• We systematically searched for methodologies pertaining to the implementation of a causally explicit framework for meta-analysis of randomized controlled trials and discussed the interpretation and scientific relevance of such causal estimands. (biomedcentral.com)
  • Systematic Review and Meta-Analysis of Randomized Controlled Trials of Liangxue Tongyu Formula on Patients With Acute Intracerebral Hemorrhage. (lifchem.com)
  • Effects of physical activity on poststroke cognitive function: a meta-analysis of randomized controlled trials. (cdc.gov)
  • BACKGROUND: Randomized controlled trials (RCTs) are frequently used to evaluate the effectiveness of health care interventions in family medicine. (ox.ac.uk)
  • RESULTS: Three studies were included: a randomised controlled trial (RCT) in adults (n = 167) (≥ 12 years), a RCT in children (n = 26) (6-11 years), and an open-label extension study of the two RCTs. (bris.ac.uk)
  • Randomised controlled clinical trials (RCTs) were included. (researchgate.net)
  • Meta-analyses of randomized controlled trials (RCTs) have been considered as the highest level of evidence in the pyramid of the evidence-based medicine. (biomedcentral.com)
  • We only identified three efforts explicitly describing a causal framework on meta-analysis of RCTs. (biomedcentral.com)
  • Although all identified methodologies provide valid causal estimates, there are limitations in the assumptions regarding the data generation process and sampling of the potential RCTs to be included in the meta-analysis which pose challenges to the interpretation and scientific relevance of the identified causal effects. (biomedcentral.com)
  • On a clinical research level and for pertinent research questions, randomized controlled trials (RCTs) undoubtedly offer the highest level of evidence compared to other study designs. (biomedcentral.com)
  • Therefore, in the first part, we focus on the published methodologies that address the identification and estimation of causal effects derived from meta-analyses of RCTs along with the underlying assumptions. (biomedcentral.com)
  • Randomized controlled trials (RCTs) in dentistry provide essential evidence for dentists to practice evidence-based dentistry . (bvsalud.org)
  • A wide range of dental topics were covered in the included RCTs conducted among children and adolescents . (bvsalud.org)
  • Some reviews use statistical methods of meta-analysis to assess and summarize the results of multiple studies. (cdc.gov)
  • Statistical analyses and quality of individual participant data network meta-analyses were suboptimal: a cross-sectional study. (jameslindlibrary.org)
  • It's a statistical process that combines findings from individual studies, typically surrounding one topic. (bistromd.com)
  • Scholars@Duke publication: Statistical analysis methods for QT/QTc prolongation. (duke.edu)
  • We publish articles on general trial methodology and research into trial processes, as well as study protocols and statistical analysis plans for randomized controlled trials, commentaries and traditional results papers - regardless of outcome or significance of findings. (biomedcentral.com)
  • Statistical analyses will evaluate the effectiveness of the supervisor-oriented model of the intervention on both supervisor and employee outcomes. (cdc.gov)
  • [1] [19] As of 2021, there is a lack of adequately controlled long-term studies examining the impact of calorie restriction in humans. (wikipedia.org)
  • METHODS: The Cochrane Central Register of Controlled Trials, MEDLINE, Embase and CINAHL were searched using medical subject headings for parastomal hernia, mesh and prevention. (lu.se)
  • Methods: A systematic review of Medline, Scopus (which encompassed Embase), Cochrane Central Register of Controlled Trials, Web of Science, and PubMed was performed to identify relevant studies comparing meshaugmented versus sutured HH repair. (edu.au)
  • By univariate and multivariate analysis using Firth logistic regression, pancreatic texture (OR = 1.205, CI = 0.103-2.476, p = 0.032) and the presence of a biliary and pancreatic stent (OR = 2.695, CI = 0.273-7.617, p = 0.027) were the significant factors affecting pancreatic fistula. (thieme-connect.de)
  • Currently focused on clinical outcomes research, systematic reviews and meta-analyses of cohort studies and randomized controlled trials, clinical practice guidelines using GRADE methodology, and administrative claims database analyses. (theconversation.com)
  • The frequency of physical and verbal violence in the subgroup analysis was statistically significantly different for countries and years. (who.int)
  • Univariate subgroup analyses are often used to help determine the generalizability of a trial's results, but may themselves be misleading. (mcmaster.ca)
  • These findings highlight the limitations of univariate subgroup analyses and illustrate that multivariate risk group analysis may be a complementary method for assessing the generalizability of the overall treatment effects observed in randomized trials. (mcmaster.ca)
  • In trials with a parallel study design a sizable number of patients seem to benefit from a placebo effect, although this effect is smaller in patients with systemic JIA. (nih.gov)
  • In total 649 patients were included in the analysis (324 received mesh). (lu.se)
  • 12 ] [ 13 ] [ 14 ] Although several meta-analyses and other retrospective studies have examined stented versus nonstented patients, they have not specifically addressed POPF rates. (thieme-connect.de)
  • Six studies with a total of 337 500 patients (PC 10 045, CC 327 455) were included for meta-analysis. (aerzteblatt.de)
  • While early cholecystectomy (surgical removal of the gallbladder independent of the means of access) has been unequivocally established as the gold standard for the management of young and fit for surgery patients with AC ( 1 3 ), the optimal management of critically ill and elderly patients with acute cholecystitis remains a topic of discussion. (aerzteblatt.de)
  • Only articles comparing CC and PC for the definitive management of critically ill patients with AC were included for meta-analysis. (aerzteblatt.de)
  • Neurons over nephrons: systematic review and meta-analysis of contrast-induced nephropathy in patients with acute stroke. (bmj.com)
  • Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial. (bmj.com)
  • BACKGROUND: The overall effect sizes estimated from randomized clinical trials may not apply similarly to all patients. (mcmaster.ca)
  • METHODS: The SOLVD prevention (4228 patients) and the SOLVD treatment (2569 patients) trials were randomized, double-blind trials that studied the effect of enalapril in patients with reduced left-ventricular function or congestive heart failure. (mcmaster.ca)
  • In a review published in the journal Chest , the researchers summarize the three large, randomized trials to date examining the use of norepinephrine and vasopressin in patients with septic shock. (medscape.com)
  • In the Vasopressin in Septic Shock Trial (VASST), 382 patients with septic shock were randomized to open-label norepinephrine with blinded norepinephrine, and 382 were randomized to open-label norepinephrine with blinded adjunctive vasopressin. (medscape.com)
  • In the Vasopressin vs Norepinephrine as Initial Therapy in Septic Shock (VANISH) trial, 204 patients with septic shock were randomized to norepinephrine and 204 to vasopressin as an initial vasoactive agent. (medscape.com)
  • The third clinical trial, published only as an abstract, randomized 387 patients with septic shock who were already receiving low doses of norepinephrine to either norepinephrine with adjunctive vasopressin or norepinephrine alone. (medscape.com)
  • [ 3 ] A meta-analysis demonstrated a significant increase in the relative risk of implant failure in patients who smoked more than 20 cigarettes per day compared with nonsmokers. (medscape.com)
  • These are headings are used for the general design, methodology, and economics of the trials. (bvsalud.org)
  • We included studies that focused on young people aged 10-19 years, implemented a positive youth development intervention, were outside school hours, and utilized a randomized controlled design. (nih.gov)
  • Twenty-four studies, involving 23,258 participants, met the inclusion criteria and were included in the analysis. (nih.gov)
  • By analysing the data derived from 351 studies, Shaw et al. (springer.com)
  • Reference lists of identified studies, clinicaltrials.gov and the WHO International Clinical Trials Registry were also searched. (lu.se)
  • RESULTS: Ten randomized trials were identified among 150 studies screened. (lu.se)
  • Systematic reviews can incorporate information from observational studies, non-randomized trials, and randomized controlled trials to clarify existing evidence about a certain topic. (cdc.gov)
  • Only a few of these studies indicate that the authors used standardized tools for quality measures to guide the review process, which is an important way of standardizing results presented in systematic reviews and meta-analyses. (cdc.gov)
  • Currently, systematic reviews of COVID-19 topics are being published at a very rapid pace, running the risk of synthesizing data from flawed, poorly designed studies, or studies with overlapping data. (cdc.gov)
  • Meta-analysis is a quantitative procedure of assessing and combining data from multiple studies. (biomedcentral.com)
  • David Myers , AIR's chief executive officer, will give an opening plenary session on Monday, September 26th on the topic, "Using evidence for practice: Implications for primary studies, systematic reviews and practice. (air.org)
  • Dr. Myers, a nationally recognized education researcher, is a leading authority on the design, implementation and analysis of experimental studies of education programs. (air.org)
  • Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. (bmj.com)
  • Combining data from similar studies (meta-analysis) can help to provide more reliable estimates of treatment effects. (jameslindlibrary.org)
  • Systematic reviews are rarely used to contextualise new results-a systematic review and meta-analysis of meta-research studies. (jameslindlibrary.org)
  • Physician trained in internal medicine, clinical epidemiology and cardiovascular research, with extensive experience (18+ years) in design, analysis, and publication of observational studies, randomized clinical trials, and meta-analyses. (theconversation.com)
  • Similar to a meta-analysis but much more comprehensive, a systematic review is a critical assessment and evaluation of all research studies that address a particular area of study. (bistromd.com)
  • It typically includes a collection of the research studies and a description of the major findings along with sometimes offering quantitative pools of data called the meta-analysis. (bistromd.com)
  • Using information obtained from Eli Lilly thorough QT studies, we examine the performance of several approaches to the analysis of QT changes, including subject-specific (individual) QT corrections and model-based QT analysis methods. (duke.edu)
  • A large analysis of 42 studies with more than 800,000 participants found that olive oil was the only source of monounsaturated fat that seemed to reduce heart disease risk ( 4 ). (medicalnewstoday.com)
  • The studies that proved to be eligible were reviewed in ature Analysis and Retrieval System Online via Ovid. (bvsalud.org)
  • RESULTS: Forty-three studies were assessed: 20 randomized controlled trials and 23 quasi-experimental designs. (cdc.gov)
  • Public health evidence often derives from cross-sectional studies and quasi-experimental studies, rather than the so-called "gold standard" of randomized controlled trials often used in clinical medicine. (cdc.gov)
  • In trials with parallel study design and a 1-D outcome, the placebo effect was 0.35 (95% confidence interval [95% CI] 0.27-0.43). (nih.gov)
  • Three potential sources of bias were assessed in each of the trial reports: (1) control of selection bias at entry, (2) control of selection bias after entry, and (3) control of bias in assessing outcome(s). (ox.ac.uk)
  • The heterogeneity of population included, study design and outcome presentation refrained from a meta-analysis. (researchgate.net)
  • However, in a recent meta-analysis, the findings are mixed, so further research is needed (Kendrick et al. (uni-trier.de)
  • False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review. (jameslindlibrary.org)
  • Trials encompasses all aspects of the performance and findings of randomized controlled trials in health. (biomedcentral.com)
  • The data were analysed using MetaXL version 5.3 and STATA version 16. (who.int)
  • There were insufficient data to conduct a formal meta-analysis. (bris.ac.uk)
  • When a randomized design is not feasible, data from observational study designs can be used to emulate a randomized experiment based on causal inference approach to obtain a valid causal estimate [ 3 , 4 ]. (biomedcentral.com)
  • Global burden of hypertension: analysis of worldwide data. (bmj.com)
  • Individual participant data meta-analyses compared with meta-analyses based on aggregate data. (jameslindlibrary.org)
  • Plus, ultimately, concrete data and conclusive analysis are needed to make evidence-based health and medical recommendations. (bistromd.com)
  • Setting Secondary analysis of data from a randomized controlled trial evaluating the effectiveness of BMI in an emergency department. (motivationalinterviewing.org)
  • Compliance with the provisions in this LCD may be monitored and addressed through post payment data analysis and subsequent medical review audits. (cms.gov)
  • There are three trials with short study durations (12-13 weeks), and pooled data found statistically and clinically significant benefits in pain. (racgp.org.au)
  • Data were extracted and compared by meta-analysis, using odds ratio and mean differences with 95% confidence intervals. (edu.au)
  • The bibliometric data were exported from the database WoS for further analysis . (bvsalud.org)
  • All the authors have approved the review procedure, data analysis, reporting and submission of the analysis outcomes. (who.int)
  • Clinical study in which a prospectively planned opportunity is included to modify trial designs and hypotheses based on analysis of data from subjects in the study. (bvsalud.org)
  • Objective: This meta-analysis systematically reviewed published randomized control trials comparing sutured versus mesh-augmented hiatus hernia (HH) repair. (edu.au)
  • This Publication Type is a child to Randomized Controlled Trial in the MeSH tree hierarchy. (bvsalud.org)
  • Administration (FDA), gatifloxacin is of the 21st century: global analysis of the ture is beyond the scope of this letter. (cdc.gov)
  • 2016). Since early 2017, a DFG-funded (LU 660/9-1) randomized controlled trial evaluating the effects of personalized treatment prediction and personalized treatment adjustment on treatment outcomes has been ongoing. (uni-trier.de)
  • A 2020 review of 31 trials noted that, in general, green tea intake significantly lowered total cholesterol and low-density lipoprotein (LDL) cholesterol. (medicalnewstoday.com)
  • This popular herbal root might reduce the effectiveness of anticoagulants, interfere with blood sugar control, counteract immunosuppressants, and affect drug metabolization. (medicalnewstoday.com)
  • The effectiveness of the intervention is currently being evaluated in a randomized controlled trial. (cdc.gov)
  • Defining Rapid Reviews: a systematic scoping review and thematic analysis of definitions and defining characteristics of rapid reviews. (jameslindlibrary.org)
  • Eligibility criteria for study selection Randomized clinical trials comparing antenatal corticosteroids with placebo or no treatment in women with a singleton pregnancy at ≥34 weeks' gestation. (bmj.com)
  • An RCT's primary objective is the minimization of biases, such as selection or allocation biases, by randomizing participants into the study groups in an unbiased fashion. (biomedcentral.com)
  • Systematic reviews are rarely used to inform study design - a systematic review and meta-analysis. (jameslindlibrary.org)
  • This is a research topic worthy of further study. (frontiersin.org)
  • A systematic literature review is wildly different from a randomized controlled trial, which is still vastly different from a prospective observational study. (bistromd.com)
  • The literature related to this topic is controversial, heterogeneous, and unclear despite the prospect of a major clinical effect.The aim of this study was to identify and systematically review the literature to assess the effect of whole body vibration treatments on bone mineral density (BMD) in postmenopausal women with a specific focus on the experimental factors that influence the stimulus. (galileo-training.com)
  • This meta-analysis examined the effects of positive youth development interventions in promoting positive outcomes and reducing risk behavior. (nih.gov)
  • Aims To investigate empirically the hypothesized relationship between counsellor motivational interviewing (MI) skills and patient change talk (CT) by analysing the articulation between counsellor behaviours and patient language during brief motivational interventions (BMI) addressing at-risk alcohol consumption. (motivationalinterviewing.org)
  • WHO urges Member States as well as international, regional and national health institutions to regularly report on AMR status to serve as an evidence base for informing strategies and devising efficient preventive and control interventions. (who.int)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • I'm Commander Ibad Khan, and I'm representing the Clinical Outreach Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Design Sequential analysis of psycholinguistic codes obtained by two independent raters using the Motivational Interviewing Skill Code (MISC), version 2.0. (motivationalinterviewing.org)
  • Observed transition frequencies, conditional probabilities and significance levels based on odds ratios were computed using sequential analysis software. (motivationalinterviewing.org)
  • We combined both SOLVD populations and compared the results of a univariate analysis to a multivariate approach in which 3 patient subgroups were defined according to baseline risks for the combined end point of death or hospitalization for heart failure. (mcmaster.ca)
  • RATE-S functional outcomes associated with ADHD symptoms, social functioning, emotional control and antisocial behaviour were given at baseline, end of treatment and three-month follow-up. (springer.com)
  • This form of support consists in sharing of information about self-management topics like coping with symptoms, diet, exercise, medication, information about what other people are doing, and information about the disease itself, or about any other relevant aspects that could lead to improved self-management, and ultimately better health. (self-management.eu)
  • To estimate the placebo effect in juvenile idiopathic arthritis (JIA) through a meta-analysis of phase III clinical trials with placebo comparator. (nih.gov)
  • In trials with a withdrawal design the inverse placebo effect is similar among the different JIA categories. (nih.gov)
  • Vitex agnus castus was the more investigated remedy (four trials, about 500 women), and it was reported to consistently ameliorate PMS better than placebo. (researchgate.net)
  • We undertook a review of methodologies on causal inference methods in meta-analyses. (biomedcentral.com)
  • Washington, D.C. - Experts from the American Institutes for Research (AIR) will present on a broad range of research topics-including Africa's unconditional cash transfers, children's literacy development, and mixed methods approaches for enhancing systematic reviews-during the What Works Global Summit (WWGS) September 26-28 in London. (air.org)
  • We investigated functional outcomes in 95 adults with ADHD who were already treated with medication and randomized to receive treatment as usual (TAU/MED) or psychological treatment (CBT/MED) using a cognitive-behavioural programme, R&R2ADHD, which employs both group and individual modalities. (springer.com)
  • The key mechanism associated with improved functional outcomes is likely to be behavioural control. (springer.com)
  • Only 1 meta-analysis used GRADE quality measures. (cdc.gov)
  • As for clinical implications, the 2021 version of the Surviving Sepsis Campaign (SSC) guidelines included a meta-analysis of 10 randomized, controlled trials that showed improved mortality associated with vasopressin use. (medscape.com)
  • Results Six trials, including 5698 singleton pregnancies, were analyzed. (bmj.com)
  • Whole Body Vibration Treatments in Postmenopausal Women Can Improve Bone Mineral Density: Results of a Stimulus Focussed Meta-Analysis. (galileo-training.com)
  • Bioinformatics analysis indicated the up-regulated proteins were significantly enriched in "GnRH secretion" and "Circadian rhythm" signaling pathway. (frontiersin.org)
  • Those behaviours were significantly more likely to be followed by patient change exploration (CT and CCT) while MI-inconsistent behaviours and ‘other’ counsellor behaviours were significantly more likely to be followed by utterances not linked with the alcohol topic and significantly less likely to be followed by CT. (motivationalinterviewing.org)
  • (http://www.itu.int/en/ITU-D/Statistics/Documents/publications/misr2015/MISR2015-w5.pdf, accessed 10 October 2017). (who.int)
  • Drawing upon decades of experience, RAND provides research services, systematic analysis, and innovative thinking to a global clientele that includes government agencies, foundations, and private-sector firms. (rand.org)
  • The Association for Behavior Analysis International® (ABAI) is a nonprofit membership organization with the mission to contribute to the well-being of society by developing, enhancing, and supporting the growth and vitality of the science of behavior analysis through research, education, and practice. (abainternational.org)
  • Abbreviated as RTC, randomized control trials are the gold standard of clinical research. (bistromd.com)
  • Although this is not a recommendation by the SSC for a specific threshold of catecholamine dose where vasopressin should be initiated, this statement represents clinician interest and the need for further research on the topic," they note. (medscape.com)
  • We conducted a budget impact analysis to estimate the total cost to the NHS of introducing ivacaftor in England. (bris.ac.uk)
  • Under a causal inference framework, the goal is to identify and compute that effect estimate that has a causally relevant interpretation on the population the trial samples from. (biomedcentral.com)
  • This report represents the first description of combined label-free quantitative proteomics and PRM analysis of targeted proteins for discovery of different proteins before and after IVR treatment in the same patient. (frontiersin.org)
  • Design Systematic review with meta-analysis. (bmj.com)
  • We are compelled by our ethical code (and our funding sources) to continue to disseminate evidence that Applied Behavior Analysis (ABA) is an effective treatment for Autism Spectrum Disorder. (abainternational.org)
  • After each training supervisors will set goals and self-monitor a behavior related to the training topic. (cdc.gov)
  • 3 New evidence from the primary care setting has been published since the last American Family Physician review of this topic. (aafp.org)
  • Several tools have been developed to meet EBPH needs, including free online resources in the following topic areas: training and planning tools, US health surveillance, policy tracking and surveillance, systematic reviews and evidence-based guidelines, economic evaluation, and gray literature. (cdc.gov)
  • Phase 1 was a review of reviews (ie, systematic reviews or meta-analyses) that were published 2010-2018. (cdc.gov)
  • Adaptative Clinical Trials as Topic and Equivalence Trials as Topic are available for 2018. (bvsalud.org)
  • Post-group treatment effects were maintained at follow-up with the exception of emotional control and the Total composite scales, which continued to improve. (springer.com)
  • This systematic review is aimed at analysing the effects of herb remedies in the above conditions. (researchgate.net)
  • N of 1 trials can be aggregated to generate group mean treatment effects: A systematic review and meta-analysis. (jameslindlibrary.org)
  • Citation: Önal Ö, Evcil FY, Batmaz K, Çoban B, Doğan E. Systematic review and meta-analysis of verbal and physical violence against healthcare workers in the Eastern Mediterranean Region. (who.int)
  • Risk factors for hypertensive crisis: importance of out-patient blood pressure control. (bmj.com)
  • This technique consists in teaching on how to analyse factors that influence your behaviour and provide you or help you to develop strategies to reduce or overcome barriers and/or support facilitators (e.g., not eating unhealthy foods when you feel depressed). (self-management.eu)
  • In the present effort, we aim to identify and review methodologies relevant to implementation of a causally explicit framework for meta-analysis and discuss the interpretation and scientific relevance of that causal estimand. (biomedcentral.com)
  • Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
  • K, Benedict S, Bener A. Haemophilus "safety-related drug labeling influenzae type b still remains a leading crobial drug therapy and "using the changes" in 2001 and is the only cause of meningitis among unvaccinated agents with optimal activity against quinolone that carries a "warning" children--a prospective CSF analysis the expected pathogens" (1). (cdc.gov)
  • This systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines ( 13 ). (aerzteblatt.de)
  • Contrast-associated acute kidney injury in the critically ill: systematic review and Bayesian meta-analysis. (bmj.com)
  • Topics to be covered in the Institute will provide opportunities for hands-on, small-group, interactive learning directly relevant to each review topic. (cornell.edu)
  • Four hundred and sixty-three articles were found, of which 11 were selected for analysis, and two central themes emerged: promotion of patient safety in cesarean deliveries by means of the surgical safety checklist and recommendations to improve quality of care in cesarean deliveries. (bvsalud.org)
  • Once a month, supervisors will also lead a scripted health and safety discussion with employees that is aligned with that month's training topic. (cdc.gov)
  • Tian N, Boring M, Kobau R, Zack M, Croft J. Active Epilepsy and Seizure Control in Adults - United States, 2013 and 2015. (cdc.gov)