Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief? (mdpi.com)
Tetrodotoxin: A New Strategy to Treat Visceral Pain? (mdpi.com)
The first report of congenital insensitivity to pain described "pure analgesia" in a performer working in a traveling show as "The Human Pincushion. (uconn.edu)
Sensory Neurons2
Nav1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory neurons and has been implicated in the pathophysiology of inflammatory and neuropathic pain. (nih.gov)
Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia. (fudan.edu.cn)
Sodium channel2
Dexmedetomidine inhibits Tetrodotoxin-resistant Na(v)1.8 sodium channel activity through G(i/o)-dependent pathway in rat dorsal root ganglion neurons. (fudan.edu.cn)
Another main one is tetrodotoxin, a sodium channel blocker, which prevents nervous system messages from getting through, therefore keeping muscles from working correctly. (hempweedwholesale.com)
Blockade1
Recent studies using an Nav1.8 antisense oligonucleotide in an animal model of chronic pain indicated that selective blockade of Nav1.8 was analgesic and could provide effective analgesia with a reduction in the adverse events associated with nonselective VGSC blocking therapeutic agents. (nih.gov)
Nociceptors2
Tetrodotoxin-resistant sodium channels are selectively expressed in nociceptors, where they have an important role in impulse initiation and action potential conductance. (medscape.com)
In particular, expression of an inhibitory (Gi-coupled) DREADD in nociceptors might enable ligand-dependent analgesia. (jneurosci.org)
Nociceptive2
However, there is a mismatch between the analgesia produced by Nav1.7 loss-of-function and the peripherally restricted Nav1.7 inhibitors, which may reflect a lack of understanding of the function of Nav1.7 in the transmission of nociceptive information. (bvsalud.org)
The purpose of this study was to determine whether inhibitory DREADDs in nociceptive afferents could be used to produce analgesia, and if so, how. (jneurosci.org)
Mechanisms2
All of these mechanisms result in analgesia or anti-inflammatory actions (Fig. 1). (medscape.com)
Altogether, our results implied significant mechanisms of CFM and EA-analgesia that involve the regulation of the TRPV1 signaling pathway. (ac.ir)
Local1
Prolonged-duration local anesthetics will be useful for postoperative analgesia. (wustl.edu)