. (bmj.com)
Antibodies recognize specific configurations (epitopes, or antigenic determinants) on the surfaces of antigens (eg, proteins, polysaccharides, nucleic acids). (msdmanuals.com)
Antibodies and antigens fit tightly together because their shape and other surface properties (eg, charge) are complementary. (msdmanuals.com)

The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography. (reliatech.de)

Zn2+ binds with higher affinity and more broadly impacts residues on the Met66 prodomain compared to the Val66 prodomain as shown by NMR and ITC. (bvsalud.org)
SRF231 binds to individual Compact disc47 particularly, blocks the Compact disc47/SIRP connections and network marketing leads to induction of tumor cell phagocytosis and tumor-intrinsic cell loss of life. (nihvp.org)
Atthetissuelevel,vitaminC is required for production of collagen and other compounds that comprise the intercellular matrix that binds cells together. (spiritsong.org)
PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. (bio-techne.com)

Both Mabs in murine (mGHR106) or humanized (hGHR106) forms were shown to have comparable specificity and affinity to intact GnRH receptor on cancer cells or to N1-29 synthetic peptides from humans and monkeys. (annexpublishers.co)

ATP, released by cells, is rapidly metabolized by extracellular nucleotidases to adenosine, a potent signaling molecule that can activate several cell surface receptors to produce myriad effects on both parenchymal and immune cells throughout the body (Figure 1 ). (jci.org)

The precise function of these receptors has not been established, but they raise the possibility that even highly selective beta2-agonists may have cardiac effects.The pharmacologic effects of beta2-adrenergic agonist drugs, including vilanterol, are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3,5-adenosine monophosphate (cyclic AMP). (drugcentral.org)
Montelukast inhibits physiologic actions of LTD4 at the CysLT1 receptors, without any agonist activity. (illnesshacker.com)
Human ANG4 is an agonist that can bind and activate Tie2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. (reliatech.de)
It is likely that mouse ANG3, like ANG2, may exert agonist or antagonist activities depending on the cell context. (reliatech.de)

The Garcia Laboratory has also determined crystal structures of many other major cytokine-receptor complexes including those of IL-1, IL-4, IL-13, IL-15, IL-17, IL-23, LIF and CNTF. (wikipedia.org)
In this context, a new molecule, B-cell activating factor (BAFF), has emerged as a positive regulator of B cell survival and differentiation functioning through various signaling pathways and potentiating the activity of various receptor complexes through pleiotropic means. (medsci.org)
Osei P, Northcote-Smith J, Fang J, Singh K, Ortu F, Suntharalingam K . The Bulk Breast Cancer Cell and Breast Cancer Stem Cell Activity of Bi-nuclear Copper(II)-Phenanthroline Complexes. (le.ac.uk)
They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. (bvsalud.org)

Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. (illnesshacker.com)
Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. (illnesshacker.com)
Montelukast selectively antagonizes leukotriene D 4 (LTD 4 ) at the cysteinyl leukotriene receptor, CysLT 1 , in the human airway. (illnesshacker.com)
Montelukast, like zafirlukast, is a leukotriene receptor antagonist used as an alternative to anti-inflammatory medications in the management and chronic treatment of asthma and exercise-induced bronchospasm (EIB). (illnesshacker.com)
Montelukast is a selective leukotriene receptor antagonist of the cysteinyl leukotriene CysLT1 receptor. (illnesshacker.com)
IgE synthesis by B cells is regulated by CD40 ligand, IL-4 and interferon-gamma, therefore inhibition of B cell antigen-specific IgE may prevent the cleavage of CD23 from B cells, having a therapeutic impact which also includes the removal of circulating free IgE, omalizumab, corticosteroids, mast cell stabilizers, leukotriene receptor antagonist, and others. (unipg.it)

The Flt-3 ( fms- Like Tyrosine kinase) Receptor, also known as Flk-2 (Fetal Liver Kinase) and Stk-1(Stem cell Tyrosine Kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. (rndsystems.com)

These structures have revealed a wide range of binding topologies and architectures, and demonstrate how convergent evolution has provided many solutions for cytokine receptors to transduce signals across the cell membrane. (wikipedia.org)
GPCRs are a class of cell membrane receptors that play a crucial role in various physiological processes. (wbsmarketing.com)
Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. (thermofisher.com)
Gonadotropin releasing hormone (GnRH), both types I and II, is a decapeptide hormone that stimulates the release of gonadotropin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the anterior pituitary through specific binding to the GnRH receptor located on the external membrane of selected cell types [ 1-3 ]. (annexpublishers.co)
Since the pioneering use of 131 I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177 Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. (snmjournals.org)
More recently, the prostate-specific membrane antigen (PSMA) has been established as a theranostic target for prostate cancer. (snmjournals.org)

Combination therapies using ralaniten with ionizing radiation were evaluated for effects on proliferation, colony formation, cell cycle, DNA damage, and Western blot analyses in human prostate cancer cells that express both full-length AR and AR-Vs. Ralaniten and a potent next-generation analog (EPI-7170) decreased expression of DNA repair genes whereas enzalutamide had no effect. (bcgsc.ca)
One possible cognate receptor for BAFF includes the Nogo receptor (NgR) and its homologs, previously established as potent inhibitors of axonal regeneration during central nervous system (CNS) injury and disease. (medsci.org)

The extracellular region of these receptors contains five immunoglobulin-like domains and the intracellular region contains a split kinase domain. (rndsystems.com)

Mast cells can influence B cell survival, proliferation and differentiation into CD138(+) cells. (unipg.it)
B cell differentiation into IgE-producing cells requires two signals provided by TH2 cells and IL-4, however IL-4, IL-1 and IL-10 as well as several hormones are critical for the development of TH2 cells, while cytokines, such as interferon (IFN)-alpha, IFN-gamma, IL-12 and transforming growth factor (TGF)-beta play a negative role. (unipg.it)
Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. (bdbiosciences.com)
GM-CSF is also a differentiation and activating factor for granulocytic and monocytic cells. (biolegend.com)

One mechanism underlying CRPC and resistance to hormonal therapies is the expression of constitutively active splice variant(s) of androgen receptor (AR-Vs) that lack its C-terminus ligand-binding domain. (bcgsc.ca)
The enigmatic plasmocytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. (bdbiosciences.com)
Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. (bio-techne.com)
The neurotensin receptor ligand 111 In/ 177 Lu-3B-227 has demonstrated high potential in imaging and therapy for several malignancies (e.g., pancreatic adenocarcinomas). (snmjournals.org)

This displayed the different peptides on the outer surfaces of the collection of viral clones, where the screening step of the process isolated the peptides with the highest binding affinity. (wikipedia.org)
In the last part, information about cell-penetrating peptides that can be used as molecular carries is mentioned with providing classification and cellular uptake mechanism of them. (intechopen.com)
For such a reason, many attempts have been made to enhance antigen-specific T cell immune responses by improving the properties of the peptides with modification of their amino acid sequences. (molcells.org)

report findings in adenosine deaminase-deficient mice that suggest the occurrence of anti-inflammatory actions of adenosine in the lung, mediated through A 1 adenosine receptors on macrophages. (jci.org)
CD4 is a 55-kDa transmembrane glycoprotein expressed on T helper cells, majority of thymocytes, monocytes, macrophages, and dendritic cells. (ptglab.com)
Granulocyte/macrophage - colony stimulating factor (GM-CSF) is a hematopoietic factor that is produced by activated T cells, B cells, mast cells, macrophages, fibroblasts and endothelial cells. (biolegend.com)
This multifunctional cytokine stimulates progenitor cells of neutrophils, eosinophils, and macrophages. (biolegend.com)

This action reduces the tubular sodium concentration and the concentration gradient between the tubular fluid and cells and thereby retards the reabsorption of sodium. (spiritsong.org)

Fluticasone furoate has been shown in vitro to exhibit binding affinity for the human glucocorticoid receptor that is approximately 29.9 times that of dexamethasone and 1.7 times that of fluticasone propionate. (drugcentral.org)

Garcia's research integrates approaches in structural biology, biochemistry and protein engineering to understand how cell surface receptors sense environmental cues through the engagement of extracellular ligands, and transduce signals. (wikipedia.org)
Extracellular adenosine is produced predominantly by the metabolism of ATP released from cells. (jci.org)
Elevations of extracellular adenosine are present in the asthmatic lung due to both increased release of ATP from cells and inhibition of ADA by local hypoxia. (jci.org)

The authors noted that β-casomorphin (BCM-7) from β-casein may function as an immunosuppressant and impair tolerance to dietary antigens in the gut immune system, which may contribute to the onset of T1D. (ift.org)
Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
In addition, suppressor immune cells such as FOXP3 + regulatory T cells (Tregs) exert dominant immune suppression to control autoreactive T and B cells. (frontiersin.org)
Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
Objectives Controlled immune responses rely on integrated crosstalk between cells and their microenvironment. (bmj.com)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
Cellular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)
Toll-Like Receptor 9 (TLR9) Gene C/T (rs352140) Polymorphisms in Adult Primary Immune Thrombocytopenia. (cdc.gov)
Vitamin D Insufficiency is Not Associated With Pediatric and Adolescent Immune Thrombocytopenia: A Study in Conjunction With its Receptor Genetic Polymorphisms. (cdc.gov)

They bind to cysteinyl leukotriene receptors (CysLT) found in the human airway. (illnesshacker.com)
Pin1 inhibition improves the efficacy of ralaniten compounds that bind to the N-terminal domain of androgen receptor. (bcgsc.ca)
Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. (bvsalud.org)

In 2012, Garcia's laboratory determined the crystal structure of a Wnt protein in complex with its cellular receptor, Frizzled. (wikipedia.org)
If a "phagemid" vector is used (a simplified display construct vector) phage particles will not be released from the E. coli cells until they are infected with helper phage, which enables packaging of the phage DNA and assembly of the mature virions with the relevant protein fragment as part of their outer coat on either the minor (pIII) or major (pVIII) coat protein. (wikipedia.org)
Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)
Adenosine can act at 4 different 7-transmembrane, G-protein-coupled receptors present on the surfaces of both infiltrating leukocytes and resident parenchymal cells. (jci.org)
That protein is the hormone insulin, which is secreted by specialized cells in the pancreas. (ift.org)
CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. (ptglab.com)
Oligonucleotide which displays specific binding to a protein or other target, often selected by an iterative cycle of affinity- based enrichment. (genomicglossaries.com)
Nuclear Receptors the nuclear receptor family consists of two types of receptors that have similar protein structure. (spiritsong.org)
Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)

Evidence for efficacy of adenosine receptor antagonism may date back to the Victorian era, when physicians noted the beneficial effects of strong black coffee in patients with bronchial asthma. (jci.org)
These anti-inflammatory actions of corticosteroids may contribute to their efficacy.UmeclidiniumUmeclidinium is long-acting muscarinic antagonist, which is often referred to as an anticholinergic. (drugcentral.org)
Fcγ receptor (FcγR) polymorphism influences the affinity of the receptor for Ig, which may, in turn, affect the efficacy of Ig-based therapies. (bmj.com)

Ralaniten Sensitizes Enzalutamide-Resistant Prostate Cancer to Ionizing Radiation in Prostate Cancer Cells that Express Androgen Receptor Splice Variants. (bcgsc.ca)
Blocking androgen receptor (AR) transcriptional activity by androgen deprivation therapy (ADT) improves the response to radiotherapy for intermediate and high risk prostate cancer. (bcgsc.ca)
The androgen receptor inhibitor (ARi), which is jointly developed by Orion and Bayer is already approved in the U.S. and Brazil and filings in the European Union and other regions are underway or planned by Bayer. (orion.fi)

An endogenous substance or a drug that can interact with a receptor and initiate a physiological or a pharmacological response characteristic of that receptor (contraction, relaxation, secretion, enzyme activation, etc. (genomicglossaries.com)

K. Christopher Garcia is an American scientist known for his research on the molecular and structural biology of cell surface receptors. (wikipedia.org)
Here we discuss the history of the study of adenosine receptor ligands for asthma and how enhanced understanding of adenosine receptor biology may aid in the rational exploitation of these receptors as therapeutic targets. (jci.org)

An additive inhibitory effect on proliferation of enzalutamide-resistant cells was achieved with a combination of ralaniten compounds with ionizing radiation. (bcgsc.ca)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
2 Prostate cancer results from the abnormal proliferation of cells within the prostate gland, which is part of a man's reproductive system. (orion.fi)
By using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), both GHR106 Mabs and the GnRH decapeptide antagonist, Antide, were shown to be bioequivalent in terms of their respective effects on genes involved in the proliferation and apoptosis of cancer cells. (annexpublishers.co)
Anti-proliferation effects of GnRH or its analogs on cancer cells of different human tissue origins have been reported and have been the molecular basis for cancer therapy [ 4 , 7-9 ]. (annexpublishers.co)

The competitive and reversible nature of antagonism was shown with human and animal origin receptors and isolated organ preparations. (drugcentral.org)

It has similar affinity to the subtypes of muscarinic receptors M1 to M5. (drugcentral.org)

Key findings include determination of the first crystal structures of the following cytokine family members in complex with their surface receptors: gp130 family (IL-6), common gamma (γc) family (IL-2), Type I Interferons (IFNα2/IFNω) and Type III Interferons. (wikipedia.org)
Cell surface receptors containing an immunoglobin domain. (embl.de)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

The overarching theme of the laboratory is to elucidate the structural and mechanistic basis of receptor activation in systems relevant to human disease, and to exploit this information to design and engineer new molecules with therapeutic properties. (wikipedia.org)
Therefore, hGHR106 can serve as a long-acting alternative to the current decapeptide GnRH antagonists for therapeutic treatments in the immunotherapy of human cancers, including those of gynecologic origin. (annexpublishers.co)

Drug is usually described b it's more prominent effects: targets specific receptors, rarely sufficiently selective to be described as specific. (freezingblue.com)

The use of biological therapies targeting key proinflammatory molecules and their receptors has emerged as a powerful tool for the control of systemic inflammatory disorders in recent years. (bmj.com)

In the mouse brain, we found that the plasticity inhibitors Nogo-A and Nogo receptor 1 (NgR1) are differentially expressed in the SVZ-OB system, in which Nogo-A identifies immature neuroblasts and NgR1 germinal astrocytes. (jneurosci.org)

Specific effects of fluticasone furoate demonstrated in in vitro and in vivo models included activation of the glucocorticoid response element, inhibition of pro-inflammatory transcription factors such as NFkB, and inhibition of antigen-induced lung eosinophilia in sensitized rats. (drugcentral.org)
In the airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation. (drugcentral.org)
Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. (drugcentral.org)

Montelukast inhibits the actions of LTD 4 at the CysLT 1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. (illnesshacker.com)
Montelukast inhibits bronchoconstriction due to antigen challenge. (illnesshacker.com)

In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
This is consistent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ stem cells. (jneurosci.org)

Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. (bdbiosciences.com)

Clear indices of cell death-myocyte disruption, coagulative necrosis, elevation of cardiac proteins in serum-are present by 24 hours. (spiritsong.org)

Among hematopoietic cells, the expression of Flt-3 was found to be restricted to the highly enriched stem/progenitor cell populations. (rndsystems.com)

Proinflammatory and bronchoconstrictive actions of adenosine in the asthmatic lung are well recognized, with the latter being mediated, in part, through A 1 receptor activation on airway smooth muscle. (jci.org)
While both proinflammatory and anti-inflammatory signals can be sent depending on the specific adenosine receptor activated, adenosine produces a net proinflammatory effect in the asthmatic airway. (jci.org)
Binding of cysteinyl leukotrienes to leukotriene receptors has been correlated with the pathophysiology of asthma, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, factors that contribute to the signs and symptoms of asthma. (illnesshacker.com)

Ability of a drug to initiate a physiologic response, activate the receptor. (freezingblue.com)

Human ANG4 is highly expressed in lung and in cultured human umbilical vein endothelial cells (HUVECs). (reliatech.de)

When the binding strength is above the threshold, the pMHCI-TCR interaction drives full T cell activation leading to multiple rounds of cell division and development of effector functions. (molcells.org)
When it is below the threshold, the pMHCI-TCR interaction tends to induce only partial activation of T cells resulting in T cell death or anergy (unresponsiveness). (molcells.org)

Activation of toll-like receptor 4 (TLR4) by tenascin-C, a matrix molecule persistently expressed at high levels in people with RA, drives chronic inflammation in models of rheumatoid arthritis (RA). (bmj.com)

Mast cell-lineage versus basophil lineage involvement in myeloproliferative and myelodysplastic syndromes: diagnostic role of cell-immunophenotyping. (bdbiosciences.com)

1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)

Killer cell inhibitory receptors. (embl.de)

As growing lines of evidence have supported a proinflammatory role for adenosine in the asthmatic lung, interest in adenosine receptor antagonists has risen. (jci.org)

Through its Fc domains, SRF231 engagement with macrophage-derived Compact disc32a acts dual reasons by eliciting FcR-mediated phagocytosis of cancers cells and performing being a scaffold to operate a FLJ14936 vehicle Compact disc47-mediated loss of life signaling into tumor cells. (nihvp.org)

The clinical relevance of this in vitro finding is unknown.Although beta2-receptors are the predominant adrenergic receptors in bronchial smooth muscle and beta1-receptors are the predominant receptors in the heart, there are also beta2-receptors in the human heart comprising 10% to 50% of the total beta-adrenergic receptors. (drugcentral.org)

1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)
SRF231 exerts antitumor activity in vitro through both phagocytosis and cell loss of life in a way reliant on the activating Fc-gamma receptor (FcR), Compact disc32a. (nihvp.org)
a partial map of receptors on human mast cells cultured in vitro. (bdbiosciences.com)

Classic pharmacological bioassays have confirmed their opioid activity, yet, in most cases, the binding affinities were several orders of magnitude less than controls, such as morphine and its derivatives. (ift.org)
Combination of Pin1 inhibitor with ralaniten promoted cell cycle arrest and had improved antitumor activity against CRPC xenografts in vivo compared to individual monotherapies. (bcgsc.ca)
7 of these binders were confirmed as antagonists (Figure 2), blocking GPCR activity. (wbsmarketing.com)
PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. (bio-techne.com)

The cysteinyl leukotrienes (LTC4 , LTD4, LTE4) are products of arachidonic acid metabolism that are released from various cells, including mast cells and eosinophils. (illnesshacker.com)

Ralaniten and EPI-7170 sensitized prostate cancer cells that express full-length AR and AR-Vs to radiotherapy whereas enzalutamide had no added benefit. (bcgsc.ca)

Detection of Flt‑3/Flk‑2 in THP‑1 Human Cell Line by Flow Cytometry. (rndsystems.com)
CD4 serves as a receptor for the human immunodeficiency virus (HIV). (ptglab.com)
Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells. (bdbiosciences.com)
Isolation and characterization of human tonsil dendritic cells. (bdbiosciences.com)
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. (bdbiosciences.com)
Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin. (bdbiosciences.com)
This DuoSet IC ELISA contains the basic components required for the development of sandwich ELISAs to measure phosphorylated human PDGF R beta (Y751) in cell lysates. (bio-techne.com)

Anatomy32

Organisms13

Diseases2

Chemicals and Drugs136

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes47

Disciplines and Occupations1

Information Science3

Health Care1

High affinity13

Antibody19

Peptide10

Antibodies8

Chromatography1

Binds4

Specificity1

Signaling molecule1

Agonist4

Complexes4

Leukotriene receptor6

Tyrosine kinase1

Membrane6

Potent2

Immunoglobulin1

Differentiation4

Ligand4

Peptides3

Macrophages4

Concentration1

Glucocorticoid receptor1

Extracellular3

Immune9

Bind3

Protein9

Efficacy3

Androgen receptor3

Enzyme1

Biology2

Proliferation6

Antagonism1

Subtypes1

Surface3

Therapeutic2

Selective1

Molecules1

Inhibitors1

Inhibition3

Montelukast2

Stem cells2

Basophils1

Proteins1

Hematopoietic1

Airway3

Physiologic1

Endothelial cells1

Interaction2

Inflammation1

Mast cell1

19992

Inhibitory1

Proinflammatory1

Cancers1

Bronchial1

Vitro3

Activity4

Eosinophils1

Prostate cancer1

Human7