• Sickle Cell A
  • The purpose of this study is to determine how often people with sickle cell anemia develop pulmonary hypertension a serious disease in which blood pressure in the artery to the lungs is elevated. (clinicaltrials.gov)
  • Men and women 18 years of age and older with sickle cell anemia may be eligible for this study. (clinicaltrials.gov)
  • blood collection (no more than 50 ml., or about 1/3 cup) to confirm the diagnosis of sickle cell anemia, sickle cell trait or beta-thalassemia (Some blood will be stored for future research testing on sickle cell anemia. (clinicaltrials.gov)
  • To determine the prevalence and prognosis of secondary pulmonary hypertension in adult patients with sickle cell anemia. (clinicaltrials.gov)
  • Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. (clinicaltrials.gov)
  • Acute pain crisis, acute chest syndrome (ACS), and secondary pulmonary hypertension are common complications of sickle cell anemia. (clinicaltrials.gov)
  • Furthermore, pulmonary hypertension is thought to occur in up to 30% of clinic patients with sickle cell anemia. (clinicaltrials.gov)
  • This study is designed to determine the prevalence and prognosis of secondary pulmonary hypertension in adult patients with sickle cell anemia, and to determine whether genetic polymorphisms in candidate genes contribute to its development or response to treatment. (clinicaltrials.gov)
  • Type
  • A type called hypochromic microcytic anemia is characterized by very small erythrocytes that have low hemoglobin concentration and hence poor coloration. (thefreedictionary.com)