DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
Leukemia, Biphenotypic, AcuteMyeloid-Lymphoid Leukemia ProteinImmunophenotypingLeukemiaLeukemia, Myeloid, AcutePrecursor Cell Lymphoblastic Leukemia-LymphomaHistone-Lysine N-MethyltransferaseRetinoblastoma Binding Proteins
Myeloid leukemiaPhenotype acute leukemiaALALLymphoidMPALChemotherapyClassificationMorphologyMalignantDiagnosisExtremely rareCasesPatientsLymphoblastic leukemiaMixed-phenotype acute leukemiaMyeloid and lymphoidClassificationLeukaemiaImmatureChromosomeMarkersClinical characteristicsBlastRearrangementsChildrenTreatmentGeneCellsRareReport
Myeloid leukemia3
  • If the score of only one lineage is higher than 2, the acute leukemia could be acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL). (wikipedia.org)
  • The 2016 WHO update also emphasizes that for bilineal MPAL, it is more important that each individual blast population would meet the criteria for B, T, or myeloid leukemia, than that the specific markers below be present. (medscape.com)
  • This diagnosis should not be made in patients with known chronic myeloid leukemia (CML) who progress to the blast phase with features of MPAL. (medscape.com)
Phenotype acute leukemia1
  • Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34;q11.2) (or BCR-ABL1 rearrangement) is also rare, accounting for less than 1% of acute leukemias. (medscape.com)
ALAL2
  • These cases are characterized as acute leukemias of ambiguous lineage (ALAL). (medscape.com)
  • Acute leukemias of ambiguous lineage, not otherwise specified (ALAL-NOS) is a rare type of acute leukemia. (biomedcentral.com)
Lymphoid3
  • Biphenotypic acute leukaemia (BAL) is an uncommon type of leukemia which arises in multipotent progenitor cells which have the ability to differentiate into both myeloid and lymphoid lineages. (wikipedia.org)
  • The cells could display both myeloid lineage and lymphoid or undifferentiated morphology. (wikipedia.org)
  • According to the original EGIL scoring system BAL is defined when scores are over two points for both myeloid and T- or B- lymphoid lineages. (wikipedia.org)
MPAL1
  • however, the 2016 WHO criteria for lineage assessment in MPAL are presented in Table 1. (medscape.com)
Chemotherapy1
Classification1
  • Before 2008, the diagnosis of BAL was based on a score system proposed by the European Group for the Immunological Classification of Leukemias (EGIL) which could differentiate from other kinds of acute leukemia. (wikipedia.org)
Morphology1
Malignant1
  • and (2) those in which the malignant (blast) clone coexpresses lineage-specific markers (formerly known as biphenotypic acute leukemias). (medscape.com)
Diagnosis1
  • As with chronic myelogenous leukemia (CML) , the myeloproliferative aspect of SCLL has a chronic phase that transforms into a myeloblastic phase, typically within 1 year of diagnosis. (medscape.com)
Extremely rare1
  • Acute undifferentiated leukemia (AUL) is extremely rare, and little is known about the frequency of this disease. (medscape.com)
Cases2
  • About 5% of acute leukaemia cases are BAL. (wikipedia.org)
  • [ 4 ] Cases of acute leukemia that may be classified in another category based on genetic or clinical features are also excluded (eg, AML with translocation t(8;21) and expression of multiple B-cell markers). (medscape.com)
Patients1
  • Findings consistent with chronic myelomonocytic leukemia have been noted in at least several patients. (medscape.com)
Lymphoblastic leukemia11
  • The different treatment regimens for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) make ALAL a challenge both diagnostically and therapeutically. (nih.gov)
  • Genomic and expression profile data for MPAL reveal mutations commonly seen in both AML and ALL, with T-/myeloid MPAL showing overlapping features with early T-cell precursor lymphoblastic leukemia. (nih.gov)
  • 13. [Clinical characteristics and outcomes of 59 patients with acute lymphoblastic leukemia positive for BCR/ABL]. (nih.gov)
  • If the score of only one lineage is higher than 2, the acute leukemia could be acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL). (wikipedia.org)
  • Precursor Lymphoblastic Leukemia Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. (nih.gov)
  • It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia. (nih.gov)
  • Acute Lymphoblastic Leukemia by Gene Expression Signature Gene expression-based patient cluster groups in acute lymphoblastic leukemia. (nih.gov)
  • 1. De Braekeleer E, Douet-Guilbert N, Le Bris MJ, Basinko A, Morel F, De Braekeleer M. Gene expression profiling of adult t(4;11)(q21;q23)-associated acute lymphoblastic leukemia reveals a different signature from pediatric cases. (sciendo.com)
  • Immunophenotypic and genotypic features, clinical characteristics and treatment outcome of adult pro-B acute lymphoblastic leukemia: results of the German multicenter trials GMALL03/87 and 04/89. (sciendo.com)
  • Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement. (sciendo.com)
  • CD10- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL). (sciendo.com)
Mixed-phenotype acute leukemia9
  • Several recent studies have explored the genomic and epigenetic landscape of mixed-phenotype acute leukemia (MPAL) and have suggested a further refinement of the World Health Organization classification to emphasize the genomic heterogeneity of MPAL. (nih.gov)
  • 6. Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force. (nih.gov)
  • 9. Multiparameter flow cytometry applications in the diagnosis of mixed phenotype acute leukemia. (nih.gov)
  • 10. [Immunophenotypic Features and Clinical Prognosis of Patients with Mixed Phenotype Acute Leukemia]. (nih.gov)
  • 11. Genomic Landscape of Mixed-Phenotype Acute Leukemia. (nih.gov)
  • 14. [Diagnosis and treatment efficacy analysis of 29 children with mixed phenotype acute leukemia]. (nih.gov)
  • 15. [Study on the clinical characteristics of 32 patients with mixed phenotype acute leukemia]. (nih.gov)
  • 18. Mixed phenotype acute leukemia: Biological profile, clinical characteristic and treatment outcomes: Report of the population-based study. (nih.gov)
  • Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34;q11.2) (or BCR-ABL1 rearrangement) is also rare, accounting for less than 1% of acute leukemias. (medscape.com)
Myeloid and lymphoid3
  • Biphenotypic acute leukaemia (BAL) is an uncommon type of leukemia which arises in multipotent progenitor cells which have the ability to differentiate into both myeloid and lymphoid lineages. (wikipedia.org)
  • Malignant C6923 Acute Bilineal Leukemia Acute Bilineal Leukemia An acute leukemia of ambiguous lineage in which there is a dual population of blasts with each population expressing markers of a distinct lineage (myeloid and lymphoid or B-and T-lymphocyte). (nih.gov)
  • Acute Leukemia of Indeterminate Lineage An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells. (nih.gov)
Classification3
  • Classification of acute leukemia involves assigning lineage by resemblance to normal progenitor cells. (nih.gov)
  • Current classification criteria have reduced the reported incidence of mixed-lineage leukemias by emphasizing fewer markers and categorizing some biphenotypic leukemias with recurrent cytogenetic abnormalities as other entities. (nih.gov)
  • Before 2008, the diagnosis of BAL was based on a score system proposed by the European Group for the Immunological Classification of Leukemias (EGIL) which could differentiate from other kinds of acute leukemia. (wikipedia.org)
Leukaemia2
  • 16. [Study on the clinical characteristics of adult biphenotypic acute leukaemia]. (nih.gov)
  • About 5% of acute leukaemia cases are BAL. (wikipedia.org)
Immature2
  • Leukemia Basophilic A rare acute myeloid leukemia in which the immature cells differentiate towards basophils. (nih.gov)
  • M6 Acute Myeloid Leukemia An acute myeloid leukemia characterized by a predominant immature erythroid population. (nih.gov)
Chromosome2
  • 4. [Clinical and laboratorial analysis for 15 adult cases of mixed phenotypic acute leukemia with Ph chromosome and/or positive BCR-ABL]. (nih.gov)
  • Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. (sciendo.com)
Markers2
  • and (2) those in which the malignant (blast) clone coexpresses lineage-specific markers (formerly known as biphenotypic acute leukemias). (medscape.com)
  • [ 4 ] Cases of acute leukemia that may be classified in another category based on genetic or clinical features are also excluded (eg, AML with translocation t(8;21) and expression of multiple B-cell markers). (medscape.com)
Clinical characteristics3
  • 1. Clinical Characteristics And Outcome Of Biphenotypic Acute Leukemia: 10 Case Reports And Literature Review. (nih.gov)
  • 7. Biphenotypic acute leukemia or acute leukemia of ambiguous lineage in childhood: clinical characteristics and outcome. (nih.gov)
  • 12. [Study on the clinical characteristics of biphenotypic acute leukemia]. (nih.gov)
Blast1
  • Characterization of the blast cells in acute leukemia with translocation (4;11): report of eight additional cases and of one case with a variant translocation. (sciendo.com)
Rearrangements2
  • 8. The Superiority of Allogeneic Hematopoietic Stem Cell Transplantation Over Chemotherapy Alone in the Treatment of Acute Myeloid Leukemia Patients with Mixed Lineage Leukemia (MLL) Rearrangements. (nih.gov)
  • Acute myeloid leukemia with MLL rearrangements: clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells. (sciendo.com)
Children2
  • Most of biphenotypic leukemia in children is due to the rearrangement of MLL Besides them, other gene abnormalities has been reported. (wikipedia.org)
  • MLL genomic breakpoint distribu- tion within the breakpoint cluster region in de novo leukemia in children. (sciendo.com)
Treatment1
  • Biology and treatment of infant leukemias. (sciendo.com)
Gene3
  • The hybrid gene product ABL/BCR is an oncogene which could lead several types of leukemia including BAL. (wikipedia.org)
  • 2. De Braekeleer M, Morel F, Le Bris MJ, Herry A, Douet-Guilbert N. The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia. (sciendo.com)
  • Identification of complex genomic breakpoint junctions in thet(9;11) MLL-AF9 fusion gene in acute leukemia. (sciendo.com)
Cells1
  • Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to decreased immunity, susceptible to infection. (wikipedia.org)
Rare1
  • Acute undifferentiated leukemia (AUL) is extremely rare, and little is known about the frequency of this disease. (medscape.com)
Report1
  • Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. (sciendo.com)