• Sex hormone-binding globulin was directly associated with age and inversely associated with BMI. (lu.se)
  • The relationship was investigated between baseline serum levels of total testosterone (T), free testosterone (FT), dehydroepiandrosterone sulfate (DHEAS), ESTRADIOL (E2), sex hormone-binding globulin (SHBG), insulin-like growth factor-1 (IGF-1) and cognitive functioning in 25 healthy older men (mean age 69.1 years). (rug.nl)
  • To address this, concentrations of testosterone, sex hormone binding globulin, androstanediol glucuronide (a metabolite of dihydrotestosterone) and estradiol were measured in stored serum specimens from men selected for the 1/3 subsample where organochlorine pesticide levels were determined. (cdc.gov)
  • Most of the circulating testosterone is bound to carrier proteins (SHBG = sex hormone-binding globulin). (cdc.gov)
  • Sex hormone-binding globulin (SHBG) is the blood transport protein for testosterone and estradiol. (cdc.gov)
  • The body releases endorphins and other hormones in sex. (abhishekbachchan.org)
  • However, it remains unclear whether in the US population circulating concentrations of sex steroid hormones vary by race/ethnicity. (cdc.gov)
  • To examine the distribution of and factors associated with event-level heterosexual anal sex and of event-level condom use during anal sex among adolescent women. (nih.gov)
  • generalized estimating equation logistic regression assessed the likelihood of anal sex or condom use during anal sex on a given day. (nih.gov)
  • About 30% of anal sex events were condom protected. (nih.gov)
  • Our findings suggest the importance of providers' screening adolescent women patients during office visits about anal sex and about condom use during anal sex, as well as asking questions about the context of these behaviors to appropriately tailor risk reduction counseling. (nih.gov)
  • Among young people in particular, alcohol intoxication is associated with such practices as having sex with a stranger or new acquaintance, having sex that doesn't involve the use of a condom and having sex with more than one person in a short span of time. (rightstep.com)
  • 4 , 5 However, a recent mathematical model has shown that gonorrhoea would not be eliminated by consistent condom use during penile-anal sex as transmission can occur between other anatomical sites. (bmj.com)
  • 6 This is consistent with a recent empirical study showing gonorrhoea positivity in MSM is increasing after adjusting for condom use during anal sex. (bmj.com)
  • Gonorrhoea transmission is still occurring in the setting of condom use for penile-anal sex. (bmj.com)
  • One of the many questions that surround the world of sex is whether oral sex can, in fact, increase your risk of cancer. (setcases.info)
  • Now whilst oral sex can put you at risk of some sexually transmitted infections the actual act itself will not cause cancer. (setcases.info)
  • Conclusion: Multiple factors are associated with variation in male testosterone, SHBG, and LH concentrations. (lu.se)
  • There's a new paper in PLoS ONE, The Distance Between Mars and Venus: Measuring Global Sex Differences in Personality *, which suggests that by measuring variation of single observed personality traits researchers are missing larger underlying patterns of difference. (discovermagazine.com)
  • In conclusion, we believe we made it clear that the true extent of sex differences in human personality has been consistently underestimated. (discovermagazine.com)
  • In this way, it will be possible to build a solid foundation for the scientific study of psychological sex differences and their biological and cultural origins. (discovermagazine.com)
  • From what I can gather the authors discovered that the differences between sexes on personality were much clearer once you looked for the correlation across numerous single measured traits. (discovermagazine.com)
  • But in regards to the evolution of sex differences there is something that I feel that I can say here. (discovermagazine.com)
  • This implies that sex differences on the genetic level may emerge via modulation of gene expression across networks of genes tuned by some 'master controllers' associated with differential sex development. (discovermagazine.com)
  • The specialized centers were selected on the basis of having at least three highly meritorious interdisciplinary research projects that explore an important issue related to sex/gender health differences. (nih.gov)
  • Given the sex differences in CAD observed in older adults, understanding sex differences in risk factors for this younger group of adults is important. (nursingcenter.com)
  • Having insight of cardiac risk factors and sex differences in the young adult population is essential to creating personalized strategies for prevention in nursing care and in this age group. (nursingcenter.com)
  • Objectives: The aims of this study were to determine the differences in CAD risk factors for young adult men and women and examine which factors are related to CAD early in life, ultimately to guide approaches for CAD prevention in primary care. (nursingcenter.com)
  • Differences between men and women in CAD risk factors included lifestyle and other chronic conditions. (nursingcenter.com)
  • Greater prevention efforts should focus on these differences in young men and women to reduce risk factors and prevent the development of CAD. (nursingcenter.com)
  • Sex differences play a role in cardiovascular diseases in adults but are not well defined in youth. (uky.edu)
  • The objective of this study is to identify sex differences in obesity-mediated cardiometabolic risk factors in adolescents. (uky.edu)
  • Conclusions: There are sex differences in the relationship between plasma cortisol and DBP in youth with obesity. (uky.edu)
  • To determine the state-based prevalence of colorectal cancer screening among U.S. adults, CDC analyzed 2010 data from the Behavioral Risk Factor Surveillance System (BRFSS). (cdc.gov)
  • the prevalence of CVD risk factors remains high. (cdc.gov)
  • Despite decades-long reductions in cardiovascular disease (CVD) mortality, CVD mortality rates have recently plateaued and even increased in some subgroups, and the prevalence of CVD risk factors remains high. (cdc.gov)
  • Risk factor prevalence among U.S. adults was assessed using data from the National Health and Nutrition Examination Survey, National Survey on Drug Use and Health, and National Health Interview Survey. (cdc.gov)
  • We hypothesized that genotype -by- sex (G × S) interactions contribute to the increased prevalence and severity. (bvsalud.org)
  • Because heritable factors appear to be responsible for 45-75% of the inter‐individual variation in body mass index (BMI), the potential impact of genetic determinants of metabolic rate upon the predisposition to obesity must be considered. (drsharma.ca)
  • This study reveals that non-genetic factors, and to a lesser extent, genetic factors appear to influence mutual eye gaze in adult chimpanzees, and is the first to report neuroanatomical correlates of mutual eye gaze variation in chimpanzees. (nature.com)
  • First, though there is widespread comparative interest in gaze-related behavior, such as mutual eye gaze and gaze following in nonhuman primates, there are few studies that have examined the potential role of genetic factors underlying individual variation in relatively large cohorts of individuals. (nature.com)
  • It has been proposed that racial/ethnic variation in prostate cancer incidence may be, in part, due to racial/ethnic variation in sex steroid hormone levels. (cdc.gov)
  • A potential explanation for the observed variations in sex and age of disease onset is the natural genetic variation within the autosomal genomes . (bvsalud.org)
  • Our results indicate that natural genetic variation affects the different heritability of periodontitis among sexes and suggest genes that contribute to inter- sex phenotypic variation in early-onset periodontitis . (bvsalud.org)
  • Rapid Increase in Reports of Syphilis Associated With Men Who Have Sex With Women and Women Who Have Sex With Men, Japan, 2012 to 2016. (who.int)
  • In this study, one searched to identify the perception of this risk between adolescents in relation to AIDS and the risk factors related to sexual practice without protection. (bvsalud.org)
  • However, researchers know relatively little about the factors that make a person more likely to drink alcohol before having sex . (rightstep.com)
  • In a study published in August 2014 in the journal Drug and Alcohol Dependence , researchers from several U.S. institutions examined the potential impact of two specific factors: the absence or presence of a current relationship and the presence of diagnosable symptoms of alcohol use disorder. (rightstep.com)
  • The researchers looked for individuals in this group who consumed alcohol before having sex in most or all circumstances. (rightstep.com)
  • After completing their work, the researchers concluded that a diagnosis for alcohol use disorder and a person's current state of relationship involvement have a combined effect on the odds of consuming alcohol before having sex. (rightstep.com)
  • Criminalisation of male-to-male sex in many countries, social denial and difficulty in reaching this population were the explanations given for the weak involvement of researchers in this area. (bmj.com)
  • Researchers have found a few risk factors that make a person more likely to develop nasal cavity (nose) and paranasal sinus cancer. (cancer.org)
  • Researchers consider a number of factors in deciding where to publish their research, such as journal reputation, readership and community, speed of publication, and citations. (springer.com)
  • In a 2022 review of studies , researchers found that male sex and cancer spread to lymph nodes typically led to worse overall survival and a higher chance of treatment failure. (healthline.com)
  • Thankfully, decades of hard work by countless researchers mean we've got a good idea of what the risk factors are. (movember.com)
  • Genetic risk factors alone are not enough to cause Alzheimer's disease, so researchers are actively exploring other factors which may play a role in the development of this disease. (alzheimer.mb.ca)
  • Your cancer stage at the time of your diagnosis is one of the most important factors that determine your chances of survival. (healthline.com)
  • The National Institutes of Health (NIH) Office of Research on Women's Health (ORWH) announces 11 new or continuing Specialized Center of Research (SCOR) on Sex and Gender Factors Affecting Women's Health Awards, as a result of the second solicitation for this program. (nih.gov)
  • Based upon the success of the first SCOR awards, ORWH has dedicated the resources to take the lead in funding these eleven centers dedicated to advancing interdisciplinary research on sex/gender factors that may improve the health of women. (nih.gov)
  • The interdisciplinary nature of these new and continuing centers will provide opportunities for innovative approaches to research on sex/gender related health effects. (nih.gov)
  • Clinicians can encounter sex and gender disparities in diagnostic and therapeutic responses. (nih.gov)
  • Sex and gender exist on spectrums. (medicalnewstoday.com)
  • The Sex Factor was an online reality TV series produced by xHamster where eight men and eight women compete to become a porn star. (wikipedia.org)
  • In Episode 1 he claimed to have had sex with 3 women prior to filming. (wikipedia.org)
  • Men reported more cardiovascular risk factors than women and developed risk factors at an earlier age. (nursingcenter.com)
  • Guerra-Infante FM, Flores-Medina S, López-Hurtado M, Zamora-Ruíz A, Sosa González IE, Narcio Reyes ML, Villagrana-Zessati R. Tumor necrosis factor in peritoneal fluid from asymptomatic infertile women. (aaem.pl)
  • I only wish that she would also recognize that it is inappropriate to try to demonize women who hold conservative views as betraying their sex. (iwf.org)
  • Some risk factors may affect heart disease risk differently in women than in men. (medlineplus.gov)
  • Women who want to be more active in their sex life may consider taking advantage of a variety of therapies. (abhishekbachchan.org)
  • Ideally directly now can clear up ceaseless the issues individuals have around sex toys and masturbation. (wallpaperstag.net)
  • Sex Toys and Masturbation are Addictive Masturbation and the utilization of grown-up toys is not misuse. (wallpaperstag.net)
  • The veritable factors show several people can get subject to utilizing sex toys to top, yet there is no withdrawal results related with the utilization of sex doll with penis. (wallpaperstag.net)
  • Disparities in risk factor prevalences were observed across age groups, genders, and racial/ethnic groups. (cdc.gov)
  • Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. (aaem.pl)
  • Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects. (aaem.pl)
  • Olsson I, Gatanaga T, Gullberg U, Lantz M, Granger GA. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. (aaem.pl)
  • These observations have suggested physiologic and pathologic roles for factor XIII in angiogenesis, atherosclerosis, and inflammation. (medscape.com)
  • Currently, a careful clinical assessment of family history of obesity and related risk factors remains the best measure of genetic risk for obesity. (drsharma.ca)
  • To date, only adults have been studied for substance use disorders with regards to a particular genetic risk factor. (georgetown.edu)
  • This may be due to inherited conditions that increase the risk of HPV infections or other genetic risk factors. (medicalnewstoday.com)
  • Modifiers which dampen this effect need to emerge, so that sex-specific selection doesn't have the side effect of dragging the other sex along in terms of trait value (this is a concern when you have traits, such as high testosterone, which might increase fitness in males, but reduce it their daughters). (discovermagazine.com)
  • Background: Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements. (lu.se)
  • Testosterone promotes the development of the secondary sex characteristics in men and serves to maintain the function of the prostate and seminal vesicles. (cdc.gov)
  • Conclusions Saliva use as a lubricant for anal sex is a common sexual practice in MSM, and it may play an important role in gonorrhoea transmission. (bmj.com)
  • Purpose: To clarify factors associated with variations in sex hormone concentrations. (lu.se)
  • Obesity and high blood pressure, which are problems associated with diabetes, are also risk factors in Alzheimer's disease and vascular dementia. (alzheimer.mb.ca)
  • She said that all I have been doing over the years is running away from the effects of the sex abuse by gambling and taking excess medication to block out the symptoms of the sex abuse," the patient said. (irishtimes.com)
  • More specifically, they found that, among people with diagnosable alcohol use disorder symptoms, not being in a relationship substantially increases the odds that drinking will precede sex . (rightstep.com)
  • Serum sterols were quantified via LC-MS/MS. Number of cardiometabolic risk factors were evaluated. (uky.edu)
  • The objective of this study was to understand factors associated with unprotected anal intercourse (UAI) with male partners among a group of MSM living in the city of Douala, Cameroon. (bmj.com)
  • Background Apart from penile-anal intercourse, other anal sexual practices (rimming, fingering and saliva use as a lubricant for anal sex) are common among men who have sex with men (MSM). (bmj.com)
  • There was a significant interaction between sex and cortisol (p=0.023) for DBP. (uky.edu)
  • Sex is one human interaction that has always had lots of myths attached to it. (setcases.info)
  • Wound healing is promoted by factor XIIIa via cross-linking of the provisional matrix, a process that influences the extracellular matrix-leukocyte interaction. (medscape.com)
  • Background: Coronary artery disease (CAD) is increasing in young adults, and greater understanding of their cardiac risk factors is essential to ensure effective prevention. (nursingcenter.com)
  • In this secondary analysis, 125 017 community-dwelling young adults were evaluated for health behaviors considered as risk factors for CAD. (nursingcenter.com)
  • It's also because it's one of the most frequent reasons people seek out sex therapists. (yourtango.com)
  • It's a firmly established fact that people who drink significant amounts of alcohol before having sex substantially increase their odds of participating in risky sexual practices and developing a sexually transmitted infection. (rightstep.com)
  • Many people with risk factors never develop these cancers, while people with these cancers may have few or no known risk factors. (cancer.org)
  • Additionally, other research indicates that genetic factors may predispose people to anorexia and other eating disorders . (medicalnewstoday.com)
  • Having a good sexual life can be a source of joy and pleasure, but for many people, depression can make it impossible to enjoy their sex. (abhishekbachchan.org)
  • For most people with depression, the best way to handle their sex life is to keep it fun and light. (abhishekbachchan.org)
  • People living in poverty and having food insecurity are disproportionally burdened by some of these risk factors for many reasons, including the low cost of energy-dense foods such as SSBs (10). (cdc.gov)
  • Additional factors that can affect metabolic rate will be discussed in subsequent posts. (drsharma.ca)
  • SSB intake is associated with weight gain, high blood pressure, type 2 diabetes, and metabolic syndrome - all of which are risk factors for cardiovascular disease, 1 of the leading causes of preventable death in the United States (2-9). (cdc.gov)
  • The 2017 Behavior Risk Factor Surveillance System database from the Center for Disease Control was utilized. (nursingcenter.com)
  • A risk factor is anything that increases your chances of getting a disease like cancer. (cancer.org)
  • Having a risk factor, or even several, does not mean that you will get the disease. (cancer.org)
  • con committedly, chronic kidney disease may be a risk factor for cancer, and there is a strong association between the two conditions due to the commonality of risk factors, often toxins. (news-medical.net)
  • HPV is the most significant risk factor for cervical cancer. (medicalnewstoday.com)
  • High blood pressure is a major risk factor for heart disease. (medlineplus.gov)
  • Another risk factor for the development of Alzheimer's disease is brain injuries. (alzheimer.mb.ca)
  • The aim of this study is to evaluate whether these anal sexual practices are risk factors for rectal gonorrhoea in MSM. (bmj.com)
  • 7 These studies suggest that sexual practices other than penile-anal sex, such as digital-anal ('fingering') and oral-anal ('rimming') sex, may play a key role in gonorrhoea transmission in MSM. (bmj.com)
  • WASHINGTON (November 13, 2017) - In a study of adolescent boys and girls, neuroscientists at Georgetown University Medical Center and Penn State University have found a sex difference in a gene linked to substance use disorders. (georgetown.edu)
  • The work is some of the first to look for genetic markers of risk in relation to adolescent brain development and how these factors relate to risk of future substance use disorders. (georgetown.edu)
  • Journey of self-discovery and growth as we break down barriers, debunk myths and promote a sex-positive environment. (redfmindia.in)
  • Risk factors for hip fracture similar to international work on risk factors for hip fracture, can be identified using the New Zealand version of the interRAI home care assessment. (springer.com)
  • Global estimates and projections of population by sex and age : the 1984 assessment. (who.int)
  • Assessment of clot stability is the most common screening test for factor XIII deficiency, even though sensitivity and specificity are low. (medscape.com)
  • Several risk factors may play a role in the development of anorexia nervosa, including social pressures, other mental health conditions, and family history and genetics. (medicalnewstoday.com)
  • Further research is the key to helping us deepen our understanding of the role of risk factors in developing Alzheimer's disease. (alzheimer.mb.ca)
  • Fibrin-fibronectin cross-linking is necessary to support the formation of the cytotrophoblastic shell at the site of placental implantation, which accounts for the role of factor XIII in the maintenance of pregnancy. (medscape.com)
  • Other factors associated with this higher risk included having had a stable male partnership at some point in one's life and not having been out of Douala for more than 4 weeks during the previous year. (bmj.com)
  • This article will use the terms "male," "female," or both to refer to sex assigned at birth. (medicalnewstoday.com)
  • Risk factors are characteristics of the person, their lifestyle and environment that contribute to the likelihood of getting the disease. (alzheimer.mb.ca)
  • Millions of Americans have CVD risk factors that place them at increased risk for having a cardiovascular event, despite the existence of proven strategies for preventing or managing CVD risk factors. (cdc.gov)
  • Consumption of sugar-sweetened beverages (SSBs) is associated with cardiovascular disease risk factors. (cdc.gov)
  • Most men who undergo treatment for prostate cancer (including surgery) experience a change to their sex life. (movember.com)
  • Take a closer look at these factors that affect your car insurance premium to clear things up - some of them also come with bonus suggestions for keeping costs down. (statefarm.com)
  • Keeping a sex diary can help you see how you are feeling and what changes need to be made. (abhishekbachchan.org)
  • From 1983 to 1987, the age-adjusted incidence rate of breast cancer varied by factor of about 5 between countries (see image below). (medscape.com)
  • Endometrial cancer invasion depends on cancer-derived tumor necrosis factor-alpha and stromal derived hepatocyte growth factor. (aaem.pl)
  • Onsrud M, Shabana A, Austgulen R, Nustad K. Comparison between soluble tumor necrosis factor receptors and CA125 in peritoneal fluids as a marker for epithelial ovarian cancer. (aaem.pl)
  • Opala T, Rzymski P, Wilczak M, Woźniak J. Evaluation of soluble tumour necrosis factor alpha receptors p55 and p75 in ovarian cancer patients. (aaem.pl)
  • What Are the Risk Factors for Nose Cancer or Sinus Cancer? (cancer.org)
  • Here we provide evidence that intrinsic risk factors contribute only modestly (less than ~10-30% of lifetime risk) to cancer development. (nature.com)
  • First, we demonstrate that the correlation between stem-cell division and cancer risk does not distinguish between the effects of intrinsic and extrinsic factors. (nature.com)
  • Collectively, we conclude that cancer risk is heavily influenced by extrinsic factors. (nature.com)
  • Figure 1: Schematic showing how intrinsic processes and extrinsic factors relate to cancer risks through stem-cell division. (nature.com)
  • Figure 2: Correlation analysis of stem-cell division and cancer risk does not distinguish contribution of extrinsic versus intrinsic factors to cancer risk. (nature.com)
  • Song, M. & Giovannucci, E. L. Cancer risk: many factors contribute. (nature.com)
  • Factors relating to sexual history may increase the risk of cervical cancer, as these may increase the risk of HPV exposure. (medicalnewstoday.com)
  • Learn more about cervical cancer risk factors here. (medicalnewstoday.com)
  • Read on to learn more about the outlook for anal cancer and the factors that affect outlook. (healthline.com)
  • Other factors that can influence the outlook of anal cancer include the following. (healthline.com)
  • Modeling studies have suggested that increasing colorectal cancer screening would have the greatest impact in reducing colorectal cancer mortality, compared with reducing risk factors or increasing treatment use ( 5,6 ). (cdc.gov)
  • What are the risk factors of prostate cancer? (movember.com)
  • H pylori is one of the major risk factors for stomach cancer. (medicinenet.com)
  • Pernicious anemia (a type of anemia due to the failure of the stomach to make intrinsic factor that is needed for vitamin B12 absorption), familial adenomatous polyposis, and Lynch syndrome (hereditary nonpolyposis colorectal cancer ) can increase the risk of stomach cancer. (medicinenet.com)
  • Because stomach cancer is caused by a variety of factors, there is no single way to prevent developing the disease. (medicinenet.com)
  • 5 Treatment as prevention may be of particular relevance for men who have sex with men (MSM), a group that accounts for more than half of these infections. (cmaj.ca)
  • This report establishes a baseline for the CVD risk factors targeted for reduction by the initiative during 2017-2021 and highlights recent changes over time. (cdc.gov)
  • ABSTRACT Factors affecting parents' decision to involve their children in clinical research have not been studied in all cultural backgrounds. (who.int)
  • within-day and recent behavior factors were the strongest influences on both outcomes. (nih.gov)
  • But there is also an evolutionary genetic aspect to sexual dimorphism we must consider: in Genetics and Analysis of Quantitative Traits the authors note that evolution of sex specific traits is not going to occur fast. (discovermagazine.com)
  • All that considered they saw and again certainly still do that utilizing any kind of contraception was an offense also considering the way that they trusted you were killing unimportant unessential individuals and consequently ought not to utilize sex for some other explanation other than start. (wallpaperstag.net)
  • The scope of research to be undertaken by the SCORs is based on three sources: the Institute of Medicine (IOM) report, Exploring the Biological Contributions to Health: Does Sex Matter? (nih.gov)
  • The authors chose these factors, in part, because no previous research efforts had focused on them in particular. (rightstep.com)
  • Objectives Research on men who have sex with men (MSM) in sub-Saharan Africa was neglected for a long time. (bmj.com)
  • Age and sex population projections for the Philippines by province, 1970-2000 / UNFPA-NCSO Population Research Project. (who.int)
  • Research is ongoing into other genetic factors too, but the link here is less clear. (movember.com)
  • There's also some evidence that suggests exposure to some chemicals may be a factor, but more research is needed. (movember.com)
  • Factors that result in the age‐related decline in energy requirements include changes in neuroendocrine factors (e.g. sympathetic activity, thyroid function, etc.) as well as a reduction in skeletal muscle quantity and quality (resulting from reduced physical activity, reduced protein intake and other less‐well‐understood factors). (drsharma.ca)
  • The two methods used to measure the enzymatic activity of factor XIII include measurement of synthetic amine incorporation into a fibrin clot, and measurement of ammonium ion release during the transglutaminase reaction. (medscape.com)
  • There are several risk factors associated with the development of chronic kidney disease. (news-medical.net)
  • HPV has been the buzzword around sexual health for a number of years now following on from the discovery of the link between this virus and the risk factors for cervical cancers. (setcases.info)
  • Better understanding the sociodemographic and behavioral factors of this high-risk population can help public health and clinical systems improve efforts to reduce SSB consumption. (cdc.gov)
  • But there are in fact many other factors involved at the same time, which may actually affect attraction more than just looks. (yourtango.com)
  • That means making time to talk to your doctor, understanding risk factors, and, if recommended, going through with any testing. (movember.com)
  • 11 The study involves 1110 serodiscordant couples (40% MSM) who engage in unprotected sex at least some of the time, with the HIV-positive partner receiving antiretroviral therapy and having a plasma viral load less than 200 copies/mL. (cmaj.ca)
  • During this time, it's helpful to speak openly about how you feel about sex. (abhishekbachchan.org)
  • Chegini N. An inverse relation between the expression of tumor necrosis factor alpha (TNF-alpha) and TNF-alpha receptor in human endometrium. (aaem.pl)
  • The man got married in his 20s but experienced severe facial pain during sex. (irishtimes.com)
  • Congenital factor XIII (FXIII) deficiency, originally recognized by Duckert in 1960, is a rare autosomal recessive disease usually associated with a severe bleeding diathesis. (medscape.com)