It acts as a selective and mixed dopamine reuptake inhibitor and releasing agent, and to a lesser extent as a norepinephrine reuptake inhibitor. (wikipedia.org)
Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from synapses , although there may be an exception in the prefrontal cortex , where evidence points to a possibly larger role of the norepinephrine transporter . (cloudfront.net)
The driving force for DAT-mediated dopamine reuptake is the ion concentration gradient generated by the plasma membrane Na + /K + ATPase . (cloudfront.net)
Monoamine2
In the most widely accepted model for monoamine transporter function, sodium ions must bind to the extracellular domain of the transporter before dopamine can bind. (cloudfront.net)
Studies using electrophysiology and radioactive-labeled dopamine have confirmed that the dopamine transporter is similar to other monoamine transporters in that one molecule of neurotransmitter can be transported across the membrane with one or two sodium ions. (cloudfront.net)
Gene2
The dopamine transporter ( DAT ) also ( sodium-dependent dopamine transporter ) is a membrane-spanning protein coded for in the human by the SLC6A3 gene , (also known as DAT1 ), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol . (cloudfront.net)
Evidence for the associations between DAT and dopamine related disorders has come from a type of genetic polymorphism , known as a variable number tandem repeat , in the SLC6A3 gene, which influences the amount of protein expressed. (cloudfront.net)
Agent1
One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. (hedweb.com)
Function1
DAT function requires the sequential binding and co-transport of two Na + ions and one Cl − ion with the dopamine substrate. (cloudfront.net)
Cell1
DAT is a symporter that moves dopamine across the cell membrane by coupling the movement to the energetically-favorable movement of sodium ions moving from high to low concentration into the cell. (cloudfront.net)
Members of the "normally" ageing population can benefit from an increased availability of acetylcholine , improved blood-flow to the brain, increased ATP production and enhanced oxygen and glucose uptake. (hedweb.com)
Back1
One year after that, Vexiau and colleagues reported six women, one of whom never admitted to using amineptine, getting severe acne concentrated in the face, back and thorax, the severity of which varied with the dosage. (wikipedia.org)
Serotonin2
A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome , aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma. (wikipedia.org)
Drugs that reduce the binding of serotonin to transporters ( serotonin reuptake inhibitors , or SRIs) are used to treat mental disorders. (wikipedia.org)