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Chromosome AberrationsAnaphaseChromosomesChromosome MappingKaryotypingChromosome BandingSister Chromatid ExchangeChromosomes, HumanIn Situ Hybridization, FluorescenceSex Chromosome AberrationsX ChromosomeChromosomes, Human, Pair 1Chromosome DisordersMicronucleus TestsMutagenicity TestsChromosome SegregationChromosome PaintingMetaphaseChromosomes, Human, Pair 11Chromosomes, Human, Pair 7Sex ChromosomesMutagensAneuploidyChromosome DeletionNuclear WarfareCorneal Wavefront AberrationCytogeneticsTranslocation, GeneticCytogenetic AnalysisChromosomes, Human, Pair 13MitosisAmericiumLymphocytesChromosomes, Human, Pair 17Chromosome BreakageChromosomes, BacterialChromosomes, Human, Pair 4ChromatidsRadiation GeneticsChromosomes, Human, Pair 6TriethylenemelamineMicronuclei, Chromosome-DefectiveChromosomes, Human, Pair 9Chromosomes, FungalChromosomes, Human, Pair 21Linear Energy TransferChromosomes, Human, Pair 18Chromosomes, PlantChromosomes, Human, 6-12 and XChromosomes, Human, Pair 16Chromosomes, Human, Pair 2Chromosomes, Human, Pair 8Chromosome PairingChromosomes, Human, Pair 22Chromosomes, MammalianChromosomal InstabilitySpindle ApparatusMutationDNA DamageChromosomes, Human, Pair 10Chromosomes, Human, Pair 19Chromosomes, Human, Pair 12Chromosomes, Human, YTrisomyChromosomes, Artificial, BacterialChromosomes, Human, Pair 5Chromosomes, Human, 1-3Chromosomes, Human, XDose-Response Relationship, RadiationChromosomes, Human, Pair 14Background RadiationChromosomes, Human, Pair 20Azure StainsMitotic IndexRadioactive Hazard ReleaseChromosomes, Human, Pair 15MosaicismCentromereStyrenesGenetic MarkersAlpha ParticlesAberrometryChromosomes, Human, 16-18HempaGamma RaysInterphaseKazakhstanChromosomes, Artificial, YeastRelative Biological EffectivenessChromosomes, Human, 13-15Cell Cycle ProteinsIsochromosomesGenetic LinkageArmeniaMeiosisNucleic Acid HybridizationChromosome InversionChromosomes, Human, 21-22 and YCricetinaeMolecular Sequence Data
MitosisHomologous chromosomesCentromereMicronucleus testsSegregation ErrorsInstabilitySingle chromosomeAbnormalitiesTelomereMutationsDiploid cellAneuploidyChromatidMetaphaseHerbicidesAbnormalInversionBridgesFragmentsDerivativeAlliumDrosophilaPairsStructuralCancerReplicationSterilityGenesGeneticAlterationsCellsMechanismsLymphocytesBreaksMeiosisBehaviorRecombinationEvidenceIncludeDiseaseRegionStructureAnalysis
Mitosis5
Homologous chromosomes2
Centromere3
Micronucleus tests1
  • A study carried out at a pilot plant for drinking water disinfection of lake water revealed mutagenic activity of three different disinfectants (sodium hypochlorite, chlorine dioxide and peracetic acid) in different seasons using in situ mutagenicity assays, both in animal (micronucleus test) and in plant organisms (anaphase chromosomal aberration and micronucleus tests). (scirp.org)
Segregation Errors2
Instability3
  • The Immunodeficiency, Centromeric region instability, Facial anomalies syndrome (ICF) is a rare autosomal recessive disease described in about 50 patients worldwide and characterized by immunodeficiency, although B cells are present, and by characteristic rearrangements in the vicinity of the centromeres (the juxtacentromeric heterochromatin) of chromosomes 1 and 16 and sometimes 9. (biomedcentral.com)
  • A persistent high frequency of these errors (chromosomal instability (CIN)) is predicted to profoundly impact tumor evolution and therapy response. (nature.com)
  • Chromosome instability (CIN) is an increased rate where chromosome acquire alterations due to errors in cell division. (encyclopedia.pub)
Single chromosome2
  • As previously stated, the disruptions in the chromosome may lead to single chromosome mutations, including deletion, duplication and inversion, among others. (wikipedia.org)
  • In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1). (lookformedical.com)
Abnormalities5
  • Changes in the structure or quantity of chromosomes , which are strands of condensed genetic material, are known as chromosomal aberrations or abnormalities. (schleiden-eifel.de)
  • However, within populations there can be found abnormalities involving the structure or number of chromosomes . (schleiden-eifel.de)
  • Their frequency depends on the concentration and the duration of treatment, i.e., increasing concentration and duration of treatment leads to a parallel increase in the frequencies of chromosome abnormalities [ 1 ]. (jabonline.in)
  • Since Boveri's theory that chromosome abnormalities promote cancer, studies have attempted to elucidate the mechanisms behind the origins of chromosomal aberrations [ 1 ] . (encyclopedia.pub)
  • Depending on the type of abnormalities, it can be classified into numerical CIN (nCIN), characterized by chromosome gains and losses, and structural CIN (sCIN) represented by chromosome translocations [ 2 ] . (encyclopedia.pub)
Telomere1
Mutations1
  • By contrast, the frequency of point mutations is less than 2-fold greater. (uchicago.edu)
Diploid cell1
  • If a normal diploid cell is 2n, the chromosome content of a double tetrasomic cell is designated. (schleiden-eifel.de)
Aneuploidy2
  • usually, at least one of the parents shows an elevated PCD frequency (range 12.6-42.5) but not variegated aneuploidy. (atlasgeneticsoncology.org)
  • examples include aneuploidy (atypical chromosome number), deletion (loss of part of a chromosome), duplications (extra copies of a region of a chromosome), inversion (when part of a chromosome breaks off and reattaches in reverse. (schleiden-eifel.de)
Chromatid1
  • Much of this DNA hypomethylation is in 1qh, 9qh, and 16qh, regions that are the site of whole-arm deletions, chromatid and chromosome breaks, stretching (decondensation), and multiradial chromosome junctions in mitogen-stimulated lymphocytes. (biomedcentral.com)
Metaphase1
Herbicides1
Abnormal1
Inversion3
  • The Precise Breakpoint Mapping in Paracentric Inversion 10q22.2q23.3 by Comprehensive Cytogenomic Analysis, Multicolor Banding, and Single-Copy Chromosome Sequencing. (metasystems-probes.com)
  • These are some of the most common cytogenetically visible rearrangements in humans - for example , the pericentric inversion of chromosome 9 is found in over. (schleiden-eifel.de)
  • A comparison of human and chimpanzee genes in the region of this inversion indicates that two genes-ROCK1 and USP14-that are adjacent on chimpanzee chromosome 17 (which corresponds to human chromosome 18) are more distantly positioned on human chromosome 18. (schleiden-eifel.de)
Bridges3
  • Chromatin bridges are easiest and most readily visible when observing chromosomes stained with DAPI. (wikipedia.org)
  • The herbicide was highly mito-inhibitory and induced chromosomal irregularities, such as stickiness, lagging, scattering, and chromosome bridges. (jabonline.in)
  • The low density and small size of these bridges, and aneuploid chromosome number biologically persistent particles makes respiratory were observed. (cdc.gov)
Fragments1
  • The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. (lookformedical.com)
Derivative1
Allium2
  • Therefore plants ( Allium cepa for chromosomal aberration test and Vicia faba for micronucleus test) were exposed to the same disinfected lake-water samples at different temperatures (10℃, 20℃ and 30℃), according the ones registered during the in situ experiment. (scirp.org)
  • Treatment of CMQW by bacterial isolate detoxified Cr(VI) minimizing chromosomal aberrations in root cells of Allium cepa L., suggesting the role of Rhizobium pusense CR02 as a promising bio-agent for Cr(VI) detoxification. (researchsquare.com)
Drosophila1
  • These data support a model in which Tum/RacGAP, via its interaction with Pbl, provides a critical link between the anaphase microtubule spindle and cytokinetic furrow formation in Drosophila cells. (biologists.com)
Pairs2
Structural2
Cancer1
  • Thousands of chromosomal aberrations have been discovered in different types of cancer. (schleiden-eifel.de)
Replication2
  • An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional. (lookformedical.com)
  • A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. (lookformedical.com)
Sterility1
  • B. This chromosomal aberration tends to manifest in males in the form of absent or delayed puberty, sterility, development of breast, etc. (schleiden-eifel.de)
Genes4
  • This occurs because loss of these genes causes an increase in chromosome fusions, either in an end-to-end manner or through topological entrapment (e.g., catenation or unresolved DNA cross-links), have also been associated with chromatin bridge formation. (wikipedia.org)
  • Calculate the recombination frequency between the A and L genes. (collepals.com)
  • Using the first nine offspring in generation III only (1-9), determine the recombination frequency between these two genes. (collepals.com)
  • Because even small segments of chromosomes can span many genes, chromosomal disorders are characteristically dramatic and often fatal. (schleiden-eifel.de)
Genetic2
  • Multicolor banding, chromosomal microarray analysis, chromosome microdissection with reverse painting, and single-copy sequencing of the rearranged chromosome were performed to determine the length and position of the inverted region as well as to rule out a genetic imbalance at the breakpoints. (metasystems-probes.com)
  • Possible approaches for cytogenomic assessment of couples with balanced chromosome rearrangements and problems like reproductive failures were considered and suggested as useful part of effective genetic counseling. (metasystems-probes.com)
Alterations1
  • The current investigation was carried out to study the effects of IM on the early growth parameters of chickpea seedlings, especially chromosomal aberrations and biochemical alterations. (jabonline.in)
Cells8
  • A high frequency of MN was observed in the TK6 cells after a short exposure (3 h) in the presence of S9 and a long exposure (26 h) without S9. (metasystems-probes.com)
  • Each cell (except for red blood cells) contains a nucleus that houses these chromosomes. (cdc.gov)
  • This premise is based on the fact that as the mitotic cell divides and the daughter cells move further apart, stress on the DNA bridge leads to breakages in the chromosome at random points. (wikipedia.org)
  • Anaphase II (draw all cells and make sure you include the crossover results). (collepals.com)
  • To overcome the limitations brought upon by cellular fixation, membrane-permeant DNA fluorophores were designed to stain DNA stoichiometrically in live-cells (supravital staining), enabling both the quantification of DNA content and the ability to track the movement of chromosomes over time. (biomedcentral.com)
  • The frequency of ICF cells with chromosomal aberrations seems to increase with passage number, 3,4,40 although this is not a consistent finding. (schleiden-eifel.de)
  • From the cytologic point of view, observations demonstrated that the mitotic frequency in root meristematic cells diminished, and that abnormality frequency increased parallel to the increase in concentrations of IM. (jabonline.in)
  • A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. (lookformedical.com)
Mechanisms1
  • Chromosomal aberrations and their mechanisms have been studied for many years in livestock. (schleiden-eifel.de)
Lymphocytes1
  • We found significant increases in the MN frequency and induced chromosomal aberrations in the lymphocytes of only one donor after ethyl-paraben exposure in the presence of S9 after a short exposure. (metasystems-probes.com)
Breaks1
Meiosis1
  • Our previous research showed that the mutant ( ny1 ) of LOC_Os07g32406 ( NY1 ), which was generated by CRISPR/Cas9 knock-out in neo-tetraploid rice, showed low pollen fertility, low seed set, and defective chromosome behavior during meiosis. (biomedcentral.com)
Behavior1
  • The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed the enormous progress in our understanding of the nature and behavior of chromosomes during the life cycle of the cell. (cshlpress.com)
Recombination1
Evidence1
  • Using one sentence for each example, explain five lines of evidence in support of the chromosome theory of heredity. (collepals.com)
Include1
  • Anaphase I (make sure you include the results of the crossover described above). (collepals.com)
Disease1
Region1
  • Tumor-treatment fields (TTFields) consist of low-intensity, intermediate-frequency, and alternating electric fields that are delivered to the tumor region by noninvasive arrays. (conditionmed.org)
Structure1
  • In an organism, any visible abnormality in chromosome number or structure from the diploid set is known as chromosomal aberration . (schleiden-eifel.de)
Analysis1