• role of aneuploidy
  • 15- 17 In this brief review, the possible mechanisms responsible for aneuploidy and the role of aneuploidy in malignancy are discussed. (bmj.com)
  • Recent progress in understanding the debated role of aneuploidy as a driver or passenger in malignant transformation, as well as how the. (lu.se)
  • Recent progress in understanding the debated role of aneuploidy as a driver or passenger in malignant transformation, as well as how the cell responds to and regulates excess genetic material in experimental settings, is also discussed in detail. (lu.se)
  • Genomic
  • Aneuploidy can be detected with the help of traditional metaphase cytogenetics, interphase cytogenetics (fluorescent in situ hybridisation (FISH), multicolour FISH, spectral karyotyping, and comparative genomic hybridisation techniques (CGH)), flow cytometry (FCM), and image cytometry (ICM). (bmj.com)
  • The aim of this study was to investigate the relationship between tobacco smoke habit, patient age, DNA aneuploidy and genomic DNA copy number aberrations (CNAs) in oral potentially malignant disorder (OPMD) and oral squamous cell carcinoma (OSCC) patients. (pubmedcentralcanada.ca)
  • DNA aneuploidy and mean nuclear genomic aberrations were associated with patients' age. (pubmedcentralcanada.ca)
  • Further studies provided also evidences of an association between DNA aneuploidy with high-risk oral mucosa subsites [ 12 ] and with genomic copy number aberrations [ 13 ]. (pubmedcentralcanada.ca)
  • genetic
  • Additionally, it has been suggested ( 21 ) that the phenotypes detected in the disomic strains may be a unique consequence of the method that was used to generate aneuploidy, in which genetic markers were used to select for rare chromosome transfer events between nuclei ( 13 ). (pnas.org)
  • Our results identified multiple distinct solutions by which the monogenic trait could be suppressed, including genetic and non-genetic mechanisms as well as frequent aneuploidy. (genetics.org)
  • The test will analyze circulating cell free fetal (ccff) nucleic acid from blood samples from pregnant women who have an increased risk indicator/s for fetal chromosomal aneuploidy and are undergoing invasive prenatal diagnosis by chorionic villus sampling (CVS) and/or genetic amniocentesis. (clinicaltrials.gov)
  • The results of the ccff aneuploidy test will be compared to the chromosomal analysis obtained via CVS or genetic amniocentesis. (clinicaltrials.gov)
  • This study will allow for first of its kind commercial PGS/D testing to detect disease-associated genetic mutations together with aneuploidy screening. (clinicaltrials.gov)
  • Meiosis II-nondisjunction may also result in aneuploidy syndromes, but only to a much smaller extent than do segregation failures in meiosis I. Division of somatic cells through mitosis is preceded by replication of the genetic material in S phase. (wikipedia.org)
  • fetus
  • This prospective blinded study will assess the diagnostic capability of an informatics enhanced SNP based technology (Parental Support) to identify pregnant women who are carrying a fetus with an aneuploidy from fee floating DNA in the maternal blood. (clinicaltrials.gov)
  • Aneuploidy of autosomes is not well tolerated and usually results in miscarriage of the developing fetus. (wikipedia.org)
  • humans
  • In humans, aneuploidy is the leading cause of spontaneous abortions and developmental disabilities, and aneuploid karyotypes are observed in greater than 90% of solid tumors ( 2 ⇓ - 4 ). (pnas.org)
  • In humans, disease conditions have been described in which aneuploidy affects the entire individual or a subset of cells. (aacrjournals.org)
  • In humans, aneuploidy is linked to pathological defects such as developmental abnormalities, mental retardation or cancer, but the underlying mechanisms remain elusive. (uni-muenchen.de)
  • frequent
  • Examples include: In cancer cells, aneuploidy is a frequent event, indicating that these cells present a defect in the machinery involved in chromosome segregation, as well as in the mechanism ensuring that segregation is correctly performed. (wikipedia.org)
  • dysplasia
  • Further, we have studied the long-term outcome for patients who had an early onset of disease and analysed the expression of cytokeratin 7 and 20 in respect to findings of dysplasia, DNA aneuploidy and colorectal cancer. (diva-portal.org)
  • genes
  • Failure of the spindle checkpoint caused by mutation of the responsible genes may be one of the important factors for the development of aneuploidy. (bmj.com)
  • Finally, we identified 23 genes whose expression is significantly altered in all aneuploids and which may thus serve as aneuploidy markers. (uni-muenchen.de)
  • cell
  • Topics include antioxidant therapies, dehydroepiandrosterone, stem cell therapies, telomere elongatation, low dose gonadotorpins in IVF-ET, and prevention of oocyte aneuploidy and infertility using hormone normalization therapies (HNTs) that lower FSH and blockade activin receptor signaling. (frontiersin.org)
  • nuclei
  • DNA aneuploidy was detected by high-resolution DNA flow cytometry (hr DNA-FCM) on DAPI stained nuclei obtained from multiple tissue samples from OPMDs/OSCCs in 220 consecutive patients. (pubmedcentralcanada.ca)
  • diploid
  • Aneuploidy has frequently been noted in many solid tumours, and occasionally a few uterine carcinoma and prostatic carcinomas have been reported to be diploid (table 1). (bmj.com)
  • progression
  • In this brief review, the various aspects of aneuploidy with special emphasis on its mechanism of development and impact on progression of cancer are discussed. (bmj.com)
  • However, the proof that DNA aneuploidy can predict the progression of given OPMD in a clinical setting is still missing and the same applies for some molecular markers, such as p53 (TP53), Cyclin D1, and podoplanin (PDPN), HIF-1alpha, E-cadherin, and p63, which were also investigated [ 14 , 15 ]. (pubmedcentralcanada.ca)
  • cellular
  • Whereas polyploidy is reasonably well tolerated on both the cellular and organismal level, aneuploidy is not, with the condition frequently being associated with death and severe developmental abnormalities in all organisms analyzed to date ( 1 ). (aacrjournals.org)
  • findings
  • The aims of these studies have been to evaluate the efficiency of the surveillance programme, analyse the impact of findings of DNA aneuploidy, and determine the outcome for patients that underwent limited resections instead of complete proctocolectomy. (diva-portal.org)
  • maternal
  • the comparison of peak profiles obtained from IUL, placental, and maternal samples confirmed the diagnosis of aneuploidy in all three cases. (hindawi.com)