• But his career was tragically cut short when he was diagnosed with amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that slowly robs people of their ability to move, speak and eventually breathe. (ama-assn.org)
  • Motor neurons (MNs) die in amyotrophic lateral sclerosis (ALS), a clinically heterogeneous neurodegenerative disease of unknown etiology. (frontiersin.org)
  • Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the central nervous system that results in a progressive loss of motor function and ultimately death. (biorxiv.org)
  • Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that leads to death. (wjgnet.com)
  • BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in death, usually from respiratory failure, within 2-3 years of symptom onset. (whiterose.ac.uk)
  • Protein aggregation is a central feature of many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS). (biomedcentral.com)
  • Neurodegenerative disorders (NDDs) such as Huntington's disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable populations of neurons. (lu.se)
  • Utreloxastat (PTC-857, EPI-857) is under development for the treatment of adult neurodegenerative diseases including glucocerebrosidase, or GBA, amyotrophic lateral sclerosis and Parkinson's disease.The therapeutic candidate is administered through oral route. (pharmaceutical-technology.com)
  • Exposure to the cyanobacteria neurotoxin BMAA may be an environmental cause of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Alzheimer's disease. (wikipedia.org)
  • Arvin Behzadi et al, Myofiber Type Shift in Extraocular Muscles in Amyotrophic Lateral Sclerosis, Investigative Opthalmology & Visual Science (2023). (reachmd.com)
  • To develop a first-in-human gene therapy for amyotrophic lateral sclerosis (ALS) using intrathecal AAV9-SOD1-shRNA administration. (neurology.org)
  • There is substantial evidence that both inflammation and oxidative damage contribute to the pathogenesis of motor neuron degeneration in the G93A SOD1 transgenic mouse model of amyotrophic lateral sclerosis (ALS). (karger.com)
  • Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). (bvsalud.org)
  • This Health Condition MedlinePlus Genetics provides information about Amyotrophic lateral sclerosis More About This Health Condition CHM2B_HUMAN CHMP family, member 2B CHMP2. (nih.gov)
  • Military service, deployments, and exposures in relation to amyotrophic lateral sclerosis etiology. (cdc.gov)
  • Data from patients with amyotrophic lateral sclerosis, who have ever reported treatments, ordered by their reporting frequency during the last 5 years. (patientslikeme.com)
  • Suicide among patients with amyotrophic lateral sclerosis. (ki.se)
  • Emergency physicians should be familiar with amyotrophic lateral sclerosis (ALS) and should consider the diagnosis in patients with motor symptoms and signs of hyperreflexia. (medscape.com)
  • It is concluded that dyspnoea in amyotrophic lateral sclerosis patients should prompt diaphragm function tests. (ersjournals.com)
  • Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease, with large variation in survival between patients. (vu.nl)
  • OBJECTIVE: The Diaphragm Pacing in patients with Amyotrophic Lateral Sclerosis (DiPALS) trial evaluated the effect of DP on survival over the study duration in patients with ALS with respiratory failure. (whiterose.ac.uk)
  • Patients suffering from Amyotrophic lateral sclerosis notice problems in dexterity and gait. (targetwoman.com)
  • Patients suffering from myotrophic Lateral Sclerosis face difficulties in chewing and swallowing. (targetwoman.com)
  • Kathy Poirier suffers from amyotrophic lateral sclerosis (ALS), which is also known as Lou Gehrig's disease. (techarp.com)
  • Amyotrophic lateral sclerosis (ALS), also known as Charcot's disease and Lou Gehrig's disease, is a disease of unknown cause characterized by slowly progressive degeneration of upper motor neurons (UMNs) and lower motor neurons (LMNs). (medscape.com)
  • ALS , formally known as amyotrophic lateral sclerosis and informally as Lou Gehrig's disease, occurs in both a less common familial form (i.e. an inherited form, known as ALS1), and perhaps independently, in a sporadic form. (snpedia.com)
  • Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is characterized by a progressive degeneration of spinal cord and cerebral cortex motor neurons, leading to muscular atrophy, paralysis, respiratory failure, and death. (rndsystems.com)
  • As a result of these developments, enthusiasm for the potential of VEGF as a therapeutic target Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is characterized by a progressive degeneration of spinal cord and cerebral cortex motor neurons, leading to muscular atrophy, paralysis, respiratory failure, and death. (rndsystems.com)
  • Amyotrophic Lateral Sclerosis or ALS is also referred to as Lou Gehrig's disease . (targetwoman.com)
  • For patient education information, see the Brain and Nervous System Center , as well as Dementia Overview , Dementia Medication Overview , and Dementia in Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) . (medscape.com)
  • Familial aggregation of amyotrophic lateral sclerosis. (ki.se)
  • 2013 Nov 13 - 'Amyotrophic lateral sclerosis (ALS) is an incurable paralytic disorder primarily typified by the selective and progressive degeneration of motoneurons in the brain and spinal cord. (qualitycounts.com)
  • Riluzole is the only FDA approved medication for controlling Amyotrophic lateral sclerosis. (targetwoman.com)
  • Physical and occupational therapy and speech pathology consultations assist the patient with amyotrophic lateral sclerosis (ALS) in maintaining strength, daily living activities, and communication skills (as demonstrated in the image below). (medscape.com)
  • Patient with amyotrophic lateral sclerosis (ALS) using eye-gaze computer device to conduct business and communicate. (medscape.com)
  • The patient disclosed that his wife, who had amyotrophic lateral sclerosis that required mechanical ventilation, had been hospitalized in a tertiary hospital in the Tel Aviv area for 9 weeks until July 19, 2007. (cdc.gov)
  • The onset of amyotrophic lateral sclerosis (ALS) is conventionally considered as commencing with the recognition of clinical symptoms. (bmj.com)
  • Symptoms of Amyotrophic Lateral Sclerosis are often mistaken for other neurological diseases. (targetwoman.com)
  • Due to its association with Parkinsons-like symptoms and also partly with amyotrophic lateral sclerosis (ALS), it has been categorized as Multiple System Atrophy to specify the symptoms. (targetwoman.com)
  • Access it online or download it at https://books.byui.edu/bio_381_pathophysiol/615__amyotrophic_lat . (byui.edu)
  • Citation on PubMed Siddique N, Siddique T. Amyotrophic Lateral Sclerosis Overview. (nih.gov)
  • Cognitive impairment in amyotrophic lateral sclerosis (ALS) is correlated with pathologic and radiographic changes in the cerebral cortex beyond the motor regions. (medscape.com)
  • Dr. Lorne Zinman , a clinician-scientist in the Hurvitz Brain Sciences Program at Sunnybrook Research Institute, was the senior author of a survey of health professionals who care for people with amyotrophic lateral sclerosis (ALS) to find out what they think about it. (sunnybrook.ca)
  • Researchers at the University of Colorado Boulder have discovered a link between an ancient protein with virus-like characteristics, called PEG10, and the development of amyotrophic lateral sclerosis (ALS). (medicalnewstoday.com)
  • In a previous editorial in this journal 1 we have argued that there are likely to be important occupational causes of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) (also commonly known as motor neuron disease) which have not yet been discovered or established. (bmj.com)
  • According to GlobalData, Phase II drugs for Amyotrophic Lateral Sclerosis have a 65% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
  • A unique type of muscle fiber found in the extraocular muscles has been shown to be resistant against the disease amyotrophic lateral sclerosis (ALS), and has been shown to even increase in proportion to compensate when other types of muscle fibers decrease in proportion. (reachmd.com)
  • Amyotrophic lateral sclerosis (ALS) is a progressive disorder of unknown origin. (ersjournals.com)
  • Amyotrophic lateral sclerosis (ALS) is a mixed lower motor neuron and upper motor neuron disorder. (byui.edu)
  • The mission of the Northeast Amyotrophic Lateral Sclerosis Consortium® (NEALS) is to rapidly translate scientific advances into clinical research and new treatments for people with Amyotrophic Lateral Sclerosis (ALS) and motor neuron disease. (neals.org)
  • Background: Amyotrophic lateral sclerosis (ALS) is a progressive fatal disease with a varying range of clinical characteristics. (cdc.gov)
  • An estimate of amyotrophic lateral sclerosis heritability using twin data. (ki.se)
  • The author propose that amyotrophic lateral sclerosis is a disease of damaged and misfolded proteins induced by environmental regulators, occurring at the level of translation and post-translation, and not at the level of the genome. (wjgnet.com)