• Olaparib, a poly (ADP-ribose) polymerase inhibitor, has demonstrated an improvement in median progression-free survival (PFS) in select patients with metastatic castration-resistant prostate cancer (mCRPC). (bmj.com)
  • Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer. (cdc.gov)
  • In this cohort study of 962 men with metastatic castration-resistant prostate cancer, mismatch repair deficiency or microsatellite instability-high was significantly more frequent in Black men than White men. (cdc.gov)
  • Genomic alterations in DNA damage response (DDR) genes are common in metastatic castration-resistant prostate cancer (mCRPC). (cdc.gov)
  • Aim 1: To assess preferences and barriers for de-implementation of chemical castration in prostate cancer. (biomedcentral.com)
  • Guided by the theoretical domains framework (TDF), urologists and patients from facilities with the highest and lowest castration rates across the VA will be interviewed to identify key preferences and de-implementation barriers for reducing castration as prostate cancer treatment. (biomedcentral.com)
  • The investigators will conduct national surveys of urologists to prioritize key barriers identified in Aim 1 for stopping incident castration as localized prostate cancer treatment using a DCE experiment design. (biomedcentral.com)
  • Aim 3: To pilot two tailored de-implementation strategies to reduce castration as localized prostate cancer treatment. (biomedcentral.com)
  • Although some patients with prostate cancer benefit from ADT in terms of survival and symptom improvement, chemical castration is also commonly performed when there is no high level evidence for use and little to no health benefits to patients raising questions of low value care. (biomedcentral.com)
  • There are no female fetishists, either for Freud or Lacan, for to speak of female fetishism would involve displacing the basic precepts of psychoanalysis -- namely the scene of castration leading to phallic fetishism. (cis-india.org)
  • The phallic mother childish fantasy shows denial's action in maintaining irrational beliefs and their effects on the sense of reality. (bvsalud.org)
  • Also McClintock points to racist, nationalistic and patriotic fetishes -- such as flags, crowns, maps, swastikas (or for instance chaddis) -- that can't be simply rendered equivalent to the disavowal of male castration anxiety. (cis-india.org)
  • Nasio makes the provocative claim that the entirety of the psychoanalytical corpus, all of its concepts, including repression, sublimation, the theory of the drives, desire, as well as the phantasm of the phallus and castration anxiety, revolves around the idea that the child desires the parents. (sunypress.edu)
  • Therein lies the castration anxiety. (metafilter.com)
  • The CDC is now promoting genital mutilation to the youth and encouraging castration using synthetic hormones and other disturbing brainwashing techniques that affirm mental illnesses and spiritual struggles regarding gender and sex. (newstarget.com)
  • Defying contemporary claims of an alleged 'death of psychoanalysis,' and in contrast with recent attempts to minimize the relevance of Oedipus for the psyche, Nasio approaches Oedipus as a legend that helps to make sense of the origins of sexual identity and neurotic suffering. (sunypress.edu)
  • Crawford adds images of skin color dilution as a type of castration to the field of race and psychoanalysis. (cornell.edu)
  • When an "irritant" becomes trapped in a mollusk, the animal senses this element and coats it with mother-of-pearl, which is the same composite it uses to build its shell (Kennedy J. P., thoughtco.com). (lu.se)
  • Denial defends narcissism against castration threat, which is not restricted to the loss of genitals, but evokes several other narcissistic wounds. (bvsalud.org)
  • In retrospect it's always difficult to make sense of why this particular incident was the catalyst. (wamc.org)
  • An internal sense of being male, female, or something else, which may or may not correspond to an individual's sex assigned at birth or sex characteristics. (msdmanuals.com)
  • My childhood makes soo much more sense now that I know where the term "Bonzai" originated from. (thetruthaboutguns.com)
  • This guy is so nuts it makes sense to let him speak for himself - here's that Associated Press transcript (someone recently countered an AP article saying "AP is fake news. (legalectric.org)
  • Washington - February 28, 2018) - Veterans for Common Sense this week was among 111 organizations to send a letter to Congressional leadership of the Armed Services committees expressing concern about possible renewed efforts to that would have a detrimental impact on research at the Congressionally-Directed Medical Research Program (CDMRP) and other medical research conducted by the U.S. Department of Defense (DoD). (veteransforcommonsense.org)
  • Planned Parenthood now offers predatory hormone castration services to minors and tries to persuade youth to accept a transgender identity. (newstarget.com)
  • Evo and Proud: Does Nyborg's study make sense? (blogspot.com)
  • Does it make sense? (blogspot.com)
  • But, yes, Nyborg's study does make sense, if only because his population projection holds true regardless of how imperfect his data may be. (blogspot.com)
  • But does that really make sense? (menoforder.com)
  • Banemanie, a Raelian Bishop-Guide in Burkina Faso was among the first women to experience the operation and discover her new sense of pleasure. (religionnewsblog.com)
  • Common Sense Media. (wikipedia.org)
  • The minister told RUV that "I believe that this is being worked on in a natural fashion, with common sense, as quickly as possible. (grapevine.is)
  • Veterans for Common Sense (VCS) is a charter and executive committee member of the DHRC. (veteransforcommonsense.org)
  • This information for parents is provided by Common Sense Media , a non-profit organization dedicated to improving kids' media lives. (netflix.com)
  • The first recorded practice of castration to intentionally produce eunuchs dates as far back as 2,000BC - more than 4,000 years ago - in the ancient city of Lagash - located in what would now be modern day Iraq. (dailymail.co.uk)
  • Eunuchs, in a modern sense, can include those who have been castrasted for health reasons, such as to treat cancer. (dailymail.co.uk)
  • and, as we learn more and more about the impacts of traditional canine neutering (castration), vasectomy surgery is becoming increasingly popular. (speakingforspot.com)
  • In the traditional sense, poaching has existed for millennia, particularly after exclusive land ownership became a thing. (schalkenbach.org)
  • As a result, the English version has a better sense of accomplishment as a story than the original version. (semo.edu)
  • An undercurrent of light-skinned blackness as a type of castration emerges within an ongoing story about the feminizing of light skin and the masculinizing of dark skin. (cornell.edu)
  • The scenes of their courtship, as Maurizio falls for Reggiani, are sweet and give a sense of the family dynamics she was marrying into. (buzzfeednews.com)
  • Predatory LGBTQ propaganda such as this chat space provides a false sense of belonging and confuses youth. (newstarget.com)
  • As he matured and became more aware of his sense of self and how he would carry himself, he began to see how homosexuals were mocked and that he was displaying some of those behaviors and stereotypes. (christianpost.com)
  • This article analyzes the unconscious family transmissions and their relationship with the simultaneous admission and nonadmission of castration. (bvsalud.org)
  • It also refers to a person's sense of personal and social identity based on those attractions, related behaviors, and membership in a community of others with similar attractions and behaviors. (msdmanuals.com)