• Sickle Cell A
  • The purpose of this study is to determine how often people with sickle cell anemia develop pulmonary hypertension a serious disease in which blood pressure in the artery to the lungs is elevated. (clinicaltrials.gov)
  • Men and women 18 years of age and older with sickle cell anemia may be eligible for this study. (clinicaltrials.gov)
  • blood collection (no more than 50 ml., or about 1/3 cup) to confirm the diagnosis of sickle cell anemia, sickle cell trait or beta-thalassemia (Some blood will be stored for future research testing on sickle cell anemia. (clinicaltrials.gov)
  • To determine the prevalence and prognosis of secondary pulmonary hypertension in adult patients with sickle cell anemia. (clinicaltrials.gov)
  • Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. (clinicaltrials.gov)
  • Acute pain crisis, acute chest syndrome (ACS), and secondary pulmonary hypertension are common complications of sickle cell anemia. (clinicaltrials.gov)
  • Furthermore, pulmonary hypertension is thought to occur in up to 30% of clinic patients with sickle cell anemia. (clinicaltrials.gov)
  • This study is designed to determine the prevalence and prognosis of secondary pulmonary hypertension in adult patients with sickle cell anemia, and to determine whether genetic polymorphisms in candidate genes contribute to its development or response to treatment. (clinicaltrials.gov)
  • disorder
  • Some types of anemia are named for the factors causing them: poor diet ( nutritional anemia ), excessive blood loss ( hemorrhagic anemia ), congenital defects of hemoglobin ( hypochromic anemia ), exposure to industrial poisons, diseases of the bone marrow ( aplastic anemia and hypoplastic anemia ), or any other disorder that upsets the balance between blood loss through bleeding or destruction of blood cells and production of blood cells. (thefreedictionary.com)
  • Type
  • A type called hypochromic microcytic anemia is characterized by very small erythrocytes that have low hemoglobin concentration and hence poor coloration. (thefreedictionary.com)