• protein
  • The position of the amino-acid change on the UniProtKB canonical protein sequence. (expasy.org)
  • The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. (expasy.org)
  • In addition, knowledge gained in the study of amyloid fibril assembly would increase our understanding of basic aspects of protein folding. (alzforum.org)
  • Now, in a seminal study by the Tycko group, solid state NMR has been used to provide the most extensive and detailed model of fibril structure yet obtained for the amyloid β-protein (Aβ). (alzforum.org)
  • 1. A method for reducing the production of soluble β-amyloid protein (βAP) in a mammalian host which expresses one or more APP isotypes and/or naturally occurring variants, said method comprising administering to the host an amount of a small molecule effective to reduce the amount of a soluble βAP present in a body fluid of the host. (google.com)
  • The plaques are composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers, a protein fold shared by other peptides such as the prions associated with protein misfolding diseases. (wikipedia.org)
  • The amyloid beta region of the protein, located in the membrane-spanning domain, is not well conserved across species and has no obvious connection with APP's native-state biological functions. (wikipedia.org)
  • sequence
  • However the central sequence KLVFFAE is known to form amyloid on its own, and probably forms the core of the fibril. (wikipedia.org)
  • wherein
  • 9. The food composition of claim 1 , wherein the acid is a liquid. (google.com)
  • 10. The food composition of claim 9 , wherein the liquid acid comprises vinegar. (google.com)
  • 11. The food composition of claim 9 , wherein the liquid acid comprises oil extracted from a pepper plant. (google.com)
  • assembly
  • The Tycko model provides a wonderful theoretical foundation for the design of experiments to test the roles of specific amino acids in controlling Aβ assembly. (alzforum.org)
  • study
  • A recent study suggested that APP and its amyloid potential is of ancient origins, dating as far back as early deuterostomes. (wikipedia.org)