Analysis yersinia pestis. Medical search. Frequent questions

Until recently, it was not certain whether the bacterium Yersinia pestis -- known to cause the plague today -- was responsible for that most deadly outbreak of disease ever. (sciencedaily.com)
June 15, 2022 The Black Death, the biggest pandemic of our history, was caused by the bacterium Yersinia pestis and lasted in Europe between the years 1346 and 1353. (sciencedaily.com)
During the analysis, plague bacterium, Yersinia pestis was detected in all three individuals," he said. (newsweek.com)
The Black Death is believed to have been the result of plague caused by infection with the bacterium Yersinia pestis . (britannica.com)
Analysis revealed that both had died of the plague - caused by a bacterium called Yersinia pestis - and that the same strain had infected them. (cosmosmagazine.com)
A 1999 paper used a genetic analysis to conclude that Y. pestis had evolved from a related bacterium, Yersinia pseudotuberculosis , between 1500 and 20,000 years ago. (cosmosmagazine.com)
Some researchers have suggested that the epidemic was caused by a virus such as Ebola , but an analysis of DNA from a London plague pit seems to settle the argument in favour of the "plague" bacterium Yersinia pestis . (newscientist.com)
To pick out the signature of Y. pestis , Poinar's team took DNA from a modern strain and made a molecular "probe" that would bind to DNA from this type of bacterium. (newscientist.com)
The Black Death was the second pandemic of the bacterium Y. pestis ("plague") in the eastern hemisphere, i.e. (ursinus.edu)
Furthermore, while COVID-19 is a human disease, the Y. pestis bacterium is enzootic and affects both humans and other mammals. (ursinus.edu)
Although people have been debating about what the real cause of the Black Death is, a scientific journal called PLoS Pathogens publish a paper showing that the pathogen responsible for the Black Death in northern and southern Europe is the Yersinia pestis bacterium (Originally called Pasteurella pestis, the organism had been renamed in 1967 to Yersinia pestis), which had most likely caused many plagues. (123helpme.com)
The bacterium that caused the bubonic plague is called Yersinia pestis. (123helpme.com)
The plague, an infectious disease caused by the bacterium Yersinia pestis , is widely considered to be responsible for the most devastating and deadly pandemics in human history. (medrxiv.org)
Three studies have shown that this bacterium emerged from the gut pathogen Yersinia pseudotuberculosis shortly after the first epidemic. (medscape.com)
The virulence of this bacterium results from the 32 Y pestis chromosomal genes and two Y pestis -specific plasmids, constituting the only new genetic material acquired since its evolution from its predecessor. (medscape.com)

We compare all five currently sequenced Y. pestis genomes and the corresponding features in Yersinia pseudotuberculosis . (asm.org)
It was shown that Y. pestis recently diverged from Yersinia pseudotuberculosis , an enteropathogen, and likely comprises a clonal lineage ( 1 , 3 , 37 , 40 ). (asm.org)
The phages exhibited relatively wide host ranges among Yersinia pseudotuberculosis and related species. (mdpi.com)
The genus Yersinia harbours three pathogenic species associated with plague ( Y. pestis ) and yersiniosis ( Y. enterocolitica and Y. pseudotuberculosis ) [ 3 ]. (biomedcentral.com)

Yersinia pestis , the causative agent of bubonic and pneumonic plagues, has undergone detailed study at the molecular level. (asm.org)
Laboratory mice are well known to be highly susceptible to virulent strains of Yersinia pestis in experimental models of bubonic plague. (pasteur.fr)
NEW YORK (GenomeWeb) - By sequencing two Late Bronze Age Yersinia pestis isolates, a team from Germany, Russia, China, and Switzerland has gleaned additional insights into the history of the notorious pathogen behind the bubonic plague. (genomeweb.com)
A phylogenetic analysis of the strains, set alongside 177 available modern and ancient Y. pestis sequences, suggested that they belonged to a previously undocumented lineage that emerged roughly 4,000 years ago, but already contained the virulence factors that set bubonic plague apart from more innocuous bacteria. (genomeweb.com)
His Yersinia pestis research includes themes of Zoology, Plague, Outbreak, Bubonic plague and Central Highlands. (research.com)
His Case fatality rate research incorporates themes from Bubonic plague, Pneumonic plague, Yersinia pestis and Pediatrics. (research.com)
Marshall et al (1967) has described an asymptomatic pharyngeal carrier state of Y pestis infection in patients with bubonic plague. (medscape.com)
There is strong evidence that Yersinia pestis , the cause of bubonic plague, led to the positive selection of FMF-associated MEFV mutations. (msdmanuals.com)

We found 453 single nucleotide polymorphisms in protein-coding regions, which were used to assess the evolutionary relationships of these Y. pestis strains. (asm.org)
The results presented here clearly demonstrate the differences between the two biovar antiqua lineages and support the notion that grouping Y. pestis strains based strictly on the classical definition of biovars (predicated upon two biochemical assays) does not accurately reflect the phylogenetic relationships within this species. (asm.org)
A comparison of four virulent Y. pestis strains with the human-avirulent strain 91001 provides further insight into the genetic basis of virulence to humans. (asm.org)
Y. pestis strains have historically been classified according to their ability to utilize glycerol and reduce nitrate and have been grouped into three main subtypes or biovars: antiqua, medievalis, and orientalis. (asm.org)
Modern genetic analysis shows that the strain of Y. pestis introduced during the Black Death is the ancestor to all existing Y. pestis strains known to cause disease in humans. (britannica.com)
Previous studies have identified Y. pestis strains from older sources, yielding different estimates for when the strain emerged. (cosmosmagazine.com)
The family of Enterobacteriaceae comprises a multitude of pathogenic strains from the genera Salmonella , Yersinia , Klebsiella and Escherichia . (biomedcentral.com)
Genome assemblies for 11 Yersinia pestis strains isolated in the Caucasus region. (pacb.com)

Bos and her colleagues retrieved Y. pestis remains from the corpses and sequenced the genomes. (cosmosmagazine.com)
Analysis of microbial genomes has contributed to the development of new antibiotics, diagnostic tools, vaccines, medical treatments, and environmental cleanup techniques. (americascupmagazine.com)
All archaeal and many bacterial genomes contain Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR-associated ( cas ) genes that have been previously implicated in a novel form of DNA repair on the basis of comparative analysis of their protein product sequences. (biomedcentral.com)
Ancient Yersinia pestis and Salmonella enterica genomes from Bronze Age Crete. (mpg.de)

114 Y. pestis isolates were screened. (usf.edu)
Our Y. pestis isolates from around 4,000 years ago possessed all the genetic characteristics required for efficient flea transmission of plague to rodents, humans, and other mammals," first author Maria Spyrou, an archaeogenetics researcher affiliated with Max Planck Institute and the University of Tübingen, said in a statement. (genomeweb.com)
Even so, an analysis of Bronze Age isolates sequenced by the University of Copenhagen's Eske Willerslev and colleagues in 2015 indicated that those early Eurasian isolates had many known virulence factors but did not contain genetic features compatible with routine transmission to humans via fleas. (genomeweb.com)
Their phylogenetic analysis indicated that the isolates in RT5 and RT6 were part of a shared lineage stemming from an ancestor that also led to the pathogens contributing to Black Death, the Justinian Plague, and 19th century plague epidemics in China. (genomeweb.com)
R2: 5-GGT GCC AGT TTC AGT AAC AC-3 (positions studies comprising a total of 77 and 260 Y. pestis isolates, 170402-170383) for initial PCR and glpD-F3: 5-CGC respectively, of the 4 biotypes ( 8,9 ). (cdc.gov)

Study on Yersinia-like bacteria in the plague natural foci of Hebei province [J]. Chines Journal of Vector Biology and Control, 2017, 28(6): 586-588. (bmsw.net.cn)
The Black Death was a plague caused by the bacteria Yersinia pestis that first entered the Mediterranean via trade ships, and proceeded to rapidly spread across Europe, Northern Africa and the Middle East in the 1300s. (newsweek.com)
The Black Death was a plague caused by the bacteria Yersinia pestis that first entered the Mediterranean via trade ships. (newsweek.com)
But unknown to the sailors, dockworkers, and the locals in Dorset County, the ship was infested with a nasty bacteria called Yersinia pestis, also known as the Black Death. (thedailybell.com)
The disease is caused by the plague bacillus, rod-shaped bacteria referred to as Yersinia pestis . (medscape.com)
Yersinia is named in honor of Alexander Yersin, who successfully isolated the bacteria in 1894 during the pandemic that began in China in the 1860s. (medscape.com)

The causative agent, Yersinia pestis , primarily infects a wide range of rodents and is transmitted via flea vectors. (asm.org)
They use similar documentation to argue that individuals were well-versed in symptoms of the plague and recognized it immediately when it showed up in a village, but they then discount this recognition when it comes to the actual discovery of the putative causative agent of the plague, Y. pestis , in 1894, or even to the 1720 Marseille outbreak I mentioned in the previous post. (scienceblogs.com)
The substrate-binding protein YfeA (also known as YPO2439 or y1897) is a polyspecific metal-binding protein that is crucial for nutrient acquisition and virulence in Yersinia pestis, the causative microbe of plague. (uky.edu)
The causative agent, Yersinia pestis , was dis- second amplified and sequenced target should confirm any covered at the beginning of the ongoing third pandemic. (cdc.gov)
Yersinia pestis, the causative agent of plague, is endemic to the Caucasus region but few reference strain genome sequences from that region are available. (pacb.com)

Without a doubt, the plague pathogen known today as Y. pestis was also the cause of the plague in the Middle Ages," says Krause, who is well known for his DNA sequencing of ancient hominin finds, which help trace relationships between types of prehistoric man and modern humans. (sciencedaily.com)

While many involved materials not on the select agent list, several did involve the use of select agents and toxins, including Bacillus anthracis (anthrax), ricin toxin, Yersinia pestis (plague), botulinum toxin, and Burkholderia mallei (glanders)-which cause disease in both animals and humans. (nationalacademies.org)
It can harbor fleas infected with Yersinia pestis, the plague bacillus. (medscape.com)

Biomarkers are currently being used to detect various forms of cancer as well as infections caused by pathogens such as Yersinia pestis and Vaccinia virus . (americascupmagazine.com)

Yersinia pestis contains genes relating to aerobactin, but they have been inactivated by a frameshift mutation, thus Y. pestis is no longer able to synthesize aerobactin. (wikipedia.org)
Comparative-genomic analysis of CRISPR and cas genes leads to the hypothesis that the CRISPR-Cas system (CASS) is a mechanism of defense against invading phages and plasmids that functions analogously to the eukaryotic RNA interference (RNAi) systems. (biomedcentral.com)

His primary areas of study are Genetics, Microbiology, Yersinia pestis, Burkholderia pseudomallei and Genome. (research.com)

In this study, we undertook extensive genome-wide comparative analyses of twelve species that conform the Pectobacterium genus. (mdpi.com)

The analyses unveiled a noteworthy heterogeneity in the pathogenicity determinants. (mdpi.com)
Our analysis provides evidence of functional loss due to mutation and deletion, coupled with pathogenic specialization through the acquisition of bacteriophage encoding a phospholipase A(2) toxin, and four superantigens, and an integrative conjugative element carrying a novel iron acquisition system with similarity to the high pathogenicity island of Yersinia pestis. (st-andrews.ac.uk)

A 93-bp deletion from the Y. pestis glp D gene encoding the glycerol-3-phos- phate dehydrogenase determines lack of glycerol fermen- tation of the Orientalis biotype ( 8,9 ). (cdc.gov)
[ 1 ] Three biovars (with minor genetic variations) have been identified within the Y pestis clone-Antiqua, Medievalis, and Orientalis. (medscape.com)

Genome-wide analysis of the early Neolithic mass-grave individuals from Talheim, Germany. (eurac.edu)

Here, we present an analysis of the 1630-31 plague outbreak in the city of Venice, using newly collected daily death records. (medrxiv.org)

Sequencing and analysis of the ( pla ) gene, located on plasmid pPCP1, the answers. (cdc.gov)

Although human disease is rare, Y. pestis is dangerous and highly infectious and thus has been identified as having potential for use in bioterrorism or as a biological weapon. (asm.org)
The ability for plague to be spread by aerosols makes Y pestis a potential agent of bioterrorism. (medscape.com)

Not only Yersinia pestis was detected in all three samples, but the high coverage of two samples allowed us to determine their evolutionary position on the phylogenetic tree. (newsweek.com)
Genetics, Phylogenetics, Phylogenetic tree, Yersinia pestis and Ecology are his primary areas of study. (research.com)

Starting with tooth samples from nine ancient individuals buried in a Russian tomb in the Smara region, Spyrou and colleagues identified two Y. pestis -infected individuals, who appeared to belong to the Srubnaya culture based on their own genetic profiles. (genomeweb.com)

Tropheryma whipplei Twist: a human pathogenic PCR assays for Y. pestis detection that endemic to central Europe. (cdc.gov)

Study on variability of Yersinia pestis in plague natural foci of Hebei province, China [J]. Chines Journal of Vector Biology and Control, 2018, 29(1): 100-102. (bmsw.net.cn)

Genetical analysis using bioinformatical tools designed for ancient DNA will be used to infer the individuals' genetical sex, kinship structure to the familiar level, and population genetics to discern their genetic affinity to other ancient and modern populations. (eurac.edu)
His research related to Genotyping, Phylogenetics, Multiple Loci VNTR Analysis, Single-nucleotide polymorphism and Genotype might be considered part of Genetics. (research.com)

The study also raises new questions about the prevalence and historical spread of Y. pestis lineages, senior author Johannes Krause, director of archaeogenetics at the Max Planck Institute for the Science of Human History and archaeological sciences researcher at the University of Tübingen, said in a statement. (genomeweb.com)

The SEG strain therefore offers an invaluable opportunity to unravel mechanisms and underlying genetic factors of resistance against Y. pestis infection. (pasteur.fr)
2 ). When using different molecular targets and the dental anthropologic and macroscopic evidence of infection) for pulp as a suitable specimen, we detected Y. pestis -specific every 3 specimens. (cdc.gov)
This was reported as the sole presentation of Y pestis infection in 4 of 27 patients in a case series published in 1992. (medscape.com)

from 3 skeletons in Marseille were processed for the Yersinia pestis DNA was recently detected in human search for Y. pestis DNA in the dental pulp. (cdc.gov)

Then they used a magnet to fish out the chips, which carried bacterial DNA belonging to a strain of Y. pestis unlike any known today. (newscientist.com)

Though they note that the time from appearance of symptoms to death averaged around 5 days (which fits in quite well with Y. pestis ), they argue that victims only became symptomatic after a long incubation period (~32 days) during which they were infectious but asymptomatic. (scienceblogs.com)
Hendrik Poinar at McMaster University in Hamilton, Ontario, Canada, and colleagues developed a technique to look for Yersinia DNA in the bones of Black Death victims. (newscientist.com)
The findings are the first confirmation that these Black Death victims were infected with Y. pestis , Poinar says. (newscientist.com)

Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. (asm.org)
Regulatory sequence analysis revealed that the gene units of both defensin 1 and defensin 2 in body lice possess decreased numbers of transcription factor-binding sites but increased numbers of microRNA binding sites, suggesting relatively lower transcription activities of body louse defensins. (bvsalud.org)

Antibiotic therapy of plague is hampered by the recent isolation of Yersinia pestis strain resistant to all of antibiotics recommended for cure. (usf.edu)

Computational analyses showed that although the SNP at the position 149 has a very minimal effect of the intrinsic disorder propensity of YopT proteins, whereas the N-terminal truncations of the YopT detected in bv. (usf.edu)
A recent and developing proteomic analysis relies on identifying proteins called biomarkers, whose expression is affected by the disease process. (americascupmagazine.com)
The production of 27 of these putative proteins was confirmed by mass spectrometry analysis. (frontiersin.org)

It has been argued that each of the biovars was associated with one of the plague pandemics ( 14 , 20 , 34 ), and recent studies have tried to provide direct evidence of whether Y. pestis was associated with any of the historical pandemics ( 15 , 44 ). (asm.org)

We now have the tools to confirm and expand the archaeological and anthropological knowledge by extending human history with molecular and genetic analyses. (eurac.edu)
The trouble with genetic analyses of diet from archaeological dental calculus. (mpg.de)
Archaeological and osteological analyses found that the soldiers ranged in age from 15-50 years. (wikipedia.org)

Yesterday I introduced criticisms that have been raised against Y. pestis causation of the Black Death and subsequent plague outbreaks. (scienceblogs.com)

For the new study, researchers used in-solution capture and deep Illumina shotgun sequencing to generate Y. pestis and human host sequences for a Bronze Age man known as RT5, producing more than 32-fold average coverage of that Y. pestis genome. (genomeweb.com)

Mice heterozygous for the three QTLs were just as resistant as SEG mice to Y. pestis challenge. (pasteur.fr)

His work blends Yersinia pestis and Economic growth studies together. (research.com)

It is necessary to focus your microscope when viewing specimens to perform a proper analysis and give an accurate diagnosis. (cdc.gov)

Im dritten Teil des Projektes werden spezifische Krankheitserreger wie Yersina pestis (der Erreger der Pest) und Mycobacterium tuberculosis aus alten menschlichen Überresten in Norditalien und Ungarn untersucht, um die evolutionäre und epidemiologische Entwicklungsgeschichte der Krankheitserreger zu rekonstruieren. (eurac.edu)
What is PEST Analysis? (web.app)

The in-depth genetical analysis will include shotgun sequencing and target-enrichment to capture human mitochondrial and autosomal DNA. (eurac.edu)
The environmental assessment, which is based on a risk analysis prepared to assess the risks associated with the field testing of this vaccine and related information, examines the potential effects that field testing this veterinary vaccine could have on the quality of the human environment. (justia.com)
Based on the risk analysis and other relevant data, we have reached a preliminary determination that field testing this veterinary vaccine will not have a significant impact on the quality of the human environment, and that an environmental impact statement need not be prepared. (justia.com)
Prevalence rates of infectious diseases in pre-modern populations are uncertain, as they are usually based only on historical records [ 5 ] and paleopathological analysis of human skeletal and mummified remains [ 6 ]. (biomedcentral.com)

Surveillance and analysis of Yersinia pestis in Yushu, Qinghai province[J]. Chines Journal of Vector Biology and Control, 2014, 25(3): 275-276. (bmsw.net.cn)

Their analysis of incubation period is also based on these same historical records. (scienceblogs.com)
Combined analysis of the written record, skeletal remains, and genomic information can provide valuable knowledge of historical infectious disease presence. (biomedcentral.com)

Anatomy1

Organisms11

Diseases4

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes14

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Humanities4

Information Science3

Health Care2

Geographicals3

Bacterium15

Pseudotuberculosis4

Bubonic8

Strains8

Genomes4

Isolates5

Bacteria6

Causative5

Pathogen1

Bacillus2

Pathogens1

Genes2

Microbiology1

Species1

Pathogenicity2

Orientalis2

Genome-wide1

Outbreak1

Plasmid1

Bioterrorism2

Phylogenetic2

Spyrou1

Pathogenic1

Variability1

Genetics2

Lineages1

Infection3

Skeletons1

Bacterial1

Victims3

Gene2

Isolation1

Proteins3

Evidence1

Archaeological3

Black Death1

Sequences1

Resistant1

Economic1

Specimens1

Pest2

Human4

Surveillance1

Historical2