• receptor
  • The data obtained with the angiotensin receptor subtype-selective compounds, losartan and PD 123319, suggest that the depressor action is an AT 1 -mediated effect and give no indication that AT 2 receptors could be involved. (ahajournals.org)
  • renin
  • Renin is the rate-limiting factor of the renin-angiotensin-aldosterone-system, which is of fundamental importance to the regulation of blood pressure. (ahajournals.org)
  • 2 The renin enhancer contains an ≈50-bp-long region, which attracts much attention because it is involved in the regulation of renin transcription by virtually all cues tested until now. (ahajournals.org)
  • An accumulating body of evidence has shown that the renin-angiotensin system is involved in the fertility problems observed in some populations. (mdpi.com)
  • Evidence of enhanced renin-angiotensin system (RAS) activity in PCOS suggests an important correlation between the RAS and PCOS [ 10 , 11 ]. (mdpi.com)
  • VTP-27999 is a new renin inhibitor with an aliskiren-like IC 50 and t 1/2 , and a much higher bioavailability. (ahajournals.org)
  • We have investigated whether there is a relation between renin dependency of two-kidney, one-clip (2K1C) hypertensive rats and the density of renal glomerular and vascular atrial natriuretic factor (ANF) receptors. (ahajournals.org)
  • Children with a history of hypertension, renal disease, cardiac disease, or diabetes mellitus as well as those taking medication that could affect BP or the renin-angiotensin system were excluded from the study. (ahajournals.org)
  • activity
  • Our experiments also address the hypothesis that angiotensinogenic depressor responses could be mediated by non-AT 1 /AT 2 receptors, because of the experiments by Haberl 6 described above and the observation that angiotensin IV and angiotensin-(1-7) have dilator or depressor activity. (ahajournals.org)
  • study
  • 11 An AT 2 -mediated dilator action is further supported by a study of Li et al, 12 who reported that angiotensin III contractile responses in rat aorta were accentuated by PD 123177 but that angiotensin II and IV responses were unaffected. (ahajournals.org)