Amino acids structural homology protein. Medical search. Frequent questions

A sequence homology search identified the protein as a member of the structural family Glyoxalase I. We have shown that the enzyme possesses glyoxalase I activity in the presence of Zn 2+ , Mg 2+ , Ni 2+ , and Co 2+ , in this order of preference. (rcsb.org)
X-ray crystallography of OIF and NGF-beta confirmed their structural and sequence homology. (the-scientist.com)
Sequence Homology, Amino Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
This graph shows the total number of publications written about "Sequence Homology, Amino Acid" by people in this website by year, and whether "Sequence Homology, Amino Acid" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "Sequence Homology, Amino Acid" by people in Profiles. (wakehealth.edu)
The aim of this study was to identify and compare regions of nucleotide sequence homology between similar genes that are abundantly expressed and maternally transmitted during Drosophila oogenesis. (marquette.edu)
is composed of two domains which, in spite of a negligible sequence homology, are characterized by very similar three dimensional folds. (expasy.org)
Interstingly, Hz-2V showed 93.5% of sequence homology with Hz-1V and with other nudiviruses, hytrosaviruses, and polydnaviruses. (umass.edu)
PlGF and VEGF share primary structural as well as limited amino acid sequence homology with the A and B chains of PDGF. (reliatech.de)
It can be an indication of distant AMINO ACID SEQUENCE HOMOLOGY and used for rational DRUG DESIGN. (bvsalud.org)

All teneurins, especially in mouse, are type II transmembrane proteins that are composed of a large extracellular C terminal domain of ~2400 amino acid residues, a single transmembrane helical domain of ~30 hydrophobic residues and an intracellular N terminal domain of ~300-375 residues. (wikipedia.org)
The linker region is made up of ~200 amino acid residues and is found immediately distal to the transmembrane domain. (wikipedia.org)
The 4 cysteine residues assist in protein folding, however, they are absent in Ten-m2 and Ten-m3. (wikipedia.org)
SP-4 (residues 192-203), SP-8 (residues 483-494), and SP-10 (residues 668-679) significantly blocked the interaction between S protein and ACE2 by biotinylated enzyme-linked immunosorbent assay, with IC 50 values of 4.30 ± 2.18, 6.99 ± 0.71, and 1.88 ± 0.52 nmol, respectively. (scienceopen.com)
Aided by molecular modelling, amino acids in the predicted phosphoinositide binding pocket of dynamin and Btk PH domains were selectively mutated in order, to identify key ligand recognition residues. (ucl.ac.uk)
1987). The deduced protein product is 113 amino acids in length and contains a sequential stretch of hydrophobic and hydrophilic residues at the carboxyl terminus. (marquette.edu)
This portion of the protein is rich in glutamic and lysine residues and is highly conserved among several species examined. (marquette.edu)
1984). These results suggest that the 3$\sp\prime$ sequences common to the genomic clones define a subset of Drosophila ribosomal proteins that share similar functional residues. (marquette.edu)
Based upon this model, 12 amino acids of DspF were identified as putative exposed substrate-binding residues. (actahort.org)
In vertebrates, rhodanese is a mitochondrial enzyme of about 300 amino-acid residues involved in forming iron-sulfur complexes and cyanide detoxification. (expasy.org)
The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PE-binding. (embl-heidelberg.de)
The fACCD were found 16.18-82.47 kDa proteins having 149-750 amino acid residues. (springeropen.com)
As a result of alternative splicing, three PlGF RNAs encoding monomeric human PlGF-1, PlGF-2 and PlGF-3 isoform precursors containing 149, 179 and 219 amino acid residues, respectively, have been described. (reliatech.de)
The predicted peptide has a high content of positively charged residues (pI = 10.5) and is, in all likelihood, a cytosolic protein. (omicsdi.org)
The current view of protein folding and stability is largely based on SAXS and DLS data13-16 and the extensive exposure of hydropho- a generic structural classification into native (N), compact dena- bic residues suggested by the finding that the heat capacity of the tured or molten globule (MG), and unfolded or denatured (D) MG state is midway between that of the N and D states7 have been conformational states1-10. (lu.se)

By using sequence alignment of herpesviruses homologs, we identified conserved amino acids in the putative pUL105 ATP binding site and in the putative pUL70 zinc finger pattern. (frontiersin.org)
Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
Rhodanese-like proteins are either composed of a single catlytic rhodanese domain, as found in glpE, or composed of two rhodanese domains, with the C-terminal domain displaying the putative catalytic Cys as observed in Rhobov and rhdA. (expasy.org)
Based on the genome sequencing results, an analysis of structural proteins and prediction of putative microRNAs of Hz-2V was performed. (umass.edu)
Sequence analysis of this fragment revealed a complete open reading frame (abiQ), which encodes a putative protein of 183 amino acids. (omicsdi.org)

Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
In the present study, we analysed the nonsynonymous single nucleotide polymorphism of GATA4, which are involved in congenital heart disease by predicting the changes in protein structures. (uni-mysore.ac.in)
To understand the role of nonsynonymous single nucleotide polymorphisms, we mutated the sequence and translated into amino acids. (uni-mysore.ac.in)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)

However, various names were assigned to these vertebrate homologs, which complicated the nomenclature of teneurin proteins. (wikipedia.org)

The embryonic Drosophila cDNA library was screened using polymerase chain reaction (PCR) and a primer derived from the EGF-like repeats region of chicken tenascin-C protein. (wikipedia.org)
The cDNA for CpHsp19.8 was 795 bp encoding 177 amino acids. (usda.gov)
The cDNA for CpHsp19.9 was 749 bp encoding 175 amino acids. (usda.gov)
The cDNA for CpHsp22.2 was 737 bp encoding 192 amino acids. (usda.gov)
and (iii) an intracellular signal-transductor of the Smad family (1530 bp cDNA, 318 amino acids) could be identified and completely characterized. (uni-wuerzburg.de)
Computer analysis of the DNA sequence of the 21C cDNA revealed a 76 percent 3$\sp\prime$ coding sequence similarity with the Drosophila acidic ribosomal protein gene, A1 (Qian et al. (marquette.edu)
Human Flt-3 cDNA encodes a 993 amino acid (aa) residue type I membrane protein with a 26 aa residue signal peptide, a 515 aa extracellular domain with 10 potential N-linked glycosylation sites, a 21 aa residue transmembrane domain and a 431 aa residue cytoplasmic domain. (rndsystems.com)
Two sets of cDNAs were recovered, and evidence from three independent assays confirmed that both sets encoded articulins: (a) Anti-articulin antibodies recognized a high molecular weight beta-galactosidase (beta-gal) fusion protein expressed in bacteria infected with lambda gt11 cDNA clones. (rupress.org)

Analysis of the protein sequences of the three CpHsps indicated the presence of 83 amino acids with homology to the a-crystallin domain. (usda.gov)
Both subfamilies have a similar protein chain fold but rather diverse sequences. (rcsb.org)
The degree of similarity between sequences of amino acids. (wakehealth.edu)
Genes adjacent to pvtramp were identified in silico to determine the degree of similarity between the protein sequences encoded by equivalent chromosomic fragments in P. falciparum and Plasmodium knowlesi . (biomedcentral.com)
No extensive sequence similarities were found between articulins and other protein sequences in various databanks. (rupress.org)
The Q33 and BM13 genomes exhibit homology, not only to P335-type, but also to elements of the 936-type phage sequences. (omicsdi.org)

The comparison of the models reveals that the higher stability of HydSL can be attributed to increased inter-subunit electrostatic interactions: the homology models reliably predict that HydSL contains at least five more inter-subunit ion pairs than HupSL. (nih.gov)
A more optimized cavity system and amino acid replacements resulting in increased conformational rigidity may also contribute to the higher stability of HydSL. (nih.gov)
The results are in accord with the general observation that with increasing temperature, the role of electrostatic interactions in protein stability increases. (nih.gov)
13 , 14 However, the amino acid perfectly maintains the stability of the mutual structural conformation of the virus S-protein and the ACE2 receptor in a holistic manner. (medsci.org)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
However, the poor structural stability and the high cost of purification and immobilization of free enzyme system limit the industrial application. (biomedcentral.com)
LeuDH and FDH with PDZ (PSD95/Dlg1/Zo-1) domain and the corresponding ligand of the metazoan (PDZlig) were fused and assembled as multiple supramolecules to improve the NAD(H) recycling efficiency and structural stability [ 19 ]. (biomedcentral.com)
The secondary structural analysis further validates the stability owing to higher α-helices. (springeropen.com)
The hydration of nonnative states is central to protein folding and stability but has been probed mainly by indirect methods. (lu.se)
Considering the widely acknowledged Accordingly, theoretical models of the MG state invariably invoke importance of protein-solvent interactions for stability and fold- a substantial internal hydration20-22. (lu.se)

In addition to 37% amino acid identity and overall structural similarity, both articulins exhibited a long core domain consisting of over 30 12-amino acid repeats with the consensus VPVPV--V--. Homology plots comparing the same or different articulins revealed larger, less regular repeats in the core domain that coincided with predicted turns in extended beta-sheets. (rupress.org)
The degree of 3-dimensional shape similarity between proteins. (bvsalud.org)

The 5' cap open reading frame encodes a variety of non-structural proteins. (medsci.org)
The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)

LPA activates at least six G-coupled protein receptors (LPA 1-6 ) stimulating different signaling pathways through heterotrimeric G proteins such as G i/0 , G 12/13 , G q/11 , and G s . (hindawi.com)

It has a structural and functional homology with matrix protein fibrillin-1 and fibrillin-2. (org.pk)
We isolated six mAbs recognizing the functional attachment protein hemagglutinin-neuraminidase (HN) and 18 mAbs against the fusion (F) protein. (cdc.gov)

Structure of the EGL-1/CED-9 complex revealed that EGL-1 adopts an extended alpha-helical conformation and induces substantial structural rearrangements in CED-9 upon binding. (nih.gov)
It is of fundamental importance in determining PROTEIN CONFORMATION . (lookformedical.com)
PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). (lookformedical.com)
Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)

This thesis describes how data generated from structural analysis of the dynamin PH domain provided a rational basis for the identification of distinct phosphoinositide ligands for the PH domains of dynamin and Bruton's tyrosine kinase (Btk). (ucl.ac.uk)
Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
Taxonomy and function of C1 protein kinase C homology domains. (embl-heidelberg.de)
These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl-heidelberg.de)
NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions. (embl-heidelberg.de)
Classical protein kinase C (PKC) family members are activated by the binding of various ligands to one of several cysteine-rich domains of the enzyme. (embl-heidelberg.de)
Nevertheless, the precise c-Jun NH2-terminal kinase inhibitor, SP600125, got no influence on the "type":"entrez-protein","attrs":"text":"SKF83959″,"term_id":"1155968032″,"term_text":"SKF83959″SKF83959-induced safety. (mycareerpeer.com)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

He localized the biologic activity to a fraction of lipid soluble acids that he termed "prostaglandin," hypothesizing that these substances originate in the prostate gland. (medscape.com)

Structural and biochemical characterisation of Pleckstrin Homology domains Pleckstrin Homology (PH) domains are modules of approximately 100-120 amino-acids found in a variety of proteins involved in intracellular signalling cascades. (ucl.ac.uk)
Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)

The epsin N-terminal homology (ENTH) domain is a structural domain that is found in proteins involved in endocytosis and cytoskeletal machinery. (wikipedia.org)
Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
The two major membrane skeletal proteins (articulins) of Euglena gracilis define a novel class of cytoskeletal proteins. (rupress.org)
We conclude that the two articulins are related members of a new class of membrane cytoskeletal proteins. (rupress.org)

Utilizing water as a nucleophile, this enzyme catalyzes the cleavage of the phosphodiester bond in structural phospholipids such as phosphatidylcholine and phosphatidylethanolamine. (wikipedia.org)
The binding of SARS-CoV spike (S) protein to cellular angiotensin-converting enzyme 2 (ACE2) is the first step in SARS-CoV infection. (scienceopen.com)
Rhodanese domains, either catalytic or inactive (i.e. where the active-site Cys is replaced by another residue), are also found associated with other protein domains such as MAPK-phosphatases or thiL, an Escherichia coli enzyme involved in thiamin and thiouridine biosynthesis. (expasy.org)

The crystal structures of protein SA0856 from Staphylococcus aureus in its apo-form and in complex with a Zn 2+ -ion have been presented. (rcsb.org)
Structural analyses revealed that all three Echinococcus factors displayed domain structures which are characteristic of the respective protein families. (uni-wuerzburg.de)
However, most PH domain containing proteins appear to be localised in membrane structures. (ucl.ac.uk)
These proteins are involved in signal transduction from ectoderm to mesenchyme during development of the fetus and are indispensable for the differentiation of ectoderm-derived structures such as eccrine sweat glands, teeth, hair, skin, and/or nails. (springer.com)
Mutations of these genes are responsible for systemic tooth agenesis, in addition to the defects of other ectodermal structures, and this review is limited to description of the function of their protein products. (springer.com)
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. (lookformedical.com)
6 LTBP2 gene (LTBP2 [MIM *602091]) has 36 exons encoding 1821 amino acid proteins with multi-domain structures. (org.pk)
The major part of his production relates to variations ranging from protein engineering to effects and mechanisms of variations in protein structures, genes and diseases. (lu.se)
For -lactalbu- min, only water molecules conserved in the human and baboon structures are shown (the structure of the bovine protein has not been reported). (lu.se)

The products of this hydrolysis are the membrane-bound lipid phosphatidic acid (PA), and choline, which diffuses into the cytosol. (wikipedia.org)
Proteins containing this domain have been found to bind PtdIns(4,5)P2 and Ins(1,4,5)P3 suggesting that the domain is a membrane-interacting module. (wikipedia.org)
60% of the peripheral membrane skeleton of Euglena gracilis consists of equimolar amounts of two proteins (articulins) with M(r)s in SDS gels of 80 and 86 kD. (rupress.org)
To understand eventually how these proteins assemble and function in maintaining cell form and membrane integrity we have undertaken a molecular characterization of articulins. (rupress.org)
Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. (hindawi.com)
The main pathway is the cleavage of membrane phospholipids into lysophospholipids by the removal of a fatty acid chain by phospholipase A (PLA1 or PLA2). (hindawi.com)
They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)

The 152 amino acid protein consists of two similar domains with α + β topology. (rcsb.org)
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
Pleckstrin is one of the rare proteins to contains two PH domains. (embl.de)
There are 196127 PH domains in 171590 proteins in SMART's nrdb database. (embl.de)
Rhodanese homology domains are structural modules of about 120 amino acids, which occur in the three major evolutionary phyla [ 9 ]. (expasy.org)
There are 58922 C1 domains in 42393 proteins in SMART's nrdb database. (embl-heidelberg.de)
C1 domains are compact alpha/beta structural units of about 50 amino acids which tightly bind two zinc ions. (embl-heidelberg.de)
We present a comprehensive list of 54 C1 domains occurring singly or doubly in 34 different proteins. (embl-heidelberg.de)
Many C1 domains and C1 domain-containing proteins bind phorbol esters, but many others do not. (embl-heidelberg.de)
Proteins containing typical C1 domains are predicted to be regulated by diacylglycerol, whereas those containing only atypical domains are not. (embl-heidelberg.de)
Two transmembrane domains were predicted in p11.7, and a DNA binding motif was found in p31.7 by amino acid sequence analysis, therefore p11.7 and p31.7 were predicted to be envelope and capsid protein, respectively. (umass.edu)
Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure. (lookformedical.com)
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. (lookformedical.com)
We unravel a coincident mechanism of lipid-induced activation of PI3KC2α at membranes that involves large-scale repositioning of its Ras-binding and lipid-binding distal Phox-homology and C-C2 domains, and can serve as a model for the entire class II PI3K family. (nature.com)

More distally is the globular domain consisting of a 700-800 amino acid residue region. (wikipedia.org)
The anti-HN mAbs all target the globular head of the HN protein and can be organized into 4 competition-binding groups that exhibit epitope diversity. (cdc.gov)
Inferences about hydration have usually been indirect (where the ous structural and dynamic information about the internal peptide chain is not, there is solvent) or have relied on uncertain (buried) and external (surface) hydration of globular proteins in premises. (lu.se)

A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. (scienceopen.com)
c) Peptide maps of the beta-gal fusion protein were similar to peptide maps of Euglena articulins. (rupress.org)
SPIDR was tested using the potent and selective 16-amino acid peptide α -conotoxin MII ligand and the α 3 β 2 -nicotinic acetylcholine receptor (nAChR) isoform. (biomedcentral.com)

The second Zn3-ion is coordinated only by residue His143 from protein molecule and one acetate ion. (rcsb.org)
Site-directed mutagenesis of the γ-aminobutyric acid type A (GABA A ) receptor β 2 subunit has demonstrated that conversion of a conserved glycine residue located at the entrance to the first transmembrane domain into the homologous ρ 1 residue phenylalanine alters the modulating effects of four different i.v. anesthetics: pentobarbital, alphaxalone, etomidate, and propofol. (aspetjournals.org)

Since discovery of teneurins in Drosophila, many other laboratories have independently described the Ten-a and Ten-m/Odz homolog proteins in different vertebrates. (wikipedia.org)

LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
Based on pharmacological and structural commonalities, the dopamine receptor family members includes five people, that are split into two subfamilies: the D1-like family members, composed of D1 and D5 receptors, as well as the D2-like family members, including D2, D3, and D4 receptors [13]. (mycareerpeer.com)
D1-like receptors possess high structural homology across varieties between proteins 445 and 488 [14]. (mycareerpeer.com)

Phospholipase D's principal substrate is phosphatidylcholine, which it hydrolyzes to produce the signal molecule phosphatidic acid (PA), and soluble choline in a cholesterol dependent process called substrate presentation. (wikipedia.org)
Phosphatidic acid is a signal molecule and acts to recruit SK1 to membranes. (wikipedia.org)
TCAPs show structural homology to the CRF family molecule and appears to influence neurite outgrowth and some behaviours relating to stress and anxiety. (wikipedia.org)
A procedure (coupled perturbation procedure, CPP) is introduced as a specific method for calculating the detailed three‐dimensional structure of a protein molecule which has a nummber of amino‐acid substitutions relative to some previously determined "parent" protein structure. (johnshopkins.edu)

Pleckstrin homology domain. (embl.de)

ones which are proposed to involved in the binding of initiation, elongation and termination factors of protein synthesis. (marquette.edu)
Further investigations by Smith concluded that aspirin and indomethacin inhibited synthesis by specifically blocking oxygenation of arachidonic acid. (medscape.com)

Additionally, PA can be converted into a number of other lipids, such as lysophosphatidic acid (lyso-PA) or diacylglycerol, signal molecules which have a multitude of effects on downstream cellular pathways. (wikipedia.org)
Growing proof shows that under pathologic circumstances further, excessive levels of ROS induced by oxidative tension can modify protein, lipids, and DNA to improve their features and activate signaling pathways leading to loss of life of retinal neurons [9]. (mycareerpeer.com)

These findings provide insight into the molecular basis for human antibody recognition of paramyxovirus surface proteins and the mechanisms of SOSV neutralization. (cdc.gov)

Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
Dopamine may be the primary catecholamine within the retina of all species, which can be synthesized through the L-amino acidity tyrosine [11]. (mycareerpeer.com)

Outside the core domain a short hydrophobic region containing four seven-amino acid repeats (consensus: APVTYGA) was identified near the carboxy terminus of the 80-kD articulin, but near the amino terminus of the 86-kD articulin. (rupress.org)
These findings shed new light on hydrophobic stabilization of proteins. (lu.se)
Whereas the N state has been character- taken to imply that hundreds of water molecules penetrate the MG ized at high resolution, many aspects of the D and MG states are protein (except for a relatively small hydrophobic core)5,7,8,17-19. (lu.se)

This led Adams and collaborator Marcelo Ratto at Universidad Austral de Chile to hypothesize that OIF was a single protein factor, conserved across species. (the-scientist.com)
This information is useful for the analyzing genetic relatedness of proteins and species. (wakehealth.edu)
Therefore, several species can be found, differing only in the length and saturation of the acyl or alkyl fatty acid chain [ 7 , 10 ]. (hindawi.com)

The main function of proteins containing this domain appears to be to act as accessory clathrin adaptors in endocytosis, epsin is able to recruit and promote clathrin polymerisation on a lipid monolayer, but may have additional roles in signalling and actin regulation. (wikipedia.org)

The present study unveils the structure-function and evolutionary aspects of 1-aminocyclopropane-1-carboxylic acid deaminase (ACCD) proteins of fungal origin. (springeropen.com)

One clone hybridized to the Minute locus 5E, a region containing the gene for acidic ribosomal protein 7/8 (Burns et al. (marquette.edu)

Blood samples from four affected and nine unaffected family members were drawn after informed consent and poured in labeled ethylene diamine tetra acetic acid (EDTA) tubes. (org.pk)
The lyophilised PlGF is supplied in lyophilized form with carrier-protein (BSA) and can be reconstituted with 50mM acetic acid or PBS/water. (reliatech.de)

Based on this large body of available data, recent research in P. vivax malaria has made use of bioinformatics tools to identify and characterize new potential anti-malarial vaccine candidates by homology comparison (e.g. (biomedcentral.com)
Snow, ME & Amzel, LM 1986, ' Calculating three‐dimensional changes in protein structure due to amino‐acid substitutions: The variable region of immunoglobulins ', Proteins: Structure, Function, and Bioinformatics , vol. 1, no. 3, pp. 267-279. (johnshopkins.edu)

Further the mutated protein secondary structure is predicted and tertiary structure is predicted using homology modeling. (uni-mysore.ac.in)
Results revealed the secondary, tertiary structural changes along with changes in free energy of folding, volume and accessible surface area. (uni-mysore.ac.in)

He is the Professor of Medical Structural Biology at Lund University. (lu.se)

Built tertiary protein models designated as ACCNK1-ACCNK40 have been deposited in the PMDB with accessions PM0083418-39 and PM0083476-93. (springeropen.com)

Amyloidosis results from the accumulation of pathogenic amyloids-most of which are aggregates of misfolded proteins-in a variety of tissues. (medscape.com)

The order of amino acids as they occur in a polypeptide chain. (lookformedical.com)

The production of the major capsid protein of phage c21 was not hindered in the cells harboring AbiQ. (omicsdi.org)

By 1964, after recognition of this basic structure, Bergstrom and colleagues successfully synthesized series 2 prostaglandins from arachidonic acid using sheep seminal fluid. (medscape.com)
Their distinct biosynthetic activity includes an endoperoxidase synthase reaction that oxygenates and cyclizes polyunsaturated fatty acid precursors (eg, arachidonic acid) to form prostaglandin G 2 (PGG2), and a peroxidase reaction that converts PGG2 to prostaglandin H 2 (PGH2), as shown below. (medscape.com)
Cyclooxygenase conversion of arachidonic acid into prostaglandin H2 (PGH2). (medscape.com)

The primary amino acid sequence of a protein is a translated version from its gene sequence which carries important messages and information concealed therein. (springeropen.com)

Furthermore, on the amino acid sequence level, all three factors shared considerable homologies with corresponding host factors. (uni-wuerzburg.de)

Furthermore, using sequence analysis of human genomic DNA, researchers concluded that the amino acids important for catalysis by COX-1 are conserved and are equally important for catalysis by COX-2. (medscape.com)

13 , 14 Despite the presence of amino acid mutations in its receptor binding domain, multiple key amino acids are changed. (medsci.org)
Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been presented. (springer.com)
Novel data were reviewed and discussed on the structure and functions of the components of TNFα-related signaling pathway, the consequences of mutations of the genes encoding these proteins, and the prospect for further investigations, which might elucidate the origin of HED. (springer.com)
Many mechanisms of protein function contribute to amyloidogenesis, including "nonphysiologic proteolysis, defective or absent physiologic proteolysis, mutations involving changes in thermodynamic or kinetic properties, and pathways that are yet to be defined. (medscape.com)

Various stress response proteins (heat shock, phage shock, cold shock) from all phyla. (expasy.org)

Coronaviruses have at least four major structural proteins, including spikes (S), membranes (M), envelopes (E), and nucleocapsid (N) proteins. (medsci.org)

Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
Domain commonly found in eukaryotic signalling proteins. (embl.de)

The primary structure, or amino acid sequence identity, of the proteins between paralogs is ~60% identical and between orthologs is ~90%, whilst between vertebrates and Drosophila or C. elegans is only 33-41% identical. (wikipedia.org)

Structural proteins are all encoded by the 3' terminus of the viral genome. (medsci.org)

C. elegans hypothetical proteins C04D8.1, K06H7.4 and ZK632.12. (embl.de)
S. cerevisiae hypothetical proteins YBR129c and YHR155w. (embl.de)

The quantitative evaluation of protein structure quality was verified with Volume Area Dihedral Angle Reporter server. (uni-mysore.ac.in)
Based on quantitative Western blot analysis, only two of the 45 (4.4%) Pandemrix-vaccinated narcoleptic patients showed specific antibody response against the NS1 protein from the H1N1pdm09 virus, indicating past infection with the H1N1pdm09 virus. (plos.org)

The SH3 domain is a 60 amino acids segment shared by diverse structural and signaling proteins [ 6 ]. (oncotarget.com)

This study describes the identification of the P. falciparum thrombospondin-related apical merozoite protein homologue in P. vivax (PvTRAMP) and examines its potential to be further evaluated as vaccine candidate. (biomedcentral.com)
The analysis was based on the presence or absence of antibody response against non-structural protein 1 (NS1) from H1N1pdm09 virus, which was not a component of Pandemrix vaccine. (plos.org)

The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)

Anatomy6

Organisms8

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes58

Disciplines and Occupations1

Information Science4

Sequence Homology10

Residues15

Putative5

Nucleotide4

Homologs1

CDNA8

Sequences6

Stability10

Similarity2

Encodes3

Heterotrimeric G protei1

Functional2

Conformation4

Kinase8

Substances1

Variety of proteins2

Cytoskeletal4

Enzyme3

Structures9

Membrane7

Domains14

Globular3

Peptide3

Residue2

Homolog1

Receptors3

Molecule4

Pleckstrin1

Synthesis2

Lipids2

Surface proteins1

Tyrosine2

Hydrophobic3

Species3

Endocytosis1

Evolutionary1

Ribosomal1

Acetic acid2

Bioinformatics2

Secondary2

Biology1

Tertiary1

Aggregates1

Occur1

Capsid protein1

Arachidonic acid3

Gene1

Considerable1

Genomic1

Mutations4

Phage1

Membranes1

Eukaryotic2

Vertebrates1

Terminus1

Hypothetical2

Quantitative2

Segment1

Vaccine2

Bind1