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  • agonists
  • Agonists stimulate the receptor, however prolonged exposure leads to a downregulation effect resulting in hypogonadism, an effect that is often medically utilized. (wikipedia.org)
  • GnRHRs
  • GnRHRs are G-protein-coupled receptors that act via G q/11 to activate PLC (phospholipase C), leading to an Ins(1,4,5) P 3 -mediated mobilization of Ca 2+ and consequent activation of calmodulin. (biochemsoctrans.org)
  • synthetic
  • 5. Product according to claim 1 , wherein said apoptosis-inducing agent is selected from agents which damage DNA, natural or synthetic ligands of the glucocorticoid receptor, or pro-apoptotic second messengers. (google.com.au)
  • suppression
  • For this reason, gonadotropin and sex hormone levels are only partially suppressed, and the degree of suppression can be dose-dependently adjusted as desired. (wikipedia.org)
  • human
  • if human chorionic gonadotropin (hCG) is not administered within four days, a daily 0.25 mg dose is started and continued until hCG is administered. (wikipedia.org)
  • ovulation
  • Also essential for ovulation is LH-induced progesterone receptor (Pgr) expression as well as progesterone production ( 8 ). (pnas.org)
  • H 2 O 2 , which is constantly produced in cells, has been implicated in several ovulation-related events such as steroid hormone production ( 20 , 21 ) and EGF receptor (EGFR) activation ( 22 ). (pnas.org)
  • Typically they are administered in the mid-follicular phase in stimulated cycles after administration of gonadotropins and prior to the administration of hCG - which is given to stimulate ovulation. (wikipedia.org)