• multiple sclerosis
  • This review aims to provide an update on the most recent evidence of therapeutically-relevant neuro-immuneinteractions following NPC transplants in animal models of multiple sclerosis, cerebral stroke and traumas of the spinal cord, and consideration of the forthcoming challenges related to the early translation of some of these exciting experimental outcomes into clinical medicines. (wingsforlife.com)
  • Alzheimer's
  • Nanowerk News ) On Wednesday Revalesio Corporation presented new data at the Alzheimer's Association International Conference that identifies the specific cellular pathways by which Revalesio's lead investigational product, RNS60, impacts Alzheimer's Disease. (nanowerk.com)
  • Defining RNS60's activity against these genes is an important link between the significant therapeutic activity demonstrated by RNS60 in mouse and cellular models where RNS60 prevented beta-amyloid induced cell death and tau-neurofibrillary tangles the most common hallmarks of Alzheimer's disease. (nanowerk.com)
  • These plasticity associated genes and associated pathways have long been targets for drug developers, but Revalesio's approach through its charge-stabilized nanostructure technology provides a new paradigm for treating Alzheimer's disease. (nanowerk.com)
  • organism
  • Screening in model organism offers the advantage of interrogating test agents, or alterations in targets of interest, in the context of fully integrated, assembled, biological systems, providing insights that could otherwise not be obtained in cellular systems. (wikipedia.org)
  • The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
  • human
  • Neuro-immune interactions of neural stem cell transplants: from animal disease models to human trials. (wingsforlife.com)
  • Stem cell technology is a promising branch of regenerative medicine that is aimed at developing new approaches for the treatment of severely debilitating human diseases, including those affecting the central nervous system (CNS). (wingsforlife.com)
  • The significant impact in vivo of experimental NPC therapies in animal models of inflammatory CNS diseases has raised great expectations that these stem cells, or the manipulation of the mechanisms behind their therapeutic impact, could soon be translated to human studies. (wingsforlife.com)
  • Not only does a rodent's small brain often preclude the use of advanced neuroimaging techniques, it is also not clear how intracerebral application of trophic factors, transplant therapies, and gene therapies in small animals might translate to the much larger human brain. (medindia.net)
  • Importantly, the brains of large animals can be studied using sensitive measures that should be highly translatable to the human condition, including MRI and PET imaging, EEG, and electrophysiology, as well as behavioral tests looking at motor and cognitive function," says Professor Jenny Morton, PhD, of the Department of Physiology, Development and Neuroscience at the University of Cambridge. (medindia.net)
  • The relevance to human biology of NHP models in Huntington's disease hold great potential value for preclinical research and development, but we need to fully consider the substantial issues of cost, long-term housing of affected animals, access of the models to HD investigators, and ethical concerns with modeling in these species," says Dr Howland. (medindia.net)
  • The mission of the 7th Aquatic Animal Mod-els of Human Disease Conference is to provide scientists using aquatic animal models a unique opportunity to exchange scientific information, identify research tools and opportunities, address environmental health issues, and encourage the utility of aquatic models for the study of human disease. (xenbase.org)
  • This venue will encourage development of an appreciation of aquatic animal models and their contributions to understanding human disease. (xenbase.org)
  • We hope to see you at the 7th Aquatic Animal Models of Human Disease Conference as it returns to Texas. (xenbase.org)
  • Genesis, the Journal of Genetics and Development will sponsor a $500 travel award for the best abstract on Xenopus research submitted by a junior researcher to the 7th Aquatic Animal Models of Human Disease Conference. (xenbase.org)
  • Animal models are used by scientists to replicate human diseases in another living animal, allowing them to study the biology of the disease and test potential treatments. (understandinganimalresearch.org.uk)
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • Although kindling is a widely used model, its applicability to human epilepsy is controversial. (wikipedia.org)
  • However, in both human epilepsy and in some animal models, evidence suggests that a process like that found in kindling does occur. (wikipedia.org)
  • Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. (wikipedia.org)
  • The publication of these results opened a completely new niche for epilepsy research and has stimulated a significant amount of studies on the subject of kindling and its relevance to human epilepsy Kindling (sedative-hypnotic withdrawal) Epileptogenesis Racine Stages (a method by which seizure severity is quantified in animal models of epilepsy) Bertram E (2007). (wikipedia.org)
  • While studies to date imply that the EETs, EET-forming epoxygenases, and EET-inactivating sEH can be manipulated to control a wide range of human diseases, clinical studies have yet to prove this. (wikipedia.org)
  • Determination of the role of the EETS in human diseases is made particularly difficult because of the large number of EET-forming epoxygenases, large number of epoxygenase substrates other than arachidonic acid, and the large number of activities, some of which may be pathological or injurious, that the EETs possess. (wikipedia.org)
  • This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
  • The directive stresses the use of the 3R principle (replacement, refinement, reduction) and animal welfare when conducting animal testing on non-human primates. (wikipedia.org)
  • Ontology
  • Uberon is a comparative anatomy ontology representing a variety of structures found in animals, such as lungs, muscles, bones, feathers and fins. (wikipedia.org)
  • One of the uses of this ontology is to integrate data from different biological databases, and other species-specific ontologies such as the Foundational Model of Anatomy. (wikipedia.org)
  • progression
  • Affecting over a hundred million individuals worldwide, retinal diseases are among the leading causes of irreversible visual impairment and blindness, and appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, pathology, and progression of these endemic diseases. (springer.com)
  • mice
  • Fleming operates its own Animal House, which can house up to 20,000 mice and has its own complete mouse histopathology unit. (wikipedia.org)
  • The Animal House has a capacity to house more than 20,000 mice and is currently the largest Mouse Unit in Greece in terms of number and variety of mice. (wikipedia.org)
  • In 1902 Lucien Cuénot published the results of his experiments using mice which showed that Mendel's laws of inheritance were also valid for animals - results that were soon confirmed and extended to other species. (wikipedia.org)
  • Rodents are commonly used in animal testing, particularly mice and rats, but also guinea pigs, hamsters, gerbils and others. (wikipedia.org)
  • While mice, rats and other rodents are by far the most widely used animals in biomedical research, recent studies have highlighted their limitations. (wikipedia.org)
  • Regarding experiments on mice in particular, some researchers have complained that "years and billions of dollars have been wasted following false leads" as a result of a preoccupation with the use of these animals in studies. (wikipedia.org)
  • Many laboratory animals, including mice and rats, are chronically stressed which can also negatively affect research outcomes and the ability to accurately extrapolate findings to humans. (wikipedia.org)
  • mutations
  • Mutations in alpha II-spectrin have been associated with early infantile epileptic encephalopathy-5, and alpha II-spectrin may be a valuable biomarker for Guillain-Barré syndrome and infantile congenital heart disease. (wikipedia.org)
  • cognitive
  • Much of what is known about feline cognition has been inferred from a combination of owner-reported behaviour, brain necropsies, and comparative cognitive neurology of related animal models. (wikipedia.org)
  • mimic
  • To date, viral PD models comprise α-synuclein and LRRK-2-based overexpression models, as well as models that mimic parkin loss of function by overexpression of the parkin substrates Pael-R, CDCrel-1, p38/JTV or synphilin-1. (epfl.ch)
  • experimental
  • In interpreting the experimental results, the limitations of those animal models should be considered. (wiley.com)
  • Elafibranor (INN, code name GFT505) is an experimental medication that is being studied and developed by Genfit for the treatment of cardiometabolic diseases including diabetes, insulin resistance, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD). (wikipedia.org)
  • and co-ordinator of the Collaborrative Approach to Meta-Analysis and Review of Animal Data in Experimental Studies (CAMARADES). (wikipedia.org)
  • The brains of experimental animals are repeatedly stimulated, usually with electricity, to induce the seizures. (wikipedia.org)
  • Kindling: An experimental model of epilepsy" (PDF). (wikipedia.org)
  • cardiac
  • In a canine model of hypothermic circulatory arrest, alpha II-spectrin breakdown products have shown to be relevant markers of neurologic injury post-cardiac surgery. (wikipedia.org)
  • fungi
  • Its diverse diet includes plants, fungi, and a variety of animals. (wikipedia.org)
  • The cytochrome P450 (CYP) superfamily of enzymes is distributed broadly throughout bacteria, archaea, fungi, plants, animals, and even viruses (see Cytochrome P450). (wikipedia.org)
  • commonly
  • Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly. (wikipedia.org)
  • species
  • This meeting is unique in that our program is not limited to a sin-gle disease, discipline, or species, and thereby will provide a breadth and diversity of topics not seen in more narrowly focused conferences. (xenbase.org)
  • treatments
  • Further understanding of the pathogenicity of autoreactive CD4 + T cells may lead to disease-specific treatments. (wiley.com)
  • approaches
  • Animal based approaches to phenotypic screening are not as amenable to screening libraries containing thousands of small molecules. (wikipedia.org)
  • researchers
  • The Boyd Group, a British group comprising animal researchers, philosophers, primatologists, and animal advocates, has recommended a global prohibition on the use of great apes. (wikipedia.org)
  • biological
  • More recently it has become popular to develop a hypothesis that a certain biological target is disease modifying, and then screen for compounds that modulate the activity of this purified target. (wikipedia.org)
  • Phenotypic screening in animal-based systems utilize model organisms to evaluate the effects of a test agent in fully assembled biological systems. (wikipedia.org)