• anesthesia
  • This procedure is usually performed under local anesthesia , and can be done by a dermatologist or plastic surgeon on an outpatient basis. (merriam-webster.com)
  • What made you want to look up local anesthesia ? (merriam-webster.com)
  • They are used in various techniques of local anesthesia such as: Topical anesthesia (surface) Topical administration of cream, gel, ointment, liquid, or spray of anaesthetic dissolved in DMSO or other solvents/carriers for deeper absorption Infiltration Brachial plexus block Epidural (extradural) block Spinal anesthesia (subarachnoid block) Iontophoresis Acute pain may occur due to trauma, surgery, infection, disruption of blood circulation, or many other conditions in which tissue injury occurs. (wikipedia.org)
  • The local adverse effects of anesthetic agents include neurovascular manifestations such as prolonged anesthesia (numbness) and paresthesia (tingling, feeling of "pins and needles", or strange sensations). (wikipedia.org)
  • 8. A method of obtaining local anesthesia in mammals as described in claim 7, wherein the weight ratio is 47:53 to 62:38. (google.com)
  • 9. A method of obtaining local anesthesia in mammals as described in claim 8, wherein the weight ratio is 55:45. (google.com)
  • 10. A method of obtaining local anesthesia in mammals as described in claim 8, wherein the weight ratio is 52:48. (google.com)
  • 11. A method of obtaining local anesthesia in mammals as described in claim 8, wherein the weight ratio is 50:50 and the combination also contains an emulsifying agent. (google.com)
  • The present invention relates to a mixture of local anesthetically active compounds in base form in order to obtain topical anesthesia through skin, process for its preparation, and method for obtaining topical local anesthesia. (google.com)
  • The object of the present invention is to obtain a possibility of utilizing local anesthetically active compounds in base form and to obtain a maximal concentration of active substance at the application on skin in order to obtain local anesthesia with as low a dose as can be. (google.com)
  • Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required. (wikipedia.org)
  • lidocaine
  • Anesthetics used for the cystoscopy include lidocaine. (medscape.com)
  • Topical 2% lidocaine (Xylocaine) is a commonly used anesthetic. (medscape.com)
  • Administer local lidocaine sprays into the nostril. (medscape.com)
  • In this multicenter, randomised, placebo-controlled, double-blind trial, hyperalgesia area around the scarce following colorectal laparoscopic surgery (piece removal) will be assessed in 3 groups of patients : group 1: continuous ropivacaine preperitoneal infusion, group 2 : intravenous lidocaine infusion, or group 3 : control group without local anesthetics. (clinicaltrials.gov)
  • 1. A locally active anesthetic agent in the form of a homogenous oil which is useful for topical or parenteral application, consisting essentially of prilocaine in the form of its base in admixture with lidocaine, in the form of its base in a weight ratio of 42:58 to 80:20 such that the resulting mixture is a homogenous oil which has a melting point of below 40 C. (google.com)
  • It is previously known, e.g. by Swedish Patent S/No. 352 239 to produce a local anesthetically active film comprising lidocaine in crystallized, microdisperse form. (google.com)
  • Sodium
  • Local anesthetics reduce impulse transmission by interfering with the mechanism of normal depolarization, binding to specific receptors located at the nerve membrane-more specifically, on the voltage-gated, tetrodoxin-sensitive sodium channel-and resulting in decreased or eliminated permeability to sodium ions, leading to interruption of nerve conduction. (lww.com)
  • Moreover, other factors of pharmacodynamic origin have been implicated, such as antagonistic effects of nucleotides or increased sodium concentration, increased afferent input from nociceptors, or receptor downregulation of the sodium channels, and often the interpretation is quite difficult because of time-dependent variations in pain or circadian changes in the duration of local anesthetic action: phenomena that are named pseudotachyphylaxis (5) . (lww.com)
  • Local anesthetics act on the voltage-gated sodium channels that conduct electrical impulses and mediate fast depolarization along nerves. (wikipedia.org)
  • Local anesthetics also act on potassium channels, but they block sodium channels more. (wikipedia.org)
  • synergistically
  • Small-dose intraspinal local anesthetics, when added to either epidural or intrathecal opioids, synergistically enhance the antinociceptive effects of the opioid dose, as demonstrated by isobolographic analysis (2) , likely because of inhibition of neuronal excitability. (lww.com)
  • ester
  • About one in 3000 white North Americans is homozygotic (i.e. has two copies of the abnormal gene) for the most common atypical form of the enzyme pseudocholinesterase, and do not hydrolyze ester anesthetics such as procaine. (wikipedia.org)
  • Drug
  • Moreover, temporary use of a local anesthetic alone can allow a "drug holiday" when opioid tolerance becomes a limiting factor for treatment. (lww.com)
  • In both the official chemical name and the proprietary name, a local anesthetic drug can be recognized by the '-caine' ending. (libretexts.org)
  • effect
  • The anesthetic effect will be evaluated using a standardized human sensory and pain model. (clinicaltrials.gov)
  • The development of tolerance to morphine is delayed, and the quality of analgesia can be improved because of the morphine-sparing effect of local anesthetics (3) . (lww.com)
  • Effects
  • There is no specific information comparing use of other topical anesthetics in children with use in other age groups, but it is possible that they may also cause unwanted effects in young children. (mayoclinic.org)