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  • development
  • To test directly the hypothesis that macrophages play a causal rather than coincidental role in the development of CNV, we used the technique of pharmacological macrophage depletion with liposomal clodronate (Cl 2 MDP-LIP) in the laser-induced model of CNV, which captures many salient pathologic and molecular features of neovascular AMD. (arvojournals.org)
  • angiogenic
  • A corneal angiogenesis assay was performed by implanting nylon discs impregnated with an angiogenic stimulator (basic fibroblast growth factor or vascular endothelial growth factor) into one cornea of female Sprague-Dawley rats. (docme.ru)
  • These data support a major role for IL-1, but not TNF␣, in angiogenesis and suggest that an additional antiarthritic mechanism afforded by IL-1 inhibitors, but not anti-TNF agents, is the suppression of the angiogenic component of pannus. (docme.ru)
  • Evidence Showing That Tumors Can Grow Without Angiogenesis and Can Switch Between Angiogenic and Nonangiogenic Phenotypes. (ox.ac.uk)
  • Neovascularization (NV) of the cornea, which can be caused by trauma, keratoplasty or infectious disease, breaks down the so called 'angiogenic privilege' of the cornea and forms the basis of multiple visual pathologies that may even lead to blindness. (jove.com)
  • retina
  • At P17, A 2A R KO mice displayed attenuated OIR compared with WT littermates, as evidenced by reduced vaso-obliteration and areas of nonperfusion in the center of the retina, reduced pathologic angiogenesis as evident by decreased non-ganglion cells and neovascular nuclei, and inhibited hypoxia-induced retinal VEGF gene expression. (arvojournals.org)
  • tumors
  • Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. (springer.com)
  • In transgenic mice overexpressing Bmx in epidermal keratinocytes, tumors induced by a two-stage chemical skin carcinogenesis treatment showed increased growth and angiogenesis. (aacrjournals.org)
  • initiation
  • This finding is provocative because angiogenesis is a critical component in the initiation and maintenance of pannus, the aggressive fibrovascular extension of synovial tissue that is responsible for the extensive bone and cartilage damage in RA (20) and experimental models of arthritis (21). (docme.ru)
  • Inflammatory
  • However, in further studies that aimed at looking into the role of Bmx in pathologic processes, Bmx overexpression in epidermal keratinocytes in the K14-Bmx mice was shown to induce skin hyperplasia, activate a number of inflammatory pathways, and to promote angiogenesis and wound healing ( 7 ). (aacrjournals.org)
  • The CM101-HP59 complex then activates complement, and initiates an inflammatory cytokine cascade which recruits CD69 positive activated granulocytes to destroy the capillaries and surrounding pathologic tissue. (wikipedia.org)
  • growth
  • Treatment with IL-1Ra yielded a dosedependent reduction in growth factor-induced corneal angiogenesis, while PEG sTNFRI did not. (docme.ru)
  • Normally, angiogenesis is a natural part of tissue growth and formation. (wikipedia.org)
  • Proliferation of the cancer cell at the metastatic site Formation of a micrometastasis inside the secondary site Progressive colonization, forming a life-threatening metastasis The potential of a tumor cell to metastasize depends on its microenvironment, or "niche" interactions with local factors promoting tumor-cell growth, survival, angiogenesis, invasion and metastasis. (wikipedia.org)
  • cancer
  • Cancer stem cells and angiogenesis. (nih.gov)
  • CM101 has been shown in a published Phase I, FDA-approved clinical trial under IND to have clinical safety and effectivity on select stage IV cancer patients, specifically targeting tumor vasculature HP59 is expressed in the adult in wound healing, and in tumor angiogenesis, as shown in mice. (wikipedia.org)
  • role
  • Despite uncertainties about the pathophysiology of the disease it has recently become apparent that angiogenesis plays a pivotal role in endometriosis. (ox.ac.uk)
  • tumor
  • Cancer researchers studying the conditions necessary for cancer metastasis have discovered that one of the critical events required is the growth of a new network of blood vessels, called tumor angiogenesis. (wikipedia.org)
  • CM101 has been shown in a published Phase I, FDA-approved clinical trial under IND to have clinical safety and effectivity on select stage IV cancer patients, specifically targeting tumor vasculature HP59 is expressed in the adult in wound healing, and in tumor angiogenesis, as shown in mice. (wikipedia.org)
  • Proliferation of the cancer cell at the metastatic site Formation of a micrometastasis inside the secondary site Progressive colonization, forming a life-threatening metastasis The potential of a tumor cell to metastasize depends on its microenvironment, or "niche" interactions with local factors promoting tumor-cell growth, survival, angiogenesis, invasion and metastasis. (wikipedia.org)