• potency
  • Methadone is different from most opioids considering its potency can vary depending on how long it is taken. (wikipedia.org)
  • It also enhances the analgesic potency of paracetamol, although a Cochrane review concluded that a dose of 100 mg is needed for an effect - double the amount contained in Saridon. (wikipedia.org)
  • REMS
  • The REMEDIES program was developed to meet the goals of the class-wide Risk Evaluation and Mitigation Strategy (REMS) for extended-release and long-acting opioid analgesics, as required by the U.S. Food and Drug Administration. (businesswire.com)
  • What is the role of accredited CME providers in the long-term evaluations for the ER/LA Opioid Analgesics REMS? (accme.org)
  • What is the role of accredited continuing education in the FDA ER/LA Opioid Analgesics REMS? (accme.org)
  • In the Extended-Release and Long-Acting Opioid Analgesics REMS, one of the elements to assure safe use is an education program for prescribers about the risks of opioid medications as well as safe prescribing and safe use practices. (accme.org)
  • The ER/LA Opioid Analgesics REMS requires the manufacturers to provide commercial support to accredited CME so that it is available free of charge or at nominal cost to prescribers. (accme.org)
  • addiction
  • The safety of opioids in noncancer patients has been an area of controversy because of confusion between physical dependence, which develops in all patients receiving opioids chronically, and addiction, which is a behavioural diagnosis that is rarely made in patients appropriately treated with opioids for pain. (hindawi.com)
  • The buprenorphine subdermal implant may be considered for maintenance therapy of opioid addiction in patients who have achieved prolonged clinical stability on low-to-moderate buprenorphine/naloxone doses. (medscape.com)
  • The sublingual tablet is used for initial detoxification treatment of opioid addiction. (medscape.com)
  • Buprenorphine
  • The purpose of this study is to determine the effectiveness of buprenorphine in treating opioid dependent individuals who abuse opioids that are prescribed for chronic pain. (clinicaltrials.gov)
  • The implant is indicated for the maintenance treatment of opioid dependence in patients who have achieved and sustained prolonged clinical stability on low-to-moderate doses of a transmucosal buprenorphine-containing product. (medscape.com)
  • It is indicated for treatment of moderate-to-severe opioid use disorder (OUD) in adults who have initiated treatment with a transmucosal buprenorphine-containing product and have been on a stable dose of transmucosal buprenorphine treatment for ≥7 days. (medscape.com)
  • respiratory
  • Now scientists at Wake Forest Baptist Medical Center report that in an animal model a novel pain-killing compound, BU08028, is not addictive and does not have adverse respiratory side effects like other opioids. (wakehealth.edu)
  • Desomorphine
  • First synthesized in Germany in 1940 and patented in the USA in 1952, it has a high potential for abuse as with any potent opioid agonist, and is sometimes found along with desomorphine as a component of the home-made opioid mixture known as "Krokodil" used in Russia and the neighboring former Soviet republics. (wikipedia.org)
  • anesthesia
  • It is ideal for analgesic action of short duration during anesthesia and in the immediate postoperative period. (medscape.com)
  • Induction of anesthesia is accomplished by using high doses of opioid (usually fentanyl or alfentanil) to maximize cardiovascular stability. (medscape.com)
  • The use of remifentanil has made possible the use of high-dose opioid and low-dose hypnotic anesthesia, due to synergism between remifentanil and various hypnotic drugs and volatile anesthetics. (wikipedia.org)
  • Drug
  • There are inpatient facilities and a few, specialized, licensed, outpatient, drug treatment programs that provide opioid detoxification using methadone. (medscape.com)
  • Enadoline is a drug which acts as a highly selective κ-opioid agonist. (wikipedia.org)
  • Allylnorpethidine (WIN-7681) is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). (wikipedia.org)
  • detoxification
  • 2) Detoxification, or controlled withdrawal with the goal of abstinence, is based on the principle of cross-tolerance in which one opioid is replaced with another and then slowly withdrawn. (medscape.com)
  • methadone
  • The sublingual tablet or film (Suboxone, Zubsolv) or the buccal film (Bunavail) may be used for induction for short-acting opioids (eg, heroin) but NOT for patients dependent on long-acting opioids (eg, methadone) because of risk for abrupt withdrawal symptoms. (medscape.com)
  • onset
  • The long term use of prescription opioid analgesics is associated with increased risk of new onset depression, shows an analysis of three large US healthcare databases. (bmj.com)
  • Remifentanil is used as an opioid analgesic that has a rapid onset and rapid recovery time. (wikipedia.org)
  • behavioral
  • As a leader in prescription pain medicine, Mallinckrodt is committed to supporting programs that educate and encourage behavioral changes for health providers and patients to ensure that analgesic opioid use is beneficial, not harmful, to people in need of pain relief," said Mario Saltarelli, MD, Chief Science Officer, Mallinckrodt Pharmaceuticals. (businesswire.com)
  • This report confirms that practical and engaging content, conveyed through a blend of learning methods, has a measurable impact as gauged by positive participant feedback and observed behavioral changes in opioid analgesic prescribing practices and use. (businesswire.com)
  • patients
  • The transdermal form of fentanyl is used only for chronic pain conditions in opioid-tolerant patients. (medscape.com)
  • REMEDIES is a novel educational platform for prescribers and is intended to improve the quality of care for opioid-tolerant pain patients," said Van Velle, President of Applied Clinical Education, a medical education company with 20 years of programming experience in the area of pain management. (businesswire.com)
  • 100 of 200 physicians enrolled met the criteria for opioid prescribing, and physician behavior increased 96% from stages A to C, with more than 300 patients documented in the ongoing program. (businesswire.com)
  • The NDA submission was based on the results of a 12-week, double-blind, randomized, placebo-controlled clinical trial with 600 opioid-experienced patients as well as supporting data from other clinical studies. (empr.com)
  • Many charts derive their data from studies conducted on opioid-naïve patients. (wikipedia.org)
  • oral
  • Two uses for opioid analgesics are as follows: (1) Oral substitution therapy or maintenance therapy or opioid agonist therapy (OAT) refers to substitution of an oral opioid for injected heroin, with the goal of reducing harmful behaviors associated with heroin use. (medscape.com)
  • prescriptions
  • The frequency of forgery and theft of different opioids appears to be largely related to the corresponding number of legitimate prescriptions. (hindawi.com)
  • adverse
  • Previous hypersensitivity (such as agranulocytosis or anaphylaxis) to metamizole or any of the excipients (e.g. lactose) in the preparation used, acute porphyria, impaired haematopoiesis (such as due to treatment with chemotherapy agents), third trimester of pregnancy (potential for adverse effects in the newborn), lactation, children with a body weight below 16 kg, history of aspirin-induced asthma and other hypersensitivity reactions to analgesics. (wikipedia.org)
  • clinical challenge
  • The REMEDIES curriculum incorporates a variety of tools that include live symposia, interactive web-based activities, a three-stage performance improvement program, and a series of three patient screening and education activities that help healthcare providers navigate the clinical challenge of opioid prescribing. (businesswire.com)
  • effects
  • In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A. It was studied as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a κ-opioid agonist. (wikipedia.org)
  • secondary
  • Abuse by secondary recipients of opioids is well documented and arises as a result of diversion by primary recipients, double-doctoring, forgery and theft. (hindawi.com)