• Extensively drug resistant-tuberculosis is defined as multidrug-resistant tuberculosis that is also resistant to any one of the fluoroquinolones and to at least one of three injectable second-line antibiotics (amikacin, capreomycin or kanamycin). (who.int)
  • A single-dose vial of 2 ml contains amikacin sulfate, base 100 mg equivalent IP. (nicolan.net)
  • For details see https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/heritage-pharmaceuticals-inc-issues-voluntary-nationwide-recall-amikacin-sulfate-injection-usp-1gm4 . (ipro.org)
  • GNPs 10-12 nm and amikacin sulfate were purchased from Sigma Aldrich, USA. (nanochemres.org)
  • The FDA granted approval of Arikayce to Insmed, Inc. The safety and efficacy of amikacin liposome inhalation suspension, an inhaled treatment taken through a nebulizer, was demonstrated in a randomized, controlled clinical trial where patients were assigned to one of two treatment groups. (wikipedia.org)
  • Denna sammanfattande information kommer från utredningsrapport för Arikayce liposomal (amikacin). (janusinfo.se)
  • Utredningsrapport för Arikayce liposomal (amikacin), 23 July 2020, EMA/473660/2020. (janusinfo.se)
  • European public assessment report (EPAR) för Arikayce liposomal (amikacin), 23 July 2020, EMA/473660/2020. (janusinfo.se)
  • Applications for marketing authorisations for Alendronic Acid/Colecalciferol Mylan (alendronic acid/colecalciferol), Arikayce (amikacin), Docetaxel Sun (docetaxel) and Kyndrisa (drisapersen) have been withdrawn. (europa.eu)
  • Amikacin injection is used to treat serious bacterial infections in many different parts of the body. (pharmakhabar.com)
  • Amikacin 500 MG Injection is an aminoglycoside antibiotic used for the short-term treatment of serious bacterial infections of the lungs, skin, abdomen, blood, brain, urinary tract, bones and joints. (pharmakhabar.com)
  • Amikacin Sulphate 500mg Injection is an antibiotic used to prevent or treat a wide variety of bacterial infections. (pharmakhabar.com)
  • Amikacin and gentamicin are the most commonly used in veterinary medicine. (wedgewoodpharmacy.com)
  • Amikacin has a broader spectrum of activity than some of the other members of this group and is often used for bacterial infections resistant to gentamicin. (wedgewoodpharmacy.com)
  • Amikacin is generally preferred over gentamicin for systemic use in neonatal foals. (wedgewoodpharmacy.com)
  • size][/b] [size=8] Discount Amikacin������ � ��������-������� �������� �������� - �����, ��������� � �������� streptomycin, netilmicin, with gentamicin being the most toxic. (dissectpodcast.com)
  • The final pharmacokinetic model analysed 358 amikacin concentrations. (nih.gov)
  • A population pharmacokinetic analysis was performed to develop an integrated pharmacokinetic model of amikacin in plasma and saliva and for the identification of covariates. (bvsalud.org)
  • Amikacin liposome inhalation suspension is the first drug approved under the US limited population pathway for antibacterial and antifungal drugs (LPAD pathway). (wikipedia.org)
  • The US Food and Drug Administration (FDA) granted the application for amikacin liposome inhalation suspension fast track, breakthrough therapy, priority review, and qualified infectious disease product (QIDP) designations. (wikipedia.org)
  • One group of patients received amikacin liposome inhalation suspension plus a background multi-drug antibacterial regimen, while the other treatment group received a background multi-drug antibacterial regimen alone. (wikipedia.org)
  • By the sixth month of treatment, 29 percent of patients treated with amikacin liposome inhalation suspension had no growth of mycobacteria in their sputum cultures for three consecutive months compared to 9 percent of patients who were not treated with amikacin liposome inhalation suspension. (wikipedia.org)
  • Amikacin is an antibiotic medication used for a number of bacterial infections. (wikipedia.org)
  • Amikacin is an aminoglycoside antibiotic that is used to treat serious gram-negative bacterial infections. (wedgewoodpharmacy.com)
  • Amikacin was selected as a proper antibiotic because it is most often used for treating severe hospital-acquired infections with multi drug resistant Gram-negative bacteria. (nanochemres.org)
  • Amikacin is an aminoglycoside antibiotic that is frequently used for the treatment of neonatal late-onset sepsis , for which therapeutic drug monitoring (TDM) is advised. (bvsalud.org)
  • However, due to the concern raised on the conduct of the OECD 201 study which was shown to be the most sensitive to the effects of amikacin, available data do not allow to conclude definitively on the potential risk of amikacin to the environment. (janusinfo.se)
  • Newborn infants apparently absorb small amounts of other aminoglycosides, but serum levels with typical three times daily dosages are far below those attained when treating newborn infections and systemic effects of amikacin are unlikely. (drlact.com)
  • Dr. Olivier's experiences in evaluating and managing large patient cohorts enrolled in bronchiectasis and mycobacterial natural history protocols, as well as his efforts to foster research partnerships with industry, have allowed assessment of novel therapeutic approaches for treating refractory NTM lung disease, such aerosolized liposomal amikacin for inhalation. (nih.gov)
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  • Furthermore, it has been shown that novel delivery systems are capable of increasing the antibacterial activity of amikacin at lower doses when compared to the conventional formulations and also aid in overcoming the development of drug-resistance, which currently is a significant threat to the healthcare system worldwide. (iisc.ac.in)
  • The antibacterial activity of amikacin-GNPs conjugate was investigated by disc diffusion and liquid broth dilution methods. (nanochemres.org)
  • Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection. (wikipedia.org)
  • Systemic amikacin is used to treat serious gram-negative infections. (wedgewoodpharmacy.com)
  • Amikacin is frequently used in topical otic-preparations to treat susceptible bacterial infections (most commonly Pseudomonas Aeruginosa). (wedgewoodpharmacy.com)
  • [ 6 ] In critically ill patients with serious gram-negative infections, higher loading doses and closer monitoring of amikacin levels are required to achieve a peak-to-MIC ratio of greater than 8-10. (medscape.com)
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  • Hypodermic delivery of amikacin is a widely adopted treatment modality for severe infections, including bacterial septicemia, meningitis, intra-abdominal infections, burns, postoperative complications, and urinary tract infections in both paediatric and adult populations. (iisc.ac.in)
  • It is concluded that for intra-abdominal infections, intravenous isepamicin given once daily is as effective as intravenous amikacin given twice daily in combination with metronidazole. (ui.ac.id)
  • Philippi B, Lalisang TJ, Th-Akib H, Setiabudy R, Hudiono J, Darmansjah I. Comparison of the efficacy and safety of isepamicin plus metronidazole and amikacin plus metronidazole in intra-abdominal infections. (ui.ac.id)
  • Using our new decision framework, altered DPF doses were proposed for piperacillin (better PTA with loading dose plus continuous infusion), but not for amikacin (studied and target population were not comparable and risk for toxicity with higher dose). (eur.nl)
  • Following the logistic regression analysis of treatment failure, new amikacin target concentrations were estimated and used in development of an alternative dosing strategy. (nih.gov)
  • The bactericidal properties of amikacin are concentration dependent and there is significant bactericidal activity even after drug concentrations are below the minimum inhibitory concentration (MIC). (wedgewoodpharmacy.com)
  • When using amikacin or other aminoglycoside antibiotics, monitoring of renal function and peak trough drug concentrations can be very useful to decrease the risks of nephrotoxicity. (wedgewoodpharmacy.com)
  • Amikacin is hydrophilic and exhibits a short half-life, which further challenges the delivery of sufficient systemic concentrations when administered by the oral or transdermal route. (iisc.ac.in)
  • Amikacin concentrations in saliva and plasma were quantified with liquid chromatography - tandem mass spectrometry . (bvsalud.org)
  • Within- and between-day imprecision were less than 6% for low to high concentrations of caffeine and amikacin controls and are less than 7.5% for MTX concentrations greater than 0.3 μmol/L and 12.3% at 0.06 μmol/L. The correlation coefficients for caffeine, amikacin, and MTX plotted for the Dimension RxL Max versus the methods used at Quest Diagnostics were 0.973, 0.986, and 0.992, respectively. (elsevierpure.com)
  • Amikacin should be used in smaller doses in the elderly, who often have age-related decreases in kidney function, and children, whose kidneys are not fully developed yet. (wikipedia.org)
  • Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guidelines based on these doses, using piperacillin and amikacin in critically ill children as proof of concept. (eur.nl)
  • In most instances, the course of treatment requires repeated bolus doses of amikacin, prolonged hospitalization, and the presence of a skilled healthcare worker for administration and continuous therapeutic monitoring to manage the severe adverse effects. (iisc.ac.in)
  • The current study focuses on the use of gold nanoparticles (GNPs) as a carrier to enhance the antibacterial effect of amikacin against P. aeruginosa . (nanochemres.org)
  • If you are a supplier of amikacin, this is a great opportunity to reach a wider audience and grow your business. (ecbasis.org)
  • 2020. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540015/11/Amikacin. (hopkinsguides.com)
  • The only Gram-positive bacteria that amikacin strongly affects are Staphylococcus and Nocardia. (wikipedia.org)
  • To examine the pharmacokinetics of amikacin and its pharmacokinetic pharmacodynamic (PKPD) relationship in neonates. (nih.gov)
  • To develop an alternative dosing strategy for amikacin in neonates. (nih.gov)
  • Therapeutic drug monitoring of amikacin in preterm and term neonates with late-onset sepsis. (bvsalud.org)
  • TDM of amikacin using saliva samples results in target attainment comparable to plasma samples and may be beneficial for (premature) neonates with late-onset sepsis . (bvsalud.org)
  • Systemic use of amikacin and other aminoglycoside antibiotics are usually reserved for serious illnesses because of the risk of nephrotoxicity and ototoxicity. (wedgewoodpharmacy.com)
  • Amikacin trough levels of more than 10 mcg/mL have been associated with significant ototoxicity and nephrotoxicity. (medscape.com)
  • [ 8 ] In one study, pharmacokinetic dosing with maintenance of trough levels below 1 mcg/mL significantly reduced the incidence of nephropathy with amikacin. (medscape.com)
  • The examples outlined within the review provides significant pieces of evidence on novel amikacin formulations in the field of antimicrobial research paving the path for future therapeutic interventions that will result in improved clinical outcome. (iisc.ac.in)
  • Methods: Piperacillin and amikacin pharmacokinetic models in critically ill children were extracted from literature. (eur.nl)
  • Results: Three studies for piperacillin (critically ill children) and one for amikacin (critically ill pediatric burn patients) were included. (eur.nl)
  • The objective of the present study is to compare the efficacy and safety of isepamicin (15 mg/kgBW IV o.d.) with amikacin (7.5 mg/kgBB b.i.d.), in conjunction with metronidazole for both drugs. (ui.ac.id)
  • In the safety and efficacy population, the clinical success rare for isepamicin and amikacin group did not differ significantly (i.e., 95% and 100%, respectively). (ui.ac.id)
  • The rates of bacteriological elimination for isepamicin and amikacin, were 95% and 100%, respectively in the efficacy and safety population, and 90% and 93%, respectively in the intent-to-treat population. (ui.ac.id)
  • Immunoassay techniques are the preferred methods of measurement of serum amikacin levels and produce comparable results with other testing techniques such as gas chromatography and microbiological assays. (medscape.com)
  • Serum amikacin levels are used to guide therapy to ensure adequate but not excessive levels. (medscape.com)
  • While it is known to cross the placenta, amikacin is only partially secreted in breast milk. (wikipedia.org)
  • Does Amikacin extracts into breast milk? (drlact.com)
  • In the intent-to-treat population, the clinical success rates for isepamicin and amikacin group were also insignifficantly different (i.e., 97% and 100%, respectively). (ui.ac.id)
  • Amikacin is also used for ophthalmic preparations, regional limb perfusion, joint lavage, and intra-articular injections. (wedgewoodpharmacy.com)
  • The mechanism of action for amikacin is through disruption of the bacterial cell wall, irreversible binding of the 30S ribosomal subunit, and inhibition of bacterial protein synthesis. (wedgewoodpharmacy.com)
  • The current review presents a comprehensive overview of the developmental history of amikacin, the mechanism of action in virulent strains as well as the occurrence of resistance, and various emerging drug delivery solutions developed both by the academia and the industry. (iisc.ac.in)
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  • In general, amikacin should be avoided in infants. (wikipedia.org)
  • Does Amikacin has any long term or short term side effects on infants? (drlact.com)
  • Older infants would be expected to absorb even less amikacin. (drlact.com)
  • Amikacin inhibits bacterial growth by binding to the 30S subunit of bacterial ribosomes and inhibiting protein synthesis. (medscape.com)
  • Conclusion: Amikacin can be considered very persistent. (janusinfo.se)
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  • The zone of growth inhibition of amikacin-GNPs complex and amikacin by disc diffusion method were 37± 0.118 and 35± 0.149 mm. (nanochemres.org)
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