The opium poppy, Papaver somniferum, is the primary source of analgesic opiate alkaloids such as morphine. (dissertation.com)
Amongst these only Morphine and Codeine have analgesic actions. (biologyease.com)
Morphine is the most important opium alkaloid used as a narcotic analgesic. (biologyease.com)
The analgesic action of morphine is mainly due to the abolition of psychic reactions to pain (a psychological component of pain). (biologyease.com)
They show pharmacological effects and are being commonly used as medicines (e.g., analgesic as morphine). (biomedcentral.com)
The benzylisoquinoline alkaloid (BIA) is a diverse category of alkaloids including berberine, morphine, sanguinarine, hydrastine and many more. (biomedcentral.com)
Benzylisoquinoline alkaloids8
Chorismic acid is a precursor to the amino acid tyrosine , the source of nitrogen in benzylisoquinoline alkaloids. (cloudfront.net)
These reactions produce ( S )- reticuline , a key branchpoint intermediate in the biosynthesis of benzylisoquinoline alkaloids. (cloudfront.net)
Many benzylisoquinoline alkaloids have been reported to show therapeutic properties and to act as novel medicines. (biomedcentral.com)
Thus it is important to collect and compile benzylisoquinoline alkaloids in order to explore their usage in medicine. (biomedcentral.com)
We extract information about benzylisoquinoline alkaloids from various sources like PubChem, KEGG, KNApSAcK and manual curation from literature. (biomedcentral.com)
This information was processed and compiled in order to create a comprehensive database of benzylisoquinoline alkaloids, called BIAdb. (biomedcentral.com)
The current version of BIAdb contains information about 846 unique benzylisoquinoline alkaloids, with multiple entries in term of source, function leads to total number of 2504 records. (biomedcentral.com)
A database of benzylisoquinoline compounds has been created, which provides comprehensive information about benzylisoquinoline alkaloids. (biomedcentral.com)
Narcotic1
Narcotic ones are analgesic drugs that possess the ability to depress the central nervous system. (biologyease.com)
Opium3
Noscapine constitutes a low percentage of the alkaloid content of opium and has been used as a cough suppressant in humans. (dissertation.com)
Thus, in addition to the analgesic effect, they also possess hypnotic and sedative actions, which further contribute to the analgesic effect. (biologyease.com)
It lacks significant hypnotic, euphoric, or analgesic effects affording it with very low addictive potential. (cloudfront.net)
Synthesis4
This thesis focuses on the design and synthesis of novel compounds to probe the emerging SAR of Noscapine related compounds. (dissertation.com)
Recent literature reported the synthesis of N-carbamoyl/N-thiocarbamoyl analogues of noscapine but the biological activity for this series of compounds was not published. (dissertation.com)
This chapter focused on the synthesis of noscapine analogues, which comprised multiple modifications on the same noscapine core to determine whether activity could be further improved. (dissertation.com)
Chapter 4 examines the synthesis of a noscapine mimetic, and the installation of an isoindolin-1-one moiety entailing of the exact substitution pattern of the noscapine phthalide. (dissertation.com)
Derivatives1
The findings from our work demonstrated that the activity of noscapine derivatives could be improved through the introduction of multiple modifications on the same core. (dissertation.com)
Antitussive1
Noscapine is often used as an antitussive medication. (cloudfront.net)
Suppress2
Current research has implicated noscapine in the ability to suppress the proliferation of various metastatic cellular lines within in vitro models. (dissertation.com)
Analgesics" are the drugs that relieve or suppress the sensation of pain by acting on the Central Nervous System (CNS) but without producing any degree of loss of consciousness. (biologyease.com)
Synthetic1
This database will also serve researchers working in the field of synthetic biology, as developing medicinally important alkaloids using synthetic process are one of important challenges. (biomedcentral.com)
Structures1
Analgesics can be divided into two types according to their structures and mechanisms of action. (biologyease.com)
Structural1
Noscapine (also known as Narcotine , Nectodon , Nospen , Anarcotine and (archaic) Opiane ) is a benzylisoquinoline alkaloid , of the phthalideisoquinoline structural subgroup, which has been isolated from numerous species of the family Papaveraceae (poppy family). (cloudfront.net)
Biological1
Alkaloids can be classified on the basis of biological activities, chemical structure and biosynthetic pathways. (biomedcentral.com)
Chemical1
These two independent modifications of the noscapine core demonstrated improvements in activity could be achieved through the chemical manipulation of different sites on the noscapine core. (dissertation.com)
Significant1
Many of the estimated 30 or more alkaloids extracted from Papaver somniferum have significant pharmaceutical value. (dissertation.com)
Species1
Alkaloids are naturally occurring secondary metabolites, low molecular weight, and nitrogen containing compounds that are found in more than 20% of plant species [ 1 ]. (biomedcentral.com)
Activity3
From the compounds synthesized in this initial series of N-substituted analogues the N-ethyl cyclic ether noscapine analogue showed activity against both PC3 and MCF-7 cancer cell lines with an EC50 of 6.7 and 3.58 μM. (dissertation.com)
We were unable to demonstrate the activity of noscapine in either cellular line (Chapter 2). (dissertation.com)
All three do not possess analgesic activity. (biologyease.com)
Current1
Current published literature examined modifications at the 7- and 9′-position separately on the noscapine scaffold. (dissertation.com)
Nowadays, non-natural alkaloids are growing rapidly as a result of bioorganic and stereochemistry research. (biomedcentral.com)
Effects2
Noscapine can increase the effects of centrally sedating substances such as alcohol and hypnotics . (cloudfront.net)
Noscapine should not be taken in conjunction with warfarin as the anticoagulant effects of warfarin may be increased. (cloudfront.net)
Potential1
Alkaloids belonging to this class are found to be pharmacologically active and show potential therapeutic properties. (biomedcentral.com)
Opiate4
Morphine is a potent opiate analgesic medication and is considered to be the prototypical opioid. (absoluteastronomy.com)
Opiate Alkaloids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
This graph shows the total number of publications written about "Opiate Alkaloids" by people in this website by year, and whether "Opiate Alkaloids" was a major or minor topic of these publications. (jefferson.edu)
Below are the most recent publications written about "Opiate Alkaloids" by people in Profiles. (jefferson.edu)
Papaverine3
The second type of alkaloids is often represented by papaverine and noscapine, and this of group chemicals are responsible for relaxes involuntary muscles. (betteraddictioncare.com)
The opium poppy also gives other alkaloids like codeine, papaverine, and so on. (herbs2000.com)
For centuries, poppy seed tea has been used for its narcotic, analgesic, antidiarrheal, or euphoric effects, or as a substitute for opiates. (medscape.com)
Teas made from the opium poppy have been used for centuries for their narcotic, analgesic, antidiarrheal, and/or euphoric effects-or as a substitute for opiates. (medscape.com)
Thebaine1
Thebaine is an opium alkaloid that has been shown to be present in the urine of individuals who have consumed poppy seeds, as well as those who have used opium. (bvsalud.org)
Codeine2
The first type, which is represented by morphine and codeine, acts upon the nervous system and provides analgesic (pain-relieving), narcotic, and potentially addicting effects. (betteraddictioncare.com)
Codeine is an analgesic, and it is often recommended to obtain relief from minor pains and aches, at times in combination with aspirin or an aspirin substitute. (herbs2000.com)
PAPAVER2
These seeds may be contaminated with latex from the Papaver somniferum L. plant rich in opium alkaloids (OAs). (bvsalud.org)
They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS . (nih.gov)
Drugs1
Nonsteroidal anti-inflammatory drugs, usually abbreviated to NSAIDs or NAIDs, but also referred to as nonsteroidal anti-inflammatory agents/analgesics or nonsteroidal Anti-inflammatory medicines , are drugs with analgesic and antipyretic effects and which have, in higher doses, anti-inflammatory. (absoluteastronomy.com)
Found2
The active pharmacological components of opium are found in its alkaloids, which can be grouped into two types. (betteraddictioncare.com)
In freebase form, the alkaloids found in opium are significantly less soluble in water than in alcohol. (opioids.wiki)
Plant1
Then a scientist was able to synthesize or copy this plant alkaloid into a chemical drug without using the original tree bark for manufacturing the drug. (rain-tree.com)
Type1
The alkaloids whose structure has been established to the present all belong to steroidal alkaloids of pregnane type. (go.jp)
Form1
Japanese name Fukki-so) (Buxaceae) and 27 kinds of new alkaloids were isolated in crystalline form. (go.jp)