Angiogenesis hepatic cells apoptosis of human hepatic stellate hepatic stellate cells. Medical search. Frequent questions

The increased proliferation and activation of hepatic stellate cells (HSCs) are associated with liver fibrosis development. (bvsalud.org)
Fibrosis is a physiological response to cellular injury in the liver and is mediated by the activation of hepatic stellate cells resulting in the replacement of hepatocytes with extracellular matrix comprised principally of collagen 1 to form a hepatic scar. (biomedcentral.com)
TGF-β has been reported to trigger the activation of hepatic stellate cells (HSCs), inducing their differentiation into fibroblasts. (spandidos-publications.com)

This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. (wikipedia.org)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
However, PDAC is characterized by an abundant tumor stroma that includes a heterogeneous mixture of immune cells, fibroblasts, endothelial cells, neurons and some molecular events. (biomedcentral.com)
In the case of the ⫽ endothelial cells men, there was also a delay, but of only 3 years. (gotomydoctor.com)

Sangre de grado ( Croton palanostigma ) induces apoptosis in human gastrointestinal cancer cells. (rain-tree.com)
et al, The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/ Akt/mTOR, JAK2/STAT3, and MAPK Pathways. (sabbiotech.cn)

Excessive activation of the TWEAK pathway in chronic injury has been described to promote pathological tissue changes including chronic inflammation, fibrosis and angiogenesis. (wikipedia.org)
In chronic liver disease, for example, TWEAK expression is enhanced and causes hepatic stellate cells, which are key regulators of liver fibrosis, to proliferate. (wikipedia.org)
Extracellular vesicles derived from mesenchymal stem/stromal cells (MSCs) have shown therapeutic effects on liver fibrosis. (biomedcentral.com)
Human transformation growth factor- beta 1 (TGF-β1) was used to induce fibrosis at optimal concentration. (biomedcentral.com)
Augmentation of HSCs apoptosis is one of the resolutions for liver fibrosis. (bvsalud.org)
The CCl4-induced liver fibrosis mouse model showed that the administration of α-mangostin significantly decreased the expression of the fibrosis markers (α-SMA, collagen-a2 (col1a2), desmin and matrix metalloproteinase-2 (MMP-2)) as well as attenuated hepatic collagen deposition and liver damage. (bvsalud.org)
In conclusion, this study demonstrates that α-mangostin attenuates the progression of liver fibrosis through inhibiting the proliferation of HSCs and triggering apoptosis signals. (bvsalud.org)
Although the novel hexaco-ordinated globin cytoglobin was identified in activated hepatic stellate cells more than 10 years ago, its role in stellate cell biology and liver fibrosis remains enigmatic. (biomedcentral.com)
The present study aimed to investigate the hepatoprotective effect of APE on CCl4‑induced hepatic fibrosis in rats. (spandidos-publications.com)
Organ coefficients, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), hexadecenoic acid (HA), laminin (LN), procollagen type III (PCIII), hydroxyproline (Hyp), glutathione (GSH‑Px), malondialdehyde (MDA), superoxide dismutase (SOD) and transforming growth factor β1 (TGF‑β1) levels were measured in rats with hepatic fibrosis. (spandidos-publications.com)
Pathological assessment of CCl4‑induced fibrotic livers revealed a significant reduction of liver injury and development of hepatic fibrosis in rats treated with APE (2.6 and 5.2 g/kg). (spandidos-publications.com)
These results suggested that APE may protect against liver damage and inhibit the progression of CCl4‑induced hepatic fibrosis. (spandidos-publications.com)
Hepatic fibrosis (HF) is recognized as one of the most prevalent types of liver disease. (spandidos-publications.com)
Early in the progression of hepatic fibrosis, a potent, fibrinogenic cytokine, transforming growth factor-β (TGF-β), was demonstrated to be locally and systemically increased in response to acute as well as chronic liver injury ( 7 ). (spandidos-publications.com)
Here, we investigated bleomycin-induced lung injury responses in young and aged mice at single-cell resolution to gain insights into the cellular and molecular contributions of aging to fibrosis. (researchgate.net)
Mesenchymal cells in the lung are crucial during development, but also contribute to the pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most common and deadly form of fibrotic interstitial lung diseases. (researchgate.net)
the effects of hypoxia and fibrosis may also play a role in obesity complications via notably ectopic-lipid accumulation in non-adipocyte cells. (springer.com)
Pancreatic stellate cells (PSCs) are now considered to be the key contributors of pancreatic fibrosis (5, 11, 135). (pancreapedia.org)

Extracellular vesicles derived from healthful primary murine hepatocytes or AML12 (alpha mouse liver) cells induced the downregulation of Acta2, Ccn2, and Col1a1 expression in aHSCs in vitro [139]. (calcium-channel.com)
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
Solated prim Ren human hepatocytes, which are listed in Table 1. (c-kitinhibitors.com)
But modest Promotoraktivit t In cellular Ren reporter assays based on typical erh Ht, probably because the CAR accumulates in the nucleus of immortalized cells, w While they Haupt Normally in the cytoplasm of primary Ren hepatocytes and liver. (c-kitinhibitors.com)
The vitamin D receptor has been reported to produce a modest 2 times the induction of CYP2C9 in prime Ren human hepatocytes by 1,25 dihydroxyvitamin D3. (c-kitinhibitors.com)

α-Mangostin-induced mitochondrial dysfunction and apoptosis in HSCs were measured by seahorse assay and caspase-dependent cleavage. (bvsalud.org)
The activation of caspase-dependent apoptosis and dysfunction of mitochondrial respiration (such as oxygen consumption rate, ATP production, and maximal respiratory capacity) were observed in α-mangostin-treated HSCs. (bvsalud.org)
HSCs undergo phenotypic changes from quiescent vitamin A storing cells, involved in maintenance of the normal basement matrix, into proliferative myofibroblast-like cells, expressing myogenic markers such as alpha smooth muscle actin (αSMA). (biomedcentral.com)
This could be considered to be part of a feedback loop as changes in ECM composition results in changes in HSC cell surface receptors, particularly integrins indicating that the ECM should not be regarded simply as an inert physical scaffold but a dynamic structure that is able to influence the phenotype of HSCs [ 2 , 8 , 9 ]. (biomedcentral.com)
HSCs express numerous cell surface receptors including both discoidin domain receptors (DDRs)-which are receptors for collagen I and many of the integrin subunits, which are a major family of cell surface receptors for extracellular molecules and play a critical role in many biological functions [ 7 , 10 ]. (biomedcentral.com)

In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)
Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)
However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. (frontiersin.org)
Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
These characteristics include inhibition of leucocyte proliferation, T cells apoptosis, and induction of macrophages along with reduced pro-inflammatory cytokines secretion. (thctotalhealthcare.com)
We also observed activation and upregulated phagocytosis in macrophages, as well as proliferation and extracellular matrix overproduction in hepatic stellate cells. (biomedcentral.com)
Briefly, after centrifugation, the cells were resuspended to a concentration of 2.5 × 106 cells/mL and cultured for 7 days in a medium supplemented with 100 ng/mL of M-CSF or 10 ng/mL of GM-CSF (both from Peprotech) to obtain, macrophages and cDCs, respectively. (ainhibitor.com)

Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. (frontiersin.org)
Importantly, we demonstrate that the overexpression of miR-148a significantly inhibits HCC cell proliferation and cell cycle progression. (spandidos-publications.com)
The progression of hepatocellular carcinogenesis is thought to involve the deregulation of genes that are critical to cellular processes, such as cell cycle control, cell growth, apoptosis, cell migration and spreading. (spandidos-publications.com)
Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
Endoglin and ALK1 receptor levels in tumor vasculature correlate inversely with prognosis in humans, whereas in mice, endoglin deficiency decelerates tumor progression. (ainhibitor.com)
These cells, surrounding the hair follicles, secrete signaling molecules that control the progression of the hair cycle. (jcadonline.com)
SD-36, which could suppress lymphoma cell growth and inhibit tumor progression in a mice model. (biomedcentral.com)

CCN1 also induced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells to promote their differentiation into cholangiocytes. (jci.org)
Since their discovery in 1993, miRNAs have been described in all multicellular organisms and are associated with a vast breadth of biological functions, including cellular proliferation, cellular differentiation and immunity, as well as tissue remodeling and various human diseases, including cancer ( 4 ). (spandidos-publications.com)
T cells must substantially increase nutrient uptake to mount a proper immune response and failure to obtain sufficient nutrients or engage the appropriate metabolic pathways can alter or prevent effector T cell differentiation and function. (elifesciences.org)
This review will discuss the metabolic adaptations necessary for T cells to meet changing biochemical needs throughout different stages of differentiation. (elifesciences.org)
Thus any modification of ECM components can be transmitted via integrins and impact on cell movement during development and proliferation, differentiation, apoptosis. (springer.com)

Mesenchymal stem and stromal cells (MSCs), defined as fibroblast-like non-hematopoietic cells, have been discovered in various organs and named after their site of origin. (biomedcentral.com)
Additionally, ß-HB combined with sorafenib or regorafenib promoted the antiproliferative and antimigratory abilities of sorafenib-resistant HCC cells by inhibiting the B-raf/mitogen-activated protein kinase pathway and mesenchymal N-cadherin-vimentin axis. (bvsalud.org)
mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/Î²-catenin signaling. (peprotech.com)
However, lineage tracing studies with hepatic stellate cells (counterparts of PSCs in the liver) have confirmed a mesenchymal origin for these cells (9). (pancreapedia.org)
6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)

The oxidative stress and inflammatory response were commonly upregulated in several cell types. (biomedcentral.com)

extracellular vesicles can alter the phenotype of their recipient cells and could prove a novel method to NASH remedy [137]. (calcium-channel.com)
Likewise, extracellular vesicles from healthier human subjects decreased human hepatic stellate cell line LX-2 activation [140]. (calcium-channel.com)
Further, inhibitory receptors present in the TME can inhibit T cell metabolism and alter T cell signaling both directly and through release of extracellular vesicles such as exosomes. (elifesciences.org)

A novel angiogenesis inhibitor impairs LoVo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation. (rain-tree.com)
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. (rain-tree.com)

TIMP-1 mediates TGF-Î²-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling. (peprotech.com)

A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)
Endothelial cell senescence or activation is dependent on the type of cytokine, ligand concentration, cell-cell interaction, MK 1775 and a multitude of other signaling molecules. (ainhibitor.com)

Leukocytes are the main source of TWEAK including human resting and activated monocytes, dendritic cells and natural killer cells. (wikipedia.org)

Some tumor cell-inherent resistance mechanisms, such as the tumor mutational burden and aberrant expression of oncogenic pathways, restrain antitumor immunity [ 10 ]. (biomedcentral.com)
As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)
In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)
In health, PSCs are known to not only play a role in regulating normal extracellular matrix turnover but are also thought to have progenitor cell functions as well as a role in innate immunity. (pancreapedia.org)
Dr. Devi's research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer. (duke.edu)

Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)

Immune cells engage in extensive and dynamic crosstalk with stromal components in the tumor tissue in addition to tumor cells, which subsequently impacts tumor suppression or promotion to a large extent. (biomedcentral.com)

We also present a thorough analysis of the role of succinate in the initiation of metabolic and epigenetic changes that contribute to the development of cancer, as well as its effects on angiogenesis, cell invasion, and migration. (scientificarchives.com)

Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in humans is encoded by the TNFSF12 gene. (wikipedia.org)
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
Recombinant Human TIMP-1 is a 20.6 kDa protein containing 184 amino acid residues. (peprotech.com)
In early culture, PSCs are polygonal in shape with abundant lipid droplets in the cytoplasm ( Figure 1B ) and express stellate cell selective markers such as desmin, glial fibrillary acidic protein (GFAP), nestin, neural cell adhesion molecule, nerve growth factor, and synemin (34, 167). (pancreapedia.org)
A ) Normal rat pancreatic stellate cells stained for cytoskeletal protein desmin. (pancreapedia.org)
With this cell model, it was reported that CYP2Cs significant levels of mRNA, protein, and activity t Induces the therapeutic reagents, glucocorticoid hormones Like the D, vitamin and endogenous metabolites Lithochols ure, Which has been shown to induce CYP2C8. (c-kitinhibitors.com)
The induction of mRNA and protein of CYP2C19 shows a large interindividual variability en t In the human liver. (c-kitinhibitors.com)

Tas13D inhibits growth of SMMC-7721 cell via suppression VEGF and EGF expression. (rain-tree.com)

It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)

Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
In this review, we discuss how infiltrating immune cells influence PDAC development and explore the contributions of complex components to the immune landscape of tumor tissue. (biomedcentral.com)
Several anti-diabetic strategies including adiponectin, ezetimibe, liraglutide, taurine, adipose tissue-derived stem cells (ADSCs) and even exercise as well as natural products such GABA tea, geniposide, guava extract, vitamin D have been shown to target autophagy. (frontiersin.org)
Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
11 However, the greater the abundance of adipose tissue in the human body, the significantly higher the yield of MSCs is compared to other tissues. (jcadonline.com)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Akt(Phospho-Ser473) Antibody #11054(left) or the same antibody preincubated with blocking peptide(right). (sabbiotech.cn)

Knock-in mice expressing a CCN1 mutant that is unable to bind α v β 5 /α v β 3 were impaired in ductular reaction, leading to massive hepatic necrosis and mortality after bile duct ligation (BDL), whereas treatment of these mice with soluble JAG1 rescued ductular reaction and reduced hepatic necrosis and mortality. (jci.org)

Despite the arsenal of defense strategies against foreign invaders, myeloid cells succumb to the instructions of an established tumor. (frontiersin.org)
Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)
Nevertheless, the majority of scientific discoveries points toward a more tumor-supporting role for myeloid cells in the TME. (frontiersin.org)
The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)

TWEAK can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. (wikipedia.org)
Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
et al, CD155 Cooperates with PD-1/PD-L1 to Promote Proliferation of Esophageal Squamous Cancer Cells via PI3K/Akt and MAPK Signaling Pathways. (sabbiotech.cn)

Hepatocellular carcinoma (HCC) typically arises in fibrotic or cirrhotic livers, which are characterized by pathogenic angiogenesis. (cancerindex.org)
Dysregulation of miRNAs is a common feature in human cancers, but this phenomenon has not been studied extensively in hepatocellular carcinoma (HCC). (spandidos-publications.com)
Primary liver cancer mainly refers to hepatocellular carcinoma (HCC), cholangiocarcinoma and hepatic angiosarcoma. (spandidos-publications.com)
In this study, a dual-luciferase assay-based screening of 537 compounds for STAT-3 inhibitors of hepatocellular carcinoma (HCC) cells was conducted, leading to the identification of genipin. (biomedcentral.com)

Human aHSCs had been inactivated in vitro by stimulation having a cocktail containing growth things, palmitic acid, and retinol, as a result major for the downregulated expression of SMA and variety 1 collagen, too because the reduction of proliferation and matrix metalloproteinase activity [129]. (calcium-channel.com)

Cell Oncol (Dordr). (cancerindex.org)

The involvement of autophagy in the development of diabetes is corroborated by affecting the physiology and role of pancreatic β cells and the homeostasis of glucose. (frontiersin.org)
Pancreatic stellate cells (PSCs) are resident cells of the pancreas, found in both the exocrine and endocrine parts of the gland. (pancreapedia.org)
The development of isolation and culture methods for PSCs in 1998 helped to unravel the mechanisms involved in the process of pancreatic fibrogenesis (5, 11) and also helped researchers to investigate the functions of these cells both in health and disease. (pancreapedia.org)
Photomicrograph showing a normal rat pancreatic section immunostained for the stellate cell selective marker desmin (left) and a corresponding line diagram (right). (pancreapedia.org)

Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)

Autophagy is a major catabolic process that maintains cell metabolism by degrading damaged organelles and other dysfunctional proteins via the lysosome. (koreascience.kr)
In the current study, we investigated the role of different extracellular matrix proteins in stellate cell proliferation, activation (alpha smooth muscle actin expression and retinoic acid uptake) and cytoglobin expression. (biomedcentral.com)

Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines. (rain-tree.com)
Members of the TGF-β superfamily, TGF-β1, TGF-β3, and BMP9, are key propagators of both inhibition and initiation of angiogenesis. (ainhibitor.com)

These excessive depositions disturb the normal structure of the hepatic lobule, resulting in misdirected blood flow through the liver, thereby impairing normal organ functioning. (spandidos-publications.com)

My research interests are broadly based on the interface of synthetic organic chemistry and medicinal chemistry, and in particular on the drug discovery of bioactive molecules to probe biological systems or act as potential therapeutic agents in neuroscience, cancer/inflammation, infectious diseases, and other human conditions. (utmb.edu)
Pathogen clearance is mediated by mechanisms such as phagocytosis, respiratory burst with the production of ROS and RNS and release of bacteriostatic peptides, but also through the cell-extrinsic initiation of inflammation via the release of proinflammatory cytokines and chemokines ( 24 ). (frontiersin.org)

The pharmacological stimulation of nitric oxide production in rats with thioacetamide-induced liver cirrhosis restored the differentiated LSEC phenotype, which subsequently led towards the apoptosis and inactivation of aHSCs [133]. (calcium-channel.com)
Impaired immune effector cell infiltration and inactivation of the immune response contribute to the poor prognosis of PDAC patients. (biomedcentral.com)

However, chimeric antigen receptor T (CAR-T) cell immunotherapy and immune checkpoint blockade (ICB), which have produced unprecedented clinical benefits in a variety of different cancers, produce promising results in only some highly selected patients with PDAC. (biomedcentral.com)
Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)

Western blot analysis of extracts from 293 cells, treatedwith EGF or calf intestinal phosphatase (CIP), using Akt(Phospho-Ser473) Antibody #11054. (sabbiotech.cn)

APAP overdose can induce hepatic toxicity, known as acetaminophen -induced liver injury (AILI). (zju.edu.cn)

The recurrence of liver cancer after hepatic resection remains a major complication with no adjuvant therapies able to prevent it. (encyclopedia.pub)
Furthermore, the high refractoriness of liver cancer to treatments has been associated with the interaction of very complex and diverse mechanisms of chemoresistance, which can act synergistically to protect tumor cells from the chemotherapy agents [ 3 ] . (encyclopedia.pub)

TIMP-1 activity was measured by its ability to inhibit human MMP-1-induced hydrolysis of a chromogenic peptide substrate at room temperature. (peprotech.com)

We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases. (nature.com)

Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and miR-21/β-catenin Axis with HJC0152. (utmb.edu)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)

Effects of taspine on proliferation and apoptosis by regulating caspase-3 expression and the ratio of Bax/Bcl-2 in A431 cells. (rain-tree.com)
We discovered differential expression of 3-hydroxymethyl glutaryl-CoA synthase 2 (HMGCS2) and the ketone body D-ß-hydroxybutyrate (ß-HB) in four sorafenib-resistant HCC cell lines. (bvsalud.org)
ß-HB treatment enhanced pyruvate dehydrogenase (PDH) expression and decreased lactate dehydrogenase (LDHA) expression and lactate production in sorafenib-resistant HCC cells. (bvsalud.org)
Intriguingly, the expression of DNMT1, which is a target of miR-148a, is inversely correlated with the expression of miR-148a in HCC cells. (spandidos-publications.com)
Our results demonstrate that cytoglobin expression is correlated with a more quiescent phenotype of stellate cells in culture and that cytoglobin is regulated by the extracellular matrix through integrin signalling dependent on activation of focal adhesion kinase. (biomedcentral.com)
Additionally, a brief summary is provided of cannabinoid receptors properties and their expression in the respiratory system and cells of the immune system. (thctotalhealthcare.com)
The advent of single-cell RNA sequencing (scRNA-seq) technology made it possible to profile the gene expression at single-cell level in complex tissues. (biomedcentral.com)

Additionally, a viable therapeutic strategy may involve triggering the cell death mechanism in cancer cells by blocking mitochondrial metabolism with a natural substance. (scientificarchives.com)
Furthermore, H 2 S donors and some H 2 S hybrids have been evaluated in many experimental models of human disease and have shown promising therapeutic results. (hindawi.com)
Therefore, exploration of the interactions between the stroma and immune cells may offer new therapeutic opportunities for PDAC. (biomedcentral.com)
Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)

ECM organization and retinol metabolism were partly restored to levels exhibited by qHSCs, and 70 of cells accumulated cytoplasmatic lipid droplets, underlining a switch in phenotype [129]. (calcium-channel.com)

Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90. (rain-tree.com)
STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)
Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. (sabbiotech.cn)
Phosphorylation of tyrosine 705 residue induced by epidermal growth factor (EGF) or interleukins can activate STAT-3 in cells [ 4 ]. (biomedcentral.com)
However, the propensity of some MAPCAs to develop stenosis rather than growth may impair the response to reconstructions.Probe sets prepared from MAPCAs, PA, and aorta mRNA were used to interrogate human genome microarrays. (stanford.edu)

Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)

NAR can be encapsulated by chitosan nanoparticles-TPP conjugates, thereby improving NAR cellular absorption and cytotoxicity against cancer cells. (scientificarchives.com)

PSCs in their native state express abundant vitamin A (retinoids) containing droplets in their cytoplasm which is a characteristic feature of the "stellate cell system" in the body (138). (pancreapedia.org)

Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
These drawbacks may be explained, at least in part, by the various phenotypes and histological characteristics of tumor liver cells and its microenvironment [ 5 ] . (encyclopedia.pub)

Among these components, EVs, responsible for the communication between various cell types, are implicated in physiology and pathology. (biomedcentral.com)
However, lipid accumulation in non-specialized cells is deleterious and can contribute to cell death resulting in the development of pathology such as NASH (Non-Alcoholic Steatohepatitis) a liver injury associated with obesity [ 12 ]. (springer.com)

Anatomy29

Organisms12

Diseases25

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes44

Disciplines and Occupations1

Information Science3

Activation of hepatic stellate cells3

Endothelial cells4

Induces apoptosis2

Fibrosis18

Hepatocytes5

HSCs5

Macrophages8

Progression8

Differentiation5

Mesenchymal7

Oxidative1

Extracellular vesicles3

Inhibitor2

Mediates1

Cytokine2

Dendritic cells1

Immunity5

Tumors2

Crosstalk1

Migration1

Protein7

Inhibits1

Anti-inflammatory1

Tissue6

Necrosis1

Myeloid5

Pathways3

Hepatocellular carcinoma4

Collagen1

Oncol1

Pancreatic4

Senescence3

Proteins2

Inhibition2

Excessive1

Inflammation2

Inactivation2

Blockade2

Intestinal1

Toxicity1

Liver Cancer2

Inhibit1

Cancers1

Invasion1

Stem2

Expression7

Therapeutic4

Lipid droplets1

Growth5

Immune responses1

Cellular1

Cytoplasm1

Phenotypes2

Pathology2