• role of aneuploidy
  • 15- 17 In this brief review, the possible mechanisms responsible for aneuploidy and the role of aneuploidy in malignancy are discussed. (bmj.com)
  • Recent progress in understanding the debated role of aneuploidy as a driver or passenger in malignant transformation, as well as how the. (lu.se)
  • Recent progress in understanding the debated role of aneuploidy as a driver or passenger in malignant transformation, as well as how the cell responds to and regulates excess genetic material in experimental settings, is also discussed in detail. (lu.se)
  • Genomic
  • Aneuploidy can be detected with the help of traditional metaphase cytogenetics, interphase cytogenetics (fluorescent in situ hybridisation (FISH), multicolour FISH, spectral karyotyping, and comparative genomic hybridisation techniques (CGH)), flow cytometry (FCM), and image cytometry (ICM). (bmj.com)
  • The aim of this study was to investigate the relationship between tobacco smoke habit, patient age, DNA aneuploidy and genomic DNA copy number aberrations (CNAs) in oral potentially malignant disorder (OPMD) and oral squamous cell carcinoma (OSCC) patients. (pubmedcentralcanada.ca)
  • DNA aneuploidy and mean nuclear genomic aberrations were associated with patients' age. (pubmedcentralcanada.ca)
  • Further studies provided also evidences of an association between DNA aneuploidy with high-risk oral mucosa subsites [ 12 ] and with genomic copy number aberrations [ 13 ]. (pubmedcentralcanada.ca)
  • somatic
  • Meiosis II-nondisjunction may also result in aneuploidy syndromes, but only to a much smaller extent than do segregation failures in meiosis I. Division of somatic cells through mitosis is preceded by replication of the genetic material in S phase. (wikipedia.org)
  • fetus
  • This prospective blinded study will assess the diagnostic capability of an informatics enhanced SNP based technology (Parental Support) to identify pregnant women who are carrying a fetus with an aneuploidy from fee floating DNA in the maternal blood. (clinicaltrials.gov)
  • Aneuploidy of autosomes is not well tolerated and usually results in miscarriage of the developing fetus. (wikipedia.org)
  • frequent
  • Our results identified multiple distinct solutions by which the monogenic trait could be suppressed, including genetic and non-genetic mechanisms as well as frequent aneuploidy. (genetics.org)
  • Examples include: In cancer cells, aneuploidy is a frequent event, indicating that these cells present a defect in the machinery involved in chromosome segregation, as well as in the mechanism ensuring that segregation is correctly performed. (wikipedia.org)
  • diploid
  • Aneuploidy has frequently been noted in many solid tumours, and occasionally a few uterine carcinoma and prostatic carcinomas have been reported to be diploid (table 1). (bmj.com)
  • mechanisms
  • In humans, aneuploidy is linked to pathological defects such as developmental abnormalities, mental retardation or cancer, but the underlying mechanisms remain elusive. (uni-muenchen.de)
  • dysplasia
  • Further, we have studied the long-term outcome for patients who had an early onset of disease and analysed the expression of cytokeratin 7 and 20 in respect to findings of dysplasia, DNA aneuploidy and colorectal cancer. (diva-portal.org)
  • The sensitivity of aneuploidy for development of dysplasia (LGD or higher) was found to be 0.50 and the specificity 0.94. (diva-portal.org)
  • result
  • Unlike single gene disorders, diseases caused by aneuploidy are the result of improper gene dosage, not nonfunctional gene product. (wikipedia.org)
  • progression
  • In this brief review, the various aspects of aneuploidy with special emphasis on its mechanism of development and impact on progression of cancer are discussed. (bmj.com)
  • However, the proof that DNA aneuploidy can predict the progression of given OPMD in a clinical setting is still missing and the same applies for some molecular markers, such as p53 (TP53), Cyclin D1, and podoplanin (PDPN), HIF-1alpha, E-cadherin, and p63, which were also investigated [ 14 , 15 ]. (pubmedcentralcanada.ca)
  • cellular
  • Whereas polyploidy is reasonably well tolerated on both the cellular and organismal level, aneuploidy is not, with the condition frequently being associated with death and severe developmental abnormalities in all organisms analyzed to date ( 1 ). (aacrjournals.org)
  • There are many different types and origins of aneuploidy, but whether there is a uniform cellular response to aneuploidy in human cells has not been addressed so far. (uni-muenchen.de)
  • cell
  • These studies suggest that aneuploidy puts significant stress on the cell, which responds to this condition in what can be viewed as an aneuploidy stress response. (aacrjournals.org)
  • Topics include antioxidant therapies, dehydroepiandrosterone, stem cell therapies, telomere elongatation, low dose gonadotorpins in IVF-ET, and prevention of oocyte aneuploidy and infertility using hormone normalization therapies (HNTs) that lower FSH and blockade activin receptor signaling. (frontiersin.org)
  • human
  • Clinical and biological significance of aneuploidy in human tumours. (bmj.com)
  • Aneuploidy is a well recognised feature of human tumours, but the investigation of its biological and clinical significance has been hampered by technological constraints. (bmj.com)
  • Surveys of cases of human aneuploidy syndromes have shown that most of them are maternally derived. (wikipedia.org)
  • cells
  • To evaluate the accuracy in the diagnosis of aneuploidies of a quantitative fluorescent polymerase chain reaction (QF-PCR) assay on trophoblastic cells recovered from transcervical cells samples (TCCs) collected by intrauterine lavage (IUL). (hindawi.com)
  • findings
  • The aims of these studies have been to evaluate the efficiency of the surveillance programme, analyse the impact of findings of DNA aneuploidy, and determine the outcome for patients that underwent limited resections instead of complete proctocolectomy. (diva-portal.org)
  • maternal
  • the comparison of peak profiles obtained from IUL, placental, and maternal samples confirmed the diagnosis of aneuploidy in all three cases. (hindawi.com)
  • present
  • Cytogenetic analysis is recommended even if the typical features of a recognized aneuploidy are present so that any associated abnormality may be detected. (biomedsearch.com)
  • cause
  • We still do not know the exact answers to these questions and there is much controversy about the cause and effect of aneuploidy related to carcinogenesis. (bmj.com)