Cancer is a complex genetic disease caused by abnormal alteration (mutations) in DNA sequences that leads to dyregulation of normal cellular processes thereby driving tumor growth. (intechopen.com)
These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)
This is part three of three articles with excerpts from "Tumor Angiogenesis as a Target for Dietary Cancer Prevention" by Dr. William Li. (ppt-health.com)
Blood vessels3
Vascular endothelial cells migrate and proliferate to form new blood vessels (eg angiogenesis) branching from pre-existing limbal vessels. (medscape.com)
In the tracheobronchial (airway) vasculature, these include the inhibition of inflammatory hyperperfusion, microvascular hyperpermeability, mucosal oedema formation, and the formation of new blood vessels (angiogenesis). (ersjournals.com)
The major structural and functional changes related to the airway circulation include the proliferation of blood vessels (angiogenesis) 2 - 4 , increased blood flow 5 , 6 , increased microvascular permeability 7 , 8 , and oedema formation in the airway wall 9 . (ersjournals.com)
Proliferation4
Not long after FGF1 and FGF2 were isolated, another group of investigators isolated a pair of heparin-binding growth factors that they named HBGF-1 and HBGF-2, while a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells, which they called ECGF1 and ECGF2. (wikipedia.org)
Genistein is an isoflavonoid found in soybeans, has antiangiogenic activity including angiogenesis inhibition, induction of apoptosis, inhibition of bFGF- and VEGF-driven cell proliferation, PDGF, G2, c-fos expression, NF-κB activation and growth factor signaling pathways. (ppt-health.com)
SPARC (secreted protein,acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-matrix interactions, cellular proliferation and differentiation, and the expression of genes encoding extracellular matrix components. (silverchair.com)
The most significant pathways and BPs that were deregulated in the primary disease condition were associated with the cell cycle and fibroblast proliferation procedures. (genominfo.org)
Inflammation3
These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)
It is involved in various metabolic processes, such as acting on white adipose tissue to upregulate brown adipose tissue-specific genes, enhancing PGC-1α expression to increase lipid oxidation, suppressing inflammation in skeletal muscles, inhibiting cardiometabolic risk factors, and suppressing endoplasmic reticulum stress in hepatoblastoma cells. (encyclopedia.pub)
Receptor2
[11] The SP receptor promoter contains regions that are sensitive to cAMP , AP-1 , AP-4 , CEBPB , [12] and epidermal growth factor . (wikidoc.org)
Its receptor - the neurokinin type 1 - is distributed over cytoplasmic membranes of many cell types (neurons, glia, endothelia of capillaries and lymphatics, fibroblasts, stem cells, white blood cells) in many tissues and organs. (wikidoc.org)
Proliferate1
A mitogenic growth factor activity was found in pituitary extracts by Armelin in 1973 and further work by Gospodarowicz as reported in 1974 described a more defined isolation of proteins from cow brain extract which, when tested in a bioassay that caused fibroblasts to proliferate, led these investigators to apply the name "fibroblast growth factor. (wikipedia.org)
VEGF1
Some of these factors (ie, acidic and basic fibroblast growth factors, interleukin 1 [IL-1], and vascular endothelial growth factor [VEGF]) have been identified and isolated from cornea and tears. (medscape.com)
Receptors3
These growth factors typically act as systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. (wikipedia.org)
In humans, 23 members of the FGF family have been identified, all of which are structurally related signaling molecules: Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). (wikipedia.org)
The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
Tissue3
[ 9 ] Deep stromal NV is serious, possibly leading to loss of optical transparency of the tissue and hence decrease visual acuity through stromal hemorrhage, scarring, and lipid deposition. (medscape.com)
HGF achieves these positive effects by preserving nerve tissue in the injured area through neuroprotective actions such as anti-inflammatory effects and angiogenesis. (biomedcentral.com)
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. (lookformedical.com)
Cancer1
HMGB1 is also related to the hallmarks of cancer as described by Hanahan and Weinberg [ 9 ]. (hindawi.com)
Biological1
We aimed to identify differentially expressed genes (DEGs), the most critical hub genes, transcription factors, signaling pathways, and biological processes (BPs) associated with the pathogenesis of primary SGC. (genominfo.org)
Cytokines2
Because these regions are related to complexed signal transduction pathways mediated by cytokines , it has been proposed that cytokines and neurotropic factors can induce NK-1. (wikidoc.org)
Also, SP can induce the cytokines that are capable of inducing NK-1 transcription factors. (wikidoc.org)
Proteins1
These independently discovered proteins were eventually demonstrated to be the same sets of molecules, namely FGF1, HBGF-1 and ECGF-1 were all the same acidic fibroblast growth factor described by Gospodarowicz, et al. (wikipedia.org)
Contrast1
In contrast, FGF7 (keratinocyte growth factor, KGF) binds only to FGFR2b (KGFR). (wikipedia.org)
Processes1
Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs. (wikipedia.org)
Therapeutic1
This study evaluates the impact of a dual therapeutic intervention utilizing hepatocyte growth factor (HGF) and hiPSC-NS/PC transplantation on motor function restoration following spinal cord injury (SCI). (biomedcentral.com)
Efficacy1
Hepatocyte growth factor (HGF) is a highly promising clinically relevant candidate for enhancing the efficacy of NS/PC transplantation. (biomedcentral.com)
Vitro2
Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
Lycopene is an angiogenesis inhibitor which suppresses signaling by PDGF and Platelet Activation Factor in vitro. (ppt-health.com)
Basic3
FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor. (wikipedia.org)
In 1975, they further fractionated the extract using acidic and basic pH and isolated two slightly different forms that were named "acidic fibroblast growth factor" (FGF1) and "basic fibroblast growth factor" (FGF2). (wikipedia.org)
while FGF2, HBGF-2, and ECGF-2 were all the same basic fibroblast growth factor. (wikipedia.org)
Crucial1
The pectin structure is a crucial factor that determines the application in the food and pharmaceutical industry. (medicdebate.org)
Activity1
The gene is located on chromosome 12q23 [ 26 ] and regulates transforming growth factor (TGF)-beta 1 activity as well as the cell cycle [ 27 ] . (encyclopedia.pub)
Effects1
Previous studies have reported that chemotherapy and radiation therapy are low effective and have several side effects such as hyposalivation, neutropenia, swallowing disorder, and several neurological difficulties [ 8 , 9 ]. (genominfo.org)
Bone1
In 1965, Urist recognized BMP as an important factor in osteogenesis and bone formation [ 17 ] . (encyclopedia.pub)
Functions2
Members FGF11, FGF12, FGF13, and FGF14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functions compared to the FGFs. (wikipedia.org)
A short stretch of acidic amino acids located between the D1 and D2 domains has auto-inhibitory functions. (wikipedia.org)
Actions1
They have been alternately referred to as "pluripotent" growth factors and as "promiscuous" growth factors due to their multiple actions on multiple cell types. (wikipedia.org)
Small1
BAIBA (C 4 H 9 NO 2 ) is a small, non-protein myokine with a molecular weight of 103.6 Da that was first discovered in human urine in 1951 [ 11 ] . (encyclopedia.pub)
Elements1
The yield of such a process is usually satisfactory, but acid extraction is energy-consuming and increases the risk of accelerated corrosion of production line elements, as well as generates large amounts of acidic industrial waste [ 3 ]. (medicdebate.org)
Activation1
Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)