• mice
  • Isogenic colon, lung, and melanoma tumor xenotransplants showed reductions in growth and tumor angiogenesis in Bmx gene-deleted ( −/− ) mice, whereas developmental angiogenesis was not affected. (aacrjournals.org)
  • In transgenic mice overexpressing Bmx in epidermal keratinocytes, tumors induced by a two-stage chemical skin carcinogenesis treatment showed increased growth and angiogenesis. (aacrjournals.org)
  • CM101 has been shown in a published Phase I, FDA-approved clinical trial under IND to have clinical safety and effectivity on select stage IV cancer patients, specifically targeting tumor vasculature HP59 is expressed in the adult in wound healing, and in tumor angiogenesis, as shown in mice. (wikipedia.org)
  • growth
  • Our findings therefore indicate that Bmx activity contributes to tumor angiogenesis and growth. (aacrjournals.org)
  • Proliferation of the cancer cell at the metastatic site Formation of a micrometastasis inside the secondary site Progressive colonization, forming a life-threatening metastasis The potential of a tumor cell to metastasize depends on its microenvironment, or "niche" interactions with local factors promoting tumor-cell growth, survival, angiogenesis, invasion and metastasis. (wikipedia.org)
  • role
  • Despite uncertainties about the pathophysiology of the disease it has recently become apparent that angiogenesis plays a pivotal role in endometriosis. (ox.ac.uk)
  • patients
  • Pathologic examination of lung biopsy, or an autopsy of patients with CTEPH, disclose the full range of pulmonary hypertensive lesions in the small pulmonary arteries . (ishlt.org)
  • effective
  • 108. A method of treating pathologic neovascularization in a subject, the method comprising:administering a therapeutically effective amount of an antibody to HtrA1 to the subject, wherein the immunizing agent used to generate the antibody includes an agent selected from an HtrA1 fragment according to SEQ. (patentsencyclopedia.com)