The best evidence supports 21 ancestries that delineate genetic structure of present-day human populations. (nature.com)
Initial efforts to characterize the movement of early humans in relation to ancestry grouped populations according to five geographical regions: Sub-Saharan Africa, Europe/the Middle East/Central Asia/South Asia, East Asia, Oceania, and the Americas 9 . (nature.com)
Glioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. (elsevierpure.com)
We estimated global and local ancestry using fastStructure and RFMix, respectively, using 1,000 genomes project reference populations. (elsevierpure.com)
Native American2
African genetic ancestry is most strongly correlated with predicted disease risk, whereas European and Native American ancestry show weaker effects. (frontiersin.org)
African Americans and Hispanics in the US have varying proportions of EA, African (AA) and Native American ancestries (NAA). (elsevierpure.com)
Genome-wide2
After attributing a regional and/or continental ancestry to each individual using genome-wide polymorphism data, we are able to capture the effect of different environmental exposures on gene expression and health-related traits, while simultaneously controlling for genetic relatedness and migration. (nature.com)
Within groups with ≥40% AA (AFR ≥0.4 ), and ≥15% NAA (AMR ≥0.15 ), genome-wide association between local EA and glioma was evaluated using logistic regression conditioned on global EA for all gliomas. (elsevierpure.com)
Genetic5
Using the largest multi-locus data set known to date, we investigated genetic differentiation of early modern humans, human admixture and migration events, and relationships among ancestries and language groups. (nature.com)
The goal of this study was to analyze the effect of ethnicity and genetic ancestry on observed disease prevalence and predicted disease risk in Colombia. (frontiersin.org)
Patterns of genetic ancestry and admixture for a cohort of 624 individuals from Medellín were compared to disease risk inferred via polygenic risk scores (PRS). (frontiersin.org)
From ∼ 1000 individuals of a founder population in Quebec, we reveal a substantial impact of the environment on the transcriptome and clinical endophenotypes, overpowering that of genetic ancestry. (nature.com)
Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. (nature.com)
Genomes1
Drawing from this founding population of individuals with largely French ancestry, we selected 1007 individuals to determine mechanisms by which genomes, the environment, and their interactions contribute to phenotypic variation. (nature.com)
Admixture1
By focusing on underlying ancestries rather than samples, confounding due to recent admixture is removed. (nature.com)
Ethnic groups2
Population distributions of Colombia's three major ethnic groups - Mestizo, Afro-Colombian, and Indigenous - were compared to disease prevalence and socioeconomic indicators. (frontiersin.org)
Disease prevalence co-varies across geographic regions, consistent with the regional distribution of ethnic groups. (frontiersin.org)
Gene1
Using a graph-based model of gene flow to estimate migration events from ancestry-specific allele frequencies 37 , we find evidence for migration events in the distant past. (nature.com)
Relationships1
The relationships between ethnicity and disease prevalence do not show an overall correspondence with the relationships between ancestry and disease risk. (frontiersin.org)
Medicine1
We discuss possible reasons for the divergent health effects of ethnicity and ancestry as well as the implication of our results for the development of precision medicine in Colombia. (frontiersin.org)
African1
African ancestry is mostly positively correlated with disease risk, and European ancestry is mostly negatively correlated. (frontiersin.org)
Individuals1
Independent of self-identified ethno-linguistic labels, the vast majority (97.3%) of individuals have mixed ancestry, with evidence of multiple ancestries in 96.8% of samples and on all continents. (nature.com)
Data2
Ancestry data support the grouping of Kwadi-Khoe, Kx'a, and Tuu languages, support the exclusion of Omotic languages from the Afroasiatic language family, and do not support the proposed Dené-Yeniseian language family as a genetically valid grouping. (nature.com)
Ancestry data yield insight into a deeper past than linguistic data can, while linguistic data provide clarity to ancestry data. (nature.com)
Account for admixture1
As such, the results from previous genome-wide association studies that do not account for admixture in their examinations of people with European ancestry should be re-evaluated. (nih.gov)
Genetically2
Ancestry data support the grouping of Kwadi-Khoe, Kx'a, and Tuu languages, support the exclusion of Omotic languages from the Afroasiatic language family, and do not support the proposed Dené-Yeniseian language family as a genetically valid grouping. (nature.com)
The study, published in Nature Communications , shows that people with European ancestry, who were previously treated as a genetically homogenous group in large-scale genetic studies, have clear evidence of mixed genetic lineages, known as admixture. (nih.gov)
Allele1
Using a graph-based model of gene flow to estimate migration events from ancestry-specific allele frequencies 37 , we find evidence for migration events in the distant past. (nature.com)
Local ancestry1
Second, we infer local ancestry (0, 1, or 2 European chromosomes) at each location in the genome and investigate the effects of ancestry proximal to the expressed gene (cis) versus ancestry elsewhere in the genome (trans). (ox.ac.uk)
Proportions2
Here, we analyze gene expression levels in African American cell lines, which differ from previously analyzed cell lines in that individuals from this population inherit variable proportions of two continental ancestries. (ox.ac.uk)
African Americans and Hispanics in the US have varying proportions of EA, African (AA) and Native American ancestries (NAA). (elsevierpure.com)
By reading population genetics papers, we realized that the pattern of genetic makeup in Europe is too detailed to be viewed on a continental level," said Daniel Shriner, Ph.D., staff scientist in the NIH Center for Research on Genomics and Global Health and senior author of the study. (nih.gov)
We show that the specific genetic makeup of northern Europe traces back to migrations from Siberia that began at least 3,500 years ago. (biorxiv.org)
Migration3
Using the largest multi-locus data set known to date, we investigated genetic differentiation of early modern humans, human admixture and migration events, and relationships among ancestries and language groups. (nature.com)
Recently, evidence from ancient DNA has brought new insights into migration events that could be linked to the advent of agriculture, and possibly to the spread of Indo-European languages. (biorxiv.org)
The genetic structure of Europeans today is the result of several layers of migration and subsequent admixture. (biorxiv.org)
Provide1
Ancestry data yield insight into a deeper past than linguistic data can, while linguistic data provide clarity to ancestry data. (nature.com)
Population2
What is clear based on our analysis, is when data from genetic association studies of people of European ancestry are evaluated, researchers should adjust for admixture in the population to uncover true links between genomic variants and traits. (nih.gov)
When the researchers considered the genetic admixture of the European population in their analysis, they found that the genomic variant that gives people the ability to digest lactose is not linked to height or level of low-density lipoprotein cholesterol. (nih.gov)
History1
European history has been shaped by migrations of people, and their subsequent admixture. (biorxiv.org)
Highly1
As an example, the researchers investigated the lactase gene, which encodes a protein that helps digest lactose and is highly varied across Europe. (nih.gov)