• rats
  • by administering teprotide to dogs and rats and observing that it inhibited the vasopressor response induced by angiotensin I. Teprotide was shown to be an effective antihyperension agent but it had limited use because of its expense and lack of oral activity. (wikipedia.org)
  • Mechanism
  • It was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process. (wikipedia.org)
  • exert
  • In 2001 and 2002, evidence emerged from 3 clinical trials to support the hypothesis, raised 30 years ago, 5 that angiotensin II might exert detrimental effects beyond the mechanical damage of high BP and be a risk factor for ischemic stroke independent of its effect on BP. (ahajournals.org)
  • effects
  • Whole licorice ( Glycyrrhiza glabra , or G. uralensis ) can cause sodium retention and increase blood pressure, thus counteracting the intended effects of ACE inhibitors. (memorialhospitaljax.com)
  • Its indications, contraindications, and side effects are as those for all ACE inhibitors. (wikipedia.org)
  • Indirectly, angiotensin II stimulates of the production of endothelin 1 and 3 (ET1, ET3) and the transforming growth factor beta-1 (TGF-β1), all of which have tissue proliferative effects that are blocked by the actions of moexipril. (wikipedia.org)
  • protein
  • It is an inhibitor of the protein kallikrein and a 60-amino acid polypeptide which was developed from a Kunitz domain through phage display to mimic antibodies inhibiting kallikrein. (wikipedia.org)
  • pathways that activate phospholipase C to convert cellular phospholipids to diacylglycerol which promotes the activation of certain isoforms of protein kinase C, pathways that elevated cellular cytosolic Ca2+ which thereby regulate Ca2+-sensitive cell signaling molecules, and pathways that inhibit adenyl cyclase which thereby lowers cellular levels of cyclic adenosine monophosphate (cAMP) to reduce the activity of cAMP-dependent signaling molecules. (wikipedia.org)
  • gene
  • HAE is caused by a mutation of the C1-inhibitor gene. (wikipedia.org)
  • Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene. (wikipedia.org)
  • liver
  • The authors report a 64-year-old Caucasian woman with a history of liver transplant on Mammalian Target Of Rapamycin (mTOR) inhibitor, who attended Emergency department with angio-oedema only on the left side of her tongue. (biomedsearch.com)
  • A number of properties distinguish it from other ACE inhibitors: It is hydrophilic, has a long half-life and tissue penetration, and is not metabolized by the liver. (wikipedia.org)
  • known
  • This enzyme is known to hydrolyze aromatic and aliphatic esters and can manage cellular cholesterol esterification levels. (wikipedia.org)
  • indicate
  • The results of the HOPE and LIFE trials, and to a lesser extent SCOPE, indicate that inhibiting the formation or action of angiotensin II prevents stroke and other vascular events (and perhaps new-onset diabetes) and suggest that a substantial proportion of the effect may be independent of BP lowering. (ahajournals.org)
  • complement levels, especially depletion of complement factors 2 and 4, may indicate deficiency of C1-inhibitor. (wikipedia.org)
  • role
  • The ability of CES1 to metabolize heroin and cocaine among other drugs has suggested a therapeutic role for the enzyme. (wikipedia.org)
  • plasma
  • Lipophilic ACE inhibitors are able to penetrate membranes more readily, thus tissue ACE may be a target in addition to plasma ACE. (wikipedia.org)