• neurons
  • Synapses were observed on the type 2 neurons, with nerve fibres originating from the intraganglionic spiral bundle. (diva-portal.org)
  • Protein Cx43 stained weakly in the spiral ligament, but intense staining in the SG may indicate that gap junctions exist between these neurons. (diva-portal.org)
  • Autapses are considered in a local area of regular network of neurons to investigate the development of spatiotemporal pattern, and emergence of spiral wave is observed while it fails to grow up and occupy the network completely. (jove.com)
  • The developed spiral wave with self-sustained property can regulate the collective behaviors of neurons as a pacemaker. (jove.com)
  • sensory
  • Integrated annotation and analysis of in situ hybridization images using the ImAnno system: application to the ear and sensory organs of the fetal mouse. (jove.com)
  • This study was carried out in 25 tissues of late gestation embryos (E14.5), with a special emphasis on the developing ear and on five distinct developing sensory organs, including the cochlea, the vestibular receptors, the sensory retina, the olfactory organ, and the vibrissae follicles. (jove.com)
  • These analyses exemplify an under-represention of "sensory" functions in the sensory gene set suggests that E14.5 is a pivotal stage between the developmental stage and the functional phase that will be fully reached only after birth. (jove.com)
  • In all mammals, the sensory epithelium for audition is located along the spiraling organ of Corti that resides within the conch shaped cochlea of the inner ear (fig 1). (jove.com)
  • There are certainly a few well documented instances of sclerotic lesions directly obliterating sensory structures within the cochlea and spiral ligament, which have been photographed and reported post-mortem. (wikipedia.org)
  • We found that the undamaged chick cochlea contains a large resting population of macrophages that reside in the hyaline cell region, immediately outside the abneural (inferior) border of the sensory epithelium. (jove.com)
  • membrane
  • Live NTHI was injected into the murine middle ear through the tympanic membrane, and histological analysis was performed after harvesting the temporal bones. (biomedcentral.com)
  • However, we did find that macrophage-depleted cochleae contained reduced numbers of proliferative mesothelial cells below the basilar membrane. (jove.com)
  • cochlear tissue
  • Western blot analysis in cochlear tissue with the same antibodies used in the immunohistochemistry demonstrated a predominant 40 and 45 kDa proteins corresponding to the molecular mass of Gsalpha, 41 kDa protein for Gialpha and 39 kDa for Goalpha. (nii.ac.jp)
  • This thesis presents results of analyses of human cochlear tissue and specimens obtained during neurosurgical transpetrosal removal of life-threatening meningeomas. (diva-portal.org)
  • human cochlea
  • KIAA1199 was later identified by cDNA microarray analysis as a cochlea-specific gene that was abundantly expressed in the human cochlea [ 4 ], and the protein it encodes has been found to play a central role in hyaluronan binding and depolymerization [ 5 ]. (hindawi.com)
  • Our knowledge of the fine structure of the Human Spiral Ganglion (HSG) is still inadequate and new treatment techniques for deafness using electric stimulation, call for further information and studies on the neuronal elements of the human cochlea. (diva-portal.org)
  • The immunostaining patterns of the tight junctional protein ZO-1 and the gap junctional proteins Cx26 and Cx43 in the human cochlea were also studied. (diva-portal.org)
  • In the immunohistochemical studies on the human cochlea, ZO-1 was expressed in tissues lining scala media, thus contributing to the formation of a closed compartment system, important for the maintenance of the specific ionic composition of the endolymph. (diva-portal.org)
  • auditory system
  • Hair cells in the developing cochlea, which are the mechanosensory cells of the auditory system, are aligned in one row of inner hair cells and three (in the base and mid-turns) to four (in the apical turn) rows of outer hair cells that span the length of the organ of Corti. (jove.com)
  • basal
  • The barrier composed of tight junctions between strial basal cells was disrupted in the gw/gw cochlea as indicated by a biotin tracer permeability assay. (wiley.com)
  • The mechanosensory hair cells are aligned in one row of inner hair cells and three rows of outer hair cells that extend along the basal to apical axis of the cochlea. (jove.com)
  • organ
  • The accompanying video includes stepwise directions for the isolation of the temporal bone from mouse pups, and subsequent isolation of the cochlea, spiral ligament, and organ of Corti. (jove.com)
  • patterns
  • 1.Patterns of immunostaining in the guinea pig cochlea using anti-G-protein (Gsalpha, Gialpha, Goalpha) antibodies were compared. (nii.ac.jp)
  • Expression analysis of KIAA1199 protein in the cochlea has been performed in mice and rats [ 1 , 11 ], where different distribution patterns for each species were described, suggesting the possibility of an even greater difference in primates. (hindawi.com)
  • neuronal
  • Guinea pigs treated with adenoviral neurotrophin-gene therapy had greater neuronal survival compared to contralateral non-treated cochleae when examined at 7 and 11 weeks post injection. (jove.com)
  • connexin
  • For example, in a patient with connexin 26-related deafness, a common cause of non-syndromic deafness, the spiral ganglion was observed to be preserved, suggesting the feasibility of cochlear implantation in this important patient population (Jun et al. (aro.org)
  • bundle
  • D1 and D2 immunolabeling was localized to cochlear nerve fibers, near the first nodes of Ranvier (D2) and in the inner spiral bundle region (D1 and D2) where presynaptic olivocochlear terminals are found. (jneurosci.org)
  • protein
  • In the common marmoset cochlea, KIAA1199 protein expression was more widespread than in rodents, with all epithelial cells, including hair cells, expressing KIAA1199. (hindawi.com)
  • We therefore examined expression of KIAA1199 protein by immunohistochemistry in cochlea from a nonhuman primate, the common marmoset ( Callithrix jacchus ). (hindawi.com)
  • oval
  • The best understood mechanism is fixation of the stapes footplate to the oval window of the cochlea. (wikipedia.org)
  • temporal bones
  • 1995). Retrospective studies of aminoglycoside ototoxicity in human temporal bones showed reduction of both hair cell and spiral ganglion cell populations. (aro.org)
  • Analysis of these temporal bones has yielded several key insights. (aro.org)
  • hair cell
  • Cochlear synaptic loss progresses from youth (4 weeks) to old age (144 weeks) and is seen throughout the cochlea long before age-related changes in thresholds or hair cell counts. (jneurosci.org)
  • loss
  • The primary form of hearing loss in otosclerosis is conductive hearing loss (CHL) whereby sounds reach the ear drum but are incompletely transferred via the ossicular chain in the middle ear, and thus partly fail to reach the inner ear (cochlea). (wikipedia.org)
  • found
  • P-gp was found only in the capillary endothelial cells of the cochlea and vestibule. (nii.ac.jp)
  • 1996) found the 4977-bp mtDNA deletion in patients with presbycusis, demonstrating that specific mtDNA defects from a single cochlea can be correlated with pathological processes. (aro.org)
  • It is found that spiral wave can be induced to occupy more area in the network under optimized noise on the network with periodical or no-flux boundary condition being used. (jove.com)
  • samples
  • Each single RNA specimen for transcriptomic analysis was obtained by combining 10 cell microdissected samples, followed by RNA extraction using the Pico Pure RNA Isolation Kit (Arcturus). (jove.com)
  • cells
  • D4 was detected in spiral ganglion cells only. (jneurosci.org)
  • The dissected cells can be used for a variety of investigations, such as transcriptomic or proteomic studies, DNA assessment or chromosomal analysis 2,3 . (jove.com)
  • An especially challenging application of LMD is transcriptome analysis, which, due to the lability of RNA 4 , can be particularly prominent when cells are dissected from tissues that are rich of RNases, such as the pancreas. (jove.com)
  • The cochlea contains many thousands of hair cells organized in extensive arrays, embedded in an electrically coupled system of supporting cells. (royalsocietypublishing.org)
  • The avian cochlea contains a population of resident macrophages, but the precise function of those cells is not known. (jove.com)
  • results
  • The results obtained from an analysis of more than 11,000 micrographs have been integrated in a newly developed knowledgebase, called ImAnno. (jove.com)
  • method
  • Localization of the electrode after cochlear implantation seems to have an impact on auditory outcome, and conebeam CT has emerged as a reliable method for visualizing the electrode array position within the cochlea. (ajnr.org)
  • noise
  • The ISO standard 7029 shows expected threshold changes due purely to age for carefully screened populations (i.e. excluding those with ear disease, noise exposure etc.), based on a meta-analysis of published data. (wikipedia.org)
  • The network keeps ordered state when self-sustained spiral wave is formed under noise and autapse in local area of network, and it independent of the selection of periodical or no-flux boundary condition. (jove.com)