Amino acids beta catenin. Medical search. Frequent questions

Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wikipedia.org)
It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)
β-Catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
Thus, β-catenin became one of the first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
The CTNNB1 gene provides instructions for making a protein called beta-catenin. (medlineplus.gov)
The beta-catenin protein is also involved in cell signaling as an essential part of the Wnt signaling pathway. (medlineplus.gov)
Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (medlineplus.gov)
They change single protein building blocks (amino acids) in the beta-catenin protein. (medlineplus.gov)
These mutations lead to an abnormally stable beta-catenin protein that is not broken down when it is no longer needed. (medlineplus.gov)
They cause the beta-catenin protein to be turned on all the time (constitutively active), which leads to the abnormal activation of certain genes. (medlineplus.gov)
This active beta-catenin protein promotes Wnt signaling longer than normal, which leads to the unchecked proliferation of kidney cells and tumor development. (medlineplus.gov)
The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
beta-Catenin, also known as CTNNB1, is a cadherin-associated protein that is involved in the regulation of cell adhesion. (bio-techne.com)
Mutagenesis experiments demonstrate that substitution of the serine residues in the glycogen synthase kinase 3beta (GSK3beta) phosphorylation consensus motif of beta-catenin inhibits ubiquitination and results in stabilization of the protein. (bioseek.eu)
Mouse P-Cadherin is an 822 amino acid (aa) protein with a 27 aa signal sequence and a 795 aa propeptide. (rndsystems.com)
APC N1819fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1819 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). (jax.org)
APC S811* results in a premature truncation of the Apc protein at amino acid 811 of 2843 (UniProt.org). (jax.org)
Wnts bind Frizzled receptors and forms complex with low-density lipoprotein receptor-related protein (LRP5 or LRP6) which results in the stabilization of intracellular beta-catenin levels. (biolegend.com)
Intracellular accumulation of beta-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote expression of Wnt target genes. (biolegend.com)
The 334 amino acid recombinant protein has a predicted molecular mass of approximately 37.4 kD. (biolegend.com)
β-Catenin serves as a central hub in Wnt signaling by engaging in crucial protein-protein interactions with both negative and positive effectors of the pathway. (anl.gov)
Direct interference with these protein-protein interactions is a biologically compelling approach toward suppression of β-catenin hyperactivity, but such interactions have proven intransigent with respect to small-molecule targeting. (anl.gov)
The MIT researchers showed in their study that they could use RESCUE to temporarily ramp up the activation of the protein beta-catenin, which could be useful in wound healing. (international-biopharma.com)
In human, AEG-1 represents a protein of 582 amino acids, and the amino acid sequences are highly conserved across vertebrates. (biomedcentral.com)
DDX5 is a 614 amino acid protein consisting of an N-terminal Q motif, an ATP binding Rec A-like domain, a hinge region, a Rec A-like helicase domain, and a C-terminal RGS-RGG motif. (bellbrooklabs.com)
In the adult brain, as the functional activation of the NMDA receptor increases, beta-catenin (cadherin-associated protein, beta 1, 88 kDa, with the HUGO-approved official symbol of CTNNB1) forms a complex with lymphoid enhancer-binding factor-1/T cell factor (LEF1/TCF), 17 18 subsequently inducing the transcription of genes related to neural plasticity. (psychiatryinvestigation.org)
The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and δ-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. (jneurosci.org)

The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. (embl.de)
A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. (embl.de)
Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove. (embl.de)
Zhang's team wanted to test RESCUE in Alzheimer's because there are only two differences between the amino acid sequence for the risk variant APOE4 and that of the non-pathogenic APOE2. (international-biopharma.com)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
This region of Cav1 also contains an amino acid sequence that interacts with cholesterol. (diff.org)
Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl-heidelberg.de)
DEAD-Box helicases are named for the core Asp-Glu-Ala-Asp (DEAD) amino acid sequence they share. (bellbrooklabs.com)
The amino acid sequence is identical to that of endogenous erythropoietin. (medscape.com)

Once in the nucleus, beta-catenin interacts with other proteins to control the activity (expression) of particular genes. (medlineplus.gov)
It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)
Recently, alpha/beta-hydrolase domain-containing (ABHD) proteins have emerged as novel pivotal regulators in lipid synthesis or degradation while their functions in ESCs have not been investigated. (inra.fr)
Here we report the discovery of a hydrocarbon-stapled peptide that directly targets β-catenin and interferes with its ability to serve as a transcriptional coactivator for T-cell factor (TCF) proteins, the downstream transcriptional regulators of the Wnt pathway. (anl.gov)
These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. (eu.org)
Domains and repeats with an ARM-like fold have been found in a number of proteins, including: ARM repeat domain, found in beta-catenins, importins, karyopherin and exportins. (eu.org)

Notably, the C-terminal segment of β-catenin can mimic the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. (wikipedia.org)
Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. (embl.de)
The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade. (thermofisher.com)
beta-catenin is a target for the ubiquitin-proteasome pathway. (bioseek.eu)
beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling pathway. (bioseek.eu)
In the current model of this pathway, the amount of beta-catenin (or its invertebrate homolog Armadillo) is tightly regulated and its steady-state level outside the cadherin-catenin complex is low in the absence of Wingless/Wnt signal. (bioseek.eu)
This motif in beta-catenin resembles a motif in IkappaB (inhibitor of NFkappaB) which is required for the phosphorylation-dependent degradation of IkappaB via the ubiquitin-proteasome pathway. (bioseek.eu)
We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin. (bioseek.eu)
Activation of the pathway was further confirmed by nuclear accumulation of beta-catenin driven by Wise. (unimib.it)
Our operate identifies miR-183-96-182 cluster gene as a downstream target regulated by b-Catenin/TCF/LEF-1 pathway in gastric cancer cells. (gpr120inhibitor.com)
Oncogenic activation of Wnt signaling can ensue from a variety of distinct aberrations in the signaling pathway, but most share the common feature of causing increased cellular levels of β-catenin by interfering with its constitutive degradation. (anl.gov)
The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN. (ouhsc.edu)
Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: the involvement of the Wnt/ß-catenin signaling pathway. (ouhsc.edu)

2002. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. . (oregonstate.edu)
2003. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. . (oregonstate.edu)

Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. (nih.gov)

Signal transduction of beta-catenin. (embl.de)

Plakoglobin (also called γ-catenin) has a strikingly similar architecture to that of β-catenin. (wikipedia.org)
Not only their ARM domains resemble each other in both architecture and ligand binding capacity, but the N-terminal β-TrCP-binding motif is also conserved in plakoglobin, implying common ancestry and shared regulation with β-catenin. (wikipedia.org)
In plakoglobin arm repeats bind alpha-catenin and N-cadherin. (embl.de)
δ-Catenin belongs to the p120 catenin (p120ctn) family of catenins and binds to the cytoplasmic domains of type 1 and 2 cadherins at a membrane proximal region that is not involved in binding of either β-catenin or plakoglobin. (jneurosci.org)

In a preclinical study, treatment with IWR-1 decreased active beta-catenin levels and reduced growth of a colorectal cancer cell line harboring APC S811* in culture ( PMID: 28179481 ). (jax.org)
In a preclinical study, treatment with G007-LK decreased active beta-catenin levels and Tcf/LEF activity, and reduced growth of a colorectal cancer cell line harboring APC S811* in culture ( PMID: 28179481 ). (jax.org)

The core of β-catenin consists of several very characteristic repeats, each approximately 40 amino acids long. (wikipedia.org)

In this work, a computational study is described to identify novel potential peptides designed by employing a database of non-natural amino acids. (mdpi.com)

Differential expression of amino acid metabolism-related genes (AAMRGs) was identified for prognostic gene selection. (frontiersin.org)
This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. (nih.gov)
Here we report that inhibition of GSK3b increases nuclear translocation of b-Catenin, which forms a complex with TCF/LEF-1 to boost miR-183-96-182 cluster gene expression in gastric cancer cells. (gpr120inhibitor.com)
Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)

In cardiac muscle, β-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. (wikipedia.org)

Three-dimensional structure of the armadillo repeat region of beta-catenin. (embl.de)
The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. (embl.de)

Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. (embl.de)
ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
2003. Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. . (oregonstate.edu)
Moreover, Abhd11 knockout disturbed GSK3beta/beta-Catenin and ERK signaling transduction. (inra.fr)
S811* retains binding with Axin1 but confers a loss of function to Apc as demonstrated by decreased beta-catenin recruitment, phosphorylation, and ubiquitination in culture ( PMID: 34352208 ), and activation of Wnt signaling in reporter assays ( PMID: 28179481 ). (jax.org)
Inhibition of GSK3b activates miR-181 expression by means of Wnt/beta-catenin signaling in HCC (34). (gpr120inhibitor.com)
Primary antibodies and primers GSK3b (3D10) mouse mAb, Lef-1 (C12A5) rabbit mAb, b-Catenin (6B3) rabbit mAb, CK1e Factor Xa list polyclonal antibody, CK2a polyclonal antibody, FoxO1 rabbit mAb and b-Catenin (L87A12) mouse mAb were purchased from Cell Signaling Technology. (gpr120inhibitor.com)
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. (anl.gov)
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/ß-Catenin Signaling. (ouhsc.edu)
CHD8 is an independent prognostic indicator that regulates Wnt/ß-catenin signaling and the cell cycle in gastric cancer. (ouhsc.edu)

2004. Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. . (oregonstate.edu)

beta-catenin, but not E-cadherin, p120(cas) or alpha-catenin, becomes stabilized when proteasome-mediated proteolysis is inhibited and this leads to the accumulation of multi-ubiquitinated forms of beta-catenin. (bioseek.eu)

Without association with the catenins, the cadherins are non-adhesive. (rndsystems.com)
Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. (rndsystems.com)

Here we show that the ubiquitin-dependent proteolysis system is involved in the regulation of beta-catenin turnover. (bioseek.eu)

Nuclear beta-Catenin activates the TCF/LEF family of transcription factors, inducing the transcription of pro-mitotic genes. (bio-techne.com)
The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. (uchicago.edu)

L..[IVLWC].E). One of, but not both, the amino acids in position P1 or P4 of the motif can be a variable hydrophobic residue for B56 binding, while P6 has the invariant glutamic acid. (eu.org)
In addition, δ-catenin, ARVCF, and p0071 also contain a PDZ binding motif at the C terminus. (jneurosci.org)

Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. (embl.de)
The primary structure of beta-catenin consists of an NH2-terminal domain (NDT), a central region represented by 12 Arm-repeats (R1-12), and a COOH-terminal end (CTD). (chemdiv.com)

Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
The dendritic phenotype observed after erbin depletion is rescued by overexpression of δ-catenin and requires a domain in δ-catenin that has been shown to regulate dendritic branching. (jneurosci.org)
Knockdown of δ-catenin cannot be rescued by overexpression of erbin, indicating that erbin is upstream of δ-catenin. (jneurosci.org)

Moreover, we uncovered a novel mechanism by which IL-37 suppressed tumor cell migration via its intracellular mature form (amino acids 46-218). (nature.com)

2002. Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)

ab109185 detects the 17 kDa carboxy-terminal subunit (subunit beta). (abcam.com)
The basic subunit of beta-crystallins. (lookformedical.com)

In addition, amino acid metabolism plays an important role in regulating tumor immunity and targeting amino acid metabolism may help to overcome immunotherapy resistance and improve existing therapies for COAD patients. (frontiersin.org)

Mouse Wnt-3a, amino acids Ser19-Lys352 (Accession # P27467) was expressed in CHO cells. (biolegend.com)

We show that short hairpin RNA-mediated knockdown of erbin and knockdown or genetic ablation of δ-catenin severely impaired dendritic morphogenesis in hippocampal neurons. (jneurosci.org)
These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of δ-catenin. (jneurosci.org)

Meanwhile, new insights into the metabolic signatures of tumors have revealed the potential of risk prediction model, which is based on the amino acid metabolism-related genes (AAMRG) ( 13 , 14 ). (frontiersin.org)
Proteína homeótica y factor de transcripción que se localiza en el núcleo celular donde activa la expresión de genes tiroideos específicos como el de la TIROGLOBULINA y el RECEPTOR DE TIROTROPINA. (bvsalud.org)

Degradation of β-catenin is thus mediated by this N-terminal segment. (wikipedia.org)

The cylindrical structure features a positively charged grove, which presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin. (embl.de)

Vertebrate catenins contain a large number of Arm-domains including 3 subfamilies: β-tencains, p120 and plakophilins 1 and 3. (chemdiv.com)

As sketched above, the ARM domain of β-catenin acts as a platform to which specific linear motifs may bind. (wikipedia.org)
In colon cancer, DDX5 and its paralog, DDX17, bind to beta-catenin to activate the transcription of various potent oncogenes, such as c-Myc and cyclin D1. (bellbrooklabs.com)

Mounting evidence have indicated that changes in amino acid metabolism contributed to the metastasis, proliferation, angiogenesis, and drug resistance of colorectal cancer ( 8 - 11 ). (frontiersin.org)

The N-terminal fragment of adaptin alpha-C and beta subunits. (eu.org)

Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. (wikipedia.org)
Apart from the well-known Warburg effect, metabolic alterations in lipid and amino acid metabolism have been observed in a number of tumors, including colorectal cancer, lung cancer, and breast cancer ( 7 ). (frontiersin.org)
δ-Catenin-null neurons have no alterations in global levels of active Rac1/RhoA. (jneurosci.org)
Knockdown of erbin results in alterations in localization of δ-catenin. (jneurosci.org)

Finally, Abhd11 knockout led to the misexpression of key metabolic enzymes related to lipid synthesis, glycolysis, and amino acid metabolism, and ABHD11 contributed to the homeostasis of lipid metabolism. (inra.fr)

Synthetic 10 amino acid peptide from internal region of human WNT7A. (thermofisher.com)
The antimicrobial peptide, beta-defensin-1, has antiviral activity against both enveloped and non-enveloped viruses. (cdc.gov)

β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)
β-catenin belongs to the catenin molecule family. (chemdiv.com)

Nucleic Acids Research. (knaw.nl)
DDX5 (Dead-Box 5 or p68) is a member of a family of 37 "DEAD-Box" ATP-dependent RNA helicases that play a role in nearly all aspects of RNA processing and also act as nucleic acid recognition receptors for viral immunity. (bellbrooklabs.com)

2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. (innatedb.com)
Beta-crystallins exist as oligomers formed from acidic (BETA-CRYSTALLIN A CHAIN) and basic (BETA-CRYSTALLIN B CHAIN) subunits. (lookformedical.com)
The main haemoglobin in adult humans is Haemoglobin A and it contains two alpha and two beta subunits. (bartleby.com)

Amino acid metabolism plays a vital role in cancer biology. (frontiersin.org)
However, the application of amino acid metabolism in the prognosis of colon adenocarcinoma (COAD) has not yet been explored. (frontiersin.org)
Here, we construct an amino acid metabolism-related risk model to predict the survival outcome of COAD and improve clinical decision making. (frontiersin.org)
Therefore, targeting the amino acid metabolism might provide novel ideas for the diagnosis and management of COAD. (frontiersin.org)

5 6 Briefly, in the context of animal models, electroconvulsive shock (ECS) induces the activation of N-methyl-D-asparate (NMDA), 7 8 and AMPA-related (DL-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid 9 ) receptors, and hippocampal neurogenesis is subsequently increased. (psychiatryinvestigation.org)

Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis. (nih.gov)
MiR-26a promotes cholangiocarcinoma by way of reducing GSK3b expression, resulting in b-Catenin activation (35). (gpr120inhibitor.com)

Excess beta-catenin promotes the uncontrolled proliferation of cells, allowing the formation of desmoid tumors. (medlineplus.gov)

Anatomy16

Organisms12

Diseases6

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes64

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care1

Protein35

Sequence9

Proteins7

Pathway17

CTNNB12

Member of the catenin1

Signal transduction1

Plakoglobin4

Active beta-catenin2

Approximately 40 amino1

Peptides1

Gene4

Adherens junctions1

Armadillo repeat2

Signaling16

Phosphorylation1

Accumulation1

Cadherins2

Regulation1

Activates2

Motif2

Repeats2

Overexpression3

Intracellular1

20021

Subunit2

Tumor1

Accession1

Morphogenesis2

Genes2

Degradation1

Interacts1

Vertebrate1

Bind2

Metastasis1

Fragment1

Alterations4

Metabolic1

Peptide2

Molecule2

Nucleic2

Subunits3

Metabolism4

Receptors1

Expression2

Tumors1