Among mycobacterium marinum. Medical search. Frequent questions

M marinum infections are rare but well described in the literature. (medscape.com)
Disseminated M marinum infection and more invasive skin infections have been reported in significantly immunosuppressed individuals. (medscape.com)
Pasnik and Smith of the Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, produced a vaccine based on the Mycobacterium marinum Ag85A gene, and tested it on Striped bass, Morone saxatilis, a species particularly susceptible to mycobacteriosis infections. (practicalfishkeeping.co.uk)
Mycobacterium marinum infections, commonly known as fish tank granuloma, produce nodular or ulcerating skin lesions on the extremities of healthy hosts. (cdc.gov)
Immunologic impairment was a frequent component of invasive M. marinum infections: 14 (40%) of case-patients received a steroid injection at the site of infection, and 9 (26%) were receiving systemic steroids for various indications. (cdc.gov)
While M.yocobacterium marinum infections usually arise from aquatic trauma in healthy hosts, delayed diagnosis and immune suppression contribute to the pathogenesis of invasive infection. (cdc.gov)
Mycobacterium marinum is a nontuberculous mycobacterium capable of causing skin and soft tissue infections. (cdlib.org)
M marinum can also cause deep infections, including tenosynovitis, arthritis, bursitis, and osteomyelitis, which are not accompanied by the characteristic skin changes. (contemporarypediatrics.com)
Mycobacterium marinum infections in man. (scialert.net)
It can also induce granulomatous infection in humans called "fish tank disease" [ 2 ] and, as other nontuberculous mycobacteria, is responsible for opportunistic infections in immune-deficient patients [ 4 ]. (biomedcentral.com)
As infections caused by nontuberculous mycobacteria (NTM) are rapidly increasing globally, a need exists for developing novel antibiotics and discovering the mechanism of resistance. (zoonoses-journal.org)
Infections caused by nontuberculous mycobacteria other than mycobacterium avium complex. (medlineplus.gov)
Mycobacterium marinum is a distant cousin to more serious infections like tuberculosis and leprosy, but it is 'exceedingly rare' for it to persist and travel deeper into the tissue as it has in Hannele, says Dr. Michael Iseman, infectious disease expert at National Jewish Health in Denver, Colo. (go.com)
In HIV-infected men who have sex with men, Pneumocystis carinii pneumonia (PCP), toxoplasmic encephalitis, fungal infections, and disseminated Mycobacterium avium complex (MAC) disease have decreased in incidence (9). (cdc.gov)
Mycobacterium tuberculosis is the leading cause of death by infections reported in many developing countries. (slu.se)
R. salmoninarum is the causative agent of bacterial kidney disease, a Gram-positive bacterium mostly known for causing chronic infections in salmonid fish, while multiple species belonging to the Mycobacterium genus have been associated with mycobacteriosis in fish as well as in human. (biomedcentral.com)
The lungs are most commonly infected, and most lung infections are caused by a group known as Mycobacterium avium complex (MAC), which includes Mycobacterium avium and Mycobacterium intracellulare . (msdmanuals.com)
Other nontuberculous mycobacteria that are not included in MAC also sometimes cause infections in people. (msdmanuals.com)

In this work, we used a calf ileal loop model to evaluate whether the preincubation of Mycobacterium avium subspecies paratuberculosis (MAP) with antibodies from healthy, MAP-positive or Lipoarabinomannan (LAM) immunized cows could affect the results of infection after 3.5 h. (hiv-pharmacogenomics.org)
ABSTRACT This study aimed to determine the occurrence of Mycobacterium avium complex and other nontuberculous mycobacteria in drinking-water in Basra governorate, Iraq and their susceptibility to several antibiotics and the effect of 0.5 mg/L of chlorine on their survival. (who.int)
The 252 isolates were identified as M. avium complex (21), M. marinum (15), M. kansasii (30), M. simiae (20), M. szulgai (19), M. xenopi (16), M. malmoense (11), M. fortuitum (37), M. chelonae (50) and M. abscessus (33). (who.int)

Mycobacterium marinum (M. marinum) is a ubiquitous waterborne organism that grows optimally at temperatures around 30°C. It is a nontuberculous Mycobacterium found in nonchlorinated water with worldwide prevalence. (uncg.edu)

Mycobacterium marinum is an atypical Mycobacterium species found in cold or warm, fresh or salted water. (medscape.com)
M marinum is water-borne atypical Mycobacterium species that commonly infects fish and amphibians. (medscape.com)
At least 150 fish and frog species, aquatic mammals (eg, dolphins), eels, oysters, African toads, and royal pythons are known to acquire natural M marinum infection. (medscape.com)
Four major LOS species, designated LOS-I to LOS-IV, have been identified and characterized in M. marinum . (biomedcentral.com)
As both species share a conserved skeleton of host-pathogen interactions, M. marinum is also widely used as a surrogate to decipher many aspects of the immunopathogenesis of tuberculosis [ 5 ]. (biomedcentral.com)
This research reported by this article was aimed at understanding the mechanism of bedaquiline resistance in the model NTM species Mycobacterium marinum ( M. marinum ). (zoonoses-journal.org)
Similar ferredoxin encoding genes were identified across Mycobacterium species, including in the pathogenic M. tuberculosis and M. ulcerans , as well as in a wide range of other bacteria such as Rhodococcus and Streptomyces . (rsc.org)
Many species of mycobacteria exist. (msdmanuals.com)
The other mycobacteria species that cause disease are discussed here. (msdmanuals.com)
ABSTRACT This research compared the numbers and types of different Mycobacterium species in soil samples taken from 2 areas of Golestan province, Islamic Republic of Iran, 1 with a high prevalence of tuberculosis and 1 with a low prevalence. (who.int)
The most common species isolated were Mycobacterium fortuitum, M. flavescens and M. chelonae. (who.int)
There are currently 71 recognized or proposed species of Mycobacterium [1], all of which, except M. tuberculosis complex and M. leprae, are considered as environmental mycobacteria and can usually be isolated from environmental samples including water, soil and dust [2]. (who.int)
Contact with different species of environmental Mycobacterium can cause acquired immunity to M. tuberculosis or increase the efficacy of BCG vaccine protection (M. vaccae, M. microti), although some species of these bacteria reduce the efficacy of BCG vaccine (M. scrofulaceum) [8,10-13]. (who.int)

No fish tank granuloma was proved in human, but 11 (9.73%) strains of Mycobacteria were isolated from Caviar fishes, that only 2 strains (1.76%) belong to M. marinum . (scialert.net)
Collectively, we conclude that the M. marinum G strains are unique and may represent a distinct virulence phenotype in HSB, but this trend was not consistent in zebrafish. (oregonstate.edu)
These proteins, (ESAT-6 and CFP-10) are absent from all BCG strains and from most non-tuberculous mycobacteria with the exception of M. kansasii, M. szulgai and M. marinum. (cdc.gov)

It is caused by the bacteria Mycobacterium marinum (M marinum) . (medlineplus.gov)
M marinum bacteria can live in fresh and salt water, unchlorinated swimming pools, and aquarium tanks. (medlineplus.gov)
Transcription analyses in both bacteria showed that rpmH is produced in excess over rnpA with down regulation in stationary phase relative to exponential phase but rnpB showed up regulation in M. marinum and down regulation in E. coli in stationary phase relative to exponential phase. (slu.se)
By contrast, obligate intracellular bacteria such as Chlamydia trachomatis and Mycobacterium leprae do, and this trait makes them a challenge to culture and study in the lab. (the-scientist.com)
Tuberculosis (TB) Tuberculosis is a chronic contagious infection caused by the airborne bacteria Mycobacterium tuberculosis . (msdmanuals.com)
The slow-growing that humans are infected with nontuber- (TB) broth to cover the lower portion of bacteria included: photochromogens, culous mycobacteria from environmen- the slant only. (who.int)

M marinum infection was once called swimming pool granuloma, but that term is rather obsolete because of the widespread use of chlorination in swimming pools. (medscape.com)
M marinum infection, often called swimming pool granuloma, is rarely associated with exposure to swimming pools because of advances in chlorination. (contemporarypediatrics.com)
Mycobacterium marinum is the etiologic agent of fish tank granuloma in human. (scialert.net)
Determination of the fish tank granuloma in Fishermen and Mycobacterium marinum infection in Caviar fishes in Ashorade, in south east Caspian Sea were our objectives. (scialert.net)
Using the zebrafish-Mycobacterium marinum infection model, we demonstrate that vascular normalization by inhibition of vascular endothelial protein tyrosine phosphatase (VE-PTP) decreases granuloma hypoxia, the opposite effect of hypoxia-inducing antiangiogenic therapy. (duke.edu)
Mycobacterium marinum, sometimes referred to as fish tank granuloma, usually eats away at only the surface of the skin. (go.com)
Here, we tested these BlaC variants under more physiological conditions using the M. marinum infection model of zebrafish, which recapitulates hallmark features of tuberculosis, including the intracellular persistence of mycobacteria in macrophages and the induction of granuloma formation. (bvsalud.org)

in 1926 and it is observed as a pathogenic mycobacterium. (wikipedia.org)
Here, crystallographic structures of the (S)-enantioselective haloalkane dehalogenase DmmarA from the waterborne pathogenic microbe Mycobacterium marinum were determined at 1.6 and 1.85â Å resolution. (bvsalud.org)

Whole genome sequence of M. marinum (M strain) was first published in 2008 and later with the emergence of Next Generation Sequencing (NGS), marinum type strain or patient isolates genome sequences were published. (wikipedia.org)
Sixty-three cases of Mycobacterium marinum infection: Clinical features, treatment and antibiotic susceptibility of causative isolates. (scialert.net)
Biochemical, molecular, and virulence characteristics of select Mycobacterium marinum isolates in hybrid striped bass Morone chrysops x M. saxatilis and zebrafish Danio rerio. (oregonstate.edu)
A panel of 15 Mycobacterium marinum isolates was characterized by biochemical tests, sequencing the ribosomal DNA intergenic spacer (ITS) region and the heat shock protein 65 gene (hsp65) and pulsed-field gel electrophoresis (PFGE). (oregonstate.edu)
A total of 252 isolates were identi- ria such as M. abscessus , M. mucogenicum , using the monophasic-biphasic culture fied as Mycobacterium spp. (who.int)
However, several studies test-tube represents a biphasic environ- M. simiae (comprising 25.8% of total have failed to identify nontuberculous ment (a liquid phase in contact with isolates), scotochromogens, identified mycobacteria in water samples, often be- solid one), while the upper portion is as M. szulgai (7.5% of total isolates) and cause of unsuitable isolation techniques single phase (solid only). (who.int)

Three weeks later, olecranon bursa aspirate fluid cultures incubated on chocolate agar and 7H11 plates at 31°C, as well as on algae slant, and mycobacterial growth indicator tubes incubated at 37°C grew M.ycobacterium marinum . (cdc.gov)

Scholars@Duke publication: Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to Mycobacterium marinum granulomas in zebrafish. (duke.edu)
The mechanisms whereby Mtb disseminates from the initial Ghon focus are not well understood, but studies in the zebrafish model of M. marinum infection suggest that Mtb is transported within infected monocytes [ 4 ]. (ersjournals.com)

For additional information on cutaneous M marinum infection, see the Medscape Reference article Dermatologic Manifestations of Mycobacterium Marinum Infection of the Skin . (medscape.com)
Feng et al described an outbreak of a cutaneous M marinum infection in China in 2008. (medscape.com)
We report a patient with cutaneous Mycobacterium marinum infection with a non-pruritic erythematous plaque on his right wrist for three months. (cdlib.org)
Incubation period and sources of exposure for cutaneous Mycobacterium marinum infection: Case report and review of the literature. (scialert.net)

the complete genome sequence of Mycobacterium tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB), the leading cause of global infectious disease mortality. (jci.org)

The lower portion of the identified as M. marinum , M. kansasii and tal sources [5]. (who.int)

Mycobacterium marinum is a waterborne pathogen of fish and other ectotherms, closely related to Mycobacterium tuberculosis . (biomedcentral.com)

Approximately one-third of the world's population is thought to be infected with the causative organism, Mycobacterium tuberculosis (Mtb) [ 3 ]. (ersjournals.com)
Mycobacterium marinum is a model organism for M. tuberculosis and it causes same cellular pathology in fish. (slu.se)

Mycobacterium spp belongs to family Mycobacteriaceae, which includes pathogens (Mycobacterium tuberculosis & Mycobacterium leprae) and nonpathogens (Mycobacterium phlei). (slu.se)

The strain marinum was first identified by Aronson[who? (wikipedia.org)
The first study evaluated a recombinant vaccine with a Brucella abortus strain RB51 vector expressing the Mycobacterium bovis Ag85A. (vt.edu)
The Mycobacterium marinum M strain was subjected to mutant selection with different concentrations of BDQ. (zoonoses-journal.org)
The M. marinum reference strain ATCC 927T did not produce mortality in HSB. (oregonstate.edu)
The results show that embryos infected with an M. marinum strain producing BlaC show lower infection levels after treatment than untreated embryos. (bvsalud.org)

antigen 85A (Ag85A) were assessed for immunostimulatory and protective effects against M. marinum. (vt.edu)
A DNA vaccine was constructed utilizing the Mycobacterium marinum Ag85A gene and a commercially-available eukaryotic expression vector. (vt.edu)

Although the majority of microbes succumb to the microbicidal environment within the phagolysosome, some pathogens (including Mycobacterium tuberculosis and Salmonella Typhimurium ) can survive and replicate within this harsh environment ( 11 , 12 ). (frontiersin.org)

The international incidence and prevalence of M marinum infection are unknown owing to a lack of surveillance. (medscape.com)
Environmental mycobacteria in area of high and low tuberculosis prevalence in the Islamic Republic of Iran. (scialert.net)
Similarly, no fish were found positive for Mycobacterium in 2017 but in 2018, the prevalence was found to be 37.03% in the Kamp river (4.08% across all rivers). (biomedcentral.com)
This survey constitutes the first insight into the prevalence rate of R. salmoninarum and Mycobacterium sp. (biomedcentral.com)
The frequencies of environmental Mycobacterium in the low-prevalence area were much higher than in the high-prevalence area, perhaps due to different environmental factors. (who.int)

A total of 35 cases of invasive M. marinum disease were then reviewed, according to patient age and sex, symptoms, source of infection, immune impairment, time to diagnosis, and type as well as duration of therapy ( 2 - 24 ) ( Table ). (cdc.gov)

The main advantage of this protocol is that it is less labor-intensive and time-consuming than the traditional method of counting colony forming units to estimate the intracellular growth of Mycobacterium tuberculosis. (jove.com)

One French study found the incidence of M marinum infection to be 0.04 per 100,000 inhabitants per year. (medscape.com)
Multicenter study of incidence of Mycobacterium marium in humans in Spain. (scialert.net)
However, the relative incidence of the environmental Mycobacterium spp. (who.int)

It was formerly known as Mycobacterium balnei. (wikipedia.org)

Initial phylogenetic studies using the gene 16S rDNA sequence data shows M. marinum is close to M. tuberculosis and M. ulcerans. (wikipedia.org)
To this end, the M. tuberculosis blaC gene was integrated into the chromosome of a blaC frameshift mutant of M. marinum. (bvsalud.org)

M marinum is a pathogen classified in Runyon group 1 and is a photochromogen, meaning it produces pigment when cultured and exposed to light. (medscape.com)
The uptake of mycobacteria by professional phagocytes, such as macrophages, is dependent upon the early recognition of the pathogen-associated molecular patterns (PAMPs) by specific pathogen recognition receptors (PRRs) that are crucial in initiating and driving the host immune response. (biomedcentral.com)
A major hallmark of mycobacteria is the very thick and highly impermeable cell envelope, which plays a critical role in innate resistance to many antimicrobial agents and in directing host-pathogen interactions [ 10 ]. (biomedcentral.com)
Ranjan, D. "Advanced Phylogenomics of the Human and Animal Pathogen Mycobac- terium Marinum" $100,000. (odu.edu)

Tissue culture grew Mycobacterium marinum. (elsevierpure.com)

2005) - Immunogenic and protective effects of a DNA vaccine for Mycobacterium marinum in fish. (practicalfishkeeping.co.uk)
Fish receiving the DNA vaccine developed protective responses to high-dose M. marinum challenge 90 days post-vaccination, as demonstrated by increased relative percent survival and by reduced splenic bacterial counts over control fish. (vt.edu)
but only the DNA vaccine showed promise for conferring protection against M. marinum challenge. (vt.edu)

M marinum is ubiquitous and is found in both salt and fresh waters. (medscape.com)

M marinum can disseminate in severely immunosuppressed individuals (eg, transplant recipients). (medscape.com)

Les espèces les plus couramment isolées étaient Mycobacterium fortuitum, M. flavescens et M. chelonae. (who.int)

Granulomas and nonspecific inflammation are characteristic of M marinum infection. (contemporarypediatrics.com)
Furthermore, VE-PTP inhibition increased the accumulation of T cells at M. marinum granulomas. (duke.edu)

M marinum infection commonly develops as a complication of skin and soft-tissue injuries exposed to aquatic equipment such as fish lines and fishhooks, among others. (medscape.com)
The vaccinated fish proved to be protected against live M. marinum for 90-days following their initial inoculation. (practicalfishkeeping.co.uk)
Fish tuberculosis, Mycobacterium marinum , in a group of Egyptian Spiny-tailed lizards, Uromastyx aegyptius. (scialert.net)
Study of different types of mycobacteria in sediments of fish breeding pools of north of Iran. (scialert.net)
However, vaccinated fish failed to demonstrate cross-protective responses after live Mycobacterium marinum challenge 70 days post-vaccination. (vt.edu)
We report a case of Mycobacterium marinum infection in a lung transplant recipient who presented with nodules on the hand and forearm following exposure to fish-tank water of a superficial hand burn. (elsevierpure.com)
For a patient with nodular lesions on the extremities, exposure to fish, fish-tank water, or swimming should suggest infection with Mycobacterium marinum. (elsevierpure.com)
The sequencing data confirmed that these fish carried Mycobacterium sp. (biomedcentral.com)
The age of the fish might also play a role, especially in the case of Mycobacterium sp. (biomedcentral.com)

Clinical presentation and therapy of Mycobacterium marinum infection as seen in 12 cases. (scialert.net)

Mycobacterium marinum is a slow growing mycobacterium (SGM) belonging to the genus Mycobacterium and the phylum Actinobacteria. (wikipedia.org)

The M. marinum surface-exposed lipooligosaccharides (LOS) are immunogenic molecules that participate in the early interactions with macrophages and modulate the host immune system. (biomedcentral.com)
Herein, we investigated the interactions between a panel of defined M. marinum LOS mutants that exhibited various degrees of truncation in the LOS structure, and human-derived THP-1 macrophages to address the potential of LOSs to act as pro- or avirulence factors. (biomedcentral.com)
However, a deeper shortening of the LOS structure was associated with increased entry of M. marinum into host cells and increased elimination of the bacilli by the macrophages. (biomedcentral.com)

M marinum infection may result in persistent ulceration, draining sinuses, or septic arthritis. (medscape.com)

A thorough history with an emphasis on possible routes of exposure is key to the diagnosis of M marinum infection. (contemporarypediatrics.com)

In Africa, M marinum has been isolated from healthy human skin and soil. (medscape.com)
Environmental mycobacteria of soil in mazenderan provience. (scialert.net)
The infection is usually caused by eating soil or drinking water that is contaminated with the mycobacteria. (msdmanuals.com)

M marinum infection occurs following skin and soft-tissue injuries that are exposed to an aquatic environment or marine animals. (medscape.com)
Retrospective study of Mycobacterium marinum skin infection. (scialert.net)
Mycobacterium marinum skin infection successfully treated with levofloxacin. (qxmd.com)
Buruli ulcer (BU) is a neglected tropical skin disease caused by Mycobacterium ulcerans . (dovepress.com)
Chronic skin ulcers consistent with Mycobacterium ulcerans disease ( Figure 1 ) were first described in The Mengo Hospital Notes (Kampala, Uganda) in 1897 by the British physician Albert Cook. (dovepress.com)

Here, we report the use of nanopore sequencing for the diagnosis of M. marinum. (bvsalud.org)

Infection is spread by the aerosol route and Mycobacterium tuberculosis must drive lung destruction to be transmitted to new hosts. (ersjournals.com)
The most highly infectious patients are those who develop cavitatory lung disease [ 1 ], since each cavity may contain up to 10 9 mycobacteria [ 5 ], and these patients can be regarded as the aerosol supershedders that drive the global pandemic. (ersjournals.com)
Lung matrix destruction is critical to the life cycle of Mycobacterium tuberculosis (Mtb). (ersjournals.com)

Mycobacterium marinum (M. marinum) is a non-tuberculous mycobacterium (NTM) that can cause infectious diseases in aquatic animals and humans. (bvsalud.org)

Similar to M. tuberculosis, M. marinum is able to replicate and survive within infected host cells. (biomedcentral.com)

M marinum infection responds slowly to appropriate antibiotic therapy. (medscape.com)

Anatomy1

Organisms16

Diseases10

Chemicals and Drugs5

Anthropology, Education, Sociology and Social Phenomena1

Infections18

Avium3

Nontuberculous mycobacterium1

Species13

Strains3

Bacteria6

Granuloma7

Pathogenic2

Isolates6

Mycobacterial1

Zebrafish2

Cutaneous4

Complete genome sequence1

Kansasii1

Waterborne1

Organism2

Leprae1

Strain5

Ag85A2

Pathogens1

Prevalence5

Invasive1

Intracellular1

Incidence3

Balnei1

Gene2

Pathogen4

Grew1

Vaccine3

Ubiquitous1

Transplant recipients1

Fortuitum1

Granulomas2

Fish9

Clinical1

Genus1

Macrophages3

Persistent1

Exposure1

Soil3

Skin5

Diagnosis1

Lung3

Aquatic1

Replicate1

Antibiotic1