Analysis lymphoma t cell. Medical search. Frequent questions

Aggressive B-cell malignancies, such as mantle cell lymphoma (MCL), are microenvironment-dependent tumors and a better understanding of the dialogs occurring in lymphoma-protective ecosystems will provide new perspectives to increase treatment efficiency. (haematologica.org)
Frequent inactivating mutations of the ATM gene have been reported in patients with rare sporadic T cell prolymphocytic leukaemia (T-PLL), B cell chronic lymphocytic leukaemia (B-CLL), and most recently, mantle cell lymphoma (MCL). (bmj.com)
Bendamustine and rituximab as induction therapy in both transplant-eligible and -ineligible patients with mantle cell lymphoma. (vchri.ca)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with indolent non-hodgkin lymphomas and mantle cell lymphoma receiving bendamustine and rituximab. (cdc.gov)
TP53 Mutation and Complex Karyotype Portends a Dismal Prognosis in Patients With Mantle Cell Lymphoma. (cdc.gov)
Genomic landscape and prognostic analysis of mantle cell lymphoma. (cdc.gov)
Clinical and functional impact of recurrent S1PR1 mutations in mantle cell lymphoma. (cdc.gov)
KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study. (cdc.gov)
Mantle Cell Lymphoma: Which Patients Should We Transplant? (cdc.gov)
A high mutation rate of immunoglobulin heavy chain variable region gene associates with a poor survival and chemotherapy response of mantle cell lymphoma patients. (cdc.gov)
TP53 mutations are common in mantle cell lymphoma, including the indolent leukemic non-nodal variant. (cdc.gov)
ATM and TP53 mutations show mutual exclusivity but distinct clinical impact in mantle cell lymphoma patients. (cdc.gov)
Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study. (cdc.gov)

Background Expansion of therapeutic strategies against diffuse large B-cell lymphoma (DLBCL) offers new opportunities to fight aggressive non-Hodgkin's lymphoma. (bmj.com)
In search for subgroups of diffuse large B-cell lymphoma (DLBCL) with different histogenetic origin and prognosis, as has been described by gene expression profiling, we examined tumor specimens from 125 patients with DLBCL, uniformly treated by either cyclophosphamideAdriamycin-vincristine-prednisone or methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin in a multicenter trial set by the Nordic Lymphoma Group 1989-1994. (aacrjournals.org)
Histologically, the lymphomatous growth was predominantly diffuse with fibrosis that induced compartmentalized cell aggregation. (nih.gov)
However, NMZL carries a somewhat worse long term outcome than the other subtypes and any of the MZL subtypes may progress in a low percentage of cases to a more aggressive lymphoma, particularly diffuse large B-cell lymphoma. (wikipedia.org)
Single-cell spatial analysis of tumor immune architecture in diffuse large B-cell lymphoma. (edu.au)
Diffuse large B-cell lymphoma is the most common histologic subtype of NHL, with ENKTL of the large bowel being less frequent ( 4 ). (frontiersin.org)
In HIV-infected individuals, systemic NHL is the most common and can be further divided into subtypes such as diffuse large B-cell lymphoma (DLBCL), Burkitt's lymphoma, T-cell lymphoma, and plasmablastic lymphoma (PBL), to name a few [ 2 ]. (hindawi.com)
HGBL, not otherwise specified (NOS) is a heterogeneous, aggressive, mature B-cell lymphoma that does not meet criteria for BL, DHL, or diffuse large B-cell lymphoma NOS. (cancernetwork.com)
Moreover, a cut-off value of positivity for MYC protein in diffuse large B-cell lymphoma (DLBCL) varies among studies at present. (elsevierpure.com)
Materials and Methods: Digital RNA quantification (Nanostring) of previously curated 188 B-cell lymphoma specimens across four subtypes, follicular lymphoma (FL), diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), primary testicular lymphoma (PTL), and plasmablastic lymphoma (PBL), was reanalyzed with focus on TBL1XR1 and NCOR1 expression, juxtaposing them with 730 ontogenically linked genes. (iiarjournals.org)
The complexities in B-cell lymphoma, including the common diffuse large B-cell lymphoma (DLBCL) subtype, originate from accumulated genetic anomalies during this differentiation process ( 3 ). (iiarjournals.org)
Background: Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) has been used to treat patients with diffuse large B-cell lymphoma (DLBCL) under National Health Insurance (NHI) scheme in Indonesia. (ui.ac.id)
Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS), is a common aggressive lymphoma in both developing and developed countries. (asianarchpath.com)
Diffuse B-Ce ll Lymphoma. (researchgate.net)
Diffuse large B-cell lymphomas (DLBCL), which were studied in this trial, are aggressive cancers that grow rapidly and represent 30 percent to 40 percent of newly diagnosed lymphomas. (nih.gov)
Most people diagnosed with diffuse large B-cell lymphoma, the most common form of aggressive NHL, will be cured by initial treatment with chemotherapy. (cancer.gov)
Based on these results, axi-cel is now the preferred treatment for people whose diffuse large B-cell lymphoma has recurred quickly or proven resistant to standard initial treatment, explained Christopher Melani, M.D., of NCI's Center for Cancer Research . (cancer.gov)
Until recently, the only treatment with the possibility of eliminating recurrent or treatment-resistant diffuse large B-cell lymphoma was more high-dose chemotherapy, followed by an autologous stem cell transplant. (cancer.gov)
Earlier findings from the ZUMA-7 trial, which began recruiting patients in 2018, led the Food and Drug Administration (FDA) to approve axi-cel in 2022 for adults with diffuse large B-cell lymphoma that wasn't eliminated by their initial treatment or that returned within 12 months of initial chemotherapy. (cancer.gov)
This combination is currently considered the standard of care for treatment-resistant or relapsed diffuse large B-cell lymphoma. (cancer.gov)
The FDA announced that the Oncologic Drugs Advisory Committee (ODAC) will meet March 9 to review the accelerated approval of polatuzumab vedotin (Polivy) plus rituximab (Rituxan) and chemotherapy for untreated diffuse large B-cell lymphoma. (medpagetoday.com)
Complex analysis of the TP53 tumor suppressor in mantle cell and diffuse large B-cell lymphomas. (cdc.gov)

Of the NHL subtypes seen in HIV-positive individuals, the incidence of DLBCL is estimated to account for almost 50% of the cases while the incidence of plasmablastic lymphoma is estimated to account for less than 5% of the cases [ 3 , 4 ]. (hindawi.com)
1 A significant minority of these cases were the especially aggressive B-cell lymphomas Burkitt lymphoma (BL) and high-grade B-cell lymphoma (HGBL), the latter of which includes the histologic subtypes HGBL with MYC and BCL2 and/or BCL6 translocations (conventionally referred to as double-hit lymphoma [DHL]) and HGBL, not otherwise specified (NOS). (cancernetwork.com)
Ghafouri and colleagues plan to expand their patient cohort and are also interested in evaluating the therapy in additional B-cell lymphoma subtypes. (aacr.org)
However, important advances have been made in understanding that this disease is comprised of at least three molecular subtypes, each derived from B cells at unique stages in their development. (nih.gov)
A similar pattern was observed for follicular-cell lymphoma, but no other lymphoma subtypes. (cdc.gov)
The association between HLA and non-Hodgkin lymphoma subtypes, among a transplant-indicated population. (cdc.gov)

His lab recently published research that used single cell technologies to study the infusion products of patients undergoing CD19 CAR T-cell therapy for large B-cell lymphomas, and how specific cell phenotypes might be predictive of efficacy and toxicity. (10xgenomics.com)
Dr. Green's lab used 10x Genomics single cell RNA-sequencing (scRNA-seq) to further our understanding of why certain patients show poor response or develop toxicities after treatment with CD19 CAR T-cell therapy for large B-cell lymphomas (LBCLs). (10xgenomics.com)
In a study published in Nature Medicine , " Characteristics of Anti-CD19 CAR T Cell Infusion Products Associated with Efficacy and Toxicity in Patients with Large B Cell Lymphomas ," Dr. Green and his team showed that treatment response could be predicted within the first week of therapy, and they discovered a monocyte-like rare cell population that could be associated with the development of ICANS. (10xgenomics.com)

P. Connor Johnson, MD, and Jeremy S. Abramson MD, MMSc, discuss available treatments for patients with Burkitt lymphoma and high-grade B-cell lymphoma. (cancernetwork.com)
This article reviews the current data and future directions in the management of Burkitt lymphoma (BL) and high-grade B-cell lymphoma (HGBL). (cancernetwork.com)
The current World Health Organization (WHO) classification defines a new disease entity of high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, making fluorescence in situ hybridization (FISH) screening for these genes mandatory. (elsevierpure.com)
In the present study, MethylCap-seq was used to characterize the genome-wide DNA methylation patterns in canine high-grade B-cell lymphoma (cHGBL). (tmu.edu.tw)

By projecting new specimens associated to relevant clinical information and sample data onto the referential map, Atlas analysis provides a detailed description of the tumor microenvironment and facilitates the development of predictive and prognostic tools. (bmj.com)
Conclusions Projection of CAR-T clinical trial data highlighted the Veracyte Biopharma Atlas as a powerful tool to stratify patients and identify key immune biomarkers linked to response to CAR T-cell therapy. (bmj.com)
While all of these MZL involve malignant B-cells, they differ not only in the tissues they involve but also in their pathophysiology, clinical presentations, prognoses, and treatments. (wikipedia.org)
2 , 3 These lymphomas have a distinct clinical behavior and a bad prognosis. (haematologica.org)
13 Despite the similarities of their malignant cells, an important difference between the two lymphomas lies in their clinical presentation and prognosis. (haematologica.org)
By capture of paraclinical, clinical and demographic data along with genetic and functional characterization of primary CLL cells in our laboratory, we assemble multidimensional data on patients with CLL through the PERSIMUNE platform. (rigshospitalet.dk)
The clinical data of 656 ENKTL patients diagnosed at 11 medical centers in the Huaihai Lymphoma Working Group from March 2014 to April 2021 were retrospectively analyzed. (bvsalud.org)
PHILADELPHIA - Bispecific anti-CD19/CD20 chimeric antigen receptor (CAR) T-cell therapy was well tolerated and showed signs of clinical efficacy in patients with relapsed/refractory B-cell lymphoma, according to phase I clinical trial data presented during Week 1 of the virtual AACR Annual Meeting 2021 , held April 10-15. (aacr.org)
Dr. Melani is a Staff Clinician and a clinical researcher specializing in lymphoma. (cancer.gov)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
The activated B-cell (ABC) subtype of DLBCL accounts for approximately 40 percent of cases and has the poorest clinical outcome with current therapy. (nih.gov)
That's according to updated results from a large randomized phase 3 clinical trial of the CAR T-cell therapy axicabtagene ciloleucel (Yescarta) . (cancer.gov)
Now, new data from the ZUMA-7 clinical trial strongly suggests that axi-cel, as this CAR T-cell therapy is often called, can offer real hope for this latter group of patients. (cancer.gov)
This landscape began to change in 2021, when the results of two large clinical trials showed that CAR T cells could improve the time that people with treatment-resistant or recurrent large B-cell lymphoma lived without their cancer getting worse. (cancer.gov)
Although CD19 chimeric antigen receptor T cells (CAR-T) therapy has shown remarkable success in B-cell malignancies, a substantial fraction of patients do not obtain a long-term clinical response. (scilifelab.se)
We identified cell-intrinsic characteristics of effector CD8+CAR-Ts correlating with response that could be used as an indicator for clinical outcome. (scilifelab.se)
Genetic errors of the human caspase recruitment domain-B-cell lymphoma 10-mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity. (medscape.com)
NCCN Clinical Practice Guidelines in Oncology: B-Cell Lymphomas, Version 5.2021. (medscape.com)
The company also highlighted progress with omidubicel , an advanced cell therapy with positive Phase 3 clinical data, as a potentially life-saving treatment option for patients in need of an allogeneic hematopoietic stem cell (bone marrow) transplant, and GDA-201 , a natural killer (NK) cell immunotherapy in Phase 1/2 development for patients with non-Hodgkin lymphoma (NHL). (biospace.com)
We also continue to expand our clinical pipeline with plans to submit an IND for our GDA-201 natural killer cell therapy, initiate a multi-center Phase 1/2 clinical study in NHL and continue to advance our R&D activities to pursue the development of genetically modified NAM-enabled NK cells in solid tumors. (biospace.com)
Thus, corticosteroids should not be given to patients with suspected CNS lymphoma until after definitive diagnosis, unless absolutely necessary because of acute clinical deterioration. (msdmanuals.com)
The Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J.{Ref 1} In 1994, the Revised European-American Lymphoma (REAL) classification attempted to apply immunophenotypic and genetic features in identifying distinct clinicopathologic NHL entities. (medscape.com)
Clinical lymphoma, myeloma & leukemia 2018 8 18 (11): 762-768. (cdc.gov)

Results Gene expression profiling, genomic analysis and proteomics by multiplex spatial technology were performed on more than 150 DLBCL samples collected at diagnosis. (bmj.com)
Others have described plasmablastic lymphoma as a unique variant of DLBCL with a propensity to develop in HIV-positive patients with frequent involvement of the oral cavity [ 3 - 5 ]. (hindawi.com)
DLBCL originates from B cells, which play a crucial role in the body's immune response. (nih.gov)
Remissions were also observed in patients with non-ABC DLBCL, suggesting a broader role for the B-cell receptor pathway in this type of lymphoma. (nih.gov)
A final analysis will provide additional insights into the safety and efficacy of ibrutinib in the treatment of DLBCL. (nih.gov)

8 , 10 - 12 Recently, genome-wide analysis of isolated tumor cells from NLPHL and THRLBCL revealed further similarities between the tumors cells of the two lymphomas. (haematologica.org)
Incidence of primary large bowel lymphomas comprises only 0.2-0.6% of large bowel malignant tumors ( 3 ). (frontiersin.org)
It is being developed based on OmniRat transgenic animal platform.Sugemalimab (Cejemly) is under development for the treatment of solid tumors including endometrial cancer, cholangiocarcinoma, recurrent head and neck squamous cell carcinoma (HNSCC). (globaldata.com)
Hodgkins Lymphoma begins when a newly developed B-lymphocyte changes, becomes cancerous and goes on to multiply several folds to form tumors or lymphomas. (medindia.net)
Over one-fifth of ABC tumors have mutations that alter the activity of the B-cell receptor. (nih.gov)
The tumors in mycosis fungoides, which are composed of cancerous T cells, are raised nodules that are thicker and deeper than plaques. (medlineplus.gov)
Overexpression of IGF-1 in serum and tissue alters the growth of normal cells and causes uncontrolled proliferation, inhibits differentiation and reduces apoptosis, resulting in the incidence and development of malignant tumors ( 10 ). (spandidos-publications.com)
One proposed mechanism to explain the failure of single targeted CD19 CAR T-cell therapy is that tumors escape CAR T-cells by ridding itself of the CD19 protein. (lls.org)
1970. Tumors of the urinary bladder: An analysis of the occupations of 1030 patients in Leeds, England. (cdc.gov)
Primary brain lymphomas, a type of primary central nervous system lymphoma, originate in neural tissue and are usually B-cell tumors. (msdmanuals.com)
Most are B-cell tumors, often immunoblastic. (msdmanuals.com)
Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)

Global Cell Therapy Virtual Symposium , which will gather leading immuno-oncology scientists to discuss their research using single cell techniques. (10xgenomics.com)
Patients with relapsed/refractory B-cell lymphoma tend to have a more aggressive disease trajectory and limited treatment options," said presenting author Sanaz Ghafouri, MD , a fellow of hematology and oncology at University of California Los Angeles Medical Center. (aacr.org)

PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
Marginal zone B-cell lymphomas, also known as marginal zone lymphomas (MZLs), are a heterogeneous group of lymphomas that derive from the malignant transformation of marginal zone B-cells. (wikipedia.org)
In consequence, these B cells progressively acquire in a step-wise fashion chromosome abnormalities, gene mutations, and/or dis-regulated genes that contribute to their becoming malignant. (wikipedia.org)
To identify novel molecular regulations, we performed a transcriptomic analysis based on the comparison of circulating MCL cells (n=77) versus MCL lymph nodes (n=107) together with RNA sequencing of malignant (n=8) versus normal B-cell (n=6) samples. (haematologica.org)
The definitive diagnosis can be made with biopsy which typically shows malignant lymphoid cells that stain positive for plasma cell markers and negative for B-cell markers. (hindawi.com)
Signaling between programmed cell death protein 1 (PD-1) and the PD-1 ligands (PD-L1, PD-L2) is essential for malignant Hodgkin Reed-Sternberg (HRS) cells to evade antitumor immunity in classical Hodgkin lymphoma (cHL). (ashpublications.org)
In malignant B cells of ABC lymphomas, these receptors provide crucial signals that promote tumor cell survival. (nih.gov)

Results We observed that the microenvironment in nodular lymphocyte-predominant Hodgkin's lymphoma is molecularly very similar to a lymph node characterized by follicular hyperplasia, while the microenvironment in T-cell/histiocyte-rich large B-cell lymphoma is clearly different. (haematologica.org)
Molecular features of high-risk follicular lymphoma. (cancer.gov)
B-cell lymphomas arise from mutations affecting B-cell differentiation, particularly within germinal centers (GCs) where B-cells interact with T follicular helper cells ( 1 ). (iiarjournals.org)
However, our findings for both liver cancer and follicular-cell lymphoma warrant follow-up to better differentiate effects of metolachlor use from other factors. (cdc.gov)

They are lymphocytes of the B-cell line that originate and mature in secondary lymphoid follicles and then move to the marginal zones of mucosa-associated lymphoid tissue (i.e. (wikipedia.org)
Most EMZLs develop in MALT and are often termed extranodal MZL of mucosa-associated lymphoid tissue or, more simply, MALT lymphomas. (wikipedia.org)
Hamzaoui N, Pringault E. Interaction of microorganisms, epithelium, and lymphoid cells of the mucosa-associated lymphoid tissue. (medscape.com)
Mucosa-associated lymphoid tissue lymphoma of the stomach: long term outcome after local treatment. (medscape.com)

The International Extranodal Lymphoma Study Group collected 137 such cases for extensive pathological review. (nih.gov)
Extranodal marginal zone lymphomas (EMZLs) are MZLs that develop in extranodal tissues. (wikipedia.org)
MZLs represent 5-17% of all Non-Hodgkin lymphomas with the extranodal, splenic, and nodal forms accounting for 50-70%, ~20%, and ~10% of all MZLs. (wikipedia.org)
Extranodal NK/T cell lymphoma is a rare non-Hodgkin lymphoma mainly involving the upper aerodigestive tract, even rarer is primary extranasal disease involving the intestine. (frontiersin.org)
The surgical samples underwent pathological analysis, and a diagnosis of extranodal NK/T cell lymphoma nasal type was confirmed. (frontiersin.org)
Extranodal NK/T cell lymphoma nasal type (ENKTL) is a subtype of non-Hodgkin lymphoma (NHL). (frontiersin.org)
Analysis of prognostic factors of extranodal NK/T-cell lymphoma treated with pegaspargase/L-asparaginase: a multicenter retrospective study]. (bvsalud.org)
Proteomic Analysis of Cerebrospinal Fluid From Patients With Extranodal NK-/T-Cell Lymphoma of Nasal-Type With Ethmoidal Sinus Metastasis. (medindia.net)
Cutaneous lymphomas represent a unique group of lymphomas and are the second most frequent extranodal lymphomas. (medscape.com)

When targeted to the CD19 antigen, this therapy can treat B-cell cancers like leukemia, lymphoma, and multiple myeloma. (10xgenomics.com)
Their prognostic roles in various cancers are established, yet their precise impact on B-cell lymphoma is elusive. (iiarjournals.org)
This therapy is most advanced in blood cancers, specifically B-cell lymphomas and leukemias, with multiple FDA approved CAR T-cells treatments targeting the CD19 protein now available. (lls.org)
Nature Medicine Oct 2020) documented a high overall response rate in patients with relapsed B-cell cancers. (lls.org)
BOSTON--( BUSINESS WIRE )-- Gamida Cell Ltd. (Nasdaq: GMDA), an advanced cell therapy company committed to cures for blood cancers and serious blood diseases, today reported financial results for the quarter ended March 31, 2021. (biospace.com)

Primary Small Lymphocytic Lymphoma of the Renal Capsule: A Histopathological Case Report. (medindia.net)
An early-phase trial of the CAR T-cell therapy lisocabtagene maraleucel (Breyanzi) in chronic lymphocytic leukemia/small lymphocytic lymphoma met the primary endpoint of objective response, Bristol Myers Squibb announced. (medpagetoday.com)

Kaposi's sarcoma, non-Hodgkin lymphoma (NHL), and invasive cervical carcinoma are among the three AIDS-defining malignancies, and, of these, Kaposi's sarcoma and AIDS-related non-Hodgkin lymphoma are the most common [ 1 ]. (hindawi.com)
High-dose chemotherapy alongside peripheral blood stem cell (PBSC) infusion has become the standard of care in different hematologic malignancies. (uni-koeln.de)
The presented analysis included five patients with B-cell malignancies that were positive for both CD19 and CD20 tumor antigen expression. (aacr.org)
are developing the drug to target B-cell malignancies, including various forms of leukemia, lymphoma and multiple myeloma. (nih.gov)
Lymphoid malignancies in patients with AT are of both B cell and T cell origin, and include Hodgkin's lymphoma, non-Hodgkin's lymphoma, and several forms of leukaemia. (bmj.com)
To address that mechanism of relapse, we initiated a first-in-human trial of dual targeted anti-CD20, anti-CD19 CAR (CAR20.19) T-cells for B-cell malignancies. (lls.org)
In the first quarter of this year, we made significant progress on key initiatives across all functions of our business, starting with omidubicel, a potentially transformative treatment option for patients with hematological malignancies," said Julian Adams, Ph.D., chief executive officer of Gamida Cell. (biospace.com)
Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of malignancies of different biology and prognosis. (medscape.com)

Janssen and Legend Biotech announced early termination of a phase III trial after an interim analysis showed that ciltacabtagene autoleucel (cilta-cel, Carvykti) met the primary endpoint of improved progression-free survival in lenalidomide (Revlimid)-refractory multiple myeloma versus two active control regimens. (medpagetoday.com)
Outpatient Autologous Stem Cell Transplants for Multiple Myeloma: Analysis of Safety and Outcomes in a Tertiary Care Center. (vchri.ca)

Using ex vivo models of primary MCL cells (n=23), we demonstrated that, through the secretion of IL32β, the tumor was able to polarize monocytes into specific MCL-associated macrophages, which in turn favor tumor survival. (haematologica.org)
Finally, we demonstrated the efficacy of selective NIK/alternative-NFkB inhibition to counteract microenvironment-dependent induction of IL32β and BAFF-dependent survival of MCL cells. (haematologica.org)
These data uncovered the IL32β/BAFF axis as a previously undescribed pathway involved in lymphoma-associated macrophage polarization and tumor survival, which could be counteracted through selective NIK inhibition. (haematologica.org)
Median progression-free and overall survival were not reached at the time of follow-up, and all responding patients continued to have CAR T-cell persistence at the time of data cutoff. (aacr.org)
Statistical analysis revealed no significant overall survival difference between CD5-, CD30- and p53-positive and negative groups. (asianarchpath.com)
This research identified the enzyme Bruton's tyrosine kinase (BTK) as a key element in the B-cell receptor pathway that is required to maintain the survival of ABC lymphoma cells. (nih.gov)
This is the first trial in nearly 30 years to significantly improve overall survival for patients with large B-cell lymphoma that is not responding to initial treatment or has relapsed," said Dr. Jason Westin, M.D., of the University of Texas MD Anderson Cancer Center, who helped lead the study. (cancer.gov)
Merck announced termination for futility of a phase III trial after an interim analysis showed the combination of pembrolizumab (Keytruda) and enzalutamide (Xtandi) was unlikely to improve survival in metastatic hormone-sensitive prostate cancer. (medpagetoday.com)
In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), providing a new powerful means for the classification, prediction of survival, and response to treatment of lymphomas. (lu.se)
The addition of consolidation chemotherapy, consolidation whole-brain radiation therapy, or high-dose chemotherapy with stem-cell rescue may improve survival. (msdmanuals.com)

The incidence of PBL is estimated to account for less than 5% of all cases of non-Hodgkin lymphoma (NHL) in HIV-positive individuals. (hindawi.com)
Non-Hodgkin lymphoma (NHL) is the seventh most common cancer in the United States, with approximately 77,000 new cases and 20,000 deaths in 2020. (cancernetwork.com)
Regionally localized PD-L1 + macrophages form a specialized microenvironmental niche for Hodgkin Reed-Sternberg cells in cHL. (ashpublications.org)
Hodgkin lymphoma may also occur in patients who have Acquired Immune Deficiency Syndrome (AIDS). (medindia.net)
Collectively, CTCL is classified as a type of non-Hodgkin lymphoma (NHL). (medscape.com)
In adults, EBV can induce the development of symptomatic infectious mononucleosis, which is a major risk factor for multiple sclerosis and Hodgkin lymphoma. (news-medical.net)
CAR T-cell therapy, a type of personalized immunotherapy, can help cure some people with aggressive non-Hodgkin lymphoma (NHL). (cancer.gov)
The LLS mission: Cure leukemia, lymphoma, Hodgkin disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
ABSTRACT In view of the widespread use of pesticides in Egypt and the increasing incidence of leukaemia and lymphoma we aimed to assess pesticide exposure and other selected variables as risk factors for lymphoproliferative disorders (leukaemia and non-Hodgkin lymphoma). (who.int)
The risk was significant for cases of non-Hodgkin lymphoma but not chronic lymphocytic leukaemia. (who.int)
For other discussions on lymphoma, see the overview topic Non-Hodgkin Lymphoma . (medscape.com)

Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
Purpose:Targeted inhibition of anaplastic lymphoma kinase (ALK) has been widely used for the treatment of advanced non-small cell lung cancer (NSCLC) with ALK rearrangements. (elsevierpure.com)
This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. (cancerindex.org)

Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
The diagnosis of CBCL is established by analysis of skin biopsy specimen, using histomorphology and cytomorphology, immunohistochemistry and phenotypic features, and genotyping and cytogenetic studies (see Workup of Cutaneous B-Cell Lymphoma). (medscape.com)

Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by chemotherapy or by radiotherapy. (medindia.net)
Advances in cancer research in the last few decades has now resulted in cure at the early stages of Hodgkins lymphoma by radiation and in the later stages by combination therapy (radiation with chemotherapy). (medindia.net)
It is essential to identify and initiate treatment early with chemotherapy and/or radiation therapy in all cases of nodal or visceral (including neural) involvement with lymphoma. (researchgate.net)
But for those who aren't, the prospects of a cure have been uncertain at best, even with additional grueling chemotherapy and stem cell transplant. (cancer.gov)
This is where a patient's healthy blood-forming stem cells are collected from the blood or bone marrow before treatment and then given back to the patient after high-dose intensive chemotherapy. (cancer.gov)
ZUMA-7 enrolled people deemed healthy enough to undergo additional high-dose chemotherapy and, potentially, an autologous stem cell transplant. (cancer.gov)
While 94% of people in the axi-cel group received their CAR T cells, only 36% of those in the standard-treatment group were able to have a stem cell transplant because in most cases their disease continued to progress despite chemotherapy, Dr. Westin explained at the ASCO meeting. (cancer.gov)
Background: specialized studies on hepatitis B virus (HBV) infection and B-NHL (B-cell Non-Hodgkin's Lymphoma) are limited, as well as prophylactic antiviral therapy for B-NHL patients with HBV infection who are receiving anticancer chemotherapy. (scirp.org)

His areas of interest include the use of novel therapies and drug combinations for the treatment of lymphomas as well as novel methods of molecular monitoring of disease and response to treatment, such as circulating tumor DNA (ctDNA). (cancer.gov)

Donor Cell Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation. (nih.gov)
The Leukemia & Lymphoma Society® (LLS) is a global leader in the fight against blood cancer. (lls.org)
The Leukemia & Lymphoma Society is a 501(c)(3) organization, and all monetary donations are tax deductible to the fullest extent allowed by tax laws. (lls.org)
Leukemia & lymphoma 2019 6 60 (12): 2899-2908. (cdc.gov)
Leukemia & lymphoma 2019 Jan 1-9. (cdc.gov)

This integrated analysis led to the discovery of microenvironment-dependent and tumor-specific secretion of interleukin-32 beta (IL32β), whose expression was confirmed in situ within MCL lymph nodes by multiplex immunohistochemistry. (haematologica.org)

Although primary mediastinal (thymic) large B-cell lymphoma has been primarily studied, its precise phenotype, molecular characteristics, and histogenesis are still a matter of debate. (nih.gov)
Molecular analysis, performed in 45 cases, showed novel findings. (nih.gov)
Use of novel methods of molecular monitoring, such as circulating tumor DNA (ctDNA), in lymphoma. (cancer.gov)
These results illustrate how an understanding of the molecular machinery inside a cancer cell can lead to new therapies which can kill tumor cells while sparing normal cells, thus greatly reducing toxicities for patients," said Staudt. (nih.gov)
1990. Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo. (cdc.gov)

It was the aim of this paper to identify prognostic factors in patients with relapsed or refractory B-cell non-Hodgkin's lymphomas, treated by radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab ( 131 I-rituximab). (karger.com)
Although long-term follow-up and analysis of additional patients are needed, our results indicate that bispecific anti-CD19/CD20 CAR in naïve memory T cells may be safe and effective in patients with relapsed or refractory B-cell lymphomas," Ghafouri said. (aacr.org)

However, it differs from other aggressive B-cell lymphomas in that it shows defective immunoglobulin production despite the expression of OCT-2, BOB.1, and PU.1 transcription factors and the lack of IgV(H) gene crippling mutations. (nih.gov)
To further our understanding of how to create better cell and gene therapies, 10x Genomics will host a Global Cell Therapy Virtual Symposium , to be held February 8-12, 2021, that will gather the global community of researchers in the cancer immunotherapy space. (10xgenomics.com)
To resolve the variability in response to CAR T-cell therapy among patients, the researchers compared single cell gene expression patterns of CAR T cells infused into patients. (10xgenomics.com)
Background Gene expression profiling has successfully identified the prognostic significance of the host response in lymphomas. (haematologica.org)
Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)
Gene expression profiling of lymphomas clearly illustrated that apart from the characteristics of the tumor cells, the microenvironment of the tumor also defines the profile of the lymphoma, and, more importantly, plays a role in predicting the prognosis. (haematologica.org)
It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. (bmj.com)
It is known to be a central component in the formation of GCs by binding and recruiting the majority of TBL1XR1/SMRT/NCOR1 complexes, a process mediated by B-cell lymphoma 6 ( BCL6 ) gene expression ( 5 ). (iiarjournals.org)
It has an essential role in B-cell development, influencing the transition of memory B-cells to plasma cells, while mutations in the TBL1XR1 gene have been observed to inhibit this progression and promote lymphomagenesis ( 7 , 8 ). (iiarjournals.org)
The AT locus was mapped to the chromosomal region 11q22-23 using genetic linkage analysis in the late 1980s and the causative gene was identified by positional cloning several years later. (bmj.com)
The association between mutation of the ATM gene and a high incidence of lymphoid malignancy in patients with AT, together with the development of lymphoma in Atm deficient mice, supports the proposal that inactivation of the ATM gene may be of importance in the pathogenesis of sporadic lymphoid malignancy. (bmj.com)
We analyzed 137 B-lineage and 30 T-lineage childhood ALL cases using microarray analysis of DNA copy number alterations and gene expression, and genome-wide cytosine methylation profiling using the HpaII tiny fragment enrichment by ligation-mediated PCR (HELP) assay. (lu.se)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repression and transcriptional activation. (lu.se)
Subsequently, inadequate regulation of cell proliferation and defective oncogene and/or suppressor gene expression promote the transition from preneoplastic conditions to neoplasia. (medscape.com)

Baseline and screening samples from axicabtagene ciloleucel (axi-cel) anti-CD19 chimeric antigen receptor (CAR) T-cell treated patients from the pivotal ZUMA-1 trial were analyzed with the same multi-omics integrative approach. (bmj.com)
While checkpoint inhibitors and monoclonal antibodies have shown success for treating some types of cancer, one of the most promising immunotherapies is chimeric antigen receptor (CAR) T-cell therapy. (10xgenomics.com)
Chimeric antigen receptor (CAR)-T cell therapy is rapidly advancing as cancer treatment, however, designing an optimal CAR remains challenging. (scilifelab.se)
Chimeric Antigen Receptor (CAR) modified T-cells are an exciting new form of immunotherapy that involves the genetic modification of one's own T-cells to redirect them against proteins on cancer cells. (lls.org)

Dr. Cambier and his laboratory discovered that in certain circumstances, subunits of the B cell antigen receptor (BCR) become dissociated rendering the receptor incompetent to transduce activating signals. (nationaljewish.org)
B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. (nationaljewish.org)

ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. (haematologica.org)
The tumor cells of both lymphomas share several characteristics, while the cellular composition of their microenvironment is clearly different. (haematologica.org)
Although for years most studies have focused on tumor cells, allowing the discovery of numerous key (epi)-genetic aberrations and oncogenic pathways, it is now widely accepted that ecosystem integration is also critical for the understanding of cancer progression. (haematologica.org)
Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
We hypothesized that targeting multiple antigens on tumor cells could be a more effective approach to minimize tumor antigen escape. (lls.org)
In this study, global GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)

By quantitative reverse transcriptase polymerase chain reaction we verified that these 20 selected cases were representative of the entire population of T-cell/histiocyte-rich large B-cell and nodular lymphocyte-predominant Hodgkin's lymphomas. (haematologica.org)
1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)
It has also been proposed that hepatitis B virus (HBV) may be an etiologic agent of Non-Hodgkin's Lymphoma (NHL) [15] - [17] , but relatively few studies have investigated the association between HBV infection and B-NHL. (scirp.org)
Based on these observations they produced antibodies against the BCR transducers, CD79a and b, and found that they "desensitize" the BCR and suppress the immune response, autoimmunity, and growth of non-Hodgkin's B lymphoma. (nationaljewish.org)
Dr. Song's research interests include the treatment of myeloma and other plasma cell dyscrasias and the use of hematopoietic stem cell transplant to treat non-Hodgkin's lymphoma. (vchri.ca)

Nodal marginal zone lymphomas (NMZs) are MZLs initially confined to lymph nodes, bone marrow, and blood. (wikipedia.org)
B-cell lymphomas account for the majority of nodal lymphomas, whereas primary cutaneous B-cell lymphomas (CBCLs) represent 20-25% of all cutaneous lymphomas. (medscape.com)

There is a low background incidence of BL worldwide (sBL), which is rarely associated with EBV and accounts for 1-2% of adult lymphoma in Western Europe and America, but eBL is associated with (EBV) in over 95% of cases and is predominant in the equatorial belt of Africa and other parts of the world where malaria is hyperendemic. (bmj.com)
Incidence of primary brain lymphomas is increasing, particularly among immunocompromised patients and older people. (msdmanuals.com)

Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. (bmj.com)
Burkitt lymphoma (BL) can be classified into three forms which differ in geographic distribution and Epstein-Barr virus (EBV) association: endemic (eBL), sporadic (sBL) and HIV-associated BL ( table 1 ). (bmj.com)

A total of 40 patients with B‑cell lymphoma during or after antibody therapy against CD20 were vaccinated twice with the BNT162b2 messenger RNA (mRNA) COVID‑19 vaccine (Pfizer, Inc. and BioNTech SE. (spandidos-publications.com)

We present a case of a patient with HIV/AIDS who presented with a tender left lower extremity cutaneous mass over a site of previous cryptococcal infection and was found to have plasmablastic lymphoma (PBL). (hindawi.com)
At the time of a 2003 review, there were only 2 reports of extraoral plasmablastic lymphoma [ 4 ]. (hindawi.com)
We present a rare case of a 63-year-old HIV-positive male who was found to have plasmablastic lymphoma on biopsy of a tender left lower extremity cutaneous mass occurring over a previous site of cryptococcal infection. (hindawi.com)

The goal of PBSC mobilization is to allow collection of sufficient CD34+ cells to proceed to transplantation. (uni-koeln.de)

It often presents as a complication of lymphoma, but it can be the presenting feature of recurrent lymphoma. (researchgate.net)
lymphoma, but it can be the p resenting feature of recurrent lym phoma. (researchgate.net)

We present a case of primary intestinal NK/T cell lymphoma with diagnostic challenge, which eventually developed into multiple intestinal perforations. (frontiersin.org)
Early diagnosis of primary intestinal NK/T cell lymphoma is frequently difficult. (frontiersin.org)
AIDS-related NHL can be categorized into systemic NHL, primary CNS lymphoma, and primary effusion lymphoma [ 2 ]. (hindawi.com)
Primary Testicular Lymphoma: Single Center Experience. (nih.gov)
Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
Mycosis fungoides is the most common type, accounting for 60% of CTCLs and almost half of all primary cutaneous lymphomas. (medscape.com)
Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primary Sjögren's Syndrome. (medscape.com)
MRI can suggest the diagnosis of primary brain lymphoma. (msdmanuals.com)
primary brain lymphomas typically recur. (msdmanuals.com)
Likewise, with primary cutaneous lymphomas associated with a poorer prognosis, treatment is different for isolated or grouped lesions than for multiple lesions (see Treatment and Management). (medscape.com)
Diseases formerly designated as reticulosis or reticulosarcomatosis are currently classified according to the World Health Organization (WHO)/European Organization for Research and Treatment of Cancer (EORTC) classification (WHO-EORTC classification) for primary cutaneous lymphomas and the WHO classification. (medscape.com)

In 1988, ALCL was added as a distinct entity to the revised Kiel classification, and in 1994, it was included in the Revised European-American Lymphoma (REAL) classification. (medscape.com)
4 In the World Health Organization (WHO) classification of 2001, T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is defined by the presence of a limited number of scattered large B cells in a background rich in T cells, with or without histiocytes. (haematologica.org)
Still, this information is not used for classification of B-cell lymphomas (BCLs). (lu.se)
This classification divides NHL into two groups: those of B-cell origin and those of T-cell/natural killer (NK)-cell origin. (medscape.com)
The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)

No prognostic conclusions could be drawn from analysis of these factors. (aacrjournals.org)
By Cox regression analysis, positivity for CD40 was shown to be a prognostic factor for OS, independent of International Prognostic Index. (aacrjournals.org)
To explore the prognostic factors of extracellular NK/ T cell lymphoma (ENKTL) treated with pegaspargase/L- asparaginase . (bvsalud.org)
prognostic factors is superior to the international prognostic index, Korean prognostic index, and prognostic index of natural killer lymphoma . (bvsalud.org)

Marginal zone B-cell lymphoma (MZL) (MALT-type) is an indolent cutaneous lymphoma, accounting for approximately 10% of all cutaneous lymphomas. (medscape.com)

Our findings raise the possibility of a lasting long-term remission with bispecific CAR T-cell therapy in patients with this aggressive disease. (aacr.org)
Conclusion: Our exploratory findings unravel the expression patterns of TBL1XR1/NCOR1 in B-cell lymphoma variants. (iiarjournals.org)
The findings revealed that vaccination with Amphiphile-CpG adjuvant induces significantly higher viral antigen-specific cytokine-producing CD8+ T cells compared to vaccination with soluble CpG. (news-medical.net)
Based on these findings, researchers looked for ways to target B-cell receptor signaling therapeutically. (nih.gov)
Findings from this study would not only be applicable to those receiving CAR20.19 T-cells but have potential to enhance outcomes for any patient receiving cell therapy. (lls.org)

Methods Veracyte Biopharma Atlas characterizes the tumor microenvironment by analyzing information from 3 different modalities: (i) proteomics (Brightplex® panels), (ii) transcriptomics (RNA sequencing and hybridization using Nanostring technology), (iii) genomics (somatic mutations by exome sequencing and/or the rearrangement of the V(D)J regions of the CDR3 receptor of T cells). (bmj.com)
With the B-cell receptor pathway as the core, our group has been part of a paradigm shift for treatment of CLL with novel targeted therapies developed also for patients with the most dismal outcome due to TP53 aberrations. (rigshospitalet.dk)
B-cell receptor diversification, essential for adaptive immunity, depends on processes like V(D)J recombination and somatic hypermutation ( 1 ). (iiarjournals.org)
Cluster of Differentiation 79 (CD79) is a transmembrane protein found exclusively in B cells that is the transducer component of B-cell receptor (BCR), generating a signal following recognition of antigen by the BCR. (nationaljewish.org)
The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)

In this context, an objective measure is needed, therefore the index of vaccination against coronavirus disease 2019 (COVID‑19) in B‑cell lymphomas treated with antibody therapy against CD20 (including after the completion of therapy) was examined. (spandidos-publications.com)

Marginal zone B cells are innate lymphoid cells that normally function by rapidly mounting IgM antibody immune responses to antigens such as those presented by infectious agents and damaged tissues. (wikipedia.org)
Splenic marginal zone lymphomas (SMZLs) are MZLs that initially are confined to the spleen, bone marrow, and blood. (wikipedia.org)
The frequency of cutaneous lymphomas is 0.3 case per 100,000 population per year, with 10% (in the United States) to 20% (in Europe) being cutaneous B-cell lymphomas (CBCLs), marginal zone lymphomas, or follicle center lymphomas (FCLs). (medscape.com)

Mycosis fungoides is the most common form of a type of blood cancer called cutaneous T-cell lymphoma. (medlineplus.gov)

While significant strides have been made in developing cell therapies to treat cancer, scientists continue to advance understanding of how to deepen efficacy and reduce toxicity of these treatments. (10xgenomics.com)
They are using single cell technologies to push boundaries, and this symposium will feature new insights in cell therapy biology and avenues for designing and optimizing next-generation therapies. (10xgenomics.com)
Novel use of targeted therapies and immunotherapy in lymphoma. (cancer.gov)
The TBL1XR1-DDR genes connection offers insights into potential DNA repair roles, paving avenues for innovative therapies in B-cell lymphomas. (iiarjournals.org)
Like all currently approved CAR T-cell therapies, axi-cel is truly personalized, in that it uses a patient's own immune cells to create the treatment . (cancer.gov)
Data from these studies will advance CAR T-cell therapies for lymphoma patients. (lls.org)

Zucca E, Bertoni F. The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance. (medscape.com)
Protease activity of the API2-MALT1 fusion oncoprotein in MALT lymphoma development and treatment. (medscape.com)
Helicobacter and gastric MALT lymphoma. (medscape.com)
Rodríguez-Sevilla JJ, Salar A. Recent Advances in the Genetic of MALT Lymphomas. (medscape.com)

The prognosis of patients who relapse after CAR T-cell therapy is dismal," Ghafouri added. (aacr.org)

Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
The chronic inflammation stimulates B-cells to rearrange their immunoglobulin heavy chain locus so that they encode B-cell receptors that recognize unnatural antigens presented by the injured issues and/or infectious agents that underlie the inflammation. (wikipedia.org)
This rearrangement results in the B-cells responding to the ab\normal antigens by taking on features of marginal B-cells and proliferating excessively. (wikipedia.org)
Bispecific CAR T cells target two tumor antigens at once and have been explored as a strategy to reduce the risk of relapse. (aacr.org)
Scientists analyzed known human CD8+ T cell epitopes from EBV antigens to design a polyepitope vaccine immunogen that incorporates 20 CD8+ T cell epitopes into an engineered protein immunogen. (news-medical.net)

6 However, using a stricter definition requiring the presence of a prominent histiocytic component as a major feature and almost complete absence of small B lymphocytes, the unique character of this lymphoma has been demonstrated. (haematologica.org)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
In addition, this modality does not eliminate all B lineage cells and thus may not be appropriate for all pathologic conditions involving B lymphocytes. (nationaljewish.org)

One type of CAR T-cell therapy targets CD19, a protein located on the surface of B cells. (10xgenomics.com)
Laboratory tests showed leukocytosis (20.79 × 10 9 /L), moderate anemia (69 g/L), increased percent of neutrophils (91.6%), increased C-reactive protein (CRP) (80.90 mg/L), procalcitonin (PCT) (5.87 ng/ml) and erythrocyte sedimentation rate (ESR) (106.0 mm/h) level, and mild hypoalbuminemia (31.0 g/L). Stool routine revealed Leukocyte ++++/HP, pus cell ++++/HP, stool blood was positive. (frontiersin.org)
1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
8 , 9 The protein is a member of a novel family of large proteins, which show sequence homology to the catalytic domain of phosphatidylinositol 3 kinase, 3 and are implicated in cell cycle regulation, signal transduction, and the response to DNA damage. (bmj.com)
The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)
In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)

Hodgkins lymphoma (HL) can occur in both children and adults. (medindia.net)
They are caused by an abnormal proliferation of white blood cells, can occur at any age, and are often marked by lymph nodes that are larger than normal, fever, and weight loss. (nih.gov)
These abnormalities occur during a person's lifetime and are found only in the DNA of cancerous cells. (medlineplus.gov)
Lymphomas tend to infiltrate the brain diffusely, often as multicentric masses adjacent to the ventricles, but may occur as solitary brain masses. (msdmanuals.com)
Lymphomas may also occur in the meninges, uvea, or vitreous humor. (msdmanuals.com)
[ 1 , 2 ] They can be defined as lymphoproliferative skin infiltrates of T-cell, B-cell, or natural killer cell lineage, which primarily occur in and remain confined to the skin in most patients, without detectable extracutaneous manifestations at diagnosis. (medscape.com)

Current technologies for treatment of many lymphomas, leukemias, transplant rejection and some autoimmune disorders include monoclonal antibodies (mAb) that target and deplete B cell populations. (nationaljewish.org)

This may be secondary to a germinal center origin or attributable to increased apoptosis via induction of bax and/or enhanced T-cell interaction, resulting in improved autologous tumor response. (aacrjournals.org)
The present study supports the concept that a sizable fraction of cases of this lymphoma are from activated germinal center or postgerminal center cells. (nih.gov)
2 , 3 , 9 Indeed, the atypical B cells of NLPHL and THRLBCL share many characteristics, including expression of pan-B-cell markers, germinal center B-cell origin and common chromosomal imbalances. (haematologica.org)
Toward a role of dendritic cells in the germinal center reaction: triggering of B cell proliferation and isotype switching. (medscape.com)

Retrieved on Sep 24, 2023 from https://www.medindia.net/patients/patientinfo/hodgkins-lymphoma.htm. (medindia.net)

Anatomy30

Organisms15

Diseases43

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes43

Disciplines and Occupations1

Information Science5

Health Care7

Mantle cell lym14

Diffuse22

Subtypes6

Large B Cell Lymp3

High-grade B-cell lym4

Clinical23

DLBCL5

Tumors12

Oncology2

Malignant7

Follicular4

Mucosa-associ4

Extranodal9

Cancers5

Small Lymphocy2

Malignancies8

Multiple myeloma2

Survival10

Hodgkin11

Anaplastic5

Cutaneous B-Cell Lym2

Chemotherapy8

Treatment of lymphomas1

Leukemia5

Immunohistochemistry1

Molecular5

Refractory2

Gene15

Chimeric antigen receptor4

Antigen receptor2

Tumor cells7

Hodgkin's5

Nodal2

Incidence2

Burkitt2

Patients with B‑cell l1

Plasmablastic lymphoma3

Transplantation1

Recurrent2

Primary11

Classification5

Prognostic4

Indolent1

Findings5

Receptor5

20191

Marginal zone3

Mycosis1

Therapies6

MALT4

Prognosis1

Antigens5

Lymphocytes3

Protein7

Occur6

Leukemias1

Germinal center4

20231