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  • peptide
  • Predicted intermolecular associations offer explanations of how mutations producing amino acid substitutions at Glu-22 (the Arctic (Gly), Dutch (Gln), and Italian (Lys) mutations) might affect peptide assembly-there is a disruption of salt-bridges formed between Glu-22 and Lys-16 on each of two antiparallel β-strands in the N-termini of adjoining Aβ monomers. (alzforum.org)
  • Although the amyloid-beta peptide is by far the commonest amyloid subunit implicated in sporadic and rarely in hereditary forms of CAA, a number of other proteins may also be involved in rare familial diseases in which CAA is also a characteristic morphological feature. (nih.gov)
  • Mutations in the APP gene and their relationship to the amino acid sequence of the Aβ peptide. (nih.gov)
  • Synthetic peptide corresponding to beta Amyloid 1-40 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). (abcam.com)
  • Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. (abcam.com)
  • Beta Amyloid 1-40 synthetic 7 amino acid peptide. (abcam.com)
  • Soluble β-amyloid peptide (βAP) is measured in biological fluids at very low concentrations, typically in the range from 0.1 ng/ml to 10 ng/ml. (google.com)
  • 7. A method for reducing soluble β-amyloid peptide (βAP) in a patient suffering from a β-amyloid peptide-related disease, said method comprising administering to the patient an amount of a small molecule effective to reduce the amount of βAP present in a body fluid of the patient. (google.com)
  • protein
  • The position of the amino-acid change on the UniProtKB canonical protein sequence. (expasy.org)
  • The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. (expasy.org)
  • In addition, knowledge gained in the study of amyloid fibril assembly would increase our understanding of basic aspects of protein folding. (alzforum.org)
  • Now, in a seminal study by the Tycko group, solid state NMR has been used to provide the most extensive and detailed model of fibril structure yet obtained for the amyloid β-protein (Aβ). (alzforum.org)
  • 1. A method for reducing the production of soluble β-amyloid protein (βAP) in a mammalian host which expresses one or more APP isotypes and/or naturally occurring variants, said method comprising administering to the host an amount of a small molecule effective to reduce the amount of a soluble βAP present in a body fluid of the host. (google.com)
  • The amyloid beta region of the protein, located in the membrane-spanning domain, is not well conserved across species and has no obvious connection with APP's native-state biological functions. (wikipedia.org)
  • vascular
  • Aβ circulates in plasma, cerebrospinal fluid (CSF) and brain interstitial fluid (ISF) mainly as soluble Aβ40 Senile plaques contain both Aβ40 and Aβ42, while vascular amyloid is predominantly the shorter Aβ40. (wikipedia.org)
  • brains
  • Maybe they lost synapses to amyloid but just had better brains, with more synapses, and, consequently, had more to lose and took longer to lose it? (evmedreview.com)
  • assembly
  • The Tycko model provides a wonderful theoretical foundation for the design of experiments to test the roles of specific amino acids in controlling Aβ assembly. (alzforum.org)
  • study
  • A recent study suggested that APP and its amyloid potential is of ancient origins, dating as far back as early deuterostomes. (wikipedia.org)
  • sporadic
  • The discovery of the apolipoprotein E (ApoE) 4 allele as a major risk factor for sporadic and late-onset familial AD has brought attention to the possible role of ApoE in neurodegenerative conditions. (biomedcentral.com)
  • proteins
  • Most investigators referring to "amyloid" in AD equate the term to Aβ, but amyloid is a more general term and refers to many types of beta-pleated sheet conformation proteins found both systemically and in the central nervous system [ 6 , 7 ]. (pubmedcentralcanada.ca)
  • vivo
  • In addition, neither the in vivo mechanisms of amyloid formation nor the factors required for this process have been properly established. (biomedcentral.com)
  • constituents
  • The data are probably most reminiscent of work by Kisilevsky (1) and others highlighting the role of sulphated constituents of the basement membrane in stimulating amyloid formation and bioactivity. (alzforum.org)
  • form
  • However the central sequence KLVFFAE is known to form amyloid on its own, and probably forms the core of the fibril. (wikipedia.org)
  • cause
  • G variant is located two nucleotides upstream of exon 22 and was shown to cause exon 22 skipping, resulting in a deletion of amino acids Gly1017- Glu1074 of SORL1. (biomedcentral.com)