• agonists
  • Agonists stimulate the receptor, however prolonged exposure leads to a downregulation effect resulting in hypogonadism, an effect that is often medically utilized. (wikipedia.org)
  • GnRHRs
  • GnRHRs are G-protein-coupled receptors that act via G q/11 to activate PLC (phospholipase C), leading to an Ins(1,4,5) P 3 -mediated mobilization of Ca 2+ and consequent activation of calmodulin. (biochemsoctrans.org)
  • antiandrogens
  • Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. (wikipedia.org)
  • Antiandrogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiprogestogens. (wikipedia.org)
  • Although the term antiandrogen is generally used to refer specifically to AR antagonists, it may also be used to describe functional antiandrogens like androgen synthesis inhibitors and antigonadotropins, including even estrogens and progestogens. (wikipedia.org)
  • suppression
  • For this reason, gonadotropin and sex hormone levels are only partially suppressed, and the degree of suppression can be dose-dependently adjusted as desired. (wikipedia.org)
  • ACETATE
  • An example is the steroidal antiandrogen cyproterone acetate, which is a potent AR antagonist, a potent progestogen and hence antigonadotropin, and a weak androgen synthesis inhibitor. (wikipedia.org)
  • For example, the progestogen and hence antigonadotropin medroxyprogesterone acetate is sometimes described as a steroidal antiandrogen, even though it is not an antagonist of the AR. (wikipedia.org)
  • human
  • if human chorionic gonadotropin (hCG) is not administered within four days, a daily 0.25 mg dose is started and continued until hCG is administered. (wikipedia.org)
  • synthetic
  • 5. Product according to claim 1 , wherein said apoptosis-inducing agent is selected from agents which damage DNA, natural or synthetic ligands of the glucocorticoid receptor, or pro-apoptotic second messengers. (google.com.au)
  • Administration
  • Typically they are administered in the mid-follicular phase in stimulated cycles after administration of gonadotropins and prior to the administration of hCG - which is given to stimulate ovulation. (wikipedia.org)